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Journal of Oceanology and Limnology 2022年第2期40卷 703-711页

作者： fernando gómez Department of Biological and Environmental Sciences and Technologies University of SalentoLecce 73100Italy

Three species of dinophysoid planktonic dinoflagellates are described from the eastern Mediterranean *** *** was collected at 70-m depth in the Ionian *** small species showed a more asymmetric midbody and a proportionally longer neck when compared to the closer relative *** individuals of Dinofurcula tricornuta *** at 154-m depth in the Marmara Sea are characterized by three posterior-oriented processes when compared to its congeneric *** is the first record of the genus Dinofurcula beyond the eastern tropical Pacific *** profunda *** at 500-m depth in the Ionian Sea is characterized by ovate hypotheca and a serrate crest-like left sulcal list when compared to its close relative *** findings evidence an undescribed biodiversity in the under-sampled subphotic depths.

关键词： deep ocean Dinophyta Dinoflagellata Mediterranean Sea mesopelagic new species

Dicroerisma (Actiniscales, Dinophyceae) in the open Pacific Ocean, a gymnodinioid dinoflagellate with an endoskeleton

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Chinese Journal of Oceanology and Limnology 2008年第1期26卷 116-120页

作者： fernando gómez Station Marine de Wimereux Université des Sciences et Technologies de Lille-Lille1 FRE 2816 ELICO CNRS 28 Avenue Foch BP 80 F-62930 Wimereux France

This study is the first to describe and illustrate the dinoflagellate genus Dicroerisma in the open Pacific Sea and in the southern hemisphere. Eleven individuals ascribed to Dicroerisma psilonereiella were encountered in subsurface waters (>70 m depth) from 34°N to 33°S. Another specimen that differs from the type is also illustrated. These findings reveal that Dicroerisma is a widespread genus and that there is tentative existence of another species within the genus.

关键词： Dicroerisma psilonereiella Actiniscales axostyle endoskeleton Dinophyceae the Pacific Ocean

Locoregional therapy and systemic cetuximab to treat colorectal liver metastases

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World Journal of gastrointestinal Oncology 2015年第6期7卷 47-54页

作者： giammaria Fiorentini Camillo Aliberti Donatella Sarti Paolo Coschiera Massimo Tilli Luca Mulazzani Paolo giordani Francesco graziano Alfonso Marqués gonzalez Raul garcía Marcos fernando gómez Mugnoz Maurizio Cantore Stefano Ricci Vincenzo Catalano Andrea Mambrini Oncology Unit Azienda Ospedaliera "Ospedali Riuniti Marche Nord"San Salvatore Hospital Oncology Radiodiagnostics Oncology Institute of VenetoInstitute for the Research and Treatment of Cancer (IRCC) Diagnostics for Images Unit and Interventional Radiology Azienda Ospedaliera "Ospedali Riuniti Marche Nord" Diagnostics for Images and Interventional Radiology Azienda USL of FerraraDelta Hospital Unit of Anestesiology La Fe University Hospital and Polytechnic Medical Imaging and Interventional and Vascular Radiology La Fe University Hospital and Polytechnic Medical Imaging Center (CDIC) Provincial Clinic Hospital Oncology Unit Azienda Ospedaliera "Carlo Poma" Department of Vascular and Interventional Radiology INRCA Hospital-IRCCS Oncology Unit Carrara General Hospital

AIM: To investigate efficacy and safety of second-line treatment with irinotecan-loaded drug-eluting beads(DEBIRI) and cetuximab(DEBIRITUX) of unresectable colorectal liver ***: Patients with the following characteristics were included in the study: unresectable hepatic metastases from colorectal carcinoma(CRC-LM), progression after first line chemotherapy(any type of chemotherapeutic drug and combination was allowed), second line treatment(mandatory), which included for each patient(unregarding the KRas status) two cycles of DEBIRI(using 100-300 μm beads loaded with irinotecan at a total dose 200 mg) followed by 12 cycles of cetuximab that was administered weekly at a first dose of 400 mg/m2 and then 250 mg/m2; good performance status(0-2) and liver functionality(alanine aminotransferase and gamma-glutamyl transferase not exceeding three times the upper limit of normal, total bilirubin not exceeding 2.5 mg/m L). Data were collected retrospectively and included: tumor response(evaluated monthly for 6 mo then every 3 mo), overall response rate(ORR), KRas status, type and intensity of adverse events(g according to the Common Terminology Criteria for Adverse Events v3.0, CTCAE), overall survival(OS) and progression free survival(PFS).RESULTS: Forty consecutive cases of CRC hepatic metastases were included in the study. Median duration of DEBIRITUX was 4.4 mo(range, 4.0-6.5). Sixteen patients(40%) received the planned 2 cycles of DEBIRI and an average of 10 cetuximab cycles. ORR of the whole sample was 50%, in particular 4 patients were complete responders(10%) and 16(40%) partial responders. The most observed side effects(g2) were: post-embolization syndrome(30%), diarrhea(25%), skin rushes(38%) and asthenia(35%). The retrospective evaluation of KRas status(24 wild type, 16 mutated) showed that the group of patients with wild type KRas had ORR significantly higher than mutant KRas. Median follow-up was 29 mo(8-48 range); median PFS was 9.8 mo and OS was

关键词： Cetuximab Irinotecan-loaded drug-elutingbeads Hepatic metastases Chemoembolization Colonrectal tumor Irinotecan

Percutaneous Ultrasound-guided Radiofrequency Thermal Ablation for Treatment of Uterine Fibroids

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Open Journal of Obstetrics and gynecology 2014年第12期4卷 716-724页

作者： Raúl garcía Marcos Javier Monleón Alicia Martínez-Varea fernando gómez guillermina Montoliú Jose J. Martínez Luis Martí-Bonmatí Antonio Pellicer Department Obstetrics and gynecology La Fe University Hospital Valencia Spain Department of Radiology Hospital Clinic Barcelona Spain Department of Radiology La Fe University Hospital Valencia Spain

Purpose: To assess the safety, efficacy and effectiveness of percutaneous radiofrequency (RF) thermal ablation to reduce symptoms of uterine fibroids. Materials and Methods: 17 premenopausal women with symptomatic uterine fibroids despite conventional medical treatment were included. The assessment of symptoms and characteristics of fibroids by vaginal ultrasound, magnetic resonance imaging (MRI) and contrast enhanced ultrasound (CEUS) was performed before starting treatment and 6 months after the procedure. Successful treatment was clinically considered if patients reported a reduction in symptoms 6 months after RF myolysis. Successful treatment was also considered if the necrosis of the fibroid was greater than 50%, 6 months after treatment. Results: The baseline score on visual analogue scale (VAS) for dysmenorrhea and intermenstrual pain was 5.76 ± 3.31 and 3.0 ± 3.4, respectively. According to a score of 0 - 3, baseline bleeding during menstruation was 2.29 ± 0.92. Six months after RF myolysis, the VAS for dysmenorrhea was 2.75 ± 3.32 (p = 0.004), whereas for intermenstrual pain it was 1.38 ± 2.56 (p = 0.02). Menstrual bleeding was reduced to 1.13 ± 0.89 (p = 0.005). Clinical success of the treatment was evident in 11 (64.7%) of the 17 patients with a 95% CI [38.6%, 84.7%]. Fourteen patients underwent MRI monitoring 6 months post-myolysis. Compared to baseline fibroid volume, ultrasound and MRI volume were 57.38% and 79.66% six months after surgery, respectively. A total of 13 patients (92.86%) had radiological success from the treatment (95% CI [64.2%, 99.6%]). Conclusion: Since percutaneous RF myolysis reduces volume and symptoms of uterine fibroids, it may be considered as a valid treatment for symptomatic fibroids.

关键词： Percutaneous Radiofrequency Thermal Ablation Myolysis Uterine Fibroids

Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

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Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele Castellani Vineet gauhar Khi Yung Fong Mario Sofer Moisés Rodríguez Socarrás Azimdjon N Tursunkulov Lie Kwok Ying Sarvajit Biligere Ho Yee Tiong Dean Elterman Abhay Mahajan Mark Taratkin Sorokin Nikolai Ivanovich Tanuj Pal Bhatia Dmitry Enikeev Nariman gadzhiev Mohammed Taif Bendigeri Jeremy Yuen-Chun Teoh Marco Dellabella fernando gómez Sancha Bhaskar Kumar Somani Thomas Reinhard William Herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy Department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Urology and Robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore Department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada Department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India Institute for Urology and Reproductive Health Sechenov UniversityMoscow119435Russian Federation Department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation Department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation Department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.H.Ho UrologyCentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China Department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom Department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(group 1)versus 2-lobe/3-lobe techniques(group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQR).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(MUI).There were 1711 patients in group 1 and 3357 patients in group *** in group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).Median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in group 1 vs 70[54–90]ml in group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in group *** 1 month,overall incontinence rate was 6.3%in group 1 versus 5.3%in group 2(P=0.12),and urge incontinence was significantly higher in group 1(55.1%vs 37.3%in group 2,Pgroup 1 versus 2.3%in group 2(P=0.06),and SUI was significantly higher in group 2(55.6%vs 24.1%in group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/MUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

Academic Stress Assessment Using Virtual Reality as an Educational Tool in Spine Surgery

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Open Journal of Modern Neurosurgery 2024年第2期14卷 114-123页

作者： Diana Chávez Lizárraga Jesús Alberto Pérez Contreras fernando Alvarado gómez Evelyn Quintero Medina Emmanuel Cantú Chávez Iván Ulises Sámano López Ana Sofía Peña Blesa Department of Neurosurgery ángeles Pedregal Ciudad de México México Department of Traumatology and Orthopedics Hospital Santa Fe Bogotá Colombia

Introduction: The evaluation of academic stress in medical students and residents is a topic of significant interest, given the considerable challenges they face during their learning process with traditional teaching methods. The use of technologies like virtual reality presents an opportunity to enhance their skills through simulations and training. The main objective of this study is to qualitatively assess the stress levels experienced by medical students and residents by integrating virtual reality into their current learning methods, aiming to improve their ability to manage stressors in their practice. Material and Methods: A questionnaire was conducted with 12 medical students and 12 Traumatology and orthopedics residents. The purpose of the questionnaire was to evaluate the levels of academic stress using the SISCO inventory. The stress levels were calculated by transforming average values into percentages, and the following criteria were assigned: 0 to 33% for Mild Stress, 34 to 66% for Moderate Stress, and 67 to 100% for Deep Stress. Then, a virtual reality class focused on spine surgery was provided. Both medical students and residents were trained using the Non Nocere SharpSurgeon software platform and Oculus Quest 2 virtual reality glasses. At the end of the session, a second questionnaire related to the practice with virtual reality was conducted with the same evaluation criteria and a comparative analysis was carried out. Results: 12 undergraduate students from Hospital Angeles Mexico, CDMX and 12 traumatology and orthopedics residents at Hospital Santa Fe, Bogota were evaluated. The students in CDMX reported an average qualitative stress of 28.50% during habitual practices, which decreased to an average of 14.67% after virtual reality practice. Residents in Bogotá experienced an average qualitative stress of 30.50% with their current learning methods but this reduced to an average of 13.92% after using virtual reality. These findings indicate that t

关键词： Virtual Reality Academic Stress Learning Strategies Spine Surgery Training

Silver Recovery from Spent Silver Oxide Button Cell by Liquid-Liquid Extraction

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Journal of Materials Science and Chemical Engineering 2015年第7期3卷 148-153页

作者： Zeferino gamino-Arroyo Antonio Tapia-Cisneros Osvaldo M.Zamacona-Saucedo Irene Cano-Rodríguez Alberto F.Aguilera-Alvarado Lorena E.Sánchez-Cadena fernando I.gómez-Castro Departamento de Ingeniería Química Universidad de Guanajuato Guanajuato México Departamento de Ingeniería Civil Universidad de Guanajuato Guanajuato México

Button cell batteries are used in clocks, thermometers, remote controls, toys and other devices, and they are usually discarded in the trash once its useful life is over. Some models of these batteries contain silver oxide. In this paper we propose liquid-liquid extraction as separation process to recover the metal. First, silver determination is performed in different models of these batteries and leaching with nitric acid is carried out. Affinity study is done between several commercial extractants for silver. The best performing extractant is the bis(2-ethylhexyl) dithiophosphoric acid (D2EHDTPA). Furthermore, a study of the extraction yields as a function of extractant concentration and time is performed. The distribution isotherm is determined;complex extracted in organic phase and stripping conditions have been identified. With the aim of obtaining industrial application, a number of steps for a countercurrent process were defined by the McCabe-Thiele method. Finally, a study was done in micropilot scale. The results show that it is possible to recover silver from this type of waste.

关键词： Silver Spent Button Cells Leaching Recovery

Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural Regeneration Research 2025年第1期20卷 186-187页

作者： fernando Jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

Morphology and distribution of Pronoctiluca (Dinoflagellata, incertae sedis) in the Pacific Ocean

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Acta Oceanologica Sinica 2013年第4期32卷 71-76页

作者： gómez fernando Department of Biological Oceanography Institute of Oceanography University of S o Paulo

The diversity and distribution of Pronoctiluca, a marine dinoflagellate of enigmatic systematic position, was studied in the vicinity of the Kuroshio and Oyashio Currents, the Philippines, Celebes, Sulu and South China Seas, western and central equatorial and southeast Pacific Ocean. The abundance of Pronoctiluca was high- er, with a wide vertical distribution, in eutrophic temperate regions, whereas it was nearly absent in surface waters of oligotrophic tropical regions. Most of the specimens corresponded to P. spinifera. Pronoctiluca pelagica, covered by hyaline layers and with no flagella, is considered as an encysted form. The bipartition was only observed in P. acuta-P, spinifera forms, that together with the occurrence of intermediate forms between P. spinifera and P. pelagica suggest that they may correspond to developmental stages of a single species. Pronoctiluca is essential to understanding the evolutionary history of the alveolates.

关键词： Alveolata basal dinoflagellates Dinophyceae heterotrophic flagellate Noctilucales plankton

Boosting hydrogen and chemicals production through ethanol electro-reforming on Pt-transition metal anodes

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Journal of Energy Chemistry 2022年第7期31卷 394-406,I0011页

作者： Alberto Rodríguez-gómez fernando Dorado Paula Sánchez Ana Raquel de la Osa Chemical Engineering Department Faculty of Chemical Sciences and TechnologyUniversity of Castilla-La Mancha

The aim of this work is to boost the combined hydrogen and added-values compounds generation(acetaldehyde, acetic acid and ethyl acetate) through ethanol electrochemical reforming using bimetallic anodes. In particular, the influence of the secondary metal on the electrochemical performance as well as on the product distribution was studied. For that purpose, Pt X/C electrocatalysts(where X corresponds to Cu, Co, Ni and Ru) were synthesized by the modified polyol method and tested in both half-cell and proton exchange membrane(PEM) cell configurations. Characterization results showed that incorporation of Ni and Co into the Pt matrix enhances the morphological properties of the material, providing smaller crystallite sizes, higher active surface areas and hence, better dispersion when comparing to Ru and Cu-based electrocatalysts. Ethanol oxidation reaction(EOR) was evaluated by cyclic, linear voltammetry and chronopotentiometry assays. Pt Co/C and Pt Ni/C exhibited the highest electrocatalytic activity at high polarization levels, which translate into an improvement of more than 30%(up to 1050 m A cm^(-2)) in the hydrogen production and chemical yields. On the other hand, Pt Ru/C results more advantageous for a lower potential interval(g the acetic acid production despite sacrificing ethanol conversion. Pt Cu/C presented the lowest results in both electrochemical performance and product distribution. Such differences in the electrochemical performance can be rationalized in terms of the synergistic effect between both metals(particle size distribution, grade of dispersion and hydrophilic behavior), which demonstrate that the incorporation of a different secondary metal plays an essential role in the EOR development.

关键词： Ethanol electrochemical reforming Bimetallic anodic electrocatalysts PEM cell High current performance Hydrogen Chemicals production