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The global climate monitor system:from climate data-handling to knowledge dissemination

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International Journal of Digital Earth 2019年第4期12卷 394-414页

作者： Juan Mariano Camarillo-Naranjo José Ignacio Álvarez-Francoso Natalia Limones-Rodríguez María fernanda Pita-López Mónica Aguilar-Alba Department of Physical Geography and Regional Analysis University of SevilleSevilleSpain Department of Human Geography University of SevilleSevilleSpain

This paper summarizes our work on building a data model and a geovisualization tool that provides access to global climate data:the Global Climate Monitor Web *** to this viewer,a complete set of climate-environmental indicators capable of displaying climate patterns on a global scale that is accessible to any potential user(scientists and laypeople)will be built and published using the same online *** data currently available correspond to the CRU TS3.21 version of the Climate Research Unit(University of East Anglia)database–a product that provides data at a spatial resolution of half of a degree in latitude and longitude,spanning January 1901 to December 2012,on a monthly *** January 2013,the datasets feeding the system have been the GHCN-CAMS temperature dataset and the Global Precipitation Climatology Centre(GPCC)First Guess precipitation ***,hydrologists,planners and non-experts users such as media workers,policymakers,non-profit organizations,teachers or students,can access useful climatological information through the Global Climate Monitor system.

关键词： Geovisualization climate indicators global climate databases open-source software

Decontamination of mobile phones and electronic devices for health care professionals using a chlorhexidine/carbomer 940■gel

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 192-198页

作者： Rafael Muniz de Oliveira Nereida Mello da Rosa Gioppo Jancineide Oliveirade Carvalho Francilio Carvalho Oliveira Thomas Jay Webster fernanda Roberta Marciano Anderson Oliveira Lobo University Hospital of the West of Parana State University of West of Parana Cascavel PR Brazil University Center for Health. Humanities and Technology of Piaui (UNINOVAFAPI). Piaui Brazil Science and Technology Institute Brasil University Itaquera SP Brazil Nanomedicine Laboratory Department of Chemical Engineering Northeastern University MA 02115 USA Materials Science and Engineering graduation program Technology Center Federal University of Piaui. PI Brazil

Though they reduce microorganism growth, current hospital disinfectants also damage many of today’s modern electronic devices such as tablets and smartphones. Herein, the efficacy of a new chlorhexidine digluconate gel (CDG) was tested as a disinfectant for mobile and electronic devices in a clinical environment. Specifically, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and methicillin resistant Staphylococcus aureus were used to infect the screen of eight smartphones. The CDG was prepared at concentrations of 2%, 4% and 6%, and tested on paper disks infected with these bacteria before being tested on the smartphones. The devices were disinfected with the CDG gel (4%) at two times: immediately and after 5 min of the bacterial contamination. In all cases, the CDG gel eliminated 100% of gram-positive and gram-negative microorganisms compared to the control (without any agent). In addition, the gel did not damage the smartphones. Therefore, our study suggests that the CDG gel may be applied to disinfect a wide range of electronic devices for health care professionals in the hospital environment.

关键词： smartphones disinfection clinical environment chlorhexidine bacteria

Noninvasive imaging assessment of non-alcoholic fatty liver disease:focus on liver scintigraphy

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World Journal of Gastroenterology 2015年第15期21卷 4432-4439页

作者： Cristiane Valle Tovo Angelo Zambam de Mattos Gabriela Perdomo Coral fernanda Schild Branco Eiji Suwa Angelo Alves de Mattos Department of Gastroenterology and Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre

Noninvasive diagnoses of nonalcoholic fatty-liver disease(NAFLD) involve the use of serologic markers and imaging methods, such as conventional ultrasonography(US),computed tomography, and magnetic resonance imaging. Although these methods are reliable for the noninvasive detection of moderate to severe fatty changes in the liver, they are not reliable for detecting nonalcoholic steatohepatitis(NASH) and fibrosis. New imaging technologies, such as US-based transient elastography, acoustic radiation force impulse and magnetic resonancebased elastography, can reportedly be used to determine the severity of liver fibrosis associated with NASH. In this context, the field of nuclear medicine through liver scintigraphy has recently been proposed, and is being explored for use in the diagnosis of NASH. More importantly, nuclear medicine may contribute to the distinction between simple steatosis and NASH. For example, the enhanced release of cytokines and the decrease in the phagocytic activity of Kupffer cells play important roles in the pathogenesis of NASH. Removal of technetium-99 m colloid from circulation by Kupffer cell phagocytosis therefore provides a valuable imaging technique. Thus, nuclear medicine is poised to provide useful tools for the evaluation of patients with NAFLD. However, the evidence is still scarce, and more studies with larger samples are needed to identify their role before they are used in clinical practice.

关键词： Liver fibrosis Liver scintigraphy Nonalcoholicfatty-liver disease diagnosis Nonalcoholic steatohepatitis Noninvasive methods

Dixy： A Connection Between the “Typographic Appearance” and the Brain of Children

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Journal of Literature and Art Studies 2014年第1期4卷 55-61页

作者： María fernanda del Real García Universidad Autónoma de Barcelona Bellaterra Spain

This study presents a comparison between three different fonts in order to know the possible influence they may have when used in educational materials for children with readers difficulties resulting from dyslexia. Two of the three selected fonts （Arial and MeMimas） are frequently used in textbooks in Spain. The third type of letter （Dixy） was specially developed for typographic research purposes, following graphic features that according to literature and previous studies on reading patterns favor the dyslexic, and could improve reading skills in these individuals. To examine the quality of reading （speed and accuracy） between fonts, a small--but significant--sample was used. Ten children in Madrid, from eight to 10 years old were examined while reading words and pseudowords with three different fonts （Arial, MeMimas, and Dixy）. The result of the study shows the influence of the shapes of the letters in the legibility of texts with familiar and unfamiliar words （pseudowords） in children with dyslexia. The study showed that using the font Dixy, despite not being known by the children, reading is more accurate than using fonts known to them, such as Arial and MeMimas. As to the reading speed, the results indicate that, although the Dixy is a font never seen before by the children, reading speed is similar to a known font for them, as is the Arial, and greater than a hand writing font such as MeMimas.

关键词： legibility letter font dyslexia reading children readers difficulties

Microbiological biostimulant promotes rooting of olive cuttings

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International Journal of Agricultural and Biological Engineering 2021年第6期14卷 207-212页

作者： Giovana Ritter Fabíola Villa Daniel Fernandes da Silva Odair Alberton fernanda Jaqueline Menegusso Tatiane Eberling Joyce Dória Western ParanáState University(Unioeste) Campus Marechal Cândido Rondon.Marechal Cândido RondonPR85960-000Brazil Paranaense University(UNIPAR) UmuaramaPR87502-210Brazil Federal University of Lavras LavrasMG37200-000Brazil

The most widely used method of olive propagation is cutting,although for some cultivars the technique is still *** objective of this work was to evaluate the use of plant growth promoter bacteria and arbuscular mycorrhizal fungi in the rooting of olive *** experiments were conducted from October 2017 to January 2018 with cuttings from 4 olive cultivars(Ascolano 315,Koroneiki,Maria da Féand Picual)from four-year-old *** first experiment consisted of 4 olive cultivars and 3 mycorrhizal species plus the control and the second experiment of 3 concentrations of commercial inoculant(Nitro1000®),containing Azospirillum brasilense plus *** cuttings were treated with 3000 mg/L of indolebutyric acid(IBA).The experimental design used in the two experiments was randomized blocks,in a 4×4 factorial scheme,containing 25 stakes per replicate and 3 *** cuttings were kept under weaver conditions and within a low rooting *** 75 d,the percentage of rooted cuttings,callus and sprouts,length of the largest root,number and length of shoots were *** use of FMA in Maria da Féand Picual has a positive response to cutting rooting and the fungi benefit the quality of the seedlings by the higher number of shoots and larger root *** relation of Azospirillum brasilense cultivar is specific,being that,the cultivar Picual does not respond to inoculation of the bacterium having less viability in the propagation by *** da Féand Koroneiki have the best percentages of rooting with the use of 75.00 and 52.00 mL/L of inoculant,respectively.

关键词： Azospirillum brasilense Arbuscular mycorrhizal fungi Propagation Olea europaea L. microorganism

Tadalafil treatment had a modest effect on endothelial cell damage and repair ability markers in men with erectile dysfunction and vascular risk

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Asian Journal of Andrology 2014年第2期16卷 290-294,I0011页

作者： Fiore Pelliccione Anatolia D'ngeli Settimio D'ndrea Arcangelo Barbonetti Alfonso Pezzella Stefano Necozione Stefano Falone fernanda Amicarelli Felice Francavilla Sandro Francavilla Department of Life Health and Environmental Sciences Section of Andrology Department of Life Health and Environmental Sciences Section of Epidemiology Department of Life Health and Environmental Sciences Section of Biological and Biotechnological Sciences University of UAquila L'Aquila Italy.

The number of the circulating angiogenic cells （CACs） and colony forming units （CFUs） derived from cultured circulating mononuclear cells （MNCs） represents a laboratory surrogate for endothelial cell repair ability. The serum of men with erectile dysfunction （ED） and vascular risk factors （VRFs） showed an increased level of endothelial cell damage/dysfunction markers and reduced the numbers of CACs and CFUs derived from the cells of healthy men. We analyzed whether treating men with ED and VRFs with the selective phosphodiesterase type 5 inhibitor tadalafil improved the endothelial cell repair ability and reduced the levels of the serum markers of endothelial cell damage/dysfunction. MNCs from healthy men were cultured with 20% serum from 36 ED patients to obtain CACs and CFUs. The ED patients were evaluated before and after 4weeks of treatment with tadalafil （20 mg every other day） or with a placebo. The tadalafil treatment improved erectile function （P = 0.0028）, but had no effect on the inhibitory effects of serum from ED patients on the CACs and CFUs derived from healthy men. The levels of endothelin-1 （P = 0.011） and tissue type plasminogen activator （P = 0.005） were reduced after treatment compared to baseline and those of the placebo group, whereas no changes were observed in the E-selectin levels. The tadalafil treatment in the ED patients with VRFs resulted in only a modest effect on the laboratory measures of the endothelial cell damage/dysfunction and repair ability. The proposed beneficial effect of phosphodiesterase type 5 inhibition on vascular homeostasis requires further analysis.

关键词： cardiovascular risk circulating angiogenic cells endothelial cell erectile dysfunction tadalafil

Analysis of the interaction between [Ru(phenanthroline)<sub>3</sub>]<sup>2+</sup>and bovine serum albumin

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Advances in Biological Chemistry 2012年第3期2卷 262-267页

作者： Laura Luzuriaga María fernanda Cerdá Laboratorio de Biomateriales Facultad de Ciencias Montevideo Uruguay

The interaction of compounds with potential use as pharmaceutical with a carrier protein as serum albumin is of great importance in their biodistribution. Albumin offers different sites for binding metallic compounds. Using a combination of spectropho-tometric and electrochemical techniques, the interaction between [Ru(phen)3]Cl2 (phen = phenantroline) and bovine serum albumin was evaluated. In particular, it was possible to calculate an apparent binding constant (Kb) of 4.4 × 103 (for concentrations expressed in M) for the main interaction site of the protein. A number of ca. 40 molecules of Ru-phen per molecule of BSA under saturation conditions, and a positive cooperative behavior towards association from the protein were found.

关键词： Saturation Graph Spectrophotometry Cyclic Voltammetry

The Representation(s) of “The Other”in Passage to India by David Lean

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Journal of Literature and Art Studies 2017年第2期7卷 179-185页

作者： fernanda Costa dos Santos Benedito Agostinho Neto University LuandaAngola

This work presents a critical approach to Passage to India, a film directed by David Lean (1984), based on the novel written by Edward Morgan Foster in 1924, focusing attention on micro representations of Indian society under British imperial power. To structure the work, the ideas of two prominent thinkers whose critical approaches are grounded on the concept of Representation and its implication in relation to perceptions of the “Other” were we selected as theoretical framework, namely Herrieta Lidchi and Stuart Hall. In this way, the work aims at highlighting the power of visual images, represented by the film, in the construction of ethnocentric images created by Imperial power(s) and their importance for the development of critical thinking in relation to residual marks of such representations in post-colonial era.

关键词： Representation Other and Post-Clonia(lism)

Mesenchymal stem cell-and extracellular vesicle-based therapies for Alzheimer's disease:progress,advantages,and challenges

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Neural Regeneration Research 2023年第8期18卷 1645-1651页

作者： Renata Guedes de Jesus Gonçalves Juliana Ferreira Vasques Almir Jordão da Silva-Junior fernanda Gubert Rosalia Mendez-Otero Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa Rio de JaneiroBrazil Plataformas Inovadoras em Terapias Avançadas Departamento de Ciência e Tecnologia-Ministério da Saúde(DECIT-MS)Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)Brazil Programa Redes de Pesquisa em Saúde no Estado do Rio de Janeiro Rio de JaneiroBrazil Instituto de Ciências Biomédicas Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Programa Redes de Pesquisa em Nanotecnologia no Estado do Rio de Janeiro Rio de JaneiroBrazil

Alzheimer's disease is a severe, highly disabling neurodegenerative disease, clinically characterized by a progressive decline in cognitive functions, and is the most common form of dementia in the elderly. For decades, the search for disease-modifying therapies has focused on the two main Alzheimer's disease histopathological hallmarks, seeking to prevent, mitigate, or clear the formation of extracellular aggregates of β-amyloid peptide and intracellular neurofibrillary tangles of tau protein, although without clinical success. Mesenchymal stem cell-based therapy has emerged as a promising alternative for the treatment of Alzheimer's disease, especially because it also targets other crucial players in the pathogenesis of the disease, such as neuroinflammation, synaptic dysfunction/loss, oxidative stress, and impaired neurogenesis. Herein, we review current knowledge of the therapeutic potential of mesenchymal stem cells and their extracellular vesicles for Alzheimer's disease, discussing the most recent findings in both preclinical and clinical trials as well as how advanced technologies have helped to overcome some limitations and contributed to stimulate the development of more effective treatments.

关键词： Alzheimer's disease amyloid-β cell therapy cell transplantation exosomes extracellular vesicles mesenchymal stem cell micro vesicles neuroinflammation tau protein