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Prospective study of total and various types of vegetables and the risk of metabolic syndrome among children and adolescents

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World Journal of Diabetes 2019年第6期10卷 362-375页

作者： Somayeh Hosseinpour-Niazi Bahar Bakhshi Ekbal Betru Parvin Mirmiran Mina Darand fereidoun azizi Nutrition and Endocrine Research center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran 19395-4763 Iran Department of Clinical Nutrition and Dietetics Faculty of Nutrition Sciences and Food Technology National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran 19395-4763 Iran Endocrine Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran 19395-4763 Iran

BACKGROUND Data available on the association between consumption of various types of vegetables and metabolic syndrome (MetS) remain inconsistent. AIM To investigate the association between the intake of various types of vegetables and MetS among children and adolescents and MetS. METHODS The Tehran Lipid and Glucose Study cohort included 424 children and adolescents initially free of MetS. At the 3.6 year follow-up, 47 new cases of MetS were identified. A 168-item semi-quantitative food-frequency questionnaire was used to collect information about total and various types of vegetables consumed, including allium-, green leafy-, fruity-, root-, stalk-, starchy-, potatoes, and cabbage. MetS was defined according to the Cook et al[32] criteria. RESULTS The median (interquartile range) of total vegetable consumption was 217 (146- 344) g/d. After adjustment for demographic characteristics and dietary intake, higher total-(≥ 350 g/d) and higher allium vegetable consumption (≥ 30 g/d) in the fourth quartile were significantly and inversely associated with risk of MetS compared to the first quartile. Consumption of green leafy vegetables in the third (21.4-38.3 g/d) versus the first quartile (≤ 13.5 g/d) demonstrated a significant inverse association with lower risk of MetS in children and adolescents;associations for other types of vegetables consumed were not significant. CONCLUSION Consumption of vegetables, especially allium and green leafy vegetables, in sufficient amounts may be beneficial in reducing the risk of MetS among children and adolescents.

关键词： Metabolic syndrome Children and adolescents Vegetable Allium Green leafy vegetables

Nitrate-nitrite-nitrosamines exposure and the risk of type 1 diabetes: A review of current data

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World Journal of Diabetes 2016年第18期7卷 433-440页

作者： Zahra Bahadoran Asghar Ghasemi Parvin Mirmiran fereidoun azizi Farzad Hadaegh Nutrition and Endocrine Research Center Research Institute for Endocrine SciencesShahid Beheshti University of Medical Sciences Endocrine Physiology Research Center Research Institute for Endocrine SciencesShahid Beheshti University of Medical Sciences Endocrine Research Center Research Institute for Endocrine SciencesShahid Beheshti University of Medical Sciences Prevention of Metabolic Disorders Research Center Research Institute for Endocrine SciencesShahid Beheshti University of Medical Sciences

The potential toxic effects of nitrate-nitrite-nitrosamine on pancreatic β cell have remained a controversial issue over the past two decades. In this study, we reviewed epidemiological studies investigated the associations between nitrate-nitrite-nitrosamines exposure, from both diet and drinking water to ascertain whether these compounds may contribute to development of type 1 diabetes. To identify relevant studies, a systematic search strategy of Pub Med, Scopus, and Science Direct was conducted using queries including the key words "nitrate", "nitrite", "nitrosamine" with "type 1 diabetes" or "insulin dependent diabetes mellitus". All searches were limited to studies published in English. Ecologic surveys, case-control and cohort studies have indicated conflicting results in relation to nitrate-nitrite exposure from drinking water and the risk of type 1 diabetes. A null, sometimes even negative association has been mainly reported in regions with a mean nitrate levels 40-80 mg/L. Limited data are available regarding the potential diabetogenic effect of nitrite from drinking water, although there is evidence indicating dietary nitrite could be a risk factor for development of type 1 diabetes, an effect however that seems to be significant in a higher range of acceptable limit for nitrate/nitrite. Current data regarding dietary exposure of nitrosamine and development of type 1 diabetes is also inconsistent. Considering to an increasing trend of type 1 diabetes mellitus(T1DM) along with an elevated nitrate-nitrite exposure, additional research is critical to clarify potential harmful effects of nitrate-nitritenitrosamine exposure on β-cell autoimmunity and the risk of T1DM.

关键词： Nitrate Nitrite Nitrosamine Type 1 diabetes

A New Diterpene Extracted from Daphne Mucronata, Effects on Human K562 and CCRF-CEM Cell Lines

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Journal of Cancer Therapy 2011年第1期2卷 71-75页

作者： Mehdi Hedayati Razieh Yazdanparast Marjan Zarif Yeganeh Laleh Hoghooghi Rad fereidoun azizi 不详

Background: Daphne Mucronata extract has a decreasing effect on the size of breast adenocarcinoma in rats. So in this study, the effect of Daphne Mucronata purified diterpene were investigated on co culture of human monocytes and two human leukemia cell lines (K562, CCRF-CEM). Materials and Methods: Each cell line mono-layer culture, in log phase growth, was treated with 10 to 160 μL of the extract (1 g/ml leave powder) and purified compound (0.94 nM). For a comparative study, Taxol (5 to 40 μM) was used in the presence and absence of LPS. Human monocytes were isolated by adhesion method. TNF-α in cultured media were measured by sensitive biotin-streptoavidin ELISA method. Results: Fifty percent of growth inhibition was shown by 160 μL (1:100 dilution, 0.5 g of the powdered leaves/ml) of the extract and 0.94 nM of the purified component, and there was more inhibition in K562 cells (P < 0.05). Four fold increases in growth inhibition was shown in co culture of isolated human monocytes and leukemia cell lines. There was a direct relationship between monocytes TNF-α secretion and growth inhibition degree. Conclusion: Daphne Mucronata extract and its purified diterpene through increasing monocytes TNF-α releasing, potentially inhibit Leukemia cell line.

关键词： TNF-α Leukemia Daphne Mucronata K562 CCRF-CEM

Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review

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World Journal of Diabetes 2014年第3期5卷 267-281页

作者： Parvin Mirmiran Zahra Bahadoran fereidoun azizi Department of Clinical Nutrition and Dietetics Faculty of Nutrition Sciences and Food Technology National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Nutrition and Endocrine Research Center and Obesity Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Endocrine Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences

Type 2 diabetes is a complicated metabolic disorder with both short- and long-term undesirable complications. In recent years, there has been growing evidence that functional foods and their bioactive compounds, due to their biological properties, may be used as complementary treatment for type 2 diabetes mellitus. In this review, we have highlighted various functional foods as missing part of medical nutrition therapy in diabetic patients. Several in vitro, animal models and some human studies, have demonstrated that functional foods and nutraceuticals may improve postprandial hyperglycemia and adipose tissue metabolism modulatecarbohydrate and lipid metabolism. Functional foods may also improve dyslipidemia and insulin resistance, and attenuate oxidative stress and inflammatory processes and subsequently could prevent the development of long-term diabetes complications including cardiovascular disease, neuropathy, nephropathy and retinopathy. In conclusion available data indicate that a functional foods-based diet may be a novel and comprehensive dietary approach for management of type 2 diabetes.

关键词： Type 2 diabetes Insulin resistance Functional foods Whole grain Legumes Nuts Fruits Herbs or spices Vegetables Prebiotics Probiotics