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作者： ferdinand an rompis 重庆医科大学

学位级别：硕士

Objective: Non-dipping of nocturnal hypertension is common in people with type 2 diabetes and is associated with increased risk of cardiovascular morbidity and mortality. This study aimed to identify the factors associated with nocturnal non-dipping of HT in people with type 2 diabetes.Methods: Data were obtained from 50 people with type 2 diabetes who had undergone ambulatory BP (blood pressure) monitoring. Dippers were defined as those with a systolic night-time BP dip over 15%. All statistical analyses were performed using SPSS version 11.0 for Windows. Normally distributed data were analysed using a non-paired Students t-test, and non-parametric tests were used for data with a skewed distribution. Chi-squared tests were used for discontinuous variables. The results were adjusted for age using binary logistic regression, using non-dipping status as the dependent variable.Results: No significant differences were seen between the mean day-time systolic BP in the dipping (145.8 mmHg) and the non-dipping (145.0 mmHg) groups (p=0.88). Non-dippers were significantly older (p<0.0001) with a higher prevalence of albuminuria (p=0.003) and of macrovascular disease (p=0.008) when compared with the dipping group. After adjustment for age, albuminuria remained more prevalent within the non-dipping group (p=0.007). There was no significant difference in glycaemic control, type of diabetes treatment, smoking status, or gender between the groups.Conclusion: Albuminuria is strongly associated with non-dipping of nocturnal BP in people with type 2 diabetes. An increase in night-time systolic BP appears to be the earliest detectable manifestation of altered BP regulation in patients with diabetes.

关键词： ambulatory blood pressure non-dipping hypertension type 2 diabetes

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Effect of calcium citrate on bone integration in a rabbit femur defect model

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Asian Pacific Journal of Tropical Medicine 2012年第4期5卷 310-314页

作者： Wei Zhang Wei Wang Qing-Yu Chen Zhong-Qin Lin Shao-Wen Cheng Dong-Quan Kou Xiao-Zhou Ying Yue Shen Xiao-Jie Cheng Peng-Fei Nie Xiu-Cui Li ferdinand an rompis Hang Huang Hua Zhang Zhong-Lin Mu Lei Peng Department of Orthopaedic Surgery the Second Affiliated Hospital of Wenzhou Medical College Department of Orthopaedic Surgery Hospital of Integrated Traditional Chinese and Western Medicine of Wenzhou Department of Respiratory Medicine Yuying Children's Hospital Affiliated to Wenzhou Medical College Trauma Center of the Affiliated Hospital of Hainan Medical College Haikou 120 Emergency Center International Nursing School of Hainan Medical College Graduate Department of Hainan Medical College The Second Affiliated Hospital of Wenzhou Medical College Trauma Center of the Affiliated Hospital of Hainan Medical College

Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods:Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A.B.C)in this *** anesthesia,defects of four sizes(1.2,1.5,2.0 and 2.5 mm) were created in each of the *** pure calcium citrate powder was placed inside the medullary compartment of the femur(Experimental),while in the contralateral femur(Control) nothing was *** defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A),6th(Group B) and 8th(Group C) weeks *** samples were analyzed for each size of defect and each healing ***:The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks,It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 *** statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th ***:Calcium citrate affects the early periods of hone defects healing mechanism in Japanese white rabbits positively,especially when the defect is not too large,We suggest further studies on calcium citrate to determine the effects of various dosages,administration ways and the experimental time on the bone defects.

关键词： Experiment Bone Fracture healing Calcium citrate

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