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The role of polymorphic cytochrome P450 gene(CYP2B6)in B-chronic lymphocytic leukemia(B-CLL)incidence and outcome among Egyptian patients

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Oncology Research 2024年第4期32卷 785-797页

作者： MENNA AL-ADL MAGDY MYOUSSEF AHMED el-SEBAIE SHERIF REFAAT AFAF el-SAID Division of Biochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt Medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75%of the total metabolism of commercially available drugs,including *** gene expression and enzyme activity of CYPs are variable between individuals,which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics,as well as differences in the efficacy and toxicity of clinically used *** research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide *** was isolated from whole blood samples of 100 de novo B-CLL cases and also from 100 sex-and age-matched healthy *** presence of the CYP2B6*9(G516T)polymorphism was examined by PCR-based allele specific amplification(ASA).Patients were further indicated for receiving chemotherapy,and then they were followed *** CYP2B6*9 variant indicated a statistically significant higher risk of B-CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,pely to achieve remission compared to those with the wild-type genotype(GG),with a response percentage of(37.5%vs.83%,respectively).In conclusion,our findings showed that the CYP2B6*9(G516T)polymorphism is associated with B-CLL susceptibility among Egyptian *** variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： B-CLL Xenobiotics Cytochromes P450 CYP2B6

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Hematobiochemical and histopathological alterations in Nile Tilapia(Oreochromis niloticus)exposed to ethidium bromide:The protective role of Spirulina platensis

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Aquaculture and Fisheries 2024年第1期9卷 93-103页

作者： Sabreen Abdullah Mervat Naguib Alaa el-Din Salah el-Din Alaa el-Din H.Sayed Zoology Department Faculty of ScienceAswan UniversityAswan81528Egypt Zoology Department Faculty of ScienceAssuit UniversityAssiut71516Egypt

Ethidium bromide(EtBr)is one of the contaminants recorded in aquatic environments whose effects have been investigated;however,there is still limited knowledge about its *** study examined the potential protective effects of Spirulina platensis(SP)against the effects of EtBr toxicity in the Nile tilapia(Oreochromis niloticus)*** were divided to five groups,viz.,a control and four treatment groups of low-dose EtBr(10μg/L),low-dose EtBr with SP(10μg/L EtBr+200 mg/L SP),high-dose EtBr(100μg/L),and high-dose EtBr with SP(100μg/L EtBr+200 mg/L SP);the exposure period was 2 *** and high doses of EtBr induced alterations in some hematological,biochemical,and histopathological *** hepatocytes,degenerated area,vacuolated hepatocytes,pyknotic nuclei,constricted and dilated blood sinusoids,and infiltration of inflammatory cells were *** peroxidation concentration was not significantly different in groups exposed to low doses of EtBr and EtBr with SP,but it was increased in groups exposed to high doses of EtBr and EtBr with SP,compared with the control *** feeding with SP,most histological and histochemical parameters restored to normal ***,SP may possess the ability to preserve the structural integrity of the hepatic and renal membranes.

关键词： Ethidium bromide Spirulina platensis Oreochromis niloticus Liver Lipid peroxidation

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Financial and non-financial determinants of the indebtedness of hospitals:the case of Poland

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Journal of Management Analytics 2024年第1期11卷 26-44页

作者： Katarzyna Miszczyńska elżbieta Antczak Department of Banking Faculty of Economics and SociologyUniversity of LodzLodzPoland Department of Spatial Econometrics Faculty of Economics and SociologyUniversity of LodzLodzPoland

The performance of Polish healthcare is still far from satisfactory,which is connected with growing indebtedness that adversely affects not only the development of healthcare but also the quality of medical services *** turn,the financial situation of hospitals depends on various indicators and the relationship between *** paper investigates the determinants of healthcare sector functioning in the context of hospitals’financial situation(dependent variable measured by total debt ratio).321 individual public units were examined between years 2007–*** specifically,the fixed effects panel data model in question measures and evaluates the impact of economic,regional,institutional,and social factors in determining the dependent *** study confirmed dependencies between financial and non-financial ratios along with their impact on the financial condition of studied *** management implications of our study lay the groundwork for the improvement of efficient resource management for public hospitals.

关键词： polish healthcare system hospitals’financial situation debt ratio panel data analysis

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Smart prediction of liquefaction-induced lateral spreading

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2310-2325页

作者： Muhammad Nouman Amjad Raja Tarek Abdoun Waleed el-Sekelly New York University(NYU)Abu Dhabi Abu Dhabi129188United Arab Emirates University of Management and Technology Lahore54372Pakistan Department of Civil and Environmental Eng. Rensselaer Polytechnic Institute(RPI)1108th StreetJEC 4049TroyNY12180USA Department of Structural Engineering Mansoura UniversityMansoura35516Egypt

The prediction of liquefaction-induced lateral spreading/displacement(Dh)is a challenging task for civil/geotechnical *** this study,a new approach is proposed to predict Dh using gene expression programming(GEP).Based on statistical reasoning,individual models were developed for two topographies:free-face and gently sloping *** with a comparison with conventional approaches for predicting the Dh,four additional regression-based soft computing models,*** process regression(GPR),relevance vector machine(RVM),sequential minimal optimization regression(SMOR),and M5-tree,were developed and compared with the GEP *** results indicate that the GEP models predict Dh with less bias,as evidenced by the root mean square error(RMSE)and mean absolute error(MAE)for training(i.e.1.092 and 0.815;and 0.643 and 0.526)and for testing(i.e.0.89 and 0.705;and 0.773 and 0.573)in free-face and gently sloping ground topographies,*** overall performance for the free-face topology was ranked as follows:GEP>RVM>M5-tree>GPR>SMOR,with a total score of 40,32,24,15,and 10,*** the gently sloping condition,the performance was ranked as follows:GEP>RVM>GPR>M5-tree>SMOR with a total score of 40,32,21,19,and 8,***,the results of the sensitivity analysis showed that for both free-face and gently sloping ground,the liquefiable layer thickness(T_(15))was the major parameter with percentage deterioration(%D)value of 99.15 and 90.72,respectively.

关键词： Lateral spreading Intelligent modeling Gene expression programming(GEP) Closed-form solution Feature importance

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Finite element method resolution and error estimators for p-Laplacian problem with a new boundary condition

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Acta Mathematica Sinica,English Series 2024年

作者： Omar el MOUTEA Hassan el AMRI Laboratory of Mathematics and Applications ENS Hassan Ⅱ University

In this article, we discuss the approach to solving a nonlinear PDE equation, specifically the p-Laplacian equation, with a general (nonlinear) boundary condition. We establish the existence and uniqueness of the solution, subject to certain assumptions outlined in this paper. To solve our nonlinear problem using the Finite element Method (FEM), we derive an appropriate variational ***, we introduce a study of the residual a posteriori-error indicator, establishing both upper and lower bounds to control the error. The upper bound is determined using averaging interpolators in some Quasi-norms defined by Barrett and Liu. Furthermore, we prove the equivalence between the residual error and the true error e=u-uh. Lastly, we perform a simulation of the p-Laplacian problem in the L-shape domain using a Matlab program in two-dimensional space.

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Immunoglobulin A glomerulonephropathy:A review

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World Journal of Clinical Cases 2024年第8期12卷 1388-1394页

作者： Mohamad el Labban Salim Surani Department of Internal Medicine Mayo Cliic Health SystemMankatoMN 56001United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United State

In this editorial,we comment on the article by Meng et al published in the World Journal of Clinical *** comprehensively review immunoglobulin A nephro-pathy(IgAN),including epidemiology,clinical presentation,diagnosis,and ***,also known as Berger's disease,is the most frequent type of primary glomerulonephritis(GN)*** is mostly found among the Asian *** presentation can be variable,from microscopic hematuria to a rapidly progressive *** 50%of patients present with single or recurring episodes of gross *** upper respiratory infection and tonsillitis often precede these *** 30%of patients present microscopic hematuria with or without proteinuria,usually detected on routine *** diagnosis relies on having a renal biopsy for pathology and immunofluorescence *** focus on risk stratification and management of *** provide a review of all the landmark studies to *** to the 2021 KDIGO(kidney disease:Improving Global Outcomes)guidelines,patients with non-variant form IgAN are first treated conservatively for three to six *** approach consists of adequate blood pressure control,reduction of proteinuria with renin-angiotensin system blockade,treatment of dyslipidemia,and lifestyle modifications(weight loss,exercise,smoking cessation,and dietary sodium restrictions).Following three to six months of conservative therapy,patients are further classified as high or low risk for disease ***-risk patients have proteinuria≥1 g/d orel of<1 g/d and stable/im-proved renal function indicates a good treatment response for patients on immu-nosuppressive therapy.

关键词： Immunoglobulin A nephropathy Glomerulonephritis Nephritic syndrome Angiotensin-converting enzyme inhibitor Angiotensin receptor blocker Systemic steroids Mycophenolate mofetil

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Rao Algorithms-Based Structure Optimization for Heterogeneous Wireless Sensor Networks

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Computers, Materials & Continua 2024年第1期78卷 873-897页

作者： Shereen K.Refaay Samia A.Ali Moumen T.el-Melegy Louai A.Maghrabi Hamdy H.el-Sayed Faculty of Computers and Artificial Intelligence Sohag UniversitySohag82524Egypt Faculty of Engineering Assiut UniversityAssiut711745Egypt College of Engineering University of Business and TechnologyJeddah23411Saudi Arabia

The structural optimization of wireless sensor networks is a critical issue because it impacts energy consumption and hence the network’s *** studies have been conducted for homogeneous networks,but few have been performed for heterogeneouswireless sensor *** paper utilizes Rao algorithms to optimize the structure of heterogeneous wireless sensor networks according to node locations and their initial *** proposed algorithms lack algorithm-specific parameters and metaphorical *** proposed algorithms examine the search space based on the relations of the population with the best,worst,and randomly assigned *** proposed algorithms can be evaluated using any routing protocol,however,we have chosen the well-known routing protocols in the literature:Low Energy Adaptive Clustering Hierarchy(LEACH),Power-Efficient Gathering in Sensor Information Systems(PEAGSIS),Partitioned-based Energy-efficient LEACH(PE-LEACH),and the Power-Efficient Gathering in Sensor Information Systems Neural Network(PEAGSIS-NN)recent routing *** compare our optimized method with the Jaya,the Particle Swarm Optimization-based Energy Efficient Clustering(PSO-EEC)protocol,and the hybrid Harmony Search Algorithm and PSO(HSA-PSO)*** efficiencies of our proposed algorithms are evaluated by conducting experiments in terms of the network lifetime(first dead node,half dead nodes,and last dead node),energy consumption,packets to cluster head,and packets to the base *** experimental results were compared with those obtained using the Jaya optimization *** proposed algorithms exhibited the best *** proposed approach successfully prolongs the network lifetime by 71% for the PEAGSIS protocol,51% for the LEACH protocol,10% for the PE-LEACH protocol,and 73% for the PEGSIS-NN protocol;Moreover,it enhances other criteria such as energy conservation,fitness convergence,packets to cluster head,and packets to the base sta

关键词： Wireless sensor networks Rao algorithms optimization LEACH PEAGSIS

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Genetic Variability and Phenotypic Correlations Study among Grain Quality Traits and Mineral elements Concentrations in Colored and Non-Colored Rice (Oryza sativa L.)

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1733-1748页

作者： Adel A.Rezk Mohamed M.el-Malky Heba I.Mohamed Hossam S.el-Beltagi Agricultural Biotechnology Department College of Agricultural and Food ScienceKing Faisal UniversityAl-Ahsa31982Saudi Arabia Plant Pathology Research Institute Agriculture Research CenterGiza12619Egypt Rice Research and Training Center Field Crop Research InstituteAgriculture Research Center33717Egypt Biological and Geological Sciences Department Faculty of EducationAin Shams UniversityCairo11511Egypt Biochemistry Department Faculty of AgricultureCairo UniversityGiza12613Egypt

Twenty-four rice genotypes were examined to assess genetic variability,heritability,and correlations for seven-grain quality traits,eight nutritional elements,and *** revealed signiﬁcant differences for the quality traits *** every trait under study,the phenotypic coefﬁcient of variation was higher than the correspon-dence genotypic coefﬁcient of *** in a broad sense varied from 29.75%for grain length to 98.31%for the elongation *** percentage recovery had a highly signiﬁcant positive correlation with milling and head rice ***,milling percentage had a highly positive correlation with head rice *** amylose percentage,all the genotypes belonged to low amylose except the Hassawi-1 variety,which had intermediate amylose *** nutrition contents of magnesium(Mg),sodium(Na),potas-sium(K),calcium(Ca),copper(Cu),manganese(Mn),zinc(Zn),iron(Fe),or protein percentage gave different variations for 24 rice genotypes under all the nutritional *** the 24 genotypes,ten rice genotypes–HighNutrient-1,HighNutrient-2,HighNutrient-9,HighNutrient-8,HighNutrient-3,Hassawi-2,HighNutrient-7,HighNutrient-6,Hassawi-1,and HighNutrient-4–had the highest heist value for all nutritional and protein con-tents,and could be used as a donor to improving new *** was a positive and signiﬁcant correlation between magnesium Mg,K,Zn and ***,K had a positive correlation with zinc Zn,Fe,and protein *** analysis was divided into two groups:theﬁrst group included all genotypes rich in nutri-ents,while the remaining genotypes with low nutritional content were included in the second group.

关键词： Amylose cluster analysis genotypes grain quality mineral nutrition rice

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Mafic and felsic magmatism in the Wadi Kalalat area, South Eastern Desert, Egypt: mineralogy, geochemistry and geodynamic evolution during the Neoproterozoic in the Nubian Shield

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Acta Geochimica 2024年第1期43卷 150-173页

作者： Adel A.Surour Ahmed A.Madani Mohamed A.el-Sobky Faculty of Science Galala UniversityNew Galala CitySuez 43511Egypt Department of Geology Faculty of ScienceCairo UniversityGiza 12613Egypt Egyptian Mineral Resources Authority P.O.Box 11517AbbasiyaCairoEgypt

In the south Eastern Desert of Egypt,two contrasting types of magmatism(mafic and felsic) are recorded in the Wadi Kalalat area,and form the Gabal el Motaghiarat and Gabal Batuga intrusions,*** two intrusions post-dates ophiolitic and arc associations represented by serpentinite and metagabbro-diorite,*** mafic intrusion has a basal ultramafic member represented by fresh peridotite,which is followed upward by olivine gabbro and anorthositic or *** mafic intrusion pertains to the Alaskan-type mafic-ultramafic intrusions in the Arabian-Nubian Shield(ANS)being of tholeiitic nature and emplaced in a typical arc *** the other hand,the Gabal Batuga intrusion comprises three varieties of fresh A-type granites of high K-calc alkaline nature,which is peraluminous and garnetbearing in parts.A narrow thermal aureole in the olivine gabbro of the mafic intrusion was developed due to the intrusion of the Batuga *** results in the development of a hornfelsic melagabbro variety in which the composition changed from tholeiitic to a calc-alkaline composition due to the addition of S_(i)O_(2),Al_(2)O_(3),alkalis,lithosphile elements(LILEs) such as Rb(70 ppm) and Y(28 ppm) from the felsic *** the thermal aureole,Rb amounts 2-8 ppm and Y lies in the range elieved that the Gabal Batuga felsic intrusion started to emplace during the waning stage of an arc system,with transition from the pre-collisional(i.e.,arc setting) to post-collisional and within plate *** from which the Gabal Batuga granites were fractionated is high-K calc-alkaline giving rise to a typical post-collisional A-type granite(A_(2)-subtype) indicating an origin from an underplating crustal ***,it is stressed here that the younger granites in the ANS are not exclusively post-collisional and within-plate but most likely they started to develop before closure of the arc *** possible source(s) of mafic magmas

关键词： Wadi Kalalat Gabal el Motaghairat mafic intrusion Gabal Batuga felsic intrusion Arc setting Post-collision Within-plate

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Immunobiodiversity:Conserved and specific immunity across land plants and beyond

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Molecular Plant 2024年第1期17卷 92-111页

作者： Baptiste Castel Karima el Mahboubi Christophe Jacquet Pierre-Marc Delaux Laboratoire de Recherche en Sciences Végétales(LRSV) Universitéde ToulouseCNRSUPSToulouse INPCastanet-TolosanFrance

Angiosperms represent most plants that humans cultivate,grow,and ***,angiosperms are only one of five major land plant *** a whole lineage,plants also include algal *** these clades represent a tremendous genetic diversity that can be investigated to reveal the evolutionary history of any given *** this review,we describe the current model of the plant immune system,discuss its evolution based on the recent literature,and propose future directions for the *** angiosperms,plant–microbe interactions have been intensively studied,revealing essential cell surface and intracellular immune receptors,as well as metabolic and hormonal defense *** diversity at the genomic and functional levels demonstrates the conservation of these pathways across land plants,some of which are beyond *** basis of the conserved mechanisms,lineage-specific variations have occurred,leading to diversified reservoirs of immune *** rare cases,this diversity has been harnessed and successfully transferred to other species by integration of wild immune receptors or engineering of novel forms of receptors for improved resistance to *** propose that exploring further the diversity of immune mechanisms in the whole plant lineage will reveal completely novel sources of resistance to be deployed in crops.

关键词： evolution MPMI immunity plant evoMPMI symbiosis

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