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Osteogenic lithium-doped brushite cements for bone regeneration

Bioactive Materials 2022年第10期7卷 403-417页

作者： K.Hurle F.r.Maia V.P.ribeiro S.Pina J.M.Oliveira F.Goetz-Neunhoeffer r.L.reis GeoZentrum Nordbayern MineralogyFriedrich-Alexander University Erlangen-Nürnberg(FAU)91054ErlangenGermany B’s research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkParque de Ciˆencia e TecnologiaZona Industrial da Gandra4805-017BarcoGuimar˜aesPortugal ICVS/3B’s–PT Government Associate Laboratory BragaGuimar˜aesPortugal

This study investigated the osteogenic performance of new brushite cements obtained from Li+-dopedβ-tricalcium phosphate as a promising strategy for bone ***(Li+)is a promising trace element to encourage the migration and proliferation of adipose-derived stem cells(hASCs)and the osteogenic differentiation-related gene expression,essential for ***-situ X-ray diffraction(XrD)and in-situ 1H nuclear magnetic resonance(1H NMr)measurements proved the precipitation of brushite,as main phase,and monetite,indicating that Li+favored the formation of monetite under certain ***+was detected in the remaining pore solution in significant amounts after the completion of *** calorimetry results showed an accelerating effect of Li+,especially for low concentration of the setting retarder(phytic acid).A decrease of initial and final setting times with increasing amount of Li+was detected and setting times could be well adjusted by varying the setting retarder *** cements presented compressive mechanical strength within the ranges reported for cancellous *** vitro assays using hASCs showed normal metabolic and proliferative *** immunodetection and gene expression profile of osteogenic-related markers highlight the incorporation of Li+for increasing the in vivo bone *** osteogenic potential of Li-doped brushite cements may be recommended for further research on bone defect repair strategies.

关键词： Lithium doping β-tricalcium phosphate Brushite cements Alkaline phosphatase activity Collagen expression Osteogenic expression Bone regeneration

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Investigation of confocal microscopy for differentiation of renal cell carcinoma versus benign *** an optical biopsy be performed?

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Asian Journal of Urology 2020年第4期7卷 363-368页

作者： Michael C.Phung Andrew r.rouse Jayce Pangilinan robert C.Bell Erika r.Bracamonte Sharfuddeen Mashi Arthur F.Gmitro Benjamin r.Lee Department of Urology University of Arizona College of MedicineArizonaUSA Department of Medical Imaging University of Arizona College of MedicineArizonaUSA Department of Pathology University of Arizona College of MedicineArizonaUSA ringgold Standard Institution Aminu Kano Teaching HospitalKanoNigeria Biomedical Engineering University of Arizona College of MedicineArizonaUSA

Objective:Novel optical imaging modalities are under development with the goal of obtaining an“optical biopsy”to efficiently provide pathologic *** such modality is confocal microscopy which allows in situ visualization of cells within a layer of tissue and imaging of cellular-level *** goal of this study is to validate the ability of confocal microscopy to quickly and accurately differentiate between normal renal tissue and ***:Specimens were obtained from patients who underwent robotic partial nephrectomy for renal *** of suspected normal and tumor tissue were extracted from the excised portion of the kidney and stained with acridine *** stained samples were imaged on a Nikon E600 C1 Confocal *** samples were then submitted for hematoxylin and eosin processing and read by an expert pathologist to provide a gold-standard diagnosis that can later be compared to the confocal ***:This study included 11 patients,17 tissue samples,and 118 confocal *** the 17 tissue samples,10 had a gold-standard diagnosis of cancer and seven were *** 118 confocal images,66 had a gold-standard diagnosis of cancer and 52 were *** confocal images were used as a training set to train eight *** observers were asked to rate the test images on a six point scale and the results were analyzed using a web based receiver operating characteristic curve *** average accuracy,sensitivity,specificity,and area under the empirical receiver operating characteristic curve for this study were 91%,98%,81%,and 0.94 ***:This preliminary study suggest that confocal microscopy can be used to distinguish cancer from normal tissue with high sensitivity and *** observers in this study were trained quickly and on only six *** expect even higher performance as observers become more familiar with the confocal images.

关键词： renal cell carcinoma Confocal microscopy Optical biopsy

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Temporal variability and sources of PFAS in the rio Grande,New Mexico through an arid urban area using multiple tracers and highfrequency sampling

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Emerging Contaminants 2024年第3期10卷 205-220页

作者： Kimberly r.Beisner rebecca E.Travis David A.Alvarez Larry B.Barber Jacob A.Fleck Jeramy r.Jasmann U.S.Geological Survey 6700 Edith Blvd NEAlbuquerqueNM87113USA U.S.Geological Survey 4200 New Haven RoadColumbiaMO65201USA U.S.Geological Survey 3215 Marine St.BoulderCO80303USA U.S.Geological Survey 6000 J St.Placer Hall.SacramentoCA95819USA

Per-and polyfluoroalkyl substances(PFAS)are ubiquitous in the environment but sources are not well defined for temporal and spatial aspects within an urban environment,and especially for an arid urban environment subject to seasonal short term high-intensity precipitation events.A focused diel sampling was conducted in the summer of 2021 to assess the temporal and spatial variability of PFAS in the rio Grande near Albuquerque,New Mexico and showed an order of magnitude increase of PFAS as it flows through the Albuquerque urban *** samples were collected at two different locations on the rio Grande in addition to wastewater treatment plant(WWTP)effluent that discharges directly to the rio Grande between the sampling ***-term high-intensity precipitation events occurred during the study period and mobilized PFAS from urban *** organic matter composed of tryptophan-like organic substances and refined fuel and fuel byproducts,characteristic of an urban signature,were also related to the precipitation *** PFAS in discharge from the WWTP was consistent over a 24-h period with slight differences in some *** presence on the rio Grande downstream of the WWTP was evidenced by a gadolinium anomaly as well as increases in several other trace elements,total dissolved nitrogen,and fluorescence indicators,in addition to *** varied depending on source contribution,where urban runoff was associated with PFOA,PFOS,and PFBA,whereas PFHxA and PFPeA were associated with wastewater *** addition,passive polar organic chemical integrative samplers(POCIS)using hydrophilic-lipid balance(HLB)sorption media were deployed for a month at two locations on the rio Grande to assess longer term PFAS *** POCIS results show some compounds(PFPeA and PFHpA)were greater than the average concentration from discrete samples,whereas other compounds(PFHxA,PFOA,PFDA,and PFNA)were lower in the POCIS,and PFOS was very simila

关键词： wastewater rio runoff

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Anisotropic Bianchi Type Ⅰ Cosmological Models with Generalized Chaplygin Gas and Dynamical Gravitational and Cosmological Constants

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Communications in Theoretical Physics 2017年第2期67卷 222-230页

作者： S.Kotambkar G.P.Singh r.Kelkar Binaya K.Bishi Department of Applied Mathematics LIT RTM Nagpur University Nagpur India Department of Mathematics VNIT Nagpur India Department of Applied Mathematics SB Jain ITMR Nagpur India

This paper deals with study of generalized Chaplygin gas model with dynamical gravitational and cosmological constants. In this paper a new set of exact solutions of Einstein field equations for spatially homogeneous and anisotropic Bianchi type Ⅰ space-time have been obtained. The solutions of the Einstein's field equations are obtained by considering(i) the power law relation between Hubble parameter H and scale factor r and(ii) scale factor of the form r =-1/t + t^2, t > 1. The assumptions lead to constant and variable deceleration parameter respectively. The physical and dynamical behaviors of the models have been discussed with the help of graphical representations. Also we have discussed the stability and physical acceptability of solutions for solution type-Ⅰ and solution type-Ⅱ.

关键词： Bianchi type Ⅰ space tine cosmological constant gravitational constant generalized Chaplygin gas

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Intelligent System Application to Monitor the Smart City Building Lighting

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Computers, Materials & Continua 2023年第5期75卷 3159-3169页

作者： Tzu-Chia Chen Ngakan Ketut Acwin Dwijendra Saurabh Singhal r.Sivaraman Amr Mamdouh Department of Industrial Engineering and Management Ming Chi University of TechnologyNew Taipei City24301Taiwan Department of Architecture Faculty of EngineeringUdayana UniversityBali80361Indonesia Department of Computer Engineering and Applications GLA UniversityMathuraUttar PradeshIndia Department of Mathematics Dwaraka Doss Goverdhan Doss Vaishnav CollegeArumbakkamUniversity of MadrasChennaiIndia Architectural Engineering Department Faculty of Engineering&TechnologyFuture University in EgyptNew Cairo11835Egyp

A smart city incorporates infrastructure methods that are environmentally responsible,such as smart communications,smart grids,smart energy,and smart *** city administration has prioritized the use of cutting-edge technology and informatics as the primary strategy for enhancing service quality,with energy resources taking *** achieve optimal energy management in themultidimensional system of a city tribe,it is necessary not only to identify and study the vast majority of energy elements,but also to define their implicit *** is because optimal energy management is required to reach this *** lighting index is an essential consideration when evaluating the comfort *** order to realize the concept of a smart city,the primary objective of this research is to create a system for managing and monitoring the lighting *** is possible to identify two distinct phaseswithin the intelligent *** data collection concludes,the monitoring system will be *** the second step,the operation of the control system is analyzed and its effect on the performance of the numerical model is *** evaluation is based on the proposed *** optimized resultswere deemed satisfactory because they maintained the brightness index value(79%)while consuming less *** intelligent implementation system generated satisfactory outcomes,which were observed 1.75 times on average.

关键词： Smart city lighting index residential building energy consumption

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Surface radioactive anomalies at Srisailam sub basin,Cuddapah basin,India

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Chinese Journal Of Geochemistry 2015年第2期34卷 265-271页

作者： Vishnu Bhoopathi S.Niranjan Kumar r.S.N.Sastry B.Srinivas Department of Applied Geochemistry Osmania University Atomic Mineral Directorate for Exploration and research

Surface radioactive survey has been carried with portable gamma ray spectrometer(PGrS) about the 45 km2 around the Srisailam sub basin,the surface radioactive anomalies were found at Chennakesavula gutta in the Srisailam sub basin of Cuddapah basin in the age of meso-neo proterozoic,*** integrated geochemical and radiometric surveys were conducted as part of research work in the Srisailam basin,it has resulted the locating of surface radioactive anomalies near the Chennakesavula *** uranium minerals are observed along with the fracture planes in the Archean basement granite in the proximity of unconformity contact of Srisailam *** granite underlies the Srisailam formation and forms the source for possible unconformity related uranium mineralisation in the Srisailam sub-basin evidence by the significant radioactive *** radioactivity recorded by PGrS reflected uraniferous nature of the radioactivity(Average total counts =195 ppm;U = 202 ppm;Th =22ppm;%K = 4.1,n = 15).

关键词：放射性异常表面印度分盆 γ射线谱仪放射性调查 m盆地地球化学

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Campaign-style U-Pb titanite petrochronology:Along-strike variations in timing of metamorphism in the Himalayan metamorphic core

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Geoscience Frontiers 2019年第3期10卷 827-847页

作者： Catherine M.Mottram John M.Cottle Andrew r.C.Kylander-Clark School of Earth and Environmental Sciences University of Portsmouth Department of Earth Science University of CaliforniaSanta Barbara

Present-day along-strike heterogeneities within the Himalayan orogen are seen at many scales, from variations within the deep architecture of the lithospheric mantle, to differences in geomorphologic surface processes. Here, we present an internally consistent petrochronologic dataset from the Himalayan metamorphic core(HMC), in order to document and investigate the causes of along-strike variations in its Oligocene-Miocene tectonic history. Laser ablation split-stream analysis was used to date and characterise the geochemistry of titanite from 47 calc-silicate rocks across >2000 km along the *** combined U-Pb-rEE-Zr single mineral dataset circumvents uncertainties associated with interpretations based on data compilations from different studies, mineral systems and laboratories, and allows for direct along-strike comparisons in the timing of metamorphic processes. Titanite dates range from ～30 Ma to 12 Ma, recording(re-)crystallization between 625 ℃ and 815 ℃. Titanite T-t data overlap with previously published P-T-t paths from interleaved peltic rocks, demonstrating the usefulness of titanite petrochronology for recording the metamorphic history in lithologies not traditionally used for thermobarometry. Overall, the data indicate a broad eastward-younging trend along the *** in the duration and timing of metamorphism within the HMC are best explained by alongstrike variations in the position of ramps on the basal detachment controlling a two-stage process of preferential ductile accretion at depth followed by the formation of later upper-crust brittle *** processes, coupled with variable erosion, resulted in the asymmetric exhumation of a younger,thicker crystalline core in the eastern Himalaya.

关键词： Himalaya Petrochronology Titanite Metamorphic petrology

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动态本体描述语言的研究

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西安工业大学学报 2014年第1期34卷 44-47页

作者：罗钧旻谢磊西安工业大学计算机科学与工程学院西安710021

为了让计算机能理解资源的语义,文中设计了一种基于互表性的动态本体描述语言.研究结果表明,通过定义动态本体的Agent、Object、Class和Ontology,得出了动态本体描述语言的基本词汇、语法结构和语义描述,使语法和其描述的语义达成一致.

关键词：互表性语义动态本体动态本体描述语言

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Computing on Phenotypic Descriptions for Candidate Gene Discovery and Crop Improvement

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Plant Phenomics 2020年第1期2卷 118-121页

作者： Ian r.Braun Colleen F.Yanarella Carolyn J.Lawrence-Dill Interdepartmental Bioinformatics and Computational Biology Iowa State UniversityAmesIA 50011USA Department of Genetics Development and Cell BiologyIowa State UniversityAmesIA 50011USA Department of Agronomy Iowa State UniversityAmesIA 50011USA

Many newly observed phenotypes are first described,then experimentally *** language-based descriptions appear in both the literature and in community *** standardize phenotypic descriptions and enable simple data aggregation and analysis,controlled vocabularies and specific data architectures have been *** simplified descriptions have several advantages over natural language:they can be rigorously defined for a particular context or problem,they can be assigned and interpreted programmatically,and they can be organized in a way that allows for semantic reasoning(inference of implicit facts).Because researchers generally report phenotypes in the literature using natural language,curators have been translating phenotypic descriptions into controlled vocabularies for decades to make the information ***,this methodology is highly dependent on human curation,which does not scale to the scope of all publications available across all of plant ***,researchers in other domains have been working to enable computation on natural *** has resulted in new,automated methods for computing on language that are now available,with early analyses showing great *** language processing(NLP)coupled with machine learning(ML)allows for the use of unstructured language for direct analysis of phenotypic ***,we have found that these automated methods can be used to create data structures that perform as well or better than those generated by human curators on tasks such as predicting gene function and biochemical pathway ***,we describe current and ongoing efforts to provide tools for the plant phenomics community to explore novel predictions that can be generated using these *** also describe how these methods could be used along with mobile speech-to-text tools to collect and analyze in-field spoken phenotypic descriptions for association genetics and breedin

关键词： stores translating enable

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Entropy contributions to phase stability in binary random solid solutions

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npj Computational Materials 2018年第1期4卷 262-271页

作者： Anus Manzoor Shubham Pandey Debajit Chakraborty Simon r.Phillpot Dilpuneet S.Aidhy Department of Mechanical Engineering University of WyomingLaramieWY 82071USA Department of Materials Science and Engineering University of FloridaGainesvilleFL 32611USA

High entropy alloys contain multiple elements in large proportions that make them prone to phase *** alloys generally have shallow enthalpy of mixing which makes the entropy contributions of similar *** a result,the phase stability of these alloys is equally dependent on enthalpy and entropy of mixing and understanding the individual contribution of thermodynamic properties is *** the overall vision of designing high entropy alloys,in this work,using density functional theory calculations,we elucidate the contributions of various entropies,i.e.,vibrational,electronic and configurational towards the phase stability of binary *** show that the contribution of electronic entropy is very small compared to the vibrational and configurational entropies,and does not play a significant role in the phase stability of *** configurational and vibrational entropies can either destabilize or can collectively contribute to stabilize the solid *** a result,even those systems that have negative mixing enthalpy can show phase instability,revealed as a miscibility gap;conversely,systems with positive mixing enthalpy can be phase stable due to entropic *** suggest that including entropic contributions are critical in the development of theoretical framework for the computational prediction of stable,single-phase high entropy alloys that have shallow mixing enthalpies,unlike ordered intermetallics.

关键词： alloys stability mixing

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