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Advances in Infectious Diseases 2020年第2期10卷 140-147页

作者： Rosa Maria Dias Larissa Rodrigues da Costa Agostilina Renata dos Santos da Cruz Ramos Andrea Graças Ferreira Frazã o Clá udia Daniele Tavares Dutra fernanda Maria Lima Moura Isameriliam Rosaulem Pereira da Silva José Luiz Fernandes Vieira Faculty of Nutrition Institute of Health Sciences Para Federal University Belem Brazil Pharmacy Faculty Campus Universitario do Guama Para Federal University Belem Brazil

Objective: To investigate the factors associated with malaria vivax infection in children and adolescents from an endemic area in the Eastern portion of the Brazilian Amazon basin. Methods: A case-control study was carried out in the municipality of Anajas, Brazil, from January 2016 to September 2017. Questionnaires were applied to the relative or the legal tutors of children and adolescents with questions regarding social and economic status, educational degree, knowledge about malaria, and the use of protective measures against mosquito bites. Anthropometric measures were performed in children and adolescents. Results: A total of 58 cases and 61 controls were included in the study. Most of the participants were male, eutrophics, and their relatives presented low educational degrees as well as low social and economic status. The knowledge of malaria was limited, but the percentage of individuals using long-lasting insecticidal nets was high. The presence of peri-domiciliary breeding sites for Anopheles vector was the most critical factor for malaria. Conclusion: The occurrence of malaria was associated with low social and economic status, a low educational degree, the unfamiliarity with malaria and the presence of breeding sites for Anopheles mosquito surrounding individual domiciles.

关键词： Infectious Diseases Malaria Epidemiology Risk Factor

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巴西磷矿泥浆中磷灰石的回收（英文）

武汉工程大学学报 2017年第6期39卷 519-528页

作者： MATIOLO Elves COUTO Hudson Jean Bianquini TEIXEIRA Michelle fernanda de Lira FREITAS Amanda Soaresde ALMEIDA Renata Nigride 矿物工艺学中心(CETEM/MCTIC) 巴西RJ21941-908 Copebras-CMOC公司巴西GO75701-970

巴西磷酸盐工业一工厂的磷灰石的生产流程一般包括:磨矿;粗细粒分级;磁选(弱磁和强磁);脱泥工艺(除去颗粒小于10μm);重晶石浮选和磷灰石浮选。研究了位于巴西戈亚斯州的Copebras工业磷矿厂的泥浆样品中的磷灰石含量,结果显示原矿中含有... 详细信息

巴西磷酸盐工业一工厂的磷灰石的生产流程一般包括:磨矿;粗细粒分级;磁选(弱磁和强磁);脱泥工艺(除去颗粒小于10μm);重晶石浮选和磷灰石浮选。研究了位于巴西戈亚斯州的Copebras工业磷矿厂的泥浆样品中的磷灰石含量,结果显示原矿中含有13.2%P_2O_5;14%CaO;19.7%SiO_2和27.7%Fe_2O_3,相当于含磷灰石(32%),针铁矿(25%),石英(18%),磷钡铝矿(5.2%).颗粒尺寸分布特征表明:特征直径(D_(32),D_(10),D_(50)和D_(90))分别为2.6μm,1.0μm,5.7μm和25μm。考虑水力旋流器(40 mm)将工艺流程分两个阶段进行脱泥,然后通过浮选柱进行磷灰石浮选,得到含有35.6%P_2O_5和主要杂质为Fe_2O_3(4.0%)和SiO_2(5.1%)的精矿,考虑到脱泥和浮选过程的质量平衡,总体回收率约为11%,P2O5回收率为30%.

关键词：磷灰石浮选矿泥浮选柱

Lycopene Supplementation Attenuates Oxidative Stress Parameters in the Plasma of Humans with Cad after Intense Exercise

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Food and Nutrition Sciences 2011年第4期2卷 241-248页

作者： Marília C. Araujo fernanda S. Soares Merieli M. Ronsani Luiz G. C. Rocha Lilian C. Vieira Luciano A. Silva Tales de Carvalho Magnus Benetti Ricardo A. Pinho 不详

To investigate the effects of moderate and intense exercise (ME,IE) and lycopene (L) supplementation on oxidative stress biomarkers in patients with CAD. Rehabilitation ***-two male volunteers with CAD (55.65 ? 2.27 years, 77.27 ? 3.95 kg, 171.9 ? 2.80 cm) were divided into four groups;ME-Placebo (n = 7), ME + L (n = 8), IE-Placebo (n = 8) and IE-L (n = 9). Blood samples (12 mL) were collected before supplementation (one cereal bars – 15 mg of syn-thetic lycopene) and exercise (45 min plus 15 min of stretching, 3/wk) and after five weeks of supplementation and 72 h after exercise. Nitrite/nitrate concentrations (NOx), lipoperoxidation (TBARS levels), protein carbonylation (PC) and superoxide dismutase (SOD) and catalase (CAT) activity were assessed in plasma. NOx decreased significantly in the ME-P, IE-P and ME-L groups at 72 h after exercise and increased in the IE-L 72 h after the last exercise session. The IE-L group demonstrated decreased TBARS at 72 h after the last exercise session. The level of PC increased only in EI-P at 72 h after the last exercise session, while only the EI-L group presented a reduction. SOD increased signifi-cantly in both placebo groups 72 h after the last exercise session and decreased in the ME-L group 72 h after in rela-tion to placebo groups. CAT increased in ME-P, IE-P and IE-L groups only at 72 h after the last exercise session. The lycopene supplementation attenuates some markers of oxidative stress associated with IE Lycopene also had dissimilar effects on some markers of oxidative stress in subjects undertaking ME versus IE.

关键词： Lycopene Coronary Artery Disease Oxidative Stress Nitric Oxide Intense Exercise

Local Cutaneous Effects Associated with Chlorhexidine-Impregnated Gel Dressing in Hematopoietic Stem Cell Transplantation Patients

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Open Journal of Nursing 2018年第2期8卷 115-129页

作者： Bruna Nogueira dos Santos Maria Carolina de Oliveira fernanda T. M. M. Braga Amanda Salles Margatho Laís C. C. Esparrachiari Renata C. de C. P. Silveira Department of General and Specialized Nursing Ribeir&#227 o Preto College of Nursing University of S&#227 o Paulo Ribeir&#227 o Preto Brazil Division of Clinical Immunology Ribeir&#227 o Preto Medical School University of S&#227 o Paulo Ribeir&#227 o Preto Brazil Department of Nursing State University of Londrina Londrina Brazil

Introduction: Hematopoietic stem cell transplantation (HSCT) often requires a central venous catheter (CVC) for quick and safe vascular access. Currently, new technologies are available to protect the catheter insertion site, such as chlorhexidine-impregnated gel dressings (CIGD). Objectives: To evaluate local cutaneous effects associated with CIGD in patients undergoing HSCT. Methods: In this cross-sectional, prospective study, we evaluated 25 HSCT patients who had a CVC inserted. Patients were visited daily to monitor the CIGD changing procedures and evaluate abnormalities of the underlying skin after dressing removal. Findings: Local erythema was the most frequently detected abnormality, although usually transient and considered secondary to the mechanical trauma of dressing removal. The most severe lesions, consisting of areas of skin loss, erythematous plaques and/or vesicles were classified as skin irritation and presented in 11 (44%) of the 25 patients. An association test showed that skin irritation was more frequent in patients who underwent allogeneic HSCT (p = 0.03). Skin irritation was most frequently observed in areas of contact with the non-woven polyester adhesive tape (n = 22;88%), which made up the adhesive margins of the dressing. The CIGD was discontinued in 6 (54%) of the 11 patients who presented severe skin injuries. Conclusion: In this study, we detected that skin irritation was more frequent in patients who underwent allogeneic HSCT. The most common skin manifestation was skin loss.

关键词： Bandages Catheterization Central Venous Catheters Hematopoietic Stem Cell Transplantation Skin Abnormalities

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柬埔寨金边大屠杀纪念馆

现代装饰 2014年第12期 118-121页

作者： Zaha Hadid Patrik Schumacher Malgorzata Kowalczyk Michal Wojtkiewicz Torsten Broeder fernanda Mugnaini Vlktor Fretyan 姜敏华 Zaha Hadia Architects(ZHA)

本案位于柬埔寨的首都金边,是由扎哈·哈迪德建筑师事务所设计的一个具有全新开拓性意义的大屠杀纪念馆。这个纪念馆也是集博物馆、研究中心、研究院、文件档案管理处和研究性图书馆为一身的综合性机构。本纪念馆的创始人Youk Chhang是... 详细信息

本案位于柬埔寨的首都金边,是由扎哈·哈迪德建筑师事务所设计的一个具有全新开拓性意义的大屠杀纪念馆。这个纪念馆也是集博物馆、研究中心、研究院、文件档案管理处和研究性图书馆为一身的综合性机构。本纪念馆的创始人Youk Chhang是一位不懈的致力于研究红色高棉暴行的人权活动家,也是柬埔寨文献中心的执行理事。纪念馆的名字Sleuk Rith意思是＂树叶的力量＂;旨在表达柬埔寨几个世纪的宗教领袖都曾用树叶记载历史、传播知识,并在严酷的统治和危险时期以此来保存文化。发生于柬埔寨红色高棉时期的大屠杀是整个东南亚历史上最大规模的屠杀行为,亦是柬埔寨历史中无法抹去的黑暗年代。金边大屠杀纪念馆的建造同它的名字一样,

关键词：纪念馆柬埔寨金建筑师事务所档案管理最大规模开拓性哈迪德

IMT504: A New and Potent Adjuvant for Rabies Vaccines Permitting Significant Dose Sparing

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World Journal of Vaccines 2012年第4期2卷 182-188页

作者： Alejandro D. Montaner Analia De Nichilo Juan M. Rodriguez Andres Hernando-Insua Juan Fló Ricardo A. Lopez Verónica Sierra Claudio Paolazzi Oscar Larghi David L. Horn Jorge Zorzopulos fernanda Elias David Horn LLC Doylestown PA USA. Immunotech S.A. Buenos Aires Argentina Instituto de Investigaciones Biomédicas Fundación Pablo Cassará Buenos Aires Argentina Instituto San Jorge Bagó Buenos Aires Argentina Instituto San Jorge Bagó Buenos Aires Argentina. nstituto de Investigaciones Biomédicas Fundación Pablo Cassará Buenos Aires Argentina

Background: Rabies virus infection causes encephalitis, which is almost always fatal. Vaccination can be extremely effective at preventing disease but is prohibitively costly. Vaccine formulations allowing dose-sparing and fewer inoculations with faster antibody response would be extremely desirable. IMT504, an immunostimulatory non-CpG oligo-deoxynucleotide, is a highly potent vaccine adjuvant. Methods: Human and rat antibody measurements, and rat chal-lenge studies were performed. Results: In rats, highly effective immune responses with IMT504 were observed even after diluting vaccine up to 1/625. In highly lethal, live intracerebral rabies challenge studies, protection occurred even with extremely dilute vaccine plus IMT504. In humans, antibody titers developed faster and were significantly higher with IMT504-adjuvanted diluted vaccine vs non-adjuvanted vaccine (full strength or diluted). All five administered IMT504-adjuvanted diluted vaccine reached protective antibodies (≥0.5 IU/ml) after the second injection. After the third injection, individuals receiving IMT504-adjuvanted diluted vaccine reached levels approximately 10 times higher than controls (M ± SEM: 31.0 ± 10.9 vs 3.40 ± 0.99 IU/ml). Conclusions: These data suggest that IMT504 may allow fewer inoculations, highly significant dose-sparing of vaccine, rapid antibody production and protection from rabies. Extensive clinical studies are necessary to confirm if the use of IMT504 will permit significantly greater access to highly effective life-saving rabies vaccines.

关键词： IMT504 Adjuvant Rabies Vaccine Human Animal

Injectable Biological Bulking Agent to Treat Stress Urinary Incontinence in Women: A Feasibility Pilot Study

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Open Journal of Urology 2022年第2期12卷 107-116页

作者： Salvador V. C. Lima Eugê nio S. Lustosa fernanda C. F. S. Calisto Evandilson G. C. De Barros Bruno C. A. Santos Fábio O. Vilar Post-Graduation Program in Surgery Department of Surgery Health Sciences Center Federal University of Pernambuco Recife Brazil Department of Surgery Center for Health Sciences Federal University of Pernambuco Recife Brazil Head of Urology Department Federal University of Pernambuco Recife Brazil

Background: Urinary incontinence mainly affects women regardless of age and, as it affects their quality of life, influences work, sex life and independence for activities of daily living. The treatment of stress urinary incontinence including urethral volume injection therapy can provide an intermediate option over non-surgical and surgical therapies. One of the mechanisms for stress continence depends on the effective coaptation of the urethra during the increase in intra-abdominal pressure. The bulking agents can be injected transurethral or periurethral retrogradely, using direct vision from a cystoscope. Purpose: To evaluate the feasibility and preliminary outcome performance of the bacterial polysaccharide gel used as biological bulking agent applied in female patients with stress urinary incontinence. Methods: A prospective clinical pilot study was performed, in a single institution, including female patients who were admitted to the urologic outpatient clinic with Stress Urinary Incontinence (SUI) without previous treatments and they were selected and underwent bulking agent procedure. The evaluation was performed at the time of enrollment and 6 months after treatment. The primary outcome was Quality of Life (QOL) using the ICIQ-SF Questionnaire. The amount of urine leakage measured by the 1-HOUR PAD-TEST was the second outcome. Results: Fifteen women (with an average age of 53 years) were submitted to the application of bacterial cellulose gel and she was analyzed. Only two patients presented unchanged incontinence. The study considered as primary outcome the improvement or disappearance of symptoms after six months of intervention. Post-intervention Quality of Life (QOL) questionnaire indicated that all of these patients related a better quality of life (62.5%). Through the PAD-test it was possible to observe a decrease in urinary leak of 85% comparing the results pre and post-intervention (BCA—Bacterial Cellulose Application) with p-value equal to 0.00000

关键词： Bulking Agents Urinary Incontinence Stress Biopolymers

Photodynamic Therapy for Medication-Related Osteonecrosis of the Jaws: A Case Report

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International Journal of Clinical Medicine 2016年第12期7卷 824-828页

作者： Mônica Simões Israel Sarah Aparecida Antero Gisele Cuba Riche Giulianna Lima Pinheiro Mayara Leonel Duarte Meira fernanda Vieira Heimlich Wagner Pinto das Chagas Nathália de Almeida Freire Maria Eliza Barbosa Ramos Rosemiro de Menezes Maciel School of Dentistry Rio de Janeiro State University Rio de Janeiro Brazil

Medication-related osteonecrosis of the jaws (MRONJ) is a relatively new disease. MARX reported first cases in 2003. MRONJ relates to oral and parenteral bisphosphonates as well as to the so-called target cancer therapies but the list of medications only grows. Although MRONJ is a relatively rare condition, it can be associated to significant morbidity with feeding limitations and intense pain. More severe cases can lead to potentially life-threatening infections. Every patient initiating bisphosphonate and/or target cancer therapy must visit a dentist before starting medication because preventive measures for MRONJ are much more effective compared to surgical management of the lesions. Surgical resolution can be especially difficult to obtain in the coexistence of certain complication factors like wider bone exposures, history of nitrogen containing bisphosphonates use (mainly zolendronate) and immunodeficiency. Recently, researchers have given attention to laser therapy associated to photosensitive agents as a possible option to management of some MRONJ lesions. Our case report demonstrates the use of photodynamic therapy in a denosumab related lesion in the mandible. It seems that denosumab related lesions are more amenable to treatment and total resolution because of the marked differences between its chemical and metabolic characteristics when compared to bisphosphonates.

关键词： Laser Phototherapy Osteonecrosis Jaws Denosumab

Photobiomodulation therapy for osteoarthritis: Mechanisms of action

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World Journal of Translational Medicine 2022年第3期10卷 29-42页

作者： Fábio Pericinoto Giolo Gabriel Silva Santos Victor Fontes Pacheco Stephany Cares Huber Kaue Franco Malange Bruno Lima Rodrigues fernanda Bassora Tomas Mosaner Gabriel Azzini Lucas Leite Ribeiro Carlos Amilcar Parada JoséFábio Santos Duarte Lana Department of Physical Therapy Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil Biomedical Science Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil Department of Orthopedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil Neurobiology of Pain and Regenerative Medicine The University of CampinasCampinas 13083-862Brazil Department of Hematology The University of CampinasCampinas 13083-878Brazil

Photobiomodulation(PBM)is a non-invasive therapeutic modality with demonstrated effects in many fields related to regenerative *** the field of orthopedics,in particular,PBM at various wavelengths has demonstrated the capacity to trigger multiple biological effects associated with protective mechanisms in musculoskeletal *** articles cited in this review show that devices operating close to or within the near infrared range at low intensities can provoke responses which favor the shift in the predominant catabolic microenvironment typically seen in degenerative joint diseases,especially osteoarthritis(OA).These responses include proliferation,differentiation and expression of proteins associated with stable cell ***,PBM can also modulate oxidative stress,inflammation and pain by exerting regulatory effects on immune cells and blocking the transmission of pain through sensory neuron fibers,without adverse ***,these effects are essential in order to control the progression of OA,which is in part attributed to exacerbated inflammation and degradative enzymatic reactions which gradually contribute to the destruction of joint *** may offer medical experts ease of application,financial viability,efficacy and lack of serious adverse ***,it may prove to be a suitable ally in the management of mild to moderate degrees of *** review explores and discusses the principal biological mechanisms of PBM and how the produced effects may contribute to the amelioration of osteoarthritic *** was reviewed using PubMed and Google Scholar in order to find studies describing the mechanisms of *** investigation included a combination of nomenclature such as:“photobiomodulation”,“phototherapy”,“laser therapy”,“PBM”,“osteoarthritis”,low level light therapy”,“inflammation”and“cartilage”.We considered only articles written in English,with access to the full text.

关键词： Photobiomodulation Low-level laser therapy Osteoarthritis Inflammation Regenerative medicine

Metabolic Syndrome: Consensus and Controversy: State of the Art

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Open Journal of Endocrine and Metabolic Diseases 2015年第9期5卷 124-130页

作者： Hamilton dos Prazeres Tavares Rafael Bottaro Gelaleti fernanda Picolo Suelma Beatriz Marques Prata Tavares Gabriela Marini Joelcio Francisco Abbade Debora Cristina Damasceno Meirelles dos Santos Paulo Adao de Campos Iracema de matos Paranhos Calderon Marilza Vieira Cunha Rudge Department of Gynecology and Obstetrics Botucatu Medical School UNESP—Universidade Estadual Paulista Botucatu Brazil Department of Gynecology and Obstetrics of the Municipal Hospital of Huambo Huambo Angola University of Sacred Heart (USC) Bauru Brazil Departament of Gynecology and Obstetric in Medical School Agostinho Neto University Luanda Angola

Metabolic syndrome is an epidemic that affects more and more people, increasing the probability of suffering metabolic and cardiovascular diseases in the short, medium or long term depending on the severity. The purpose of this article is to review the metabolic syndrome, assessing consensus, controversy and prevalence. The methodology was the preparation of a literature review on various health care databases, which were from 43 articles published from 2010 to 2015, in the general population. SM rate ranges from 0% to 90% depending on genders, ages and regions. There is still lack of consensus on cutoffs of diagnostic criteria. Thus, it is concluded that the prevalence of metabolic syndrome is being increased, urging the need for early diagnosis and treatment to promote the health of the global population.

关键词： Metabolic Syndrome X Prevalence Consensus