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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Exposure of aboriginal people to methylmercury due to gold mining in the Amazon, Brazil

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journal of Environmental Sciences 2000年第S1期12卷 45-50页

作者： Hirokatsu Akagi 1, Koichi Haraguchi 1, Yoshihide Kinjo 1, olaf Malm 2, fernando j. P. branches 2, jeans R. j. Guimaraes 2 (1.National Institute for Minamata Disease, Minamata, Kumamoto 867, japan 2. Institute de Biofisica Carlos Chagas Filho,

This paper outlines the results of our study aiming at evaluating the actual extent of human exposure to Hg mainly in Tapajos River Basin in central Amazonia, which is considered to be the oldest and most productive gold mining area in the Amazon. Human hair and blood as well as fish samples were collected from gold mining areas and various fishing villages located at different distances from main gold mining areas, and analyzed for total mercury(T Hg) and methylmercury (MeHg) with new methods recently being developed in our laboratory. The results to date showed the inhabitants of fishing villages particularly in the upstream Tapajos areas were constantly exposed to MeHg at abnormally high levels, with little confounding exposure to inorganic Hg. A highly significant correlation between Hg in hair and blood was observed in fishing villages, and the ratios of hair Hg to blood Hg were very close to 250g, generally established for MeHg. While, the levels of MeHg in hair and blood of gold miners and goldshop workers were low, indicating that they were mainly exposed to Hg in inorganic form. From these data, together with the levels of MeHg in fish, Hg contamination mechanisms are discussed.

关键词： methylmercury pollution human exposure gold mining Amazon

Hidden in plain sight:Morphological and phylogenetic evidence for Bouteloua arizonica,a species distinct from Bouteloua aristidoides(Poaceae,Chloridoideae)

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Plant Diversity 2021年第2期43卷 125-133页

作者： Luis fernando Cuellar-Garrido Maria Elena Siqueiros-Delgado Herbario Luz Maria Villarreal de Puga Del Instituto de Botanica(IBUG) Departamento de Botanica y ZoologíaCentro Universitario de Ciencias Biologicas y AgropecuariasUniversidad de GuadalajaraCamino Ing.Ramon Padilla Sanchez 2100CP 45200ZapopanJaliscoMexico Departamento de Biologia Centro de Ciencias BioasicasUniversidad Autonoma de AguascalientesAvenida Universidad 940CP 20131AguascalientesMexico

Two varieties of Bouteloua aristidoides have been recognized,the widespread *** and the more narrowly distributed *** two varieties differ in inflorescence form even more than that seen between many other closely related species of *** therefore asked whether these taxa might be better regarded as distinct species.A total of 93 vouchers were studied by using morphometry(principal components analysis and statistical tests),leaf micromorphology,ancestral state reconstruction,and/or molecular(ITS,trnC-rpoB and trnT-L-F)phylogenetic *** from the ITS tree,all results supported elevation of *** *** to the rank of species,thus the new combination Bouteloua arizonica(***)***&Columbus *** ***.,is *** and combined chloroplast-nuclear molecular trees depicted *** as monophyletic(even in sympatric populations with ***)and reveals phylogenetic structure within *** for which the presence of new undescribed varieties of ***(different from ***)is *** differs from *** in having fewer branches per inflorescence,a bigger branch with more spikelets,and a shorter branch *** electron microscopy revealed the presence of papillae on leaves of *** as a clear *** mature plants of *** from seeds in a greenhouse revealed a strong cleistogamous nature for this species for which gene flow in sympatric populations with *** seems unlikely.A taxonomic treatment and distribution map for identification of *** is provided.

关键词： Ancestral state reconstruction Bouteloua arizonica Cleistogamy Morphology Phylogeny Sympatry

Blood pressure gradients in cerebral arteries:a clue to pathogenesis of cerebral small vessel disease

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Stroke & Vascular Neurology 2017年第3期2卷 108-117页

作者： Pablo j Blanco Lucas o Müller j David Spence National Laboratory for Scientific Computing PetrópolisBrazil National Institute of Science and Technology in Medicine Assisted by Scientific Computing INCT-MACCPetrópolisBrazil Stroke Prevention&Atherosclerosis Research Centre Robarts Research InstituteWestern UniversityLondon

rationale The role of hypertension in cerebral small vessel disease is poorly *** the base of the brain(the‘vascular centrencephalon’),short straight arteries transmit blood pressure directly to small resistance vessels;the cerebral convexity is supplied by long arteries with many branches,resulting in a drop in blood *** small vessel disease(lipohyalinosis)causes the classically described lacunar infarctions at the base of the brain;however,periventricular white matter intensities(WMIs)seen on MRI and WMI in subcortical areas over the convexity,which are often also called‘lacunes’,probably have different *** We studied pressure gradients from proximal to distal regions of the cerebral vasculature by mathematical *** and results Blood flow/pressure equations were solved in an Anatomically Detailed Arterial Network(ADAN)model,considering a normotensive and a hypertensive *** parameters were suitably modified to account for structural changes in arterial vessels in the hypertensive *** predict a marked drop in blood pressure from large and medium-sized cerebral vessels to cerebral peripheral *** blood pressure in the brachial artery is 192/113 mm Hg,the pressure in the small arterioles of the posterior parietal artery bed would be only 117/68 mm *** the normotensive case,with blood pressure in the brachial artery of 117/75 mm Hg,the pressure in small parietal arterioles would be only 59/38 mm *** These findings have important implications for understanding small vessel *** marked pressure gradient across cerebral arteries should be taken into account when evaluating the pathogenesis of small WMIs on *** small vessel disease,affecting the arterioles at the base of the brain should be distinguished from small vessel disease in subcortical regions of the convexity and venous disease in the periventricular white matter.

关键词： cerebral Blood pathogenesis

PGE mineralization and melt composition of chromitites in Proterozoic ophiolite complexes of Eastern Sayan,Southern Siberia

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Geoscience Frontiers 2017年第4期8卷 721-731页

作者： o.Kiseleva S.Zhmodik V.S.Sobolev Institute of Geology and Mineralogy SB RAS Novosibirsk State University

The ospino-Kitoi and Kharanur ultrabasic massifs represent the northern and southern ophiolite branches respectively of the Upper onot ophiolitic nappe and they are located in the southeastern part of the Eastern Sayan（SEPES ophiolites）.Podiform chromitites with PGE mineralization occur as lensoid pods within dunites and rarely in harzburgites or serpentinized *** chromitites are classified into type I and type Ⅱ based on their Cr~#.Type I（Cr~# = 59-85） occurs in both northern and southern branches,whereas type Ⅱ（Cr~# = 76-90） occurs only in the northern *** contents range from ∑PGE 88-1189 ppb,Pt/Ir0.04-0.42 to ∑PGE 250-1700 ppb,Pt/Ir 0.03-0.25 for type I chromitites of the northern and southern branches *** type Ⅱ chromitites of the northern branch have ∑PGE contents higher than that of type Ⅰ（468-8617 ppb,Pt/Ir 0.1-0.33）.Parental melt compositions,in equilibrium with podiform chromitites,are in the range of boninitic melts and vary in Al_2o_3,Tio_2 and Feo/Mgo contents from those of type I and type Ⅱ *** melt compositions for type Ⅰ chromitites are（Al_2o_3）_（melt） = 10.6—13.5 wt.%,（Tio_2）_（melt） = 0.01-0.44 wt.%,（Fe/Mg）_（melt） = 0.42-1.81;those for type Ⅱ chromitites are：（Al_2o_3）_（melt） = 7.8-10.5 wt.%,（Tio_2）_（melt） = 0.01-0.25 wt.%,（Fe/Mg）_（melt） = *** are further divided into os-Ir-Ru（Ⅰ） and Pt-Pd（Ⅱ） based on their PGE *** type Ⅰ chromitites show only the os-Ir-Ru pattern whereas type Ⅱ shows both os-Ir-Ru and Pt-Pd *** mineralization in type Ⅰ chromitites is represented by the os-Ir-Ru system,whereas in type Ⅱ it is represented by the os-Ir-Ru-Rh-Pt *** results indicate that chromitites and PGE mineralization in the northern branch formed in a suprasubduction setting from a fluid-rich boninitic melt during active ***,the chromitites and PGE mineralization of the southern branch could have formed in a spreading zone *** peridotites have

关键词： Chromitites PGE mineralization os-Ir-Ru and Pt-Pd patterns ophiolite Eastern Sayan Parental melt

Changes in leaflet shape and seeds per pod modify crop growth parameters, canopy light environment, and yield components in soybean

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The Crop journal 2020年第2期8卷 351-364页

作者： julieta S.Bianchi Alvaro Quijano Carlos o.Gosparini Laboratorio de Fisiología Vegetal Facultad de Ciencias AgrariasUniversidad Nacional de Rosario(UNR)Campo Experimental J.VillarinoP.O.Box 142125 ZavallaSanta FeArgentina Instituto de Investigaciones en Ciencias Agrarias de Rosario(IICAR) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)–UNRCampo Experimental J.VillarinoP.O.Box 142125 ZavallaSanta FeArgentina Consejo de Investigaciones de la UNR(CIUNR) Campo Experimental J.VillarinoP.O.Box 142125 ZavallaSanta FeArgentina

Seed number(SN)is the component most strongly associated with yield in *** depends on pod number(PN)and seeds per pod(SPP).Whereas SPP is a relatively stable component,PN is strongly influenced by environmental and management ***,the environmental cues involved in PN regulation are not completely *** influence of increasing SPP on other yield components is *** trials were conducted in two growing seasons using two pairs of lanceolate(L)and ovate(o)nearisogenic lines,sown at low(LD)and high(HD)plant densities to evaluate the effect of leaflet shape on crop growth parameters,canopy red/far-red(R/FR)ratio,their relationships with pod initiation,PN,and yield;and the effect of increasing SPP on PN,SN,and yield.L canopies showed a higher number of pods initiated(PI)than o canopies owing to the increase of PI on *** association between PI and crop growth rate during the pod set period was *** was negatively associated with leaf area index(LAI)and light *** contrast,a positive association between PI and canopy R/FR ratio was *** latter association was sustained irrespective of whether the LAI was below or above its critical value,providing experimental evidence that R/FR ratio is positively associated with pod initiation in soybean *** increase in SPP produced a direct and steady increase in SN regardless of PN and plant density.A yield increase was observed for the L-LD treatment,which combined the increased SPP of L lines with the highest PN of L-LD *** results have implications for crop management and breeding strategies aimed at increasing the yield potential of soybean.

关键词： soybean breeding shape

Effect of Different Sowing Dates on Disease Initiation and Development of Roselle (Hibiscus sabdariffaL.) Leaf Spot Disease Caused by Coniella musaiensisVar. hibisciin Makurdi, Central Nigeria

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journal of Geoscience and Environment Protection 2017年第11期5卷 94-101页

作者： K.D.Apeyuan A.o.Nwankiti o.A.H.oluma E.j.Ekefan Department of Integrated Science College of EducationKatsina-AlaNigeria Department of Crop and Environmental Protection University of Agriculture MakurdiNigeria Department of Biological Sciences University of Agriculture MakurdiNigeria

The experiment was conducted mainly to investigate the effect of change in sowing dates on disease severity of Roselle (Hibiscus sabdariffa L) leaf spot caused by Coniella musaiensis Var hibisci, plant height, number of branches, number of fruits and calyx yield of Roselle (H. sabdariffa L). Five dates were selected with an interval of fourteen days (14) between the dates for two years (2003 and 2004) to determine the most appropriate time to sow the crop using two Roselle accessions;green (Acc1) and red (Acc3).The first date was determined by the establishment of the rains in the season. It was observed that change in sowing dates had significant (p = 0.05) effect on disease severity but not on plant height, number of branches, number of fruits and calyx yield. Plants sown on july 18/27 had lowest disease indices;and are thus the best and therefore recommended for cropping of Roselle.

关键词： Accession Sowing Date Disease Severity Hibiscus sabdariffa L. Yield. Coniella musaiensis Var hibisci

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柑桔体细胞杂种对柑桔脚腐病的抗病性研究

植物病理学报 1997年第4期27卷 361-364页

作者：周长河邓秀新 Grosser j.o.W 华中农业大学柑桔研究所美国弗罗里达大学柑桔研究与教育中心

本文采用叶片接种法和枝条接种法对２５个柑桔种类体细胞杂种或品种进行了抗脚腐病鉴定，结果表明：体细胞杂种中枳＋酸橙、枳＋甜橙为高抗类型；酸橙＋兰普来檬、枳＋印度酸桔；蚝壳刺＋哈姆甜橙、酸橙＋澳洲指桔为抗性；酸橙＋印度酸... 详细信息

本文采用叶片接种法和枝条接种法对２５个柑桔种类体细胞杂种或品种进行了抗脚腐病鉴定，结果表明：体细胞杂种中枳＋酸橙、枳＋甜橙为高抗类型；酸橙＋兰普来檬、枳＋印度酸桔；蚝壳刺＋哈姆甜橙、酸橙＋澳洲指桔为抗性；酸橙＋印度酸桔为中抗。建立了叶片接种法的抗病性分级标准。初步分析了柑桔体细胞杂种的抗性规律。

关键词：柑桔体细胞杂种脚腐病抗病性柑桔类果树

整体护理剪切式用于基层医院—健康教育的应用

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实用医技杂志 2002年第7期9卷 554-555页

作者：纪春静武警黄金第七支队医院山东烟台264001

基层医院在我国占一定比例 ,其特点是危重病人少 ,常见病、多发病就诊率高。随着新的医疗模式的诞生 ,人们的健康意识日趋完善 ,逐步认识到人是“生物 -心理 -社会”的人 ,要达到真正意义上的健康 ,就需要对病人进行全方位的护理即整体... 详细信息

基层医院在我国占一定比例 ,其特点是危重病人少 ,常见病、多发病就诊率高。随着新的医疗模式的诞生 ,人们的健康意识日趋完善 ,逐步认识到人是“生物 -心理 -社会”的人 ,要达到真正意义上的健康 ,就需要对病人进行全方位的护理即整体护理。其中健康教育已成为主角 ,且有“廉价的保健对策”之称。把整体护理剪切化 ,其中适合基层的部分—健康教育引入基层 ,从而提高护理水平。

关键词：健康教育整体护理应用