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^(11)C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls:a cross-sectional study

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Neural Regeneration Research 2021年第12期16卷 2494-2498页

作者： Aline Morais de Souza Milena sales Pitombeira Larissa Estessi de Souza Fabio Luiz Navarro Marques Carlos Alberto Buchpiguel Caroline Cristiano Real Daniele de Paula Faria Laboratory of Nuclear Medicine(LIM43) Department of Radiology and OncologyFaculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil department of Neurology Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil

^(11)C-PK11195 is a positron emitter tracer used for Positron Emission Tomography(PET)imaging of innate immune cell activation in studies of neuroinflammatory *** the image quantitative analysis,it is necessary to quantify the intact fraction of this tracer in the arterial plasma during imaging acquisition(plasma intact fraction).Due to the complexity and costs involved in this analysis it is important to evaluate the real necessity of individual analysis in each 11C-PK11195 PET imaging *** purpose of this study is to compare 11CPK11195 plasma metabolization rate between healthy controls and multiple sclerosis(MS)patients and evaluate the interference of sex,age,treatment,and disease phenotype in the tracer intact fraction measured in arterial plasma samples.11C-PK11195 metabolization rate in arterial plasma was quantified by high performance liquid chromatography in samples from MS patients(n=50)and healthy controls(n=23)at 20,45,and 60 minutes after 11C-PK11195 *** were also stratified by sex,age,treatment type,and MS *** results showed no significant differences in the metabolization rate of healthy controls and MS patients,or in the stratified *** conclusion,11C-PK11195 metabolization has the same rate in patients with MS and healthy controls,which is not affected by sex,age,treatment,and disease ***,these findings could contribute to exempting the necessity for tracer metabolization determination in all 11C-PK11195 PET imaging acquisition,by using a population metabolization rate *** study procedures were approved by the Ethics Committee for Research Projects Analysis of the Hospital das Clinicas of the University of Sao Paulo Medical School(approval No.624.065)on April 23,2014.

关键词： ^(11)C-PK11195 HPLC kinetic modeling metabolization multiple sclerosis neuroinflammation PET imaging PET tracer radiometabolites

Unlocking a novel determinant of athletic performance:The role of the gut microbiota,short-chain fatty acids,and“biotics”in exercise

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Journal of Sport and Health Science 2023年第1期12卷 36-44页

作者： Kate M.sales Raylene A.Reimer Faculty of Kinesiology University of CalgaryCalgaryAB T2N 1N4Canada department of Biochemistry&Molecular Biology Cumming School of MedicineUniversity of CalgaryCalgaryAB T2N 4N1Canada

The gut microbiota refers to the collection of trillions of intestinal microorganisms that modulate central aspects of health and disease through influential effects on host ***,a connection has been made between the gut microbiota and *** investigations demonstrated the beneficial effects of exercise on the gut microbiota,with cross-sectional studies revealing positive correlations between exerciseassociated states,and healthy gut microbiota and exercise interventions showed post-intervention increases in the abundance of beneficial bacterial *** recent investigations have focused on exploring the reverse relationship:the influence of the gut microbiota on exercise *** investigations have revealed that certain bacterial taxa may enhance endurance exercise performance by augmenting various aspects of lactate ***,short-chain fatty acids—which modulate metabolism at various organ sites,including within skeletal muscle—have been shown to enhance endurance exercise capacity in *** review highlights what is currently known about the connection between the gut microbiota and exercise,with a particular focus on the ergogenic potential of the gut microbiota and how it may be leveraged to enhance endurance exercise performance.

关键词： Exercise performance Gut microbiota Short-chain fatty acids

Light Front Boson Model Propagation

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Communications in Theoretical Physics 2011年第6期55卷 1029-1040页

作者： Jorge Henrique sales Alfredo Takashi Suzuki Universidade Estadual de Santa Cruz km 16 Rodovia Ilheus-Itabuna-45662-900-IlheusBABrazil Instituto de Fisica Teorica UNESP-Universidade Estadual PaulistaRua Dr.Bento Teobaldo Ferraz 271-Bl.ⅡBarra Funda01140-070Sao PauloSao PauloBrazil

The scope and aim of this work is to describe the two-body interaction mediated by a particle （either the scalar or the gauge boson） within the light-front formulation. To do this, first of all we point out the importance of propagators and Green functions in Quantum Mechanics. Then we project the covariant quantum propagator onto the light front time to get the propagator for scalar particles in these coordinates. This operator propagates the wave function from x＋ = 0 to x＋〉 0. It corresponds to the definition of the time ordering operation in the light front time x＋. We calculate the light-front Green＇s function for 2 interacting bosons propagating forward in x＋. We also show how to write down the light front Green＇s function from the Feynman propagator and finally make a generalization to N bosons.

关键词： insert light-front bosons propagation

GO FAIR Brazil:A Challenge for Brazilian Data Science

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Data Intelligence 2020年第1期2卷 238-245,316,317页

作者： Luana sales Patricia Henning Viviane Veiga Maira Murrieta Costa Luis fernando Sayao Luiz Olavo Bonino da Silva Santos Luis Ferreira Pires Instituto Brasileiro em Informacao em Ciencia e Tecnologia Rio de Janeiro-RJ22290-160Brazil Universidade Federal do Estado do Rio de Janeiro Rio de Janeiro-RJ22290-240Brazil Fundacao Oswaldo Cruz Rio de Janeiro-RJ21040-900Brazil Ministerio da Ciencia TecnologiaInovacoes e ComunicacoesEsplanada dos MinisteriosBloco R-BrasiliaDFCEP 70067-900Brazil Comissao Nacional de Energia Nuclear Rua Gal.Severianon 90 Bairro:BotafogoCEP 22290-901-Rio de JaneiroBrazil GO FAIR International Support&Coordination Office(GFISCO) Leiden 2333 AAThe Netherlands University of Twente Enschede 7522 NHThe Netherlands

The FAIR principles,an acronym for Findable,Accessible,Interoperable and Reusable,are recognised worldwide as key elements for good practice in all data management *** understand how the Brazilian scientific community is adhering to these principles,this article reports Brazilian adherence to the GO FAIR initiative through the creation of the GO FAIR Brazil Office and the manner in which they create their implementation *** contextualise this understanding,we provide a brief presentation of open data policies in Brazilian research and government,and finally,we describe a model that has been adopted for the GO FAIR Brazil implementation *** Brazilian Institute of Information in Science and Technology is responsible for the GO FAIR Brazil Office,which operates in all fields of knowledge and supports thematic implementation ***,GO FAIR Brazil-Health is the first active implementation network in operation,which works in all health domains,serving as a model for other fields like agriculture,nuclear energy,and digital humanities,which are in the process of adherence *** report demonstrates the strong interest and effort from the Brazilian scientific communities in implementing the FAIR principles in their research data management practices.

关键词： FAIR principles GO FAIR GO FAIR Brazil Open Science Research data

Quantitative Progress Evaluation of Post-stroke Patients Using a Novel Bimanual Cable-driven Robot

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Journal of Bionic Engineering 2021年第6期18卷 1331-1343页

作者： Thiago Alves Rogério sales Gonçalves Giuseppe Carbone Laboratory of Automation and Robotics School of Mechanical EngineeringFederal University of UberlândiaUberlândia38400-902Brazil department of Mechanical Energy and Management EngineeringUniversity of Calabria87036RendeItaly

Rehabilitation is the most effective way to reduce motor impairments in post-stroke *** process demands several hours with a specialized *** resources and personnel shortages,the literature reports a high interest in robotic assisted rehabilitation ***,cable-driven robotic architectures are attracting significant research interest for post-stroke ***,the existing cable-driven robots are mostly unilateral devices allowing the rehabilitation only of the most affected *** leaves unaddressed the rehabilitation of bimanual activities,which are predominant within the common Activities of Daily Living(ADL).Thus,this paper presents a specific novel design to achieve bimanual rehabilitation tasks that has been named as BiCAR ***,this paper provides a full insight on the BiCAR system as well as on its dedicated developed software *** particular,BiEval software has been developed as based on a serious game strategy and a virtual reality environment to track the patient exercising duration,motion ranges,speeds,and forces over time for achieving a quantitative assessment of the rehabilitation ***,the paper presents the BiCAR/BiEval capabilities by referring to a pilot Randomized Controlled Trial(RCT).The clinical trials have been used to validate the BiCAR/BiEval in terms of engineering feasibility and user acceptance to achieve an innovative cost-oriented integrated hardware/software device for the bimanual assistive rehabilitation of post-stroke patients.

关键词： Cable-driven robots Low cost Stroke rehabilitation Bimanual Progress tracking Serious games

Evaluation of inflammatory activity in Crohn's disease and ulcerative colitis

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World Journal of Gastroenterology 2012年第9期18卷 872-881页

作者： Eduardo Garcia Vilela Henrique Osvaldo da Gama Torres Fabiana Paiva Martins Maria de Lourdes de Abreu Ferrari Marcella Menezes Andrade Aloísio sales da Cunha Internal Medicine department Faculty of MedicineFederal University of Minas Gerais Gastroenterology Alfa Institute Clinic HospitalFederal University of Minas Gerais Complementary Propedeutic department Faculty of MedicineFederal University of Minas Gerais Faculty of Medicine Federal University of Minas Gerais

Crohn's disease and ulcerative colitis evolve with a relapsing and remitting *** of inflammatory state is crucial for the assessment of disease activity and for tailoring ***,no simple diagnostic test for monitoring intestinal inflammation is *** markers give only indirect assessments of disease *** or endoscopical examinations accurately assess inflammatory activity,but they are invasive,time consuming and expensive and therefore are unsuitable for routine *** procedures are not applicable for ulcerative *** usefulness of ultrasound and Doppler imag-ing in assessing disease activity is still a matter of discussion for Crohn's disease,and an increased interest in computed tomography enterograph (CTE) has been seen,mainly because it can delineate the extent and severity of bowel wall inflammation,besides detecting extraluminal *** now,the available data concerning the accuracy of magnetic resonance enterography in detecting disease activity is less than *** to this,clinical activity indices are still commonly used for both diseases.

关键词： Crohn's disease Ulcerative colitis Inflamma-tory bowel disease Diagnostic test Therapy Inflamma-tory markers

Calibration and validation of FAO-AquaCrop model to estimate the total biomass and yacon root yield

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International Journal of Agricultural and Biological Engineering 2020年第3期13卷 123-128页

作者： Ramon Amaro de sales Alexandre Cândido Xavier Evandro Chaves de Oliveira Fábio Luiz de Oliveira Diego Mathias Natal da Silva Sávio da Silva Berilli departament of Plant Science Federal University of ViçosaMinas GeraisBrazil Center of Agrarian Sciences and Engineering Federal University of Espirito SantoEspírito SantoBrazil Federal Institute of Education Science and Technology of Espírito Santo-Campus ItapinaEspírito SantoBrazil Federal Institute of Education Science and Technology of Southeast Minas Gerais-Campus ManhuaçuMinas GeraisBrazil

Due to the current water scarcity in the world,it is extremely important to improve the use of this natural and exhaustible resource in agriculture,by contributing to increase agricultural production and *** models of crop growth simulation were developed to predict the edaphoclimatic effects on crop *** models are calibrated and validated for a given region using the data generated from field ***,the objective of this study was to calibrate and validate the FAO AquaCrop model for yacon(Smallanthus sonchifolius)crop in a tropical *** experiment was conducted in an experimental area located in the municipality of Ibatiba,state of Espírito Santo(Brazil)during the years of 2013 and *** calibration was done using the Autumn planting and validation with the Winter and Spring *** the statistical analysis,the coefficient of determination,Willmott concordance index,bias for the systematic error,root mean square error and the mean absolute error to test the model performance were *** general,the FAO AquaCrop model predicted the root yield,total biomass and harvest index with acceptable accuracy,and with deviations of less than 6%for total and root *** planting of yacon showed a reduction in yield as well as total biomass.

关键词： Smallanthus sonchifolius root yield simulation modelling agrometeorology

Nursing education,continue education and in service training,research and digital technology application

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International Journal of Nursing Sciences 2017年第4期4卷 341-342页

作者： Eloiza sales Correia Brazilian Federal Council of Nurses(COFEN) Brazil

*** education in Brazil *** Regulated by laws:LDB-Law no 9.394/96,Law 775/49-Braziliam nursing teaching law;Private nursing(Law n°2.604/55 e 7.498/860)and Nursing Services;Minimum schooling time for undergraduate:4,000 h/10 se-mesters of face-to-face study including 20%compulsory curricular internship;Supervised internship required.

关键词： Nursing education nursing

Litterfall dynamics and soil carbon and nitrogen stocks in the Brazilian palm swamp ecosystems

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Forest Ecosystems 2020年第3期7卷 499-510页

作者： Gracielle de Brito sales Taynan Aquilles Marinho Lessa Daniela Aparecida Freitas Maria das Dores Magalhães Veloso Maria Ligia de Souza Silva Luiz Arnaldo Fernandes Leidivan Almeida Frazão Instituto de Ciências Agrárias Universidade Federal de Minas GeraisAvenida Universitária1000Montes ClarosMG39404-547Brazil Universidade Estadual de Montes Claros Avenida Professor Rui Braga S/NMontes ClarosMG39401-089Brazil Universidade Federal de Lavras Campus UniversitárioCP 3037LavrasMG37299-000Brazil

Background: This study aimed to determine the litterfall production, accumulation, decomposition rate and nutrient stocks, and to estimate the soil carbon(C) and nitrogen(N) stocks in three palm swamp ecosystems with different land use intensities in the Southeast of ***: Three palm swamp ecosystems with different land use intensities were evaluated: Agua Doce(AD),conserved area;Capivara(CV), area with small agricultural practices;and Buriti Grosso(BG), area with an intensive land use. Produced and accumulated litterfall from the Cerrado areas surrounding the palm swamps were collected from October 2014 to September 2015, and the Ca, Mg, K, and P concentrations were determined in the dry and rainy seasons. Soil samples were collected in the surrounding Cerrado and within the palm swamps until 100 cm soil depth to determine bulk density and soil C and N contents and ***: Annual litterfall production in the Cerrado surrounding palm swamps was similar in AD(3.58 Mg·ha^-1·year^-1) and CV(3.79 Mg·ha^-1·year^-1), and was lower in BG(2.84 Mg·ha^-1·year^-1), and was more intense during the dry season. Furthermore, litterfall accumulation was higher in CV(7.12 Mg·ha^-1·year^-1) and BG(6.75 Mg·ha^-1·year^-1), culminating in lower decomposition rates. AD showed the highest decomposition rate(0.60) due to its vegetation structure and conservation. The macronutrient contents from the production and accumulated litterfall had a low influence of the land use, decreasing in the following order: Ca > K > Mg > P. Soils in CV and BG palm swamp areas showed higher values of C and N contents, due to the use of land for agricultural crops and cattle raising in an extensive(rangeland) system. The BG palm swamp, showed the highest C(124.03 Mg·ha^-1) and N(10.54 Mg·ha^-1) stocks due to the land use history with different agricultural practices over ***: The litterfall dynamics in the Cerrado surrounding palm swamps was more affected by climatic variables t

关键词： Nutrient cycling Soil fertility Soil organic matter decomposition rate