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UVA1光疗法治疗脂质渐进性坏死

世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 28-29页

作者： Beattie P.E. Dawe R.S. Ibbotson S.H. ferguson j. 刘艳 Western Infirmary Glasgow G11 6NT United Kingdom Dr.

The primary c ause of collagen degeneration in necrobiosis lipoidica (NL) is proposed to be immunologically mediated vascular disease. Ultraviolet (UV)A1 has been used successfully to treat scleroderma in which both vascular damage and collagen dysregulation also occur. We treated six patients with NL [(five women; mean age of 32 years (range 22-70) and mean disease duration of 2.9 years (range 6 months to 5 years)] with a high-output ultraviolet (UV)A1 2-kW filtered metal halide source (Dr; Dermalight ultrA 1) having an emission spectrum of 340-440 nm. All patients had NL on the shins, which had been unresponsive to potent topical corticosteroid therapy (n = 6) and had responded minimally or not at all to TL-01UVB (n = 2), topical psoralen plus UVA(PUVA) soaking (n = 2) or oral PUVA(n = 1) therapy. Patients received a variable number of total exposures (15-51), given 3-5 times weekly. NL resolved completely in one patient; this patient had minimal improvement after the first course of 16 exposures, but after a further 13 exposures, resolution occurred 6 months later. Two subj.cts obtained moderate improvement in their overall disease severity after 15 and 24 exposures, while two had only minimal improvement after 15 and 51 exposures. The remaining patient had no improvement after 16 treatments. Patients with the shortest disease duration had the greatest response. UVA1 therapy may be of benefit for the treatment of NL as an adj.vant therapy to topical corticosteroids or as a second-line alternative to other phototherapies, and may have a superior outcome in a proportion of patients.

关键词：脂质渐进性坏死 UVA1 光疗法胶原变性硬皮病补骨脂素免疫介导金属卤化物局部激素中度缓

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UVA1红斑的量效与时程特征

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 25-26页

作者： Beattie P.E. Dawe R.S. ferguson j. Ibbotson S.H. 潘敏 Photobiology Unit Ninewells Hospital and Medical School Ninewells AvenueDundee DD1 9SYUnited Kingdom

Obj.ctive: To determine the time course and dose-response characteristics of UV-A1 erythema in the Tayside region of Scotland. Design: Adult volunteers (skin types I and II [n=13]- and III and IV [n=11])were exposed to geometric dose series of UV-A1 irradiation from a high-output source on photoprotected lower back and inner forearm skin. Setting: Photobiology unit in a university hospital. MainOutcomeMeasures: The minimal erythema dose (MED) was recorded visually and erythema was assessed obj.ctively by erythema meter at 4, 8, 24, and 48 hours after exposure. Results: Peak erythema (lowest visual MED) was seen at 8 hours on the back and arm in 11 subj.cts with skin types I and II and on the back at 8 hours in 9 subj.cts and on the arm at 4 hours in 10 subj.cts with skin types III and IV. The lowest median (range) MED was 20 j.cm2 (14- 56 j.cm2) on the back and 42 j.cm2 (20 to >80 j.cm2) on the arm at 8 hours for subj.cts with skin types I and II and 28 j.cm2 (20- 112 j.cm2) at 8 hours on the back and 56 j.cm2 (28- 80 j.cm2) at 4 hours on the arm for subj.cts with skin types III and IV. The D0.025, an obj.ctive measure that corresponds approximately to the visual MED, demonstrated a broad peak from 8 to 24 hours. Conclusions: Our local population is more erythemally sensitive to UV-A1 radiation than reports suggest. Daily dose regimens may risk cumulative erythema. Lower starting doses should be used in this population. The wide range of MEDs highlights the need for MED testing.

关键词：最小红斑剂量 UVA1 时程量效 Ⅳ型皮肤大学医院观察指标受试者照射苏格兰

低危宫颈癌妇女单纯子宫切除术与根治性子宫切除术的比较

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中国临床药理学杂志 2024年第8期40卷 1159-1159页

作者： PLANTE M KWON j.S ferguson S 王超群

回顾性资料显示,早期低危宫颈癌患者参数浸润发生率较低,这就提出了这些患者是否需要根治性子宫切除术的问题。然而,比较根治性和单纯性子宫切除术结果的大型随机试验数据缺乏。本研究进行了一项多中心、随机、非劣效性试验,比较了低危... 详细信息

回顾性资料显示,早期低危宫颈癌患者参数浸润发生率较低,这就提出了这些患者是否需要根治性子宫切除术的问题。然而,比较根治性和单纯性子宫切除术结果的大型随机试验数据缺乏。本研究进行了一项多中心、随机、非劣效性试验,比较了低危宫颈癌(病变≤2cm,间质浸润有限)患者的根治性子宫切除术和单纯性子宫切除术,包括淋巴结评估。主要结局是3年盆腔肿瘤复发(盆腔复发)。预先规定的3年盆腔复发组间差异的非劣效性界限为4个百分点。

关键词：根治性子宫切除术盆腔肿瘤回顾性资料间质浸润宫颈癌患者盆腔复发预先规定低危

对光照射治疗有反应的银屑病史不能预测UVB的疗效

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 18-18页

作者： Dawe R.S. ferguson j. 田中伟 PhotobiologyUnit Department of Dermatology Ninewells Hosp.and Medical SchoolDundee DD1 9SYUnitedKingdom

We prospectively asked 146 consecutive patients starting narrow-band UVB (NB-UVB) for psoriasis about the effects of sunlight on their ***-eight (60%) patients reported improvementwith sunlight, six(4%) reported worsening, and 52(36%) had not noted any change in their psoriasis with sunlight ***, 101 (69%) were recorded to reach clearance or minimal residual activity (MRA), 24(16.5%) to achieve moderate improvement, and 21(14.5%)-had other recorded outcomes (mainly ‘did not attend’), with UVB ***-two (72%) of the 58 who did not report improvement with sunlight went on to clearance/MRA with UVB compared to 59/88(67%) of those who did report improvement (95%confidence interval for difference in percentage improving, -10%to 20%.P = 0.49).Patientsreplies to questions about how their psoriasis responds to sunlight do not appear to predict response to UVB phototherapy in our patient population.

关键词：银屑 UVB 照射治疗日光照射微小残留病

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心衰患者的抑郁症状与炎症反应

世界核心医学期刊文摘（心脏病学分册） 2006年第1期2卷 28-28页

作者： Ferketich A. K. ferguson j. P. Binkley P. F. 宁宁 Dr. Ohio State University School of Public Health B-116 Starling-Loving Hall 320 West 10th Avenue Columbus OH 43210 United States

Background: Psychological depression has been linked to heart failure, both an antecedent to and as a risk factor for poor outcomes among patients with existing heart failure. Elevated levels of proinflammatory cytokines have been proposed as a possible physiological link between the 2 conditions. The obj.ctive of this study was to examine the proinflammatory cytokines interleukin(IL)-6, IL-1β, and tumor necrosis factor alpha(TNFα) in heart failure patients with and without elevated symptoms of depression. Methods: Thirty-two heart failure patients were recruited from an outpatient heart failure clinic. Depressive symptoms were measured with the Beck Depression Inventory(BDI), and a patient was classified as having elevated symptoms of depression if he/she scored ≥10. The cognitive affective subscale score of the BDI, which measures depressed mood independent of physical symptoms, was also examined. Results: In the multiple linear regression models controlling for age, sex, smoking, and antidepressant medication use, there was no relation between BDI score and IL-6(P=.7612) or IL-1β(P=.8261). However, there was a statistically significant positive relation between BDI score and TNFα(P=.0374). There was also a significant relation between an elevated cognitive-affective score and TNFα(P=.0322) but no association with IL-6(P=.8593) or IL-1β(P=.3737). Conclusions: The association between TNFαand the cognitive-affective subscale, which eliminates the physical signs and symptoms that are shared by depression and heart failure, demonstrates a depression-specific activation of proinflammatory cytokines that may promote disease progression and mortality in patients with heart failure.

关键词：心衰患者抑郁症状肿瘤坏死因子-α(TNF-α) 炎症反应细胞因子白细胞介素 Beck抑郁量表细胞因子水平不良预后量表评分 IL-1β

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UVA1光疗法治疗生殖器萎缩性硬化苔藓

世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 32-32页

作者： Beattie P.E. Dawe R.S. ferguson j. Ibbotson S.H. 潘敏 Western Infirmary Glasgow G11 6NT United Kingdom Dr.

Background. Lichen sclerosus (LS) is characterized histologically by an inflammatory T-cell infiltrate, sclerosis and thickening of the dermis, and epidermal atrophy. Ultraviolet (UV) A1 therapy has been shown to be effective in the management of morphea and scleroderma, diseases that have some histological and clinical similarities with LS, and more recently in extragenital LS. Aim. To determine the effectiveness of UVA1 therapy for genital LS. Methods. Seven women with severe genital LS uncontrolled by ultrapotent topical corticosteroids, with a median age of 62 years (range 48-78) and disease duration of 6-47 years, were treated with UVA1 therapy from a high output source. After completion of UVA1 therapy, a clinician and the patient graded the overall response of symptoms and physical signs. Results. Five patients improved with therapy. Three obtained moderate improvement in overall disease severity and two had minimal improvement. Of these five, one relapsed within 3 months and another after a year. Both had a further course of UVA1 therapy, resulting in minimal improvement in one and moderate improvement in the other. In the remaining three, disease severity had improved to a point where intermittent use of topical corticosteroids resulted in acceptable control. Discussion. UVA1 therapy may be of benefit in the management of vulval LS, a disease that is often poorly responsive to standard therapies. The therapy is well tolerated and could provide an acceptable therapeutic option for patients with severe disease.

关键词：生殖器萎缩 UVA1 光疗法严重度硬斑病表皮萎缩硬皮病组织病理学间断应用皮质激素

Molecular Analysis of Legume Nodule Development and Autoregulation

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j.urnal of Integrative Plant Biology 2010年第1期52卷 61-76页

作者： Brett j. ferguson Arief Indrasumunar Satomi Hayashi Yu-Hsiang Lin Dugald E. Reid Peter M. Gresshoff ARC Centre of Excellence for Integrative Legume Research The University of Queensland

Legumes are highly important food, feed and biofuel crops. With few exceptions, they can enter into an intricate symbiotic relationship with specific soil bacteria called rhizobia. This interaction results in the formation of a new root organ called the nodule in which the rhizobia convert atmospheric nitrogen gas into forms of nitrogen that are useable by the plant. The plant tightly controls the number of nodules it forms, via a complex root-to-shoot-to-root signaling loop called autoregulation of nodulation （AON）. This regulatory process involves peptide hormones, receptor kinases and small metabolites. Using modern genetic and genomic techniques, many of the components required for nodule formation and AON have now been isolated. This review addresses these recent findings, presents detailed models of the nodulation and AON processes, and identifies gaps in our understanding of these process that have yet to be fully explained.

关键词： Molecular Analysis of Legume Nodule Development and Autoregulation

Mechanistic action of gibberellins in legume nodulation

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j.urnal of Integrative Plant Biology 2014年第10期56卷 971-978页

作者： Satomi Hayashi Peter M.Gresshoff Brett j.ferguson Centre for Integrative Legume Research The University of Queensland

Legume plants are capable of entering into a symbiotic relationship with rhizobia *** results in the formation of novel organs on their roots,called nodules,in which the bacteria capture atmospheric nitrogen and provide it as ammonium to the host *** molecular and physiological changes are involved in the formation and establishment of such *** phytohormones are known to play key roles in this ***（gibberellic acids;GAs）,a class of phytohormones known to be involved in a wide range of biological processes（i.e.,cell elongation,germination）are reported to be involved in the formation and maturation of legume nodules,highlighted by recent transcriptional analyses of early soybean symbiotic ***,we summarize what is currently known about GAs in legume nodulation and propose a model of GA action during nodule *** from a wide range of studies,including GA application,mutant phenotyping,and gene expression studies,indicate that GAs are required at different stages,with an optimum,tightly regulated level being key to achieve successful *** acids appear to be required at two distinct stages of nodulation：（i）early stages of rhizobia infection and nodule primordium establishment;and（ii）later stages of nodule maturation.

关键词： Gibberellic acid legume nodulation phytohormone plant development rhizobia symbiosis

iStent inj.ct trabecular microbypass stent implantation with cataract extraction in open-angle glaucoma:early clinical experience

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Eye and Vision 2020年第3期7卷 266-274页

作者： Tanner j.ferguson Zachary Dockter Adam Bleeker Kayla L.Karpuk j.stin Schweitzer Mitch j.Ibach j.hn P.Berdahl Cole Eye Institute Cleveland ClinicClevelandOHUSA University of South Dakota Sanford School of Medicine Sioux FallsSDUSA Cleveland Eye Clinic ClevelandOHUSA Vance Thompson Vision Sioux FallsSDUSA

Background:Retrospective,consecutive case series to evaluate the implantation of two second-generation trabecular microbypass stents in combination with cataract surgery in a real-world,clinical ***:The series included 56 eyes implanted with the iStent inj.ct device with *** series consisted of eyes with primary open-angle glaucoma(n=52)and pseudoexfoliative glaucoma(n=4).Primary outcome measures included intraocular pressure(IOP)and number of glaucoma *** outcomes included the need for secondary surgical intervention and the incidence of IOP spikes≥10 mmHg and≥15 ***:IOP was reduced by 21%to 14.7±2.9 mmHg(pj.ct device with concomitant cataract surgery effectively provides a sustained reduction in IOP with a markedly improved medication burden out to 6 months *** safety profile is excellent.

关键词： Micro-invasive glaucoma surgery Minimally invasive glaucoma surgery MIGS Trabecular microbypass stent Open-angle glaucoma