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Empowering Taxpayers Through Technology-Driven Services and Education

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Belt and Road Initiative Tax Journal 2024年第1期 5-8页

作者： ferenc Vágujhelyi National Tax and Customs Administration Hungary

What tasks do technological changes taking place in the world impose on tax administrations,and at the same time,what opportunities do they create in enforcing the principle of public responsibility?How can innovations like European Digital Identity Wallet(EUDIW) be applied in the authentication environment?What assistance can the authorities provide in the integrity of taxpayers' business data?What developments are seen in the work of the Hungarian tax administration to use transaction-based data to contribute to a more modern public administration system and,last but not least,to a fair public burden?How does blockchain as a technology platform support data integrity?How does personalized and easy-to-understand communication revolutionize customer information?These questions are answered in this article.

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Modeling Expected Failure Considering Repair Time and Degradation: A Rail System Case Study

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Journal of Transportation Technologies 2024年第2期14卷 236-254页

作者： Maryam Hamidi Atefe Sedaghat Amir Gharehgozli ferenc Szidarovszky Department of Industrial and Systems Engineering Lamar University Beaumont TX USA Department of Systems and Operations Management California State University Northridge CA USA Department of Mathematics Corvinus University of Budapest F&#337v&#225mt&#233r 8 Budapest Hungary

The repeated failures of any equipment or systems are modeled as a renewal process. The management needs an assessment of the number of future failures to allocate the resources needed for fast repairs. Based on the idea of expectation by conditioning, special Volterra-type integral equations are derived for general types of repairs, considering the length of repair and reduced degradation of the idle object. In addition to minimal repair and failure replacement, partial repairs are also discussed when the repair results in reduction of the number of future failures or decreases the effective age of the object. Numerical integration-based algorithm and simulation study are performed to solve the resulting integral equation. Since the geometry degradation in different dimensions of a rail track and controlling and maintaining defects are of importance, a numerical example using the rail industry data is conducted. Expected number of failures of different failure type modes in rail track is calculated within a two-year interval. Results show that within a two-year period, anticipated occurrences of cross level failures, surface failures, and DPI failures are 2.4, 3.8, and 5.8, respectively.

关键词： Renewal Theory Expected Number of Failures Partial Repair Minimal Repair

Restricted Summability of Fourier Transforms and Local Hardy Spaces

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Acta Mathematica Sinica,English Series 2010年第9期26卷 1627-1640页

作者： ferenc WEISZ Department of Numerical Analysis Etvs L. University

A general summability method, the so-called θ-summability is considered for multi-dimensional Fourier transforms. Under some conditions on θ, it is proved that the maximal operator of the θ-means defined in a cone is bounded from the amalgam Hardy space W（hp, e∞） to W（Lp,e∞）. This implies the almost everywhere convergence of the θ-means in a cone for all f ∈ W（L1, e∞） velong to L1.

关键词： Wiener amalgam spaces local Hardy spaces 0-summability of Fourier transforms atomic decomposition

Thermal Reversion of Plant Phytochromes

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Molecular Plant 2020年第3期13卷 386-397页

作者： Cornelia Klose ferenc Nagy Eberhard Schafer Institute of Biology II University of Freiburg79104 FreiburgGermany Institute of Plant Biology Biological Research CentreTemesvari krt.626726 SzegedHungary

Phytochromes are red/far-red reversible photoreceptors essential for plant growth and *** signaling is mediated by the physiologically active far-red-absorbing Pfr form that can be inactivated to the red-absorbing Pr ground state by light-dependent photoconversion or by light-independent thermal reversion,also termed dark *** the term“dark reversion”is justified by historical reasons and frequently used in the literature,“thermal reversion”more appropriately describes the process of light-independent but temperature-regulated Pfr relaxation that not only occurs in darkness but also in light and is used throughout the *** reversion is a critical parameter for the light sensitivity of phytochrome-mediated responses and has been studied for decades,often resulting in contradictory *** reversion is an intrinsic property of the phytochrome molecules but can be modulated by intra-and intermolecular interactions,as well as biochemical modifications,such as *** this review,we outline the research history of phytochrome thermal reversion,highlighting important predictions that have been made before knowing the molecular *** further summarize and discuss recent findings about the molecular mechanisms regulating phytochrome thermal reversion and its functional roles in light and temperature sensing in plants.

关键词： phytochrome phyA phyB thermal reversion dark reversion in vivo spectroscopy

Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon

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World Journal of Gastroenterology 2012年第7期18卷 601-608页

作者： ferenc Sipos Orsolya Galamb Cell Analysis Laboratory 2nd Department of Internal MedicineSemmelweis University1088 BudapestHungary Molecular Medicine Research Unit Hungarian Academy of Sciences1051 BudapestHungary

Epithelial-to-mesenchymal and mesenchymal-to-epi- thelial transitions are well established biological events which have an important role in not just normal tissue and organ development, but in the pathogenesis of diseases. Increasing evidence has established their presence in the human colon during colorectal carcinogenesis and cancer invasion, chronic inflammation-related fibrosis and in the course of mucosal healing. A large body of evidence supports the role for transforming growth factor-13 and its downstream Smad signaling, the phosphatidylinositol 3＇-kinase/Akt/mTOR axis, the Ras-mitogen-activated protein kinase/Snail/Slug and FOXC2 pathway, and Hedgehog signaling and microR- NAs in the development of colorectal cancers via epi- thelial-to-mesenchymal transition. C-met and Frizzled-7, among others, seem to be the principle effectors of mesenchymal-to-epithelial transition, hence have a role not just in mucosal regeneration but in the progression of colonic wall fibrosis. Here we discuss a role for these pathways in the initiation and development of the transition events. A better understanding of their induction and regulation may lead to the identification of pathways and factors that could be potent therapeu- tic targets. The inhibition of epithelial-to-mesenchymal transition using mTOR kinase inhibitors targeting theATP binding pocket and which inhibit both mTORC1 and mTORC2, RNA aptamers or peptide mimetics, such as a Wnt5A-mimetic, may all be useful in both cancer treatment and delaying fibrosis, while the induction of mesenchymal-to-epithelial transition in induced pluripotent stem cells may enhance epithelial healing in the case of severe mucosal damage. The preliminary results of the current studies are promising, but more clinical investigations are needed to develop new and safe therapeutic strategies for diseases of the colon.

关键词： Epithelial-to-mesenchymal transition Mesen-chymal-to-epithelial transition Colorectal cancer Fibrosis Mucosal healing

Effect of ageing on colonic mucosal regeneration

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World Journal of Gastroenterology 2011年第25期17卷 2981-2986页

作者： ferenc Sipos Katalin Leiszter Zsolt Tulassay 2nd Department of Internal Medicine Semmelweis University Molecular Medicine Research Unit Hungarian Academy of Sciences

The physiologic and pathologic cellular and molecular changes occurring with age in the human colon affect both the inflammatory process leading to mucosal injury and the regenerative capacity of the *** the one hand,age-related telomere shortening and inflamm-ageing may lead to the development of colonic inflammation,which results in epithelial *** the other hand,the altered migration and function of regenerative stem cells,the age-related methylation of mucosal healing-associated genes,together with the alterations of growth factor signaling with age,may be involved in delayed mucosal *** connections of these alterations to the process of ageing are not fully *** understanding and customtailored modification of these mechanisms are of great clinical importance with regard to disease prevention and modern therapeutic ***,we aim to summarize the age-related microscopic and molecular changes of the human colon,as well as their role in altered mucosal healing.

关键词： Colon Mucosal repair Ageing Colorectalcancer Telomere shortening DNA methylation

Isolated lymphoid follicles in colon: Switch points between inflammation and colorectal cancer?

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World Journal of Gastroenterology 2011年第13期17卷 1666-1673页

作者： ferenc Sipos Gyrgyi Müzes 2nd Department of Internal Medicine Semmelweis University

Gut-associated lymphoid tissue is supposed to play a central role in both the organization of colonic repair mechanisms and colorectal carcinogenesis. In inflammatory conditions, the number, diameter and density of isolated lymphoid follicles (ILFs) increases. They are not only involved in immune surveillance, but their presence is also indispensable in normal mucosal regeneration of the colon. In carcinogenesis, ILFs may play a dual role. On the one hand they may support tumor growth and the metastatic process by vascular endothelial growth factor receptor signaling and producing a specific cytokine and cellular milieu, but on the other hand their presence is sometimes associated with a better prognosis. The relation of ILFs to bone marrow derived stem cells, follicular dendritic cells, subepithelial myofibroblasts or crypt formation, which are all involved in mucosal repair and carcinogenesis, has not been directly studied. Data about the putative organizer role of ILFs is scattered in scientific literature.

关键词： Isolated lymphoid follicle Colon Mucosal repair Colorectal cancer Epithelial stem cell Myofibroblast Follicular dendritic cell Mesenchymal-epithelial transition Epithelial-mesenchymal transition

Anti-tumor immunity,autophagy and chemotherapy

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World Journal of Gastroenterology 2012年第45期18卷 6537-6540页

作者： Gyrgyi Mzes ferenc Sipos 2nd Department of Internal Medicine Semmelweis University1088 BudapestHungary

Autophagy or self-digestion of cells is activated upon various stressful stimuli and has been found to be a survival and drug resistance pathway in ***,genetic studies support that autophagy can act as a tumor ***,defective autophagy is implicated in tumorigenesis,as *** precise impact of autophagy on malignant transformation has not yet been clarified,but recent data suggest that this complex process is mainly directed by cell types,phases,genetic background and *** of autophagy to anticancer immune responses may indicate a novel aspect in cancer chemotherapy.

关键词： Cancer Autophagy Chemotherapy Antitu-mor immunity Cell death

Issues and opportunities of stem cell therapy in autoimmune diseases

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World Journal of Stem Cells 2019年第4期11卷 212-221页

作者： Gy?rgyi M?zes ferenc Sipos Immunology Team 2nd Department of Internal MedicineSemmelweis University

The purpose of regenerative medicine is to restore or enhance the normal function of human cells, tissues, and organs. From a clinical point of view, the use of stem cells is more advantageous than differentiated cells because they can be collected more easily and in larger quantities, their proliferation capacity is more pronounced, they are more resistant in cell culture, their aging is delayed, they are able to form a number of cell lines, and they are able to promote vascularization of tissue carriers. The therapeutic use of stem cells for disease modification, immunomodulation, or regenerative purposes are undoubtedly encouraging, but most studies are still in their early stages, and the clinical results reported are not clear with regard to therapeutic efficacy and potential side effects. Uniform regulation of the clinical application of stem cells is also indispensable for this highly customizable, minimally invasive, individualized therapeutic method to become a successful and safe treatment alternative in many different autoimmune and autoinflammatory disorders.

关键词： Stem cell therapy Autoimmune Autoinflammatory Immunomodulation Disease modification