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Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin

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World Journal of Gastroenterology 2013年第26期19卷 4166-4171页

作者： Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas fernando fernández-baares Departments of Gastroenterology Hospital Universitari Mútua Terrassa Centro de Investigación Biomédica en Red de Enfer-medades Hepáticas y Digestivas (CIBERehd) Departments of Pathology Hospital Universitari Mútua Terrassa

AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients.

关键词： Helicobacter pylori Iron-deficiency anaemia Iron refractoriness Gluten-sensitive enteropathy Menopause

Impact of mass screening for gluten-sensitive enteropathy in working population

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World Journal of Gastroenterology 2009年第11期15卷 1331-1338页

作者： Meritxell Mariné fernando fernández-baares Montserrat Alsina Carme Farré Montserrat Cortijo Rebeca Santaolalla Antonio Salas Margarita Tomàs Elias Abugattas Carme Loras Ingrid Ordás Josep M Viver Maria Esteve Department of Gastroenterology University Hospital of Mútua de TerrassaResearch Foundation Mútua de TerrassaUniversity of Barcelona08221 TerrassaCataloniaSpain Department of Immunology(Catlab) University Hospital of Mútua de TerrassaResearch Foundation Mútua de TerrassaUniversity of Barcelona08221 TerrassaCataloniaSpain Department of Biochemistry Sant Joan de DéuHospitalEsplugues08950 CataloniaSpain Occupational Health Department Egarsat(Prevention Society)Sant Cugat del Vallès08173 CataloniaSpain Department of Pathology University Hospital of Mútua de TerrassaResearch Foundation Mútua de TerrassaUniversity of Barcelona08221 TerrassaCataloniaSpain

AIM:To assess:(1)frequency and clinical relevanceof gluten sensitive enteropathy(GSE)detected by serology in a mass screening program;(2)sensitivity of antitransglutaminase(tTGA)and antiendomysium antibodies(EmA);and(3)adherence to gluten-free diet(GFD)and follow-up. METHODS:One thousand,eight hundred and sixtyeight subjects recruited from an occupational health department underwent analysis for tTGA and EmA and, if positive,duodenal biopsy,DQ2/DQ8 genotyping, clinical feature recording,blood tests,and densitometry were ***>98%of individuals had tTGA <2 U/mL,this value was established as the cut-off limit of normality and was considered positive when confirmed twice in the same *** to a GFD and follow up were registered. RESULTS:Twenty-six(1.39%)subjects had positive tTGA and/or EmA,and 21 underwent biopsy:six Marsh Ⅲ(oneⅢa,fourⅢb,oneⅢc),nine MarshⅠand six Marsh 0(frequency of GSE 1:125).The sensitivity of EmA for GSE was 46.6%(11.1%for MarshⅠ,100% for MarshⅢ),while for tTGA,it was 93.3%(88.8% for MarshⅠ,100%for MarshⅢ).All 15 patients with abnormal histology had clinical features related to ***ⅠandⅢsubjects had more abdominal pain than Marsh 0(P=0.029),and a similar trend was observed for distension and *** differences in the percentage of osteopenia were found between MarshⅠandⅢ(P=0.608).Adherence to follow-up was 69.2%.Of 15 GSE patients,66.7%followed a GFD with 80%responding to it. CONCLUSION:GSE in the general population is frequent and clinically relevant,irrespective of histological *** is the marker of *** screening programs are useful in identifying patients who can benefit from GFD and follow-up.

关键词： Antitransglutaminase and antiendomysiumantibodies Celiac disease Lymphocytic enteritis Massscreening

Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy:Role of faecal immunochemical test

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World Journal of Gastroenterology 2020年第1期26卷 70-85页

作者： Noel Pin-Vieito María J Iglesias David Remedios Lorena Rodríguez-Alonso Francisco Rodriguez-Moranta VictoriaÁlvarez-Sánchez fernando fernández-bañares Jaume Boadas Eva Martínez-bauer Rafael Campo Luis Bujanda Ángel Ferrandez Virginia Piñol Daniel Rodríguez-Alcalde Jordi Guardiola Joaquín Cubiella Gastroenterology Department Complexo Hospitalario Universitario de OurenseCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd)Ourense 32005Spain Department of Gastroenterology and Hepatology University Hospital of Bellvitge-IDIBELLL'Hospitalet de LlobregatBarcelona 08907Spain.Ciber de Epidemiología y Salud Pública(CIBERESP)Spain Gastroenterology Department Complejo Hospitalario de PontevedraPontevedra 36001Spain Gastroenterology Department Hospital Universitari Mútua de TerrassaCIBERehdTerrassa 08221Spain Gastroenterology Department Consorci Sanitari de TerrassaTerrassa 08221Spain Gastroenterology Department Hospital de SabadellCorporacióSanitària Donostia Hospital Biodonostia InstituteUniversity of the Basque Country UPV/EHUCIBERehdSan Sebastian 20010Spain Servicio de Aparato Digestivo Hospital Clínico UniversitarioIIS AragónUniversity of ZaragozaCIBERehdZaragoza 50009Spain Gastroenterology Department Hospital Dr.Josep TruetaGirona 17007Spain Digestive Disease Section Hospital Universitario de MóstolesMadrid 28935Spain

baCKGROUND Faecal immunochemical test(FIT)has been recommended to assess symptomatic patients for colorectal cancer(CRC)***,some conditions could theoretically favour blood originating in proximal areas of the gastrointestinal tract passing through the colon unmetabolized.A positive FIT result could be related to other gastrointestinal cancers(GIC).AIM To assess the risk of GIC detection and related death in FIT-positive symptomatic patients(threshold 10μg Hb/g faeces)without *** Post hoc cohort analysis performed within two prospective diagnostic test studies evaluating the diagnostic accuracy of different FIT analytical systems for CRC and significant colonic lesion *** patients with gastrointestinal symptoms referred consecutively for colonoscopy from primary and secondary healthcare,underwent a quantitative FIT before undergoing a complete *** without CRC were divided into two groups(positive and negative FIT)using the threshold of 10μg Hb/g of faeces and data from follow-up were retrieved from electronic medical records of the public hospitals involved in the *** determined the cumulative risk of GIC,CRC and upper *** rate(HR)was calculated adjusted by age,sex and presence of significant colonic *** We included 2709 patients without CRC and a complete baseline colonoscopy,730(26.9%)with FIT≥10μgr Hb/*** a mean time of 45.5±20.0 mo,a GIC was detected in 57(2.1%)patients:An upper GIC in 35(1.3%)and a CRC in 14(0.5%).Thirty-six patients(1.3%)died due to GIC:22(0.8%)due to an upper GIC and 9(0.3%)due to ***-positive subjects showed a higher CRC risk(HR 3.8,95%CI:1.2-11.9)with no differences in GIC(HR 1.5,95%CI:0.8-2.7)or upper GIC risk(HR 1.0,95%CI:0.5-2.2).Patients with a positive FIT had only an increased risk of CRC-related death(HR 10.8,95%CI:2.1-57.1)and GIC-related death(HR 2.2,95%CI:1.1-4.3),with no differences in upper GIC-related death(HR 1.4,95%CI:0.6-3.3).An

关键词： Colonoscopy Colorectal cancer Faecal immunochemical test Gastric cancer Gastroesophageal cancer Gastrointestinal cancer Symptoms

Hydrogen production from dry reforming of methane,using CO_(2)previously chemisorbed in the Li_(6)Zn_(1-x)Ni_(x)O_(4)solid solution

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Journal of Environmental Sciences 2025年第3期149卷 535-550页

作者： Yocelin B.González-González fernando Plascencia-Hernández Rubén Mendoza-Cruz Heriberto Pfeiffer Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de MéxicoCircuito exterior s/nCiudad UniversitariaDel.CoyoacánCP 04510CdMxMexico

Li_(6)ZnO_(4)was chemically modified by nickel addition,in order to develop different compositions of the solid solution Li_(6)Zn_(1-x)Ni_(x)O_(4).These materials were evaluated bifunctionally;analyzing their CO_(2)capture performances,aswell as on their catalytic properties for H_(2)production via dry reforming of methane(DRM).The crystal structures of Li_(6)Zn_(1-x)Ni_(x)O_(4)solid solution samples were determined through X-ray diffraction,which confirmed the integration of nickel ions up to a concentration around 20 mol%,meanwhile beyond this value,a secondary phase was *** results were supported by XPS and TEM ***,dynamic and isothermal thermogravimetric analyses of CO_(2)capture revealed that Li_(6)Zn_(1-x)Ni_(x)O_(4)solid solution samples exhibited good CO_(2)chemisorption efficiencies,similarly to the pristine Li_(6)ZnO_(4)chemisorption trends ***,a kinetic analysis of CO_(2)isothermal chemisorptions,using the Avrami-Erofeev model,evidenced an increment of the constant rates as a function of the Ni *** Ni^(2+)ions incorporation did not reduce the CO_(2)capture efficiency and kinetics,the catalytic properties of thesematerialswere evaluated in the DRM *** demonstrated that nickel ions favored hydrogen(H_(2))production over the pristine Li_(6)ZnO_(4)phase,despite a second H2 production reaction was determined,methane ***,Li_(6)Zn_(1-x)Ni_(x)O_(4)ceramics can be employed as bifunctional materials.

关键词： Dry reforming of methane(DRM) CO_(2)chemisorption H_(2)production Solid solution Li_(6)ZnO_(4)

Interpolation of Closed Ideals of Bilinear Operators

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Acta Mathematica Sinica,English Series 2025年第1期41卷 209-230页

作者： fernando Cobos Luz M.fernandez-Cabrera Anton Martinez Departamento de Analisis Matematico y Matematica Aplicada Facultad de MatematicasUniversidad Complutense de MadridPlaza de Ciencias 328040 MadridSpain Seccion Departamental del Departamento de Analisis Matematico y Matematica Aplicada Facultad de Estudios EstadιsticosUniversidad Complutense de Madrid28040 MadridSpain Departamento de Matematica Aplicada I Escuela de Ingenierιa IndustrialUniversidad de Vigo36200 VigoSpain

We extend the(outer)measureγ_(I) associated to an operator ideal I to a measureγ_(I) for bounded bilinear *** I is surjective and closed,and J is the class of those bilinear operators such thatγ_(I)(T)=0,we prove that J coincides with the composition bideal I?*** I satisfies theΣ_(r)-condition,we establish a simple necessary and sufficient condition for an interpolated operator by the real method to belong to ***,if in addition I is symmetric,we prove a formula for the measureγ_(I) of an operator interpolated by the real *** particular,results apply to weakly compact operators.

关键词： Measures associated to bideals of operators real interpolation measure of weak noncompactness of a bilinear operator adjoint operator of a bilinear operator

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural Regeneration Research 2025年第1期20卷 186-187页

作者： fernando Jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

Multi-Step Clustering of Smart Meters Time Series:Application to Demand Flexibility Characterization of SME Customers

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 869-907页

作者： Santiago bañales Raquel Dormido Natividad Duro Department of Computer Sciences and Automatic Control Universidad Nacional de Educación a Distancia(UNED)Madrid28040Spain Iberdrola Innovation Middle East Doha210177Qatar

Customer segmentation according to load-shape profiles using smart meter data is an increasingly important application to vital the planning and operation of energy systems and to enable citizens’participation in the energy *** study proposes an innovative multi-step clustering procedure to segment customers based on load-shape patterns at the daily and intra-daily time *** meter data is split between daily and hourly normalized time series to assess monthly,weekly,daily,and hourly seasonality patterns *** dimensionality reduction implicit in the splitting allows a direct approach to clustering raw daily energy time series *** intraday clustering procedure sequentially identifies representative hourly day-unit profiles for each customer and the entire *** the first time,a step function approach is applied to reduce time series *** attributes embedded in surveys are employed to build external clustering validation metrics using Cramer’s V correlation factors and to identify statistically significant determinants of load-shape in energy *** addition,a time series features engineering approach is used to extract 16 relevant demand flexibility indicators that characterize customers and corresponding clusters along four different axes:available Energy(E),Temporal patterns(T),Consistency(C),and Variability(V).The methodology is implemented on a real-world electricity consumption dataset of 325 Small and Medium-sized Enterprise(SME)customers,identifying 4 daily and 6 hourly easy-to-interpret,well-defined *** application of the methodology includes selecting key parameters via grid search and a thorough comparison of clustering distances and methods to ensure the robustness of the *** research can test the scalability of the methodology to larger datasets from various customer segments(households and large commercial)and locations with different weather and socioeconomic conditio

关键词： Electric load clustering load profiling smart meters machine learning data mining demand flexibility demand response

Aptamers as new promising entities for therapeutics:our experience from the neurological diseases

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Neural Regeneration Research 2025年第12期20卷 3523-3524页

作者： Macarena Hernández-Jiménez fernando de Castro Neurovascular Research Unit Pharmacology and Toxicology DepartmentComplutense UniversityMadridSpain AptaTargets S.L. Avda.Cardenal Herrera OriaMadridSpain Instituto de Investigación Hospital 12 de Octubre MadridSpain Instituto Cajal-CSIC MadridSpain

based on data from Global Burden of Disease,Injuries,and Risk Factors(2024),disorders of the central nervous system(CNS)are an important cause of death or long-term disability,representing the top-ranked contributor to global disability adjusted life *** group of pathological conditions includes congenital and neurodevelopmental disorders,cerebrovascular diseases,and neurodegenerative diseases,and induce the disruption of brain growth,brain and/or spinal cord damage,and cognitive,sensory,or motor function ***,despite the huge impact of these diseases on the lives of patients,there is a lack of available therapeutic options and the investigation in the field represents real interest in the scientific community nowadays.

关键词： diseases congenital impairment