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Modernization of Medicine in the Ottoman Empire and Its Effects on Forensic Sciences

Journal of Forensic Science and Medicine 2018年第4期4卷 213-220页

作者： ferat buran Erdem Ozkara The Council of Forensic Medicine sanliurfa Branch OfficeSanhurfaTurkey department of Forensic Medicine Faculty of MedicineDokuz Eylul UniversityIzmirTurkey

Modernization in medicine began in the Ottoman Empire in the 19^(th)*** that time,medical education had been provided through the traditional master-apprentice practices and its methods had relied on custom or *** most important of these reforms was in 1827,when the first medical schools in surgical and clinical branches were opened in *** lack of contemporary understanding in medical education until that time had caused an underdevelopment in forensic sciences as it had in various other *** the reform movements,the contents of the forensic medicine curriculum,mainly influenced by the French medical schooling,touched upon all areas of forensic sciences such as pathology,toxicology,organic chemistry,neuropsychiatry,gynecology,handwriting analysis and *** was noteworthy to see such rapid development in scientific modernization considering the fact that,before the reform movements,the religion had a repressive effect and it was forbidden to even perform laboratory tests or examinations on *** the modem Turkish Republic,founded in 1923 after World War I,scientific reforms gained momentum and began competing with the modem *** that,after a letter sent to the Turkish Government by Albert Einstein in 1933,the contemporary Turkish universities embraced the scientists who escaped from the Nazi regime.

关键词： Forensic medicine history of forensic medicine legal medicine medical history Ottoman Empire Turkish Republic

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How inflammation influences psychiatric disease

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World Journal of Psychiatry 2024年第3期14卷 342-349页

作者： Eduardo ferat-Osorio JoséLuis Maldonado-García Lenin Pavón División de Investigación Clínica de la Coordinación de Investigación en Salud Instituto Mexicano del Seguro SocialMexico City 06720Mexico Departamento de Bioquímica Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacán 04510Ciudad de MéxicoMexico Departamento de Inmunología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Laboratorio de Psicoinmunología Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico

Recent studies highlight the strong correlation between infectious diseases and the development of neuropsychiatric *** this editorial,we comment on the article“Anti-infective therapy durations predict psychological stress and laparoscopic surgery quality in pelvic abscess patients”by Zhang et al,published in the recent issue of the World Journal of Psychiatry 2023;13(11):*** discussion highlighted the potential consequences of anxiety,depression,and psychosis,which are all linked to bacterial,fungal,and viral infections,which are relevant to the impact of inflammation on the sequelae in mental health as those we are observing after the coronavirus disease 2019 *** focus specifically on the immune mechanisms triggered by inflammation,the primary contributor to psychiatric ***,pathophysiological mechanisms such as organ damage,post-injury inflammation,and infectioninduced endocrine alterations,including hypocortisolism or autoantibody formation,significantly contribute to the development of chronic low-grade inflammation,promoting the emergence or development of psychiatric alterations in susceptible *** inflammation can have long-term effects on patients,a multidisciplinary treatment plan can avoid complications and debilitating health issues,and it is crucial to recognize and address the mental health implications.

关键词： Inflammation infection Depression Pelvic inflammatory disease Psychiatric complication

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墨西哥化学集团执行生态设计(DFE)

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生态毒理学报 2005年第2期27卷 47-51页

作者： Margarita ferat 蔡学娣 Grupo DESC SA de CV Bosque de Ciruelos No. 29 Col. Bosques de las Lomas Deleg. Cuajimalpa 05120 Mexico DF Mexico

本文总结了一家墨西哥企业在化学品部门研发领域执行生态设计(DfE)的经验.DfE是一种可持续发展战略.它可以被用于检测潜在的环境风险,开发新产品和新工艺.DfE手册一出版,就分几个步骤循序渐进地开始执行.希望利益相关者采用DfE是出于信... 详细信息

本文总结了一家墨西哥企业在化学品部门研发领域执行生态设计(DfE)的经验.DfE是一种可持续发展战略.它可以被用于检测潜在的环境风险,开发新产品和新工艺.DfE手册一出版,就分几个步骤循序渐进地开始执行.希望利益相关者采用DfE是出于信念而不是义务.因此,十分强调教育和机遇的确认.在项目的最后阶段,选择了两个正在开展的技术项目进行分析:一个尚处于试验阶段,另一个已经处于商业阶段.

关键词：墨西哥化学品集团可持续发展战略利益相关者开发新产品研发领域生态设计技术项目环境风险新工艺义务选择信念手册试验商业企业经验教育

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Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery

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World Journal of Gastroenterology 2005年第47期11卷 7473-7479页

作者： Nestor González-Roldán Eduardo ferat-Osorio Rosalía Aduna-Vicente Isabel Wong-Baeza Noemí Esquivel-Callejas Horacio Astudillo-de la Vega Patricio Sánchez-Fernández Lourdes Arriaga-Pizano Miguel Angel Villasís-Keever Constantino López-Macías Armando Isibasi Unidad de Investigación Médica en Inmunoquímica Hospital de EspecialidadesCentro Médico Nacional Siglo ⅩⅪInstituto Mexicano del Seguro Social (IMSS)México Laboratorio de Oncología Molecular Unidad de Investigación Médica en Enfermedades OncológicasHospital de OncologíaCentro Médico Nacional Siglo ⅩⅪIMSSMéxico Servicio de Gastrocirugía Hospital de EspecialidadesCentro Médico Nacional Siglo ⅩⅪIMSSMéxico Unidad de Investigación en Epidemiología Clínica Hospital de PediatríaCentro Médico Nacional Siglo ⅩⅪIMSSMéxico

AIM： To evaluate the surface expression of triggering receptor on myeloid cell 1 （TREM-1）, class Ⅱ major histocompatibility complex molecules （HLA-DR）, and the expression of the splicing variant （svTREH-1） of TREM-1 in septic patients and those subjected to major abdominal surgery. METHODS： Using flow cytometry, we examined the surface expression of TREM-1 and HLA-DR in peripheral blood monocytes from 11 septic patients, 7 elective gastrointestinal surgical patients, and 10 healthy volunteers, svTREM-1 levels were analyzed by RT-PCR. RESULTS： Basal expression of TREM-1 and HLA- DR in healthy volunteers was 35.91±14.75 MFI and 75.8±18.3%, respectively. In septic patients, TREM-1 expression was 59.9±23.9 MFI and HLA-DR expression was 44.39±20.25%, with a significant difference between healthy and septic groups （P〈0.05） for both molecules. In the surgical patients, TREM-1 and HLA-DR expressions were 56.8±20.85 HFI and 71±13.8% before surgery and 72.65±29.92 MFI and 72.82±22.55% after surgery. TREM-1 expression was significantly different （P = 0.0087） between the samples before and after surgery and svTREM-1 expression was 0.8590± 0.1451 MF1, 0.8820±0.1460 MF1, and 2.210±0.7873 MF1 in the healthy, surgical （after surgery） and septic groups, respectively. There was a significant difference （P = 0.048） in svTREM-1 expression between the healthy and surgical groups and the septic group. CONCLUSION： TREM-1 expression is increased during systemic inflammatory conditions such as sepsis and the postoperative phase. Simultaneous low expression of HLA-DR molecules correlates with the severity of illness and increases susceptibility to infection. Additionally, TREM-1 expression is distinctly different in surgical patients at different stages of the inflammatory response before and after surgery. Thus, surface TREM-1 appears to be an endogenous signal during the course of the inflammatory response, svTREM-1 expression is significantly increased during sepsis, appearing to be a

关键词： TRFM-1 HLA-DR SIRS CARS Sepsis

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