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Exercise sustains the hallmarks of health

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Journal of Sport and Health Science 2023年第1期12卷 8-35页

作者： Yan Qiu Benjamin fern.n.ez-García H.Immo Lehmann Guoping Li Guido Kroemer Carlos López-Otín Junjie Xiao Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)School of MedicineShanghai UniversityNantong 226011China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Health Research Institute of the Principality of Asturias(ISPA) Oviedo 33011Spain department of Morphology and Cell Biology AnatomyUniversity of OviedoOviedo 33006Spain Cardiovascular division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA Centre de Recherche des Cordeliers Equipe labellisee par la Ligue contre le cancerUniversite de Paris CiteSorbonne UniversiteInserm U1138Institut Universitaire de FranceParis 75231France Metabolomics and Cell Biology Platforms Institut Gustave RoussyVillejuif 94805France Institut du Cancer Paris CARPEM Department of BiologyHopital Europeen Georges PompidouAP-HPParis 75015France departamento de Bioquımica y Biologıa Molecular Facultad de MedicinaInstituto Universitario de OncologıaUniversidad de OviedoOviedo 33006Spain Centro de Investigacion Biomedica en Red Enfermedades Cancer(CIBEROnC) Oviedo 33006Spain

Exercise has long been known for its active role in improving physical fitness and sustaining *** moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative and therapeutic strategy for various *** is well-documented that exercise maintains and restores homeostasis at the organismal,tissue,cellular,and molecular levels to stimulate positive physiological adaptations that consequently protect against various pathological *** we mainly summarize how moderate-intensity exercise affects the major hallmarks of health,including the integrity of barriers,containment of local perturbations,recycling and turnover,integration of circuitries,rhythmic oscillations,homeostatic resilience,hormetic regulation,as well as repair and ***,we summarize the current understanding of the mechanisms responsible for beneficial adaptations in response to *** review aimed at providing a comprehensive summary of the vital biological mechanisms through which moderate-intensity exercise maintains health and opens a window for its application in other health *** hope that continuing investigation in this field will further increase our understanding of the processes involved in the positive role of moderate-intensity exercise and thus get us closer to the identification of new therapeutics that improve quality of life.

关键词： Beneficial effects of exercise Exercise-related physiological adaptations Hallmarks of health Moderate-intensity exercise Therapeutic exercise

Tracking the change in Spanish greenhouse gas emissions through an LMdI decomposition model:A global and sectoral approach

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Journal of Environmental Sciences 2024年第5期139卷 114-122页

作者： Paula fern.n.ez González María José Presno Manuel Landajo department of Applied Economics University of OviedoAuda del Cristos/n 33011 OviedoSpain

The reduction of GHG emissions to reverse the greenhouse effect is one of the main challenges in this *** this paper we pursue two ***,we analyze the evolution of GHG emissions in Spain in 2008–2018,at both the global and sectoral levels,with the variation in emissions decomposed into a set of determining ***,we propose several actions specifically oriented to more tightly controlling the level of *** results showed a remarkable reduction(18.44%)in GHG emissions,mainly due to the intensity effect,but also to the production-per-capita *** detected somewhat different patterns among the various sectors *** the intensity effect was the most influential one in the agricultural,transport,and others sectors,the production-per-capita effect was predominant in the case of *** carbonization effect was revealed as crucial in the commerce *** above findings highlight the importance of the energy efficiency measures taken in recent years in the Spanish economy,also pointing to the need to deepen those strategies and to propose new measures that entail greater efficiency in *** efforts in areas like innovation,R&d,diffusion of more eco-friendly technologies,and a greater use of greener energies all prove to be essential reduction actions to fight the greenhouse effect.

关键词： LMdI decomposition Spain GHG emissions

ddRAd sequencing-based genotyping for population structure analysis in cultivated tomato provides new insights into the genomic diversity of Mediterranean‘da serbo’type long shelf-life germplasm

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Horticulture Research 2020年第1期7卷 1047-1060页

作者： Salvatore Esposito Teodoro Cardi Gabriele Campanelli Sara Sestili María Josédíez Salvador Soler Jaime Prohens Pasquale Tripodi CREA Research Centre for Vegetable and Ornamental Crops Pontecagnano(SA)Italy CREA Research Centre for Vegetable and Ornamental Crops Monsampolo del Tronto(AP)TrontoItaly Instituto de Conservación y Mejora de la Agrodiversidad Valenciana Universitat Politècnica de València46022 ValenciaSpain

double digest restriction-site associated sequencing(ddRAd-seq)is a flexible and cost-effective strategy for providing in-depth insights into the genetic architecture of germplasm *** this methodology,we investigated the genomic diversity of a panel of 288 diverse tomato(Solanum lycopersicum L.)accessions enriched in‘da serbo’(called‘de penjar’in Spain)long shelf life(LSL)materials(152 accessions)mostly originating from Italy and *** rest of the materials originate from different countries and include landraces for fresh consumption,elite cultivars,heirlooms,and breeding *** from their LSL trait,‘da serbo’landraces are of remarkable interest for their *** identified 32,799 high-quality SnPs,which were used for model ancestry population structure and non-parametric hierarchical *** genetic subgroups were revealed,clearly separating most‘da serbo’landraces,but also the Spanish germplasm,suggesting a subdivision of the population based on type and geographical *** disequilibrium(Ld)in the collection decayed very rapidly withinn investigated SnPs showing contrasted minor frequency allele(MAF)in‘da serbo’materials,resulting in the identification of high frequencies in this germplasm of several mutations in genes related to stress tolerance and fruit maturation such as CTR1 and ***,a mini-core collection of 58 accessions encompassing most of the diversity was selected for further exploitation of key *** findings suggest the presence of a genetic footprint of the‘da serbo’germplasm selected in the Mediterranean ***,we provide novel insights on LSL‘da serbo’germplasm as a promising source of alleles for tolerance to stresses.

关键词： germplasm breeding shelf

design,fabrication,characterization and reliability study of CMOS-MEMS Lorentz-force magnetometers

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Microsystems & nanoengineering 2022年第5期8卷 17-41页

作者： J.J.Valle J.M.Sánchez-Chiva d.fern.n.ez J.Madrenas department of Electronic Engineering Universitat Politècnica de CatalunyaJordi Girona 1 i 3Edifici C408034 BarcelonaSpain Sorbonne Université CNRSLaboratoire de Recherche en Informatique(LIP6)UMR76064 place Jussieu75005 ParisFrance Institut de Física d’Altes Energies(IFAE) The Barcelona Institute of Science and Technology(BIST)Edifici Cn.Facultat Ciències NordUniversitat Autónoma de Barcelona08193 Bellaterra(Barcelona)Spain

This article presents several design techniques to fabricate micro-electro-mechanical systems(MEMS)using standard complementary metal-oxide semiconductor(CMOS)*** were applied to fabricate high yield CMOS-MEMS shielded Lorentz-force magnetometers(LFM).The multilayered metals and oxides of the back-end-of-line(BEOL),normally used for electronic routing,comprise the structural part of the *** most important fabrication challenges,modeling approaches and design solutions are *** that predict the Q factor,sensitivity,Brownian noise and resonant frequency as a function of temperature,gas pressure and design parameters are presented and validated in characterization tests.A number of the fabricated magnetometers were packaged into Quad Flat no-leads(QFn)*** show this process can achieve yields above 95%when the proper design techniques are *** CMOS not being a process for MEMS manufacturing,estimated performance(sensitivity and noise level)is similar or superior to current commercial magnetometers and others built with MEMS ***,typical offsets present in Lorentz-force magnetometers were prevented with a shielding electrode,whose efficiency is ***,several reliability test results are presented,which demonstrate the robustness against high temperatures,magnetic fields and acceleration shocks.

关键词： Lorentz magnetometer characterization

Reflux-synthesized bulk and diluted W-nb-O mixed oxide bronzes for the valorization of short-chain oxygenates aqueous mixtures

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Chinese Journal of Catalysis 2019年第11期40卷 1778-1787页

作者： d.delgado A.fern.n.ez-Arroyo n.La Salvia M.E.domine Jose M.López nieto Instituto de Tecnología Química Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas Avenida de los Naranjos s/n 46022 Valencia Spain

This work reports the preparation of bulk and KIT-6-diluted W-nb-O mixed oxide bronzes by a reflux method. The influence of the incorporation of nb and a mesoporous silica on the physicochemical features of the catalysts is studied. The addition of nb favors the formation of single-phase oxide bronze structure, with improved Lewis acidity;while the incorporation of KIT-6 gives rise to well-dispersed mixed metal oxide particles on the diluter. These diluted W-nb-O catalysts present enhanced surface areas and mesopore volumes. The materials have been tested in the valorization of an aqueous model mixture (acetol/propanal/ethanol/acetic acid/water weight ratio of 5/25/10/30/30), through C-C bond formation reactions. The increase in the Lewis nature of surface acid sites stands as the key point to maximize the total organic yield during the reaction (C5-C10 products). The best catalysts maintain their catalytic behavior after five consecutive uses.

关键词： KIT-6 W-nb-O oxides Aqueous oxygenates Biomass feedstocks C-C bond formation

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

during the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

dirac operator on the sphere with attached wires

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Chinese Physics B 2016年第4期25卷 335-338页

作者： E n Grishanov d A Eremin d A Ivanov I Yu Popov Ogarev Mordovia State University Bolshevistskaya Str. 68 Saransk Russia ITMO University Kroverkskiy pr. 49 St. Petersburg 197101 Russia

An explicitly solvable model for tunnelling of relativistic spinless particles through a sphere is suggested. The model operator is constructed by an operator extensions theory method from the orthogonal sum of the dirac operators on a semi- axis and on the sphere. The transmission coefficient is obtained. The dependence of the transmission coefficient on the particle energy has a resonant character. One observes pairs of the Breit-Wigner and the Fano resonances. It correlates with the corresponding results for a non-relativistic particle.

关键词： dirac operator nanostructure tunnelling solvable model

Clinicopathological differences,risk factors and prognostic scores for western patients with intestinal and diffuse-type gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1162-1174页

作者： Cristina díaz del Arco Lourdes Estrada Muñoz Luis Ortega Medina Elena Molina Roldán MÁngeles Cerón nieto Soledad García Gómez de las Heras M Jesús fern.n.ez Aceñero department of Surgical Pathology Hospital Clínico San CarlosMadrid 28040Spain department of Legal Medicine Psychiatry and PathologyComplutense University of MadridMadrid 28040Spain department of Surgical Pathology Hospital Rey Juan CarlosMadrid 28933Spain department of Basic Medical Sciences Rey Juan Carlos UniversityMadrid 28933Spain

BACKGROUnd In the molecular era,the Laurén system is still a cost-effective and widely implemented classification for gastric cancer(GC)and it has been recently associated with clinical,histological and molecular features of these *** recent advances in the understanding of the molecular biology of GC,there is a need to develop new prognostic tools for patient stratification in clinical ***,the identification of easily available prognostic factors in patients with intestinal and diffuse-type tumors can significantly improve risk assessment and patient stratification in *** To identify clinicopathological differences,risk factors,and to develop costeffective prognostic scores for patients with intestinal and diffuse-type *** Retrospective study of all patients undergoing surgery for GC at a tertiary referral center from 2001 to 2019.286 cases met inclusion criteria(intestinal:190,diffuse:96).Clinical data and gross findings were *** specimens were reviewed by two independent pathologists and a detailed protocol for histologic evaluation was *** tissue microarrays(TMAs)were constructed and sections of the TMA block were immunostained for HERCEPTEST,MSH2,MSH6,MLH1 and *** analyses were performed and prognostic scores were developed based on hazard *** Intestinal and diffuse-type GC showed different epidemiological,clinicopathological and prognostic *** tumors were significantly associated with younger age,less symptomatology,flat morphology,deeper invasion,perineural infiltration,advanced stage at diagnosis,administration of adjuvant therapy and poorer *** lesions were fungoid or polypoid,showed necrosis,desmoplasia,microsatellite instability and HERCEPTEST positivity and were diagnosed at earlier *** depth,desmoplasia,macroscopic type and lymph node involvement were independently related to the Laurén ***,intestinal and diffuse GC were asso

关键词： Gastric cancer Clinicopathological Score Prognosis Laurén Molecular

Online voltage estimation and control for smart distribution networks

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Journal of Modern Power Systems and Clean Energy 2016年第1期4卷 40-46页

作者： RAGHAVEndRA P d.n.GAOnKAR national Institute of Technology Karnataka(nITK) SurathkalMangaloreKarnataka 575025India

The increasing deployment of distributed Generation(dG) technologies introduces power quality challenges to the grid, in particular steady state voltage rise at the connection point for dG units. In most distribution networks,control and monitoring of grid parameters is missing, as well as system security is at risk. Smart grid technologies have the capability to realize the real-time measurements and on-load voltage controls. With the steady implementation of smart grid technologies throughout the existing distribution networks, the online voltage control can be achieved ensuring the power quality and voltage levels within the statutory limits. This study presents a methodology for the estimation of voltage profile in a smart distribution network with dG for the online voltage control, taking into account different line X/R ratios and laterals. This method is based on maximum and minimum voltage estimation by remote terminal units(RTUs) placed only at dG connected bus and at capacitor connected bus. Voltage regulation is carried out based on RTUs estimated values. This work is tested on two radial distribution networks with/without dGs and laterals. Comparative results for voltage magnitudes estimated with different methodology are presented. The reported simulation results show that the method presented is capable of estimating the voltage profile along the distribution network with dGs for the online voltage control, considering different line X/R ratios and laterals.

关键词： distributed generation Power quality Smart grid Voltage rise