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Journal of Oceanology and Limnology 2022年第2期40卷 703-711页

作者： fernando gómez Department of Biological and Environmental Sciences and Technologies University of SalentoLecce 73100Italy

Three species of dinophysoid planktonic dinoflagellates are described from the eastern Mediterranean *** *** was collected at 70-m depth in the Ionian *** small species showed a more asymmetric midbody and a proportionally longer neck when compared to the closer relative *** individuals of Dinofurcula tricornuta *** at 154-m depth in the Marmara Sea are characterized by three posterior-oriented processes when compared to its congeneric *** is the first record of the genus Dinofurcula beyond the eastern tropical Pacific *** profunda *** at 500-m depth in the Ionian Sea is characterized by ovate hypotheca and a serrate crest-like left sulcal list when compared to its close relative *** findings evidence an undescribed biodiversity in the under-sampled subphotic depths.

关键词： deep ocean Dinophyta Dinoflagellata Mediterranean Sea mesopelagic new species

Dicroerisma (Actiniscales, Dinophyceae) in the open Pacific Ocean, a gymnodinioid dinoflagellate with an endoskeleton

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Chinese Journal of Oceanology and Limnology 2008年第1期26卷 116-120页

作者： fernando gómez Station Marine de Wimereux Université des Sciences et Technologies de Lille-Lille1 FRE 2816 ELICO CNRS 28 Avenue Foch BP 80 F-62930 Wimereux France

This study is the first to describe and illustrate the dinoflagellate genus Dicroerisma in the open Pacific Sea and in the southern hemisphere. Eleven individuals ascribed to Dicroerisma psilonereiella were encountered in subsurface waters (>70 m depth) from 34°N to 33°S. Another specimen that differs from the type is also illustrated. These findings reveal that Dicroerisma is a widespread genus and that there is tentative existence of another species within the genus.

关键词： Dicroerisma psilonereiella Actiniscales axostyle endoskeleton Dinophyceae the Pacific Ocean

How likely is it to beat the target at different investment horizons: an approach using compositional data in strategic portfolios

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Financial Innovation 2024年第1期10卷 886-902页

作者： fernando Vega-gámez Pablo J.Alonso-gonzález Economics Department Universidad de AlcaláPlaza de La Victoria 228802Alcaláde HenaresMadridSpain EDM gestión SgIIC Partner-DirectorPaseo de la Castellana 7828046MadridSpain

Strategic portfolios are asset combinations designed to achieve investor objectives.A unique feature of these investments is that portfolios must be rebalanced periodically to maintain the initially established *** paper introduces a methodology to estimate the probability of not exceeding a specific profitability target with this type of portfolio to determine if this kind of build portfolio makes obtaining certain profitability targets *** with a specific distribution of fixed-income and equity securities were randomly replicated and their performance was studied over different time *** data from 2004 to 2021 was *** the sum of all asset weights invariably equals the unit,the original data were transformed using the compositional data *** these transformed data,the probabilities were estimated for each analyzed *** study also performed a sensitivity analysis of the estimated probabilities,modifying the weight of specific assets in the portfolio.

关键词： Compositional data Investment horizons Logit models Probability Strategicportfolios

Locoregional therapy and systemic cetuximab to treat colorectal liver metastases

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World Journal of gastrointestinal Oncology 2015年第6期7卷 47-54页

作者： giammaria Fiorentini Camillo Aliberti Donatella Sarti Paolo Coschiera Massimo Tilli Luca Mulazzani Paolo giordani Francesco graziano Alfonso Marqués gonzalez Raul garcía Marcos fernando gómez Mugnoz Maurizio Cantore Stefano Ricci Vincenzo Catalano Andrea Mambrini Oncology Unit Azienda Ospedaliera "Ospedali Riuniti Marche Nord"San Salvatore Hospital Oncology Radiodiagnostics Oncology Institute of VenetoInstitute for the Research and Treatment of Cancer (IRCC) Diagnostics for Images Unit and Interventional Radiology Azienda Ospedaliera "Ospedali Riuniti Marche Nord" Diagnostics for Images and Interventional Radiology Azienda USL of FerraraDelta Hospital Unit of Anestesiology La Fe University Hospital and Polytechnic Medical Imaging and Interventional and Vascular Radiology La Fe University Hospital and Polytechnic Medical Imaging Center (CDIC) Provincial Clinic Hospital Oncology Unit Azienda Ospedaliera "Carlo Poma" Department of Vascular and Interventional Radiology INRCA Hospital-IRCCS Oncology Unit Carrara General Hospital

AIM: To investigate efficacy and safety of second-line treatment with irinotecan-loaded drug-eluting beads(DEBIRI) and cetuximab(DEBIRITUX) of unresectable colorectal liver ***: Patients with the following characteristics were included in the study: unresectable hepatic metastases from colorectal carcinoma(CRC-LM), progression after first line chemotherapy(any type of chemotherapeutic drug and combination was allowed), second line treatment(mandatory), which included for each patient(unregarding the KRas status) two cycles of DEBIRI(using 100-300 μm beads loaded with irinotecan at a total dose 200 mg) followed by 12 cycles of cetuximab that was administered weekly at a first dose of 400 mg/m2 and then 250 mg/m2; good performance status(0-2) and liver functionality(alanine aminotransferase and gamma-glutamyl transferase not exceeding three times the upper limit of normal, total bilirubin not exceeding 2.5 mg/m L). Data were collected retrospectively and included: tumor response(evaluated monthly for 6 mo then every 3 mo), overall response rate(ORR), KRas status, type and intensity of adverse events(g according to the Common Terminology Criteria for Adverse Events v3.0, CTCAE), overall survival(OS) and progression free survival(PFS).RESULTS: Forty consecutive cases of CRC hepatic metastases were included in the study. Median duration of DEBIRITUX was 4.4 mo(range, 4.0-6.5). Sixteen patients(40%) received the planned 2 cycles of DEBIRI and an average of 10 cetuximab cycles. ORR of the whole sample was 50%, in particular 4 patients were complete responders(10%) and 16(40%) partial responders. The most observed side effects(g2) were: post-embolization syndrome(30%), diarrhea(25%), skin rushes(38%) and asthenia(35%). The retrospective evaluation of KRas status(24 wild type, 16 mutated) showed that the group of patients with wild type KRas had ORR significantly higher than mutant KRas. Median follow-up was 29 mo(8-48 range); median PFS was 9.8 mo and OS was

关键词： Cetuximab Irinotecan-loaded drug-elutingbeads Hepatic metastases Chemoembolization Colonrectal tumor Irinotecan

Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural Regeneration Research 2025年第1期20卷 186-187页

作者： fernando Jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

Percutaneous Ultrasound-guided Radiofrequency Thermal Ablation for Treatment of Uterine Fibroids

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Open Journal of Obstetrics and gynecology 2014年第12期4卷 716-724页

作者： Raúl garcía Marcos Javier Monleón Alicia Martínez-Varea fernando gómez guillermina Montoliú Jose J. Martínez Luis Martí-Bonmatí Antonio Pellicer Department Obstetrics and gynecology La Fe University Hospital Valencia Spain Department of Radiology Hospital Clinic Barcelona Spain Department of Radiology La Fe University Hospital Valencia Spain

Purpose: To assess the safety, efficacy and effectiveness of percutaneous radiofrequency (RF) thermal ablation to reduce symptoms of uterine fibroids. Materials and Methods: 17 premenopausal women with symptomatic uterine fibroids despite conventional medical treatment were included. The assessment of symptoms and characteristics of fibroids by vaginal ultrasound, magnetic resonance imaging (MRI) and contrast enhanced ultrasound (CEUS) was performed before starting treatment and 6 months after the procedure. Successful treatment was clinically considered if patients reported a reduction in symptoms 6 months after RF myolysis. Successful treatment was also considered if the necrosis of the fibroid was greater than 50%, 6 months after treatment. Results: The baseline score on visual analogue scale (VAS) for dysmenorrhea and intermenstrual pain was 5.76 ± 3.31 and 3.0 ± 3.4, respectively. According to a score of 0 - 3, baseline bleeding during menstruation was 2.29 ± 0.92. Six months after RF myolysis, the VAS for dysmenorrhea was 2.75 ± 3.32 (p = 0.004), whereas for intermenstrual pain it was 1.38 ± 2.56 (p = 0.02). Menstrual bleeding was reduced to 1.13 ± 0.89 (p = 0.005). Clinical success of the treatment was evident in 11 (64.7%) of the 17 patients with a 95% CI [38.6%, 84.7%]. Fourteen patients underwent MRI monitoring 6 months post-myolysis. Compared to baseline fibroid volume, ultrasound and MRI volume were 57.38% and 79.66% six months after surgery, respectively. A total of 13 patients (92.86%) had radiological success from the treatment (95% CI [64.2%, 99.6%]). Conclusion: Since percutaneous RF myolysis reduces volume and symptoms of uterine fibroids, it may be considered as a valid treatment for symptomatic fibroids.

关键词： Percutaneous Radiofrequency Thermal Ablation Myolysis Uterine Fibroids

Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

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Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele Castellani Vineet gauhar Khi Yung Fong Mario Sofer Moisés Rodríguez Socarrás Azimdjon N Tursunkulov Lie Kwok Ying Sarvajit Biligere Ho Yee Tiong Dean Elterman Abhay Mahajan Mark Taratkin Sorokin Nikolai Ivanovich Tanuj Pal Bhatia Dmitry Enikeev Nariman gadzhiev Mohammed Taif Bendigeri Jeremy Yuen-Chun Teoh Marco Dellabella fernando gómez Sancha Bhaskar Kumar Somani Thomas Reinhard William Herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy Department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Urology and Robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore Department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada Department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India Institute for Urology and Reproductive Health Sechenov UniversityMoscow119435Russian Federation Department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation Department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation Department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.H.Ho UrologyCentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China Department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom Department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(group 1)versus 2-lobe/3-lobe techniques(group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQR).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(MUI).There were 1711 patients in group 1 and 3357 patients in group *** in group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).Median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in group 1 vs 70[54–90]ml in group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in group *** 1 month,overall incontinence rate was 6.3%in group 1 versus 5.3%in group 2(P=0.12),and urge incontinence was significantly higher in group 1(55.1%vs 37.3%in group 2,Pgroup 1 versus 2.3%in group 2(P=0.06),and SUI was significantly higher in group 2(55.6%vs 24.1%in group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/MUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

Academic Stress Assessment Using Virtual Reality as an Educational Tool in Spine Surgery

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Open Journal of Modern Neurosurgery 2024年第2期14卷 114-123页

作者： Diana Chávez Lizárraga Jesús Alberto Pérez Contreras fernando Alvarado gómez Evelyn Quintero Medina Emmanuel Cantú Chávez Iván Ulises Sámano López Ana Sofía Peña Blesa Department of Neurosurgery ángeles Pedregal Ciudad de México México Department of Traumatology and Orthopedics Hospital Santa Fe Bogotá Colombia

Introduction: The evaluation of academic stress in medical students and residents is a topic of significant interest, given the considerable challenges they face during their learning process with traditional teaching methods. The use of technologies like virtual reality presents an opportunity to enhance their skills through simulations and training. The main objective of this study is to qualitatively assess the stress levels experienced by medical students and residents by integrating virtual reality into their current learning methods, aiming to improve their ability to manage stressors in their practice. Material and Methods: A questionnaire was conducted with 12 medical students and 12 Traumatology and orthopedics residents. The purpose of the questionnaire was to evaluate the levels of academic stress using the SISCO inventory. The stress levels were calculated by transforming average values into percentages, and the following criteria were assigned: 0 to 33% for Mild Stress, 34 to 66% for Moderate Stress, and 67 to 100% for Deep Stress. Then, a virtual reality class focused on spine surgery was provided. Both medical students and residents were trained using the Non Nocere SharpSurgeon software platform and Oculus Quest 2 virtual reality glasses. At the end of the session, a second questionnaire related to the practice with virtual reality was conducted with the same evaluation criteria and a comparative analysis was carried out. Results: 12 undergraduate students from Hospital Angeles Mexico, CDMX and 12 traumatology and orthopedics residents at Hospital Santa Fe, Bogota were evaluated. The students in CDMX reported an average qualitative stress of 28.50% during habitual practices, which decreased to an average of 14.67% after virtual reality practice. Residents in Bogotá experienced an average qualitative stress of 30.50% with their current learning methods but this reduced to an average of 13.92% after using virtual reality. These findings indicate that t

关键词： Virtual Reality Academic Stress Learning Strategies Spine Surgery Training

Silver Recovery from Spent Silver Oxide Button Cell by Liquid-Liquid Extraction

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Journal of Materials Science and Chemical Engineering 2015年第7期3卷 148-153页

作者： Zeferino gamino-Arroyo Antonio Tapia-Cisneros Osvaldo M.Zamacona-Saucedo Irene Cano-Rodríguez Alberto F.Aguilera-Alvarado Lorena E.Sánchez-Cadena fernando I.gómez-Castro Departamento de Ingeniería Química Universidad de Guanajuato Guanajuato México Departamento de Ingeniería Civil Universidad de Guanajuato Guanajuato México

Button cell batteries are used in clocks, thermometers, remote controls, toys and other devices, and they are usually discarded in the trash once its useful life is over. Some models of these batteries contain silver oxide. In this paper we propose liquid-liquid extraction as separation process to recover the metal. First, silver determination is performed in different models of these batteries and leaching with nitric acid is carried out. Affinity study is done between several commercial extractants for silver. The best performing extractant is the bis(2-ethylhexyl) dithiophosphoric acid (D2EHDTPA). Furthermore, a study of the extraction yields as a function of extractant concentration and time is performed. The distribution isotherm is determined;complex extracted in organic phase and stripping conditions have been identified. With the aim of obtaining industrial application, a number of steps for a countercurrent process were defined by the McCabe-Thiele method. Finally, a study was done in micropilot scale. The results show that it is possible to recover silver from this type of waste.

关键词： Silver Spent Button Cells Leaching Recovery

Altered microRNA composition in the uterine lumen fluid in cattle(Bos taurus)pregnancies initiated by artificial insemination or transfer of an in vitro produced embryo

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Journal of Animal Science and Biotechnology 2025年第1期16卷 76-91页

作者： fernando H.Biase Sarah E.Moorey Julie g.Schnuelle Soren Rodning Martha Sofia Ortega Thomas E.Spencer School of Animal Sciences Virginia Polytechnic Institute and State University175 W Campus DrBlacksburgVA 24061USA Department of Animal Science University of TennesseeKnoxvilleTN 37996USA Department of Clinical Sciences Auburn UniversityAuburnAL 36849USA Department of Animal Science Auburn UniversityAuburnAL 36849USA Department of Animal and Dairy Sciences University of Wisconsin MadisonMadisonWI 53706USA Division of Animal Sciences University of MissouriColumbiaMO 65211USA

Background MicroRNAs(miRNAs)are presented in the uterine lumen of many mammals,and in vitro experiments have determined that several miRNAs are important for the regulation of endometrial and trophoblast *** aim was to identify and contrast the miRNAs present in extracellular vesicles(EVs)in the uterine lumen fluid(ULF)at the onset of attachment in cattle pregnancies(gestation d 18)initiated by artificial insemination(AI)or by the trans-fer of an in vitro-produced blastocyst(IVP-ET).A third group had no conceptus after the transfer of an IVP *** The abundance of 263 annotated miRNAs was quantified in the EVs collected from *** was an increase in the transcript abundance of 20 miRNAs in the ULF EVs from the AI pregnant group,while 4 miRNAs had a lower abundance relative to the group not containing a ***,4 miRNAs were more abun-dant in ULF EVs in the AI pregnant group relative to IVP-ET group(bta-mir-17,bta-mir-7-3,MIR7-1,MIR18A).Specific miRNAs in the ULF EVs were co-expressed with messenger RNAs expressed in extra-embryonic tissues and endome-trium,including genes that are known to be their *** The results provide biological insights into the participation of miRNAs in the regulation of trophoblast proliferation and differentiation,as well as in endometrium *** knowledge that in vitro cultured embryos can contribute to the altered abundance of specific miRNAs in the uterine lumen can lead to the development of cor-rective approaches to reduce conceptus losses during the first month of pregnancy in cattle.

关键词： Artificial reproductive technology Cattle Conceptus Embryos Endometrium Small RNA