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低危宫颈癌妇女单纯子宫切除术与根治性子宫切除术的比较

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中国临床药理学杂志 2024年第8期40卷 1159-1159页

作者： PLANTE M KWON j S ferguson S 王超群

回顾性资料显示,早期低危宫颈癌患者参数浸润发生率较低,这就提出了这些患者是否需要根治性子宫切除术的问题。然而,比较根治性和单纯性子宫切除术结果的大型随机试验数据缺乏。本研究进行了一项多中心、随机、非劣效性试验,比较了低危... 详细信息

回顾性资料显示,早期低危宫颈癌患者参数浸润发生率较低,这就提出了这些患者是否需要根治性子宫切除术的问题。然而,比较根治性和单纯性子宫切除术结果的大型随机试验数据缺乏。本研究进行了一项多中心、随机、非劣效性试验,比较了低危宫颈癌(病变≤2cm,间质浸润有限)患者的根治性子宫切除术和单纯性子宫切除术,包括淋巴结评估。主要结局是3年盆腔肿瘤复发(盆腔复发)。预先规定的3年盆腔复发组间差异的非劣效性界限为4个百分点。

关键词：根治性子宫切除术盆腔肿瘤回顾性资料间质浸润宫颈癌患者盆腔复发预先规定低危

Mechanistic action of gibberellins in legume nodulation

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journal of Integrative Plant Biology 2014年第10期56卷 971-978页

作者： Satomi Hayashi Peter M.Gresshoff Brett j.ferguson Centre for Integrative Legume research The University of Queensland

Legume plants are capable of entering into a symbiotic relationship with rhizobia *** results in the formation of novel organs on their roots,called nodules,in which the bacteria capture atmospheric nitrogen and provide it as ammonium to the host *** molecular and physiological changes are involved in the formation and establishment of such *** phytohormones are known to play key roles in this ***（gibberellic acids;GAs）,a class of phytohormones known to be involved in a wide range of biological processes（i.e.,cell elongation,germination）are reported to be involved in the formation and maturation of legume nodules,highlighted by recent transcriptional analyses of early soybean symbiotic ***,we summarize what is currently known about GAs in legume nodulation and propose a model of GA action during nodule *** from a wide range of studies,including GA application,mutant phenotyping,and gene expression studies,indicate that GAs are required at different stages,with an optimum,tightly regulated level being key to achieve successful *** acids appear to be required at two distinct stages of nodulation：（i）early stages of rhizobia infection and nodule primordium establishment;and（ii）later stages of nodule maturation.

关键词： Gibberellic acid legume nodulation phytohormone plant development rhizobia symbiosis

iStent inject trabecular microbypass stent implantation with cataract extraction in open-angle glaucoma:early clinical experience

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Eye and Vision 2020年第3期7卷 266-274页

作者： Tanner.j.ferguson Zachary Dockter Adam Bleeker Kayla L.Karpuk justin Schweitzer Mitch j.Ibach john P.Berdahl Cole Eye Institute Cleveland ClinicClevelandOHUSA University of South Dakota Sanford School of Medicine Sioux FallsSDUSA Cleveland Eye Clinic ClevelandOHUSA Vance Thompson Vision Sioux FallsSDUSA

Background:retrospective,consecutive case series to evaluate the implantation of two second-generation trabecular microbypass stents in combination with cataract surgery in a real-world,clinical ***:The series included 56 eyes implanted with the iStent inject device with *** series consisted of eyes with primary open-angle glaucoma(n=52)and pseudoexfoliative glaucoma(n=4).Primary outcome measures included intraocular pressure(IOP)and number of glaucoma *** outcomes included the need for secondary surgical intervention and the incidence of IOP spikes≥10 mmHg and≥15 ***:IOP was reduced by 21%to 14.7±2.9 mmHg(prative from 18.7±5.8 mmHg at ***,the mean number of glaucoma medications was 1.5±0.9 and reduced by 39%to 0.9±1.2(preased from 30%at baseline.55%of eyes were medication-free at 6 months,up from 18%at *** were no severe postoperative *** eyes underwent an additional glaucoma ***:Implantation of the iStent inject device with concomitant cataract surgery effectively provides a sustained reduction in IOP with a markedly improved medication burden out to 6 months *** safety profile is excellent.

关键词： Micro-invasive glaucoma surgery Minimally invasive glaucoma surgery MIGS Trabecular microbypass stent Open-angle glaucoma

Molecular Analysis of Legume Nodule Development and Autoregulation

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journal of Integrative Plant Biology 2010年第1期52卷 61-76页

作者： Brett j. ferguson Arief Indrasumunar Satomi Hayashi Yu-Hsiang Lin Dugald E. reid Peter M. Gresshoff ArC Centre of Excellence for Integrative Legume research The University of Queensland

Legumes are highly important food, feed and biofuel crops. With few exceptions, they can enter into an intricate symbiotic relationship with specific soil bacteria called rhizobia. This interaction results in the formation of a new root organ called the nodule in which the rhizobia convert atmospheric nitrogen gas into forms of nitrogen that are useable by the plant. The plant tightly controls the number of nodules it forms, via a complex root-to-shoot-to-root signaling loop called autoregulation of nodulation （AON）. This regulatory process involves peptide hormones, receptor kinases and small metabolites. Using modern genetic and genomic techniques, many of the components required for nodule formation and AON have now been isolated. This review addresses these recent findings, presents detailed models of the nodulation and AON processes, and identifies gaps in our understanding of these process that have yet to be fully explained.

关键词： Molecular Analysis of Legume Nodule Development and Autoregulation

Why interleukin-10 supplementation does not work in Crohn's disease patients

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World journal of Gastroenterology 2013年第25期19卷 3931-3941页

作者： Gareth j Marlow Dominique van Gent Lynnette r ferguson Discipline of Nutrition Faculty of Medical and Health Sciences The University of Auckland Auckland 1142 New Zealand Gareth J Marlow Lynnette R Ferguson Nutrigenomics New Zealand The University of Auckland

Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are chronic intestina disorders, which are on the increase in "Westernised" countries. IBD can be caused by both genetic and environmental factors. Interleukin-10 (IL-10) is an immunoregulatory cytokine that has been identified as being involved in several diseases including IBD. Studies have shown that polymorphisms in the promoter region reduce serum levels of IL-10 and this reduction has been associated with some forms of IBD. Mouse models have shown promising results with IL-10 supplementation, as such IL-10 supplementation has been touted as being a possible alternative treatment for CD in humans. Clinical trials have shown that recombinant human IL-10 is safe and well tolerated up to a dose o 8 μg/kg. However, to date, the results of the clinica trials have been disappointing. Although CD activity was reduced as measured by the CD activity index IL-10 supplementation did not result in significantly reduced remission rates or clinical improvements when compared to placebo. This review discusses why IL-10supplementation is not effective in CD patients currently and what can be addressed to potentially make IL-10 supplementation a more viable treatment option in the future. Based on the current research we conclude that IL-10 supplementation is not a one size fits all treatment and if the correct population of patients is chosen then IL-10 supplementation could be of benefit.

关键词： Inflammatory bowel disease Crohn’s disease Interleukin-10 recombinant human interleukin-10

Climate reconstruction based on Pollen Analysis in Inner Mongolia, North China from 51.9 to 30.6 kaBP

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Acta Geologica Sinica(English Edition) 2013年第5期87卷 1444-1459页

作者： LI Suping David K.ferguson WANG Yong LI jinfeng YAO jianxin Key Laboratory of Stratigraphy and Palaeontology Institute of Geology Chinese Academy of Geological Sciences Institute of Palaeontology University of Vienna State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of Sciences

The palynomorph assemblage of lake sediments younger than 51.9 kaBP from Wulagai Gobi in Inner Mongolia was analyzed to reconstruct the vegetation and climate. From 51.9 to 30.6 kaBP, the vegetation was arid to semi-arid grassland with only slight changes. According to the palynomorphs, trees and shrubs were very rare. The large number and diversity of algae indicate the presence of a lake. Quantitative climatic conditions were reconstructed using the Best Analogues Method. The results indicate that the annual mean temperature was higher than that at present. The combination of temperature and annual precipitation suggests a change in the climate from cool dry to warm dry and then cool humid. Our results show that the annual precipitation values were mostly higher than that at present but were lower than 400 mm. It infers that the study area was already within the arid to semi-arid regions but with a stronger influence of the summer monsoon during 51.9 to 30.6 kaBP than at present. With slight differences mainly in time scale, the changing trend of the annual temperature curve is consistent with the other climatic records from Antarctica, Greenland, Hulu Cave （East China）, and the Tibetan Plateau during the last glacial period. From 30.6 kaBP to present, very few palynomorphs were detected in the samples. Hence, no information about the vegetation and climate could be extracted. Combined with other studies during Late Pleistocene, we presume that the reason for the lack of pollen during this period was caused by an abrupt temperature fall after 30.6 kaBP or that the lacustrine conditions were unsuitable for pollen deposition. It was probably incurred by the oxidation on land prior to deposition. But for those samples only with algae, it might be caused by the fact that algae could finish their life history in a very short time in a seasonal lake.

关键词： paleoclimate paleovegetation pollen analysis Late Pleistocene Inner Mongolia

Catalyzing Singlet Fission by Transition Metals:Second versus Third row Effects

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Precision Chemistry 2023年第9期1卷 555-564页

作者： Yuxuan Hou Ilias Papadopoulos Yifan Bo Anna-Sophie Wollny Michael j.ferguson Lukas A.Mai rik r.Tykwinski Dirk M.Guldi Department of Chemistry University of AlbertaEdmontonAlberta T6G 2G2Canada Department of Chemistry and Pharmacy&Interdisciplinary Center for Molecular Materials(ICMM) Friedrich-Alexander-University Erlangen-Nuremberg91058 ErlangenGermany Department of Applied Chemistry Graduate School of EngineeringCenter for Molecular Systems(CMS)Kyushu University744 Moto-okaNishi-kuFukuoka 819-0395Japan

The synthesis and characterization of platinum(II)and palladium(II)complexes bearing two(dimers Pt(L_(pc))_(2)Cl_(2)and Pd(L_(pc))_(2)Cl_(2)),one(monomers Pt(L_(pc))(L_(ref))Cl_(2)and Pd(L_(pc))(L_(ref))-Cl_(2)),or no(reference compounds Pt(L_(ref))_(2)Cl_(2)and Pd(L_(ref))_(2)Cl_(2))pentacene-based pyridyl ligands are *** properties of the dimers are probed by means of steady-state and time-resolved transient absorption measurements in compar-ison to the monomer and model *** results document that despite enhanced spin−orbit coupling from the presence of heavy atoms,intramolecular singlet fission(iSF)is not challenged by intersystem *** thus yields correlated triplet pairs and even uncorrelated triplet excited states upon ***,significant separation of the two pentacenyl groups facilitates decoupling of the two ***,the mechanism of iSF is altered depending on the respective metal center,that is,Pt(II)versus Pd(II).The dimer based on Pt(II),Pt(L_(pc))2Cl_(2),exhibits a direct pathway for the iSF and forms a correlated triplet pair with singlet−quintet spin-mixing within 10 ns in variable *** the other hand,the dimer based on Pd(II),Pd(L_(pc))_(2)Cl_(2),leads to charge transfer mixing during the population of the correlated triplet pair that is dependent on solvent ***,Pd(L_(pc))_(2)Cl_(2)gives rise to a stable equilibrium between singlet and quintet correlated triplet pairs with lifetimes of up to 170 *** differences in the size and polarizability,when contrasting platinum(II)with palladium(II),are the most likely rationale for the underlying trends.

关键词： metal complexes singlet fission pentacene dimers ultrafast spectroscopy electronic coupling

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海相碳酸盐层系中石油的生成和运移——述评

地质科技情报 1989年第S1期8卷 20-27页

作者： j.ferguson 陈建渝

本文回顾了研究碳酸盐源岩的近期文献。这些文献中,特别重要的是提到了该碳酸盐岩的岩石学、沉积环境以及与有机质相关的详细内容,证明了用于其它源岩的沉积和环境标准对于碳酸盐岩来说同样走有充分根据的。给出的资料确认了粘土矿物在... 详细信息

本文回顾了研究碳酸盐源岩的近期文献。这些文献中,特别重要的是提到了该碳酸盐岩的岩石学、沉积环境以及与有机质相关的详细内容,证明了用于其它源岩的沉积和环境标准对于碳酸盐岩来说同样走有充分根据的。给出的资料确认了粘土矿物在碳酸盐岩中的催化作用是最小的。另一个要强调的特征是自生烃。文中回顾了自生烃的两种形式认识上的说法,即:油或气确实走原地的并且在发现的地方生成,或者它能在碳酸盐岩的块体内运移。依据公开的或尚未公开的试验工作所提供的资料提出了文中的一些主要结论。

关键词：海相碳酸盐源岩生烃粘土矿物生油岩沉积环境干酪根类型排驱有机碳含量饱和烃

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关于海相碳酸盐层序中原油生成与运移的综述

地质地球化学 1990年第6期18卷 31-38页

作者： j.ferguson 陈松乔

回顾了近年来发表的碳酸盐生油岩方面的文献,尤其是那些详细论述了生油岩岩性和其沉积环境以及生油岩中的有机质等方面的文献。业已证明,适用于其他生油岩的沉积和环境判据,对于碳酸盐同样是有效的。有证据表明,这些生油岩中的粘土矿物... 详细信息

回顾了近年来发表的碳酸盐生油岩方面的文献,尤其是那些详细论述了生油岩岩性和其沉积环境以及生油岩中的有机质等方面的文献。业已证明,适用于其他生油岩的沉积和环境判据,对于碳酸盐同样是有效的。有证据表明,这些生油岩中的粘土矿物的催化作用是微不足道的。所强调的另一特征是“同生源”。文献中列出的证据要求人们重视两种“同生源”模型:1)油气完全是在原地形成并储集起来的;2)油气形成后经过运移并在碳酸盐杂岩体中储集起来。模拟实验得到的结果,无论是已发表的还是未发表的,都将说明上述结论的正确性。

关键词：石油生成运移碳酸值层序