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Implementation outcomes of a sensory integration therapy program with computerized dynamic posturography in patients with balance and sensory dysfunction

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Journal of Otology 2023年第1期18卷 26-32页

作者： Francisco Javier Gonzalez Eslait Paola Andrea Escudero Trivino Yaidy Viviana Giraldo Vergara Monica Andrea Morales Garcia Vanessa fernanda Lucero Gutierrez Universidad del Valle Audiological and Otological Balance CenterImbanaco Clinic-Grupo Quiron SaludCaliColombia Research Institute.Imbanaco Clinic-Grupo Quiron Salud CaliColombia

Objective:We describe the first-year implementation experience of an Instrumented Sensory Integration Therapy Program in Audiological&Balance Center ***:This is a retrospective descriptive *** included Seventy-three adults with diagnoses of acute,episodic,or chronic vestibular *** were classified into the following two groups:group 1 included 46 individuals treated with ISIT plus VRT,and group 2 included 27 individuals treated only with ***:The Sensory Organization Test(SOT)for both groups showed a statistical significance for all three sensory inputs;visual systems(G1:p=0.0003;G2:p=0.0337),vestibular system(G1:p<0.0001;G2:p=0.0003),and balance as demonstrated by compound balance score(G1:p<0.0001;G2:p=0.0035),and balance percentage deficit(G1:p<0.0001;G2:p=0.0078).Conclusions:The severity and complexity of functional neurological disorders in the context of vestibular syndromes seem to require between 10 and 20 therapy sessions,and combined ISIT plus VRT appears to be more effective than ISIT as a monotherapy.

关键词： Posturography Vestibular rehabilitation therapy Dizziness handicap inventory

Absence of galectin-3 attenuates neuroinflammation improving functional recovery after spinal cord injury

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Neural Regeneration Research 2016年第1期11卷 92-93页

作者： Caio Andrade Prins fernanda Martins Almeida Ana Maria Blanco Martinez Laboratorio de Neurodegeneracao e Reparo-Departamento de Patologia-Faculdade de Medicina-HUCFF-UFRJ-Rio de Janeiro-RJ Brazil Instituto de Ciencia Biomedicas UFRJRio de JaneiroRJBrazil

After spinal cord injury （SCI）, a cascade of events begins. At first, there is physical damage with disruption of the blood-brain barrier （BBB） and the integrity of the nervous tissue. The disruption of central ner- vous system （CNS） BBB alters the endothelial permeability, the protein and chemokines expression and the propensity to release in situ inflam- matory cytokines, overcoming anti-inflammatory signals, facilitating the attraction and entry of immune system cells into the injured spinal cord parenchyma （Gaudet et al., 2011）. As a result, there is a neuroin- flammatory response with changes in blood flow, edema, cell infiltra- tion, apoptosis and release of axonal growth inhibitory factors. Nerve function loss occurs when the nerve impulse propagation is interrupted and do not reach its target. This disorder encompasses neuron and glia apoptosis, accompanied by Wallerian degeneration of disconnected axons, and CNS cells exposure to a hostile microenvironment that hampers axon regeneration （Mautes et al., 2000; Harkey et al., 2003）.

关键词： galectin disruption permeability facilitating attraction cascade macrophages cytokines morphologic exposure

Upregulation of the APE1 and H2AX genes and miRNAs involved in DNA damage response and repair in gastric cancer

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Genes & Diseases 2019年第2期6卷 176-184页

作者： fernanda S.Manoel-Caetano Ana Flávia T.Rossi Gabriela Calvet de Morais Fábio Eduardo Severino Ana Elizabete Silva Department of Biology UNESPSāo Paulo State UniversityCampus of Sāo Josédo Rio PretoRua Cristòvāo Colombo226515.054-000Sāo Josédo Rio PretoSāo PauloBrazil Department of Surgery and Orthopedics Faculty of MedicineUNESPSāo Paulo State UniversityCampus of BotucatuAv.Prof.Mário Rubens Guimarāes Montenegros/n18.618-687BotucatuSāo PauloBrazil

Gastric cancer remains one of the leading causes of cancer-related death worldwide,and most of the cases are associated with Helicobacter pylori *** bacterium promotes the production of reactive oxygen species(ROS),which cause DNA damage in gastric epithelial *** this study,we evaluated the expression of important genes involved in the recognition of DNA damage(ATM,ATR,and H2AX)and ROS-induced damage repair(APE1)and the expression of some miRNAs(miR-15a,miR-21,miR-24,miR-421 and miR-605)that target genes involved in the DNA damage response(DDR)in 31 fresh tissues of gastric *** v3.1.1 was used to construct the postulated miRNA:mRNA interaction *** performed by real-time quantitative PCR exhibited significantly increased levels of the APE1(RQ=2.55,p<0.0001)and H2AX(RQ=2.88,p=0.0002)genes beyond the miR-421 and miR-605 in the gastric cancer *** addition,significantly elevated levels of miR-21,miR-24 and miR-421 were observed in diffuse-type gastric *** analysis reinforced some of the gene:gene(ATM/ATR/H2AX)and miRNA:mRNA relationships obtained also with the interaction ***,our findings show that tumor cells from gastric cancer presents deregulation of genes and miRNAs that participate in the recognition and repair of DNA damage,which could confer an advantage to cell survival and proliferation in the tumor microenvironment.

关键词： DNA damage response DNA repair Gastric cancer Gene expression microRNA

Therapeutic effect of Streptococcus thermophilus CRL 1190-fermented milk on chronic gastritis

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World Journal of Gastroenterology 2010年第13期16卷 1622-1630页

作者： Cecilia Rodríguez Marta Medici fernanda Mozzi Graciela Font de Valdez Centro de Referencia para Lactobacilos (CERELA)-CONICET Cátedra Microbiología Superior Facultad de Bioquímica Química y Farmacia Universidad Nacional de Tucumán

AIM: To investigate the potential therapeutic effect of exopolysaccharide (EPS)-producing Streptococcus thermophilus (S. thermophilus) CRL 1190 fermented milk on chronic gastritis in Balb/c mice. METHODS: Balb/c mice were fed with the fermented milk for 7 d after inducing gastritis with acetyl-salicylic acid (ASA, 400 mg/kg body weight per day for 10 d). Omeprazole was included in this study as a positive therapeutic control. The gastric in? ammatory activity was evaluated from gastric histology and in? ammation score, number of interleukin-10 (IL-10), interferon-γ (INFγ) and tumor necrosis factor-α (TNF-α) cytokine-producing cells in the gastric mucosa, and thickness of the mucus layer. RESULTS: Animals receiving treatment with the EPS-producing S. thermophilus CRL 1190 fermented milk showed a conserved gastric mucosa structure similar to that of healthy animals. In? ammation scores of the fermented milk-treated mice were lower than those of mice in the gastritis group (0.2 ± 0.03 vs 2.0 ± 0.6, P < 0.05). A marked decrease in INFγ+ (15 ± 1.0 vs 28 ± 1.2, P < 0.05) and TNF-α+ (16 ± 3.0 vs 33 ± 3.0, P < 0.05) cells and an increase in IL-10+ (28 ± 1.5 vs 14 ± 1.3, P < 0.05) cells compared to the gastritis group, was observed. Also, an increase in the thickness of the mucus gel layer (2.2 ± 0.6 vs 1.0 ± 0.3; 5.1 ± 0.8 vs 1.5 ± 0.4 in the corpus and antrum mucosa, respectively, P < 0.05) compared with the gastritis group was noted. A milk suspension of the purif ied EPS from S. thermophilus CRL1190 was also effective as therapy for gastritis.

关键词： Lactic acid bacteria Probiotics Gastritis Streptococcus thermophilus Exopolysaccharides

Mechanisms involved in cancer stem cell resistance in head and neck squamous cell carcinoma

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Cancer Drug Resistance 2023年第1期6卷 116-137页

作者： Juliana Mota Siqueira Daniele Heguedusch Camila Oliveira Rodini Fabio Daumas Nunes Maria fernanda Setúbal Destro Rodrigues Department of Stomatology Discipline of Oral and Maxillofacial PathologySchool of DentistryUniversity of São PauloSao Paulo 05508-000Brazil Department of Biological Sciences Bauru School of DentistryUniversity of Sao PauloSão Paulo 17012-230Brazil Biophotonics Applied to Health Sciences Nove de Julho UniversityUNINOVESao Paulo 01504-001Brazil

Despite scientific advances in the Oncology field,cancer remains a leading cause of death *** and cellular heterogeneity of head and neck squamous cell carcinoma(HNSCC)is a significant contributor to the unpredictability of the clinical response and failure in cancer *** stem cells(CSCs)are recognized as a subpopulation of tumor cells that can drive and maintain tumorigenesis and metastasis,leading to poor prognosis in different types of *** exhibit a high level of plasticity,quickly adapting to the tumor microenvironment changes,and are intrinsically resistant to current chemo and *** mechanisms of CSC-mediated therapy resistance are not fully ***,they include different strategies used by CSCs to overcome challenges imposed by treatment,such as activation of DNA repair system,anti-apoptotic mechanisms,acquisition of quiescent state and Epithelial-mesenchymal transition,increased drug efflux capacity,hypoxic environment,protection by the CSC niche,overexpression of stemness related genes,and immune *** elimination of CSCs seems to be the main target for achieving tumor control and improving overall survival for cancer *** review will focus on the multi-factorial mechanisms by which CSCs are resistant to radiotherapy and chemotherapy in HNSCC,supporting the use of possible strategies to overcome therapy failure.

关键词： Head and neck squamous cell carcinoma cancer stem cell chemotherapy radiotherapy therapy resistance

A Dynamic Planner as a Sustainable Planning Way： A Bridge between the Law, Technical Knowledge and the Local Population

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Journal of Civil Engineering and Architecture 2015年第5期9卷 615-625页

作者： fernanda Nascimento Corghi Diogenes Cortijo da Costa Architecture and Urbanism and Applied Arts Department Federal University of S6o Jo6o del-Rei S6o Jo6o del-Rei 36307352Brazil Faculty of Civil Engineering and Architecture and Urbanism State University of Campinas Campinas 13083852 Brazil

The social and environmental demands in Brazilian cities are usually neglected by the local municipal powers due to a heavy bias toward speculative capital. The main issue is a public administration that benefits the private initiative instead of popular and environmental values and needs. Despite federal efforts at the end of the 20th and beginning of the 21 st century, water resources and urban reform policies are not able to ensure a connection between these two issues in the urban environment. Aiming at showing a new approach of citizenship and environmental rights in a developing country, Bauru, a Brazilian city located in the state of S^o Paulo, was used as a study case. In this scenario, the research is based on the action research method, in which a dynamic profile of the researchers was adopted in order to solidify environmental and social issues in the urban planning process. This article shows the advantages in using the river basin as an urban planning territory in the city master plan, and providing continuous technique support to the citizen, through the role played by the researcher-planner between government and population, as a way to possibly reach social and environmental interests. The territorial perception of the river basin by citizens brings effective environmental and social results.

关键词： Urban policy water policy river basin administrative land division governance planning action research.

More than Just a Game: The Power of Social Media on Super Bowl XLVI

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Social Networking 2014年第2期3卷 142-145页

作者： fernanda Bruno dos Santos Jonice Oliveira Graduate School in Computing Science (PPGI) Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brasil

The evolution of social media in the recent years promoted the appearance of a new category: social media based on check-in. It enables the user to define their identity through information sharing. This paper aims to show the evolution of these media highlighting the effects and changes they cause in society through Super Bowl XLVI scenario, besides indicating the important role they have for the companies and marketing.

关键词： Social Media Data Mining Marketing Social Networks Gamification

Chondrogenic potential of mesenchymal stem cells from horses using a magnetic 3D cell culture system

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World Journal of Stem Cells 2021年第6期13卷 645-658页

作者： Joice Fülber fernanda R Agreste Sarah R T Seidel Eric D P Sotelo Ângela P Barbosa Yara M Michelacci Raquel Y A Baccarin Departamento de Clínica Médica Medicina Veterinária e ZootecniaUniversidade de São PauloSão Paulo 05506-270Brazil Departamento de Bioquímica Escola Paulista de MedicinaUniversidade Federal de São PauloSão Paulo 04044-020Brazil

BACKGROUND Mesenchymal stem cells(MSCs)represent a promising therapy for the treatment of equine joint diseases,studied due to their possible immunomodulatory characteristics and regenerative ***,the source of most suitable MSCs for producing cartilage for regenerative processes in conjunction with biomaterials for an enhanced function is yet to be *** To compare the chondrogenicity of MSCs derived from synovial fluid,bone marrow,and adipose tissue of horses,using the aggrecan *** MSCs from ten horses were cultured,phenotypic characterization was done with antibodies CD90,CD44 and CD34 and were differentiated into *** 3D cell culture system in which biocompatible nanoparticles consisting of gold,iron oxide,and poly-L-lysine were added to the cells,and they were forced by magnets to form one *** microspheroids were exposed to a commercial culture medium for 4 d,7 d,14 d,and 21 *** extraction was performed,and aggrecan was quantified by enzyme-linked immunosorbent *** sulfate and aggrecan in the microspheroids were identified and localized by *** All cultured cells showed fibroblast-like appearance,the ability to adhere to the plastic surface,and were positive for CD44 and CD90,thus confirming the characteristics and morphology of *** soluble protein concentrations were higher in the microspheroids derived from adipose *** aggrecan concentration and the ratio of aggrecan to soluble proteins were higher in microspheroids derived from synovial fluid than in those derived from bone marrow,thereby showing chondrogenic *** from all sources expressed aggrecan and keratan sulfate when observed using confocal immunofluorescence *** sources of MSCs can synthesize aggrecan,however,MSCs from synovial fluid and adipose tissue have demonstrated better biocompatibility in a 3D environment,thus suggesting chondrogenic superiority

关键词： Cellular therapy Chondrocytes Aggrecan Keratan sulfate

Lime and orange essential oils and D-limonene as a potential COVID-19 inhibitor:Computational,in chemico,and cytotoxicity analysis

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Food Bioscience 2023年第1期51卷 1151-1158页

作者： Aldrey Nathalia Ribeiro Correa Patrícia Weimer Rochele Cassanta Rossi Jessica fernanda Hoffmann Letícia Scherer Koester Edna Sayuri Suyenaga Cristiano Dietrich Ferreira Instituto Tecnologico em Alimentos para Saúde Universidade do Vale do Rio dos Sinos93022-750Sao LeopoldoRSBrazil Programa de Pos-Graduaçao em Ciencias Farmacˆeuticas Universidade Federal do Rio Grande do Sul90610-000Porto AlegreRSBrazil Programa de Pos-Graduaçao em Toxicologia e Analises Toxicologicas Universidade Feevale93352-000Novo HamburgoRSBrazil

The COVID-19 pandemic has substantially impacted the world health systems,causing public health concerns,and the search for new compounds with antiviral activity is of extreme *** molecules with bioactive potential are a trend,with essential oils(Eos)being the focus of recent ***,this study evaluates in chemico the D-limonene inhibitory activities in the viral genome of SARS-CoV-2 and analyzes the cytotoxic potential and safety profile of D-limonene and lime and orange EOs with a high content of *** EOs were extracted and characterized,and the in chemico computational analysis for the determination as a potential anti-SARS-CoV-2 was performed with D-limonene,the major compound in *** cytotoxicity analysis of EOs and Dlimonene was carried out with MRC-5 and HaCaT,and the preliminary safety profile was also evaluated by the HET-CAM assay.D-limonene was suggested as a promising compound for anti-SARS-CoV-2 research,since the molecule does not provide mutagenic and cytotoxic fragments,and does not have irritating potential when diluted,in addition to having favorable pharmacokinetic characteristics,through in chemico ***,the results reveal the antiviral potential of lime and orange EOs,as well as their major *** this sense,further studies should be conducted to understand the antiviral mechanisms.

关键词： Essential oils D-limonene anti-Sars-CoV-2 COVID-19