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Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge Soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. Teixeira Maria Helena Marumo Bellini Natanael gomes da silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

Euborellia annulipes Mortality and Predation on Diatraea saccharalis Eggs after Application of Chemical and Biological Insecticides

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Agricultural Sciences 2023年第1期14卷 11-22页

作者： Rodrigo Marin Arroyo Joice Mendonça De Souza Gilmar da silva Nunes dagmara gomes Ramalho Sergio antonio De Bortoli UNESP S&#227 o Paulo State University Jaboticabal SP Brazil Manserv Porto Nacional Tocantins Brazil

Chemical and biological insecticides have been frequently used in sugarcane fields to control insects-pests, including the sugarcane borer, Diatraea saccharalis. Among the products used, those based on chlorantraniliprole and Metarhizium anisopliae entomopathogenic fungus, stand out. Euborellia annulipes is an insect of the order Dermaptera considered a potential predator of sugarcane borer eggs. This study aimed to evaluate the direct and indirect effects of the bioinsecticide based on M. anisopliae (Metarril®) and the chemical insecticide chlorantraniliprole (Altacor®) on the mortality of E. annulipes nymphs and adults, the predation and feeding preference of earwigs in eggs treated with the formulated products. Predator mortality was evaluated for seven days after treatment, while the effect on predation was analyzed by preference tests with and without choice, using prey eggs. The products tested were selective to the predator, causing ≤ 2% mortality and not affecting predation. The application of M. anisopliae on sugarcane borer eggs favored the food preference of fourth-instar nymphs, males, and females of the predator. Our results show that Metarril® and Altacor® can be used to control D. saccharalis when associated with the predator E. annulipes.

关键词： Sugarcane Borer Biological Control Food Preference Earwigs

Impacts of COVID-19 on children and adolescents:A systematic review analyzing its psychiatric effects

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World Journal of Psychiatry 2022年第11期12卷 1313-1322页

作者： Italo Wanderson de Moura Gabriel danielly Gonçalves Sombra Lima Jeully Pereira Pires Nélio Barreto Vieira Aloisio antonio gomes de Matos Brasil Yara Talita gomes Pereira Erika Galvao de Oliveira HildsonLeandro de Menezes Nadia Nara Rolim Lima Alberto Olavo Advíncula Reis Ruan Neto Pereira Alves Uanderson Pereira da silva Jucier Gonçalves Junior Modesto Leite Rolim-Neto School of Medicine Faculty of Medicine of Juazeiro do Norte-FMJ/IDOMEDJuazeiro do Norte 63040-360CearaBrazil School of Medicine Federal University of CaririBarbalha 63048-080CearaBrazil Mais Médicos Program Federal Government of Brazil-Ministry of HealthIguatu 63048-080CearaBrazil Julio Alves de Lira Hospital and Maternity Hospital HALHMBelo Jardim 55157-290PernambucoBrazil Nursing Department Doctor Leão Sampaio University Center-UNILEAOJuazeiro do Norte 63.041-140CearaBrazil Julio Alves de Lira Hospital and Maternity Hospital JALHMBelo Jardim 55157-290PernambucoBrazil Graduate Program(Post-Doctoral)in Neuro-Psychiatry UFPERecife 50670-901PernambucoBrazil Postgraduate Program(Master’s and Doctorate)in Public Health University of São Paulo-USPSão Paulo 01246-904São PauloBrazil School of Education USPSão Paulo 05508-040São PauloBrazil Internal Medicine-Division of Rheumathology at Hospital das Clínicas São Paulo UniversitySão Paulo 01246-903São PauloBrazil

OBJECTIVE To summarize the most relevant data from a systematic review on the impact of COVID-19 on children and adolescents,particularly analyzing its psychiatric *** This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA)guidelines and included experimental studies(randomized-individually or pooled-and non-randomized controlled trials),observational studies with a group for internal comparison(cohort studies-prospective and retrospective-and case-control)and qualitative studies in the period from 2021 to *** The search identified 325 articles;we removed 125 *** selected 200 manuscripts,chosen by title and selected *** excluded 50 records after screening titles and abstracts,as they did not meet the inclusion *** retrieved 150 records selected for a full *** excluded 90 text articles and we selected 25 records for the(n)***:Due to the short period of data collection,from 2021 to 2022,there is a possibility of lack of relevant studies related to the mental health care of children and *** addition,there is the possibility of publication bias,such as only significant findings being *** The impact of COVID-19 on the mental health of children and adolescents is of great concern to child and youth *** such as fear,anxiety,panic,depression,sleep and appetite disorders,as well as impairment in social interactions caused by psychic stress,are punctual markers of pain and psychic suffering,which have increasing impacts on the mental health panorama of children and adolescents globally,particularly in vulnerable and socially at-risk populations.

关键词： Child psychiatry Adolescent psychiatry Mental health COVID-19 Kids Teens

短跑运动员血浆中脑源性神经营养因子水平较普通人群显著升高(英文)

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Neuroscience Bulletin 2011年第5期27卷 325-329页

作者： Paulo Roberto Correia Fulvio Alexandre Scorza Sérgio gomes da silva Aline Pansani Michelle Toscano-silva antonio Carlos de Almeida Ricardo Mario Arida 圣保罗联邦大学生理学系圣保罗联邦大学神经内外科系 So Joo del-Rei联邦大学实验与计算神经生物学实验室

目的目前研究发现锻炼能增强健康人血液中脑源性神经营养因子(BDNF)的水平。BDNF水平的改变常发现于耐力运动而非力量锻炼。本研究旨在探讨厌氧型活动(如短跑)是否能改变人血浆中BDNF的浓度。方法对22名巴西100米短跑运动员,包括14名过... 详细信息

目的目前研究发现锻炼能增强健康人血液中脑源性神经营养因子(BDNF)的水平。BDNF水平的改变常发现于耐力运动而非力量锻炼。本研究旨在探讨厌氧型活动(如短跑)是否能改变人血浆中BDNF的浓度。方法对22名巴西100米短跑运动员,包括14名过去4年间参加过国际级奥林匹克及户外世锦赛的运动员(国际级)和8名只参加过本国比赛的运动员(国内级),以及15名此前从未参加过任何运动比赛的健康对照人群,用ELISA法检测其血浆中BDNF的水平。结果与对照组相比,国际级和国内级短跑运动员血浆中BDNF的水平均显著升高。此外,国际级短跑运动员血浆中BDNF的水平显著高于国内级运动员。结论血浆中BDNF水平的升高可能与运动加强有关。

关键词：脑源性神经营养因子体育运动短跑血浆大脑人类

Evaluation of Renewable Energy Vulnerability to Climate Change in Brazil: A Case Study of Biofuels and Solar Energy

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Smart Grid and Renewable Energy 2015年第8期6卷 221-232页

作者： antonio Oscar jr. Wanderson Luiz silva Vera Ruffato Renata Barreto Marcos Freitas Federal University of Rio de Janeiro Rio de Janeiro Brazil

This study aims to calculate indicators and indexes to subsidize the analysis of vulnerability and adaptation of the renewable energy sector to climate change in Brazil, focusing on biofuels and solar energy. For biofuels, in general, the Brazilian coast will be a propitious area for agricultural productivity during the XXI century, but these are areas historically intended for occupation and development of the urbanization process, that is, with limited land availability and supply for primary production. In some parts of the Northeast, Midwest and South of the country, offer for the cultivation land will be reduced. For the solar energy is observed that Brazil has area and highly expressive power for the use of this power, both today and in the coming decades, especially in the North, Northeast and Midwest. In statistical terms, the Mann-Kendal test and Sen’s Bend point to a very weak tendency to useful radiation indicator in all regions of Brazil by 2100. In addition, it is projected a significant increase in mean air temperature by the end of XXI century across the country that can mean a reduction in power conversion capability, which is sensitive to ambient temperature variations, especially in the Midwest and North of the country.

关键词： Renewable Energy Climate Change Brazil Biofuels Solar Energy

Correlation between Rainfall and Cold Fronts with Gamma Ray Measurements near Ground Level in Southeastern Brazil

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Journal of Environmental Science and Engineering(B) 2017年第3期6卷 115-120页

作者： Inacio Malmonge Martin Marcelo Pego gomes Marco antonio Ferro Franklin Andrade silva Physics Department Technological Institute of Aeronautics--tTA Sao Jose dos Campos SP 12228-900 Brazil Aeronautical and Space Institute--IAE Sao Jose dos Campos SP 12228-900 Brazil

Pancreatic paracoccidioidomycosis simulating malignant neoplasia:Case report

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World Journal of Gastroenterology 2013年第34期19卷 5750-5753页

作者： Talles Bazeia Lima Maria Aparecida Custódio Domingues Carlos antonio Caramori Giovanni Faria silva Cássio Vieira de Oliveira Fábio da silva Yamashiro Letícia de Campos Franzoni Lígia Yukie Sassaki fernando gomes Romeiro Division of Gastroenterology Department of Internal MedicineBotucatu School of MedicineRubio JuniorDistrict S/N18618-970 So PauloBrazil Department of Pathology Botucatu School of MedicineRubio Junior District S/N18618-970 So PauloBrazil

Paracoccidioidomycosis is a systemic granulomatous disease caused by fungus,and must be considered in the differential diagnosis of intra-abdominal tumors in endemic *** report a rare case of paracoccidioidomycosis in the pancreas.A 45-year-old man was referred to our institution with a 2-mo history of epigastric abdominal pain that was not diet-related,with night sweating,inappetence,weight loss,jaundice,pruritus,choluria,and acholic feces,without signs of sepsis or palpable *** ultrasonography(US)showed a solid mass of approximately 7 cm×5.5 cm on the pancreas *** computerized tomography showed dilation of the biliary tract,an enlarged pancreas(up to 4.5 in the head region),with dilation of the major pancreatic *** patient underwent exploratory laparotomy,and the surgical description consisted of a tumor,measuring 7 to 8 cm with a poorly-defined margin,adhering to posterior planes and mesenteric vessels,showing an enlarged bile *** drainage of the biliary tract,Rouxen-Y gastroenteroanastomosis,lymph node excision,and biopsies were performed,but malignant neoplasia was not *** analysis showed chronic pancreatitis and a granulomatous chronic inflammatory process in the choledochal lymph ***-alcohol resistant bacillus and fungus screening were ***-needle aspiration of the pancreas was performed under US *** smear was compatible with infection by Paracoccidioides *** report a rare case of paracoccidioidomycosis simulating a malignant neoplasia in the pancreas head.

关键词： Paracoccidioidomycosis Pancreas Fungus infection Pancreatic tumors Differential diagnosis

xSPIDER_ML:Proposal of a Software Processes Enactment Language Compliant with SPEM 2.0

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Journal of Software Engineering and Applications 2012年第6期5卷 375-384页

作者： Carlos Portela Alexandre Vasconcelos antonio silva Elder silva Mariano gomes Maurício Ronny Wallace Lira Sandro Oliveira Informatics Center Federal University of PernambucoRecifeBrazil Institute of Exact and Natural Sciences Federal University of ParáBelémBrazil

SPEM (Software Process Engineering Metamodel Specification) is the software processes modeling standard defined by OMG (Object Management Group). However, the process enactment support provided by this standard has many deficiencies. Therefore, the main objective of this paper is to propose a language for software process enactment based upon SPEM 2.0 concepts. First, we will present a critical analysis of the SPEM standard approach for enactment. Then, we will present xSPIDER_ML, an enactment language, and describe its structure, components and associated rules. In order to evaluate the proposed language, a case study is performed through a RUP (Rational Unified Process) process instantiation. The language presented in this paper is part of a support set of tools for flexible software process enactment. Additionally, this set of tools is in compliance with software process quality models.

关键词： Software Process Enactment Language SPEM RUP

Cecum Dieulafoy＇s Lesion Presenting with Recurrent Lower Gastrointestinal Bleeding： Case Report

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Journal of Pharmacy and Pharmacology 2018年第3期6卷 254-258页

作者： Ludmila Resende Guedes Silas Castro de Carvalho Vitor Nunes Arantes Arthur Manoel Braga de Albuquerque gomes daniel antonio de Albuquerque Terra Nathalia da silva Braga Nicoly Eudes da silva Dias Endoscopy Unit of Alfa Institute of Gastroenterology at Hospital das Clinicas da Universidade Federal de Minas Gerais (UFMG) Belo Horizonte MG 30130100 Brazil

Introduction: Gastrointestinal Dieulafoy"s lesion is a rare entity, of unknown etiology, and corresponds to an arterial malformation at the submucosal space that can be a source of life-threatening hemorrhage. We report a case of a Cecum Dieulafoy"s bleeding lesion that was managed endoscopically with a favorable outcome. Case report: Female, 70-year-old, diagnosed with type 2 diabetes, hypothyroidism, and chronic heart failure associated with rheumatic mitral stenosis, submitted to biological valve replacement in 2006 and with permanent atrial fibrillation using vitamin K antagonist anticoagulant for thrombosis prophylaxis. Her background includes a stroke in 2004 without any permanent disability. In 2016, the patient experienced voluptuous and painless lower gastrointestinal bleeding with severe acute anemia, requiring hospital admission, fluid resuscitation and blood transfusion. Urgent colonoscopy revealed a small reddish vascular malformation at the cecum with oozing active bleeding, about 3 mm in size. Initially argon plasma coagulation was performed with satisfactory and immediate hemostasis. One week later, she recurred with hematochezia. The lesion at the cecum was reassessed and it was possible to notice a large caliber vessel surrounded by a normal appearance mucosa, compatible with Dieulafoy"s lesion and it was treated with an endoscopic clip placement with a good long-term response. Conclusion: Endoscopy is the method of choice for diagnosis of Dieulafoy"s lesion and may provide efficient treatment with mechanical hemostasis such as endoclip placement with a high success rate.

关键词： Dieulafoy"s lesion lower gastrointestinal bleeding endoscopy endoscopic clip