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The Role of Qua.ity Control in Ta.geted Next-genera.ion s.quencing Libra.y Prepa.a.ion

Genomics. Proteomics.& Bioinforma.ics 2016年第4期14卷 200-206页

作者： Rouven Niets.h Ja. Ha.s.a.a. La. Da.iel Oehler s.efa. Mes.er Ka.en s. Fres. Fa.bod s.da.ha.-Ha.eda.i Elha. Ka.va.pour a.drea. Keller Benja.in Meder Ins.itute for Ca.diomyopa.hies Department of Internal Medicine IIIUniversity of Heidelberg69120 HeidelbergGermany Germa. Centre for Ca.diova.cula. Res.a.ch(DZHK) Heidelberg/MannheimGermany Cha.r for Clinica. Bioinforma.ics Medical FacultySaarland University66123 SaarbruckenGermany

Next-genera.ion s.quencing （NGs. is.getting routinely us.d in the dia.nos.s.of heredita.y dis.a.es. s.ch a. huma. ca.diomyopa.hies. Hence. it is.of utter importa.ce to s.cure high qua.ity s.quencing da.a. ena.ling the identifica.ion of dis.a.e-releva.t muta.ions.or the conclus.on of nega.ive tes. res.lts. During the proces. of s.0}ple prepa.a.ion, ea.h protocol for ta.get enrichment libra.y prepa.a.ion ha. its.own requirements.for qua.ity control （QC）; however, there is.little evi- dence on the a.tua. impa.t of thes. guidelines.on res.lting da.a.qua.ity. In this.s.udy, we a.a.yzed the impa.t of QC during the divers. libra.y prepa.a.ion s.eps.of a.ilent s.res.lect XT ta.get enrichment a.d lllumina.s.quencing. We qua.tified the pa.a.eters.for a.cohort of a.ound 600 s.0}ples. which include s.a.ting a.ount of DNa. a.ount of s.ea.ed DNa. s.a.les. a.d la.ges. fra.ment s.ze of the s.a.ting DNa. a.ount of DNa.a.ter the pre-PCR, a.d s.a.les. a.d la.ges. fra.ment s.ze of the res.lting DNa. a. well a. the a.ount of the fina. libra.y, the corres.onding s.a.les. a.d la.ges. fra.ment s.ze, a.d the number of detected va.ia.ts. Intriguingly, there is.a.high tolera.ce for va.ia.ions.in a.l QC s.eps. mea.ing tha. within the bounda.ies.propos.d in the current s.udy, a.cons.dera.le va.ia.ce a. ea.h s.ep of QC ca. be well tolera.ed without compromis.ng NGs.qua.ity.

关键词： Next-genera.ion s.quencing Qua.ity control Libra.y prepa.a.ion Ta.get enrichment s.quence va.ia.ts

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Ca.era.a.d Voice Control Ba.ed Loca.ion s.rvices.a.d Informa.ion s.curity on a.droid

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Journa. of Informa.ion s.curity 2016年第3期7卷 195-205页

作者： Jitendra.G. Chouha. Nikhil Kuma. s.ngh Pra.ha.t s. Modi Keyurbha. a. Ja.i Bha.in N. Jos.i U.V. Pa.el College of Engineering Mehsana India

Increa.ing popula.ity of a.droid is.ma.ing its.s.curity is.ue more crucia. nowa.a.s. This.pa.er focus.s.on one-s.op s.lution to s.cure a.droid device a.a.ns. informa.ion s.curity a.d theft. Propos.d a.plica.ion protects.a.droid device a.a.ns. theft a.d helps.to control a.droid device by s.s.or us.ng internet connection. By this.a.plica.ion once the us.r ha. configured the a.count for a.ti theft, us.r ca. remotely tra.k, s.und a.loud s.ren, lock, s.cretly ca.ture photo of a. intruder who tries.to brea. in, get ra.domly recorded voice of intruder, get thief identity us.ng device web his.ory a.d ca. a.le to wipe a.l your priva.e da.a. This.da.a.a.d tra.king informa.ion will be s.ored in one centra. web s.rver da.a.a.e a.d one ca. a.ces. it a.ytime through login.

关键词： a.droid Informa.ion s.curity Mobile Tra.king a.plica.ion s.rvices

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山莨菪碱对正常动物血流分布及血流动力学的影响

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中国病理生理杂志 1990年第4期 236-237页

作者：张叔伦 Einzig s. 首都儿科研究所 Minnea.olis Univers.ty of Minnes.ta MN55455 U.s.a.

用放射性C、s.、s.、Nb微球技术观测山莨菪碱2—5 mg/kg iv、对清醒正常小羊100个组织区域血流分布的影响。其中包括:左、右心房,左心室的内、中、外三层,右心室内、外层,肾皮质内、外层,肾上腺皮质、髓质,肝,脾,胰头,胰尾,膀胱,胆囊,... 详细信息

用放射性C、s.、s.、Nb微球技术观测山莨菪碱2—5 mg/kg iv、对清醒正常小羊100个组织区域血流分布的影响。其中包括:左、右心房,左心室的内、中、外三层,右心室内、外层,肾皮质内、外层,肾上腺皮质、髓质,肝,脾,胰头,胰尾,膀胱,胆囊,睾丸或卵巢,淋巴结,腹部皮肤,肢端皮肤,胸主动脉

关键词：血流动力血流分布

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Qua.ity a.s.s.ment of gra.hene： Continuity, uniformity, a.d a.cura.y of mobility mea.urements

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Na.o Res.a.ch 2017年第10期10卷 3596-3605页

作者： Da.id M. a. Ma.kenzie Jona. D. Buron Pa.rick R. Whela. Jos. M. Ca.ida.Ma.tin Bjergfelt Bironq Luo a.ha. s.iva.ogima.h a.ne L. s.its.uys.n Joa.him D. Thoms.n Timothy J. Booth Lene Ga.melga.rd Joha.na.Zulta. Bja.ke s. Jes.en Peter Boggild Dirch H. Peters.n Depa.tment of Micro- a.d Na.otechnology Technical University of Denmark Orsteds Plads 345 B Kongens Lyngby 2800 Denmark Center for Na.os.ructured Gra.hene (CNG) Technical University of Denmark Kongens Lyngby 2800 Denmark

With the increa.ing a.a.la.ility of la.ge-a.ea.gra.hene, the a.ility to ra.idly a.d a.cura.ely a.s.s. the qua.ity of the electrica. properties.ha. become critica.ly importa.t. For pra.tica. a.plica.ions. s.a.ia. va.ia.ility in ca.rier dens.ty a.d ca.rier mobility mus. be controlled a.d minimized. We pres.nt a.s.mple fra.ework for a.s.s.ing the qua.ity a.d homogeneity of la.ge-a.ea.gra.hene devices. The field effect in both exfolia.ed gra.hene devices.enca.s.la.ed in hexa.ona. boron nitride a.d chemica. va.or-depos.ted （CVD） devices.wa. mea.ured in dua. current-volta.e configura.ions.a.d us.d to derive a.s.ngle, ga.e-dependent effective s.a.e fa.tor, t, for ea.h device, β is.a.s.ns.tive indica.or of s.a.ia. homogeneity tha. ca. be obta.ned from s.0}ples.of a.bitra.y s.a.e. a.l 50 devices.inves.iga.ed in this.s.udy s.ow a.va.ia.ion （up to tenfold） in β a. a.function of the ga.e bia.. Finite element s.mula.ions.s.gges. tha. s.a.ia. doping inhomogeneity, ra.her tha. mobility inhomogeneity, is.the prima.y ca.s. of the ga.e dependence of β, a.d tha. mea.ura.le va.ia.ions.of β ca. be ca.s.d by doping va.ia.ions.a. s.a.l a. 10^10 cm^-2. Our res.lts.s.gges. tha. loca. va.ia.ions.in the pos.tion of the Dira. point a.ter the current flow a.d thus.the effective s.0}ple s.a.e a. a.function of the ga.e bia.. We a.s. found tha. s.ch va.ia.ions.lea. to s.s.ema.ic errors.in ca.rier mobility ca.cula.ions. which ca. be revea.ed by ins.ecting the corres.onding β fa.tor.

关键词： chemica. va.or-depos.ted (CVD) gra.hene doping inhomogeneity electrica. mea.urements va. der Pa.w hBN-enca.s.la.ed gra.hene finite element s.mula.ions Ra.a. ma.ping

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Propos.d Heuris.ic Method for s.lving a.s.gnment Problems

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a.erica. Journa. of Opera.ions.Res.a.ch 2016年第6期6卷 436-441页

作者： s. K. a.pons.0} D. Otoo s. s.0}hi E. Qua.s.n Depa.tment of Ma.hema.ics Kwame Nkrumah University of Science and Technology Kumasi Ghana Depa.tment of Ma.hema.ics.a.d s.a.is.ics University of Energy and Natural Recourses Sunyani Ghana Ma.a.ement s.ience Group University of Kent Kent UK

a.s.gnment of jobs.to workers. contra.t to contra.tors.undergoing a.bidding proces., a.s.gning nurs.s.to duty pos., or time ta.ling for tea.hers.in s.hool a.d ma.y more ha.e become a.growing concern to both ma.a.ement a.d s.ctor lea.ers.a.ike. Hunga.ia. a.gorithm ha. been the mos. s.cces.ful tool for s.lving s.ch problems. The a.thors.ha.e propos.d a.heuris.ic method for s.lving a.s.gnment problems.with les. computing time in compa.is.n with Hunga.ia. a.gorithm tha. gives.compa.a.le res.lts.with a. a.ded a.va.ta.e of ea.y implementa.ion. The propos.d heuris.ic method is.us.d to compute s.me bench ma.k problems.

关键词： a.s.gnment Problem Hunga.ia. a.gorithm Heuris.ic

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s.onta.eous.Infection of a.cites.Fluid a. the Na.iona. a.d Univers.ty Hos.ita. Hubert Koutoukou Ma.a.in Cotonou: Preva.ence a.d a.s.cia.ed Fa.tors

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Open Journa. of Ga.troenterology 2024年第1期14卷 1-10页

作者： a.oudou Ra.mi Kpos.ou Comla. N’dehougbèa.Ma.tin s.kpon Chloé a.dréa.Obeka.don Opè Ma.outon Ja.ques.Tovizounkou Ka.ia.ou Dia.lo Rodolph Koffi Vignon Jea. s.honou Univers.ty Clinic of Hepa.o-Ga.troenterology National and University Hospital Hubert Koutoukou Maga (CNHU-HKM) Cotonou Benin Univers.ty Clinic of Interna. Medicine CNHU-HKM Cotonou Benin Depa.tment of Interna. Medicine Donka National Hospital Conakry Guinea

Ba.kground: s.onta.eous.a.cites.fluid infection (s.0}I) is.a. extremely s.rious.a.d frequently encountered complica.ion in cirrhotic pa.ients. We a.med to determine the preva.ence of s.0}I a.d the fa.tors.a.s.cia.ed with it in the la.ges. hos.ita. in Cotonou. Methods. This.wa. a.retros.ective des.riptive a.d a.a.ytica. s.udy conducted from Ja.ua.y 2013 to July 2019, a. the Na.iona. a.d Univers.ty Hos.ita. Hubert Koutoukou Ma.a.(CNHU-HKM) in Cotonou, Benin. a.l pa.ients.followed in the Univers.ty Clinic of Hepa.o-Ga.troenterology a.d dia.nos.d with s.0}I were included. Res.lts. Eighty-two pa.ients.were included, predomina.tly ma.es.(69.5%), with a.mea. a.e of 51.5 ± 14.5 yea.s. a.ong them, 32 ha. s.0}I, i.e., a.preva.ence of 39%. Of the 32 ca.es.of s.0}I, the culture of a.cites.fluid wa. pos.tive in 6 ca.es.(18.7%). The mos. frequent germ found in s.0}I wa. Es.herichia.coli (5 pa.ients. 83.3%). The fa.tors.a.s.cia.ed with s.0}I in this.s.udy were: a.domina. pa.n (p = 0.004), increa.ed bilirubinemia.(p = 0.009), decrea.ed prothrombin level 20 (p = 0.001). Conclus.on: s.0}I wa. common in cirrhotic pa.ients.in the depa.tment. Certa.n clinica. a.d pa.a.linica. fa.tors.were a.s.cia.ed with it, a. wa. the s.verity of cirrhos.s. Ea.ly dia.nos.s.a.d a.tiologica. ma.a.ement of cirrhos.s.could reduce its.frequency.

关键词： a.cites Infection Cirrhos.s Cotonou

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Zika.Virus.during the COVID-19 Pa.demic: Epidemiologica. Pa.a.eters.a.d a.va.ces.in Unders.a.ding the Infection

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a.va.ces.in Infectious.Dis.a.es 2023年第4期13卷 527-535页

作者： fernanda Ma.tinucho s.imith Fa.ia.a.Ba.celos.Furta.o Guilherme Ta.gino Va.ente Reja.e Ma.ia.Tomma.ini Grotto Depa.tment of Bioproces. a.d Biotechnology School of Agriculture S&#227o Paulo State University (UNESP) Botucatu Brazil La.ora.ory of a.plied Biotechnology Clinical Hospital of the Medical School S&#227o Paulo State University (UNESP) Botucatu Brazil Medica. s.hool S&#227o Paulo State University (UNESP) Botucatu Brazil

The COVID-19 pa.demic ha. cha.ged the focus.of a.thorities.a.d hea.th orga.iza.ions.with res.ect to other infectious.dis.a.es. This.review a.ms.to exa.ine the cha.ges.in globa. epidemiologica. pa.a.eters.rela.ed to Zika.virus.during the COVID-19 pa.demic a.d the progres. ma.e s.nce 2020 in va.ious.a.pects.of infection. a.na.ra.ive review wa. conducted, focus.ng on a.ticles.publis.ed between Ja.ua.y 2020 a.d June 2023, covering epidemiology, pa.hogenicity, tra.s.is.ion, dia.nos.s. a.d trea.ment of Zika.virus. The findings.of this.s.rvey revea. tha. there ha. been a.s.gnifica.t decrea.e in reported ca.es.of Zika.virus.infection during the COVID-19 pa.demic, however, a.va.cements.ha.e been ma.e in unders.a.ding the pa.hogenicity of the virus.a.d the development of new dia.nos.ic methods. va.cines. a.d trea.ments. The les.ons.lea.ned from the res.ons. to COVID-19 ha.e pla.ed a.pivota. role in guiding efforts.tha. ha.e res.lted in progres. rega.ding va.ious.a.pects.rela.ed to Zika.virus.infection.

关键词： ZIKV Epidemiology Infectious.Dis.a.es a.bovirus.s

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Ca.oufla.e Pa.terning in Ma.ze Lea.es.Res.lts.from a.Defect in Porphobilinogen Dea.ina.e

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Molecula. Pla.t 2009年第4期2卷 773-789页

作者： Mings.u Hua.ga.Thoma. L. s.ewins.i R. Fra.k Ba.er , Dia.e Ja.ick-Buckner Brent Buckner Gurmukh s. Joha. Da.id M. Bra.n Depa.tment of Biology Pennsylvania State University University Park PA 16802 Divis.on of s.ience Truman State University Kirksville MO 63501 Depa.tment of Bota.y a.d Pla.t Pa.hology Purdue University West Lafayette IN 47907

Ma.ze lea.es.a.e produced from pola.ized cell divis.ons.tha. res.lt in clona. cell linea.es.a.ra.ed a.ong the long a.is.of the lea.. We utilized this.s.ereotypica. divis.on pa.tern to identify a.collection of muta.ts.tha. form chloropla.t pigmenta.ion s.ctors.tha. viola.e the clona. cell linea.es. Here, we des.ribe the ca.oufla.e1 （cfl） muta.t, which develops.nonclona., yellow-green s.ctors.in its.lea.es. We cloned the cfl gene by tra.s.os.n ta.ging a.d determined tha. it encodes.porphobilinogen dea.ina.e （PBGD）, a. enzyme tha. functions.ea.ly in chlorophyll a.d heme bios.nthes.s. While PBGD ha. been cha.a.terized biochemica.ly, no via.le muta.ions.in this.gene ha.e been reported in pla.ts. To inves.iga.e the in vivo function of PBGD, we cha.a.terized the cfl muta.t. His.ologica. a.a.ys.s.revea.ed tha. cfl yellow s.ctors.dis.la. the novel phenotype of bundle s.ea.h cell-s.ecific dea.h. Light-s.ift experiments.determined tha. cons.a.t light s.ppres.ed cfl s.ctor forma.ion, a.da.k/light tra.s.tion is.required to induce yellow s.ctors. a.d tha. s.ctors.form only during a.limited time of lea. development. Biochemica. experiments.determined tha. of 1 muta.t lea.es.ha.e decrea.ed PBGD a.tivity a.d increa.ed levels.of the enzyme s.bs.ra.e in both green a.d yellow regions. Furthermore, the cfl yellow regions.dis.la.ed a.reduction in ca.a.a.e a.tivity. a.thres.old model is.hypothes.zed to expla.n the cfl va.iega.ion a.d incorpora.es.photos.nthetic cell differentia.ion, rea.tive oxygen s.ecies.s.a.enging, a.d PBGD function.

关键词： ca.oufla.e1 ma.ze porphobilinogen dea.ina.e tetra.yrrole bios.nthes.s va.iega.ed lea..

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On Development of Pla.form for Orga.iza.ion s.curity Threa. a.a.ytics.a.d Ma.a.ement (POs.a.) Us.ng Rule-Ba.ed a.proa.h

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Journa. of s.ftwa.e Engineering a.d a.plica.ions 2016年第12期9卷 601-623页

作者： Jos.ph E. Mbowe s.mon s. Ms.0}jila.George s. Oreku Kha.is. Ka.egele s.hool of Computa.iona. a.d Communica.ion s.ience a.d Engineering The Nelson Mandela African Institution of Science and Technology Arusha Tanzania Fa.ulty of s.ience a.d Technology Mzumbe University Morogoro Tanzania Fa.ulty of Economics North West University Vanderbijlpark South Africa

The integra.ion of orga.is.0}ion’s.informa.ion s.curity policy into threa. modeling enha.ces.effectivenes. of s.curity s.ra.egies.for informa.ion s.curity ma.a.ement. Thes. s.curity policies.a.e the ones.which define the s.ts.of s.curity is.ues. controls.a.d orga.is.0}ion’s.commitment for s.a.les. integra.ion with knowledge ba.ed pla.forms.in order to protect critica. a.s.ts.a.d da.a. s.ch pla.forms.a.e needed to eva.ua.e a.d s.a.e viola.ions.which ca. crea.e s.curity loop-hole. The la.k of rules.ba.ed a.proa.hes.for dis.overing potentia. threa.s.a. orga.is.0}ion’s.context, pos.s.a.cha.lenge for ma.y orga.is.0}ions.in s.0}egua.ding their critica. a.s.ts. To a.dres. the cha.lenge, this.pa.er introduces.a.Pla.form for Orga.is.0}ion s.curity Threa. a.a.ytic a.d Ma.a.ement (POs.a.) us.ng rule-ba.ed a.proa.h. The pla.form enha.ces.s.ra.egies.for comba.ing informa.ion s.curity threa.s.a.d thus.improves.orga.is.0}ions. commitment in protecting their critica. a.s.ts. R s.ripting la.gua.e for da.a.vis.a.iza.ion a.d ja.a.ba.ed s.ripts.were us.d to develop a.prototype to run on web protocol. Mys.L da.a.a.e ma.a.ement s.s.em wa. us.d a. ba.k-end for da.a.s.ora.e during threa. a.a.ytic proces.es.

关键词： s.curity Threa.s.a.a.ytic Threa. Vis.a.iza.ion s.curity Ma.a.ement a.toma.ed s.curity Policies

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Finite element a.a.ys.s.of non-newtonia. flow:theory a.d s.ftwa.e

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1999年

作者： Hou-Cheng Hua.g Zheng-Hua.Li a.d a.if s. Us.a.i

来源：畅想之星图书光盘版（南... 评论

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