检索结果-南通市图书馆

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

引用

Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien francesca Cicchetti frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal doPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficient scar-free knock-ins of several kilobases in plants by engineered CRISPR-Cas endonucleases

引用

Molecular Plant 2024年第5期17卷 824-837页

作者： Tom Schreiber Anja Prange Petra Schafer Thomas Iwen Ramona Grutzner Sylvestre marillonnet Aurelie Lepage marie Javelle Wyatt Paul Alain Tissier Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Limagrain Centre de RechercheRoute d’EnnezatCS 9012663720 ChappesFrance

In plants and mammals,non-homologous end-joining is the dominant pathway to repair DNA doublestrand breaks,making it challenging to generate knock-in *** this study,we identified two groups of exonucleases from the herpes virus and the bacteriophage T7 families that conferred an up to 38-fold increase in homology-directed repair frequencies when fused to Cas9/Cas12a in a tobacco mosaic virus-based transient assay in Nicotiana *** achieved precise and scar-free insertion of several kilobases of DNA both in transient and stable transformation *** Arabidopsis thaliana,fusion of Cas9 to a herpes virus family exonuclease led to 10-fold higher frequencies of knock-ins in the first generation of *** addition,we demonstrated stable and heritable knock-ins in wheat in 1%of the primary *** together,our results open perspectives for the routine production of heritable knock-in and gene replacement events in plants.

关键词： homology-directed repair knockin gene replacement CRISPR-Cas 50 exonuclease plants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Weak Vertical Diffusion Allows maintenance of Cold Halocline in the Central Arctic

引用

Atmospheric and Oceanic Science Letters 2009年第3期2卷 148-152页

作者： Ilker fer Geophysical Institute University of Bergen & Bjerknes Centre for Climate ResearchBergen Norway

In spring preceding the record minimum summer ice cover detailed microstructure measurements were made from drifting pack ice in the Arctic Ocean, 110 km from the North Pole. Profiles of hydrography, shear, and temperature microstructure collected in the upper water column covering the core of the Atlantic Water are analyzed to determine the diapycnal eddy diffusivity, the eddy diffusivity for heat, and the turbulent flux of heat. Turbulence in the bulk of the cold halocline layer was not strong enough to generate significant buoyancy flux and mixing. Resulting turbulent heat flux across the upper cold halocline was not significantly different than zero. The results show that the low levels of eddy diffusivity in the upper cold halocline lead to small vertical turbulent transport of heat, thereby allowing the maintenance of the cold halocline in the central Arctic.

关键词： Arctic Ocean cold halocline layer turbulence mixing heat flux Atlantic Water

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

不同淀粉/中性洗涤纤维比例饲粮对育肥牦牛生长性能、屠宰性能及肉品质的影响

引用

动物营养学报 2024年第5期36卷 3094-3105页

作者：马宗亮张怀达富兰李斌峰官久强赵洪文武志娟罗晓林张翔飞西南民族大学青藏高原动物遗传资源保护与利用四川省教育部重点实验室成都610041 四川省草原科学研究院成都611731 青海牛必乐农牧科技有限公司西宁800001 青海农牧科技职业学院湟源812100

本试验旨在探究不同淀粉/中性洗涤纤维(starch/NDF,SN)比例饲粮对育肥牦牛生长性能、屠宰性能及肉品质的影响。选取51头体况良好、体重[(247.48±24.02)kg]相近的健康雄性牦牛,随机分为3组(每组17个重复,每个重复1头牛),分别饲喂不同碳... 详细信息

本试验旨在探究不同淀粉/中性洗涤纤维(starch/NDF,SN)比例饲粮对育肥牦牛生长性能、屠宰性能及肉品质的影响。选取51头体况良好、体重[(247.48±24.02)kg]相近的健康雄性牦牛,随机分为3组(每组17个重复,每个重复1头牛),分别饲喂不同碳水化合物结构饲粮,分别为低SN比例(LSN组)、中SN比例(MSN组)、高SN比例(HSN)饲粮,SN比例分别为0.41、0.51、0.64。舍饲饲养115 d。结果表明:HSN组牦牛平均日增重显著高于LSN组(P0.05);各组牦牛在胴体长、胴体胸深、胴体深、胴体后腿围、胴体后腿长、胴体后腿宽、大腿肌肉厚差异不显著(P>0.05),HSN组牦牛屠宰率显著高于LSN组(P0.05),剪切力显著低于LSN组(P0.05)。综上所述,育肥牦牛对高SN比例饲粮具有良好的适应性,高SN比例饲粮能够促进牦牛增重、提高产肉性能并改善肉品质。

关键词：牦牛淀粉中性洗涤纤维生长性能肉品质

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Seed Priming with MgCl_(2),CaCl_(2),and ZnCl_(2) as a Biofortification Based-Approach Induces Changes in Anise Seedlings Emergence

引用

Phyton-International Journal of Experimental Botany 2023年第8期92卷 2461-2471页

作者： Sibel day Nilüfer Koçak-Şahin Department of Field Crops Faculty of AgricultureAnkara UniversityAnkara06110Türkiye

Aromatic and medicinal plant species having small seeds haveﬁeld emergence problems due to low nutrient ***,Pimpinella anisum seeds were hydro and osmoprimed with 100 mM MgCl_(2),CaCl_(2),and ZnCl_(2),for 2,4,and 8 h each to compare their growth attributes during germination and seedling establishment *** seeds were used as *** hydro and osmo primed seeds were dried for 48 h before,they were sown in plastic trays in growth room conditions to see the impact of treatments on seedling emergence and *** maximum root length(12.90 cm),fresh weight(256.30 mg plant^(-1)),and mean emergence time(MET)were recorded from 8 h MgCl_(2) primed ***,the maximum(97.50,and 98.00%)emergence percentage was observed using 8 h MgCl_(2) primed seeds and nontreated seeds(control treatment).The evaluation of parameters like chlorophyll contents and electrical conductivity showed the 8 h MgCl_(2) priming as the optimum *** evaluation of parameters like chlorophyll contents and electrical conductivity showed the 8 h MgCl_(2) priming as the optimum *** result suggests MgCl_(2) priming worked synergistically and improved seed-ling growth attributes under greenhouse *** chlorophyll content ranged 25.94–35.69 SPAD *** highest chlorophyll content was obtained from the seedlings obtained from 4 h CaCl_(2) treatment,which were statistically similar to the chlorophyll contents of the seedlings obtained after 8 h MgCl_(2) treatment and nontreated seeds(control treatment).All other treatments showed inhibition in the chlorophyll contents and growth attributes of the *** conclusion,MgCl_(2) osmopriming treatments were signiﬁcantly promotive and better compared to hydro-priming and osmopriming treatments including control treatment in terms of anise seeds germination and emergence.

关键词： Pimpinella anisum L seed treatment hydropriming osmopriming electrolytes leakage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Remains of the day:Biliary complications related to single-port laparoscopic cholecystectomy

引用

World Journal of Gastroenterology 2014年第3期20卷 843-851页

作者： Pierre Allemann Nicolas Demartines markus Schfer Department of Visceral Surgery University Hospital CHUV

AIM: To assesse the rate of bile duct injuries (BDI) and overall biliary complications during single-port laparoscopic cholecystectomy (SPLC) compared to conventional laparoscopic cholecystectomy (CLC).

关键词： Bile ducts Cholecystectomy Single port Single incision

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The 3,4-dimethoxybenzyl group as solubilizing protective group for the in situ deprotection/deposition of extended aromatic thiolate monolayers

引用

Nano Research 2023年第1期16卷 1695-1702页

作者： Adrian Wiesner Sonja Katzbach dariusz Bebej martina Dettenhöfer Michael Zharnikov Andreas Terfort Institut für Anorganische und Analytische Chemie Johann Wolfgang Goethe Universität FrankfurtMax-von-Laue-Straße 7Frankfurt am Main D-60438Germany Angewandte Physikalische Chemie Universität HeidelbergIm Neuenheimer Feld 253Heidelberg D-69120Germany

While self-assembled monolayers(SAMs)of aromatic thiolates are frequently used in a wide range of applications,their formation is often hampered by the low solubilities of their *** we introduce the 3,4-dimethoxybenzyl group as a protective group for the thiol moiety,which increases the solubility and stability of the precursor,but becomes cleaved off during monolayer formation,especially at elevated temperature(60°C)and in presence of protons(trifluoroacetic acid).For a series of substituted terphenylthiols as model systems,it could be demonstrated by using ellipsometry,infrared-reflection absorption spectroscopy,and scanning-tunneling microscopy that the resulting SAMs have the same structure and quality as the ones obtained from the respective unprotected *** protective group has the additional advantage to be stable under Pdcatalyzed C–C bond formation reaction conditions,facilitating the syntheses of the respective precursors.

关键词： self-assembled monolayers protective group solubility scanning-tunneling microscopy infrared-reflection absorption spectroscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于Mel-GADF与ConvNeXt-T的变压器铁心松动故障诊断方法

引用

电力自动化设备 2024年第3期44卷 217-224页

作者：万可力马宏忠崔佳嘉王健河海大学能源与电气学院江苏南京211100

为解决传统梅尔(Mel)时频谱图对变压器铁心松动程度识别率较低的问题,提出一种基于梅尔-格拉姆角差场(Mel-GADF)时频谱图与ConvNeXt-T网络相结合的变压器铁心松动故障诊断模型。将变压器声纹信号生成Mel时频谱图,同时将原始声纹数据经... 详细信息

为解决传统梅尔(Mel)时频谱图对变压器铁心松动程度识别率较低的问题,提出一种基于梅尔-格拉姆角差场(Mel-GADF)时频谱图与ConvNeXt-T网络相结合的变压器铁心松动故障诊断模型。将变压器声纹信号生成Mel时频谱图,同时将原始声纹数据经过格拉姆角场(GAF)变换得到格拉姆角和场(GASF)与GADF这2种时频谱图;生成Mel-GASF与Mel-GADF这2种特征融合的时频谱图来弥补Mel时频谱图的低频缺失问题;将3种时频谱图放入ConvNeXt-T网络进行训练对比,选出效果最佳的诊断模型。以型号为S13-M-200/10的变压器为对象进行空载试验,对不同铁心松动程度下的声纹信号进行分析,分析结果表明,将Mel-GADF作为特征时频谱图结合ConvNeXt-T网络,可将测试集准确率从传统Mel时频谱图的98.273%提升至99.500%,提升了1.227个百分点。

关键词：变压器铁心松动 Mel时频谱图格拉姆角场卷积神经网络迁移学习

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermophysical properties of the Ni-based alloy Nimonic 80A up to 2400 K

引用

Rare Metals 2006年第5期25卷 529-531页

作者： B.Wilthan R.Tanzer W.Schützenhfer G.Pottlacher Institute of Experimental Physics Graz University of TechnologyPetersgasse 168010 GrazAustria Bhler Edelstahl GmbH Mariazellerstrasse 258605 KapfenbergAustria

Nimonic 80A is a nickel-chromium alloy which is strengthened by additions of titanium and aluminium. The alloy is used for high temperature, high strength applications. Wire shaped Nimonic 80A samples are resistively volume heated as part of a fast capacitor discharge circuit. Time resolved measurements with sub-μs resolution of current through the specimen are performed with a Pearson probe, voltage drop across the specimen is measured with knife-edge contacts and ohmic voltage dividers and the radiance temperature of the sample with a pyrometer. These measurements allow to determine heat of fusion as well as heat capacity and electrical resistivity at initial geometry of Nimonic 80A as a function of temperature in the solid and in the liquid phase up to 2400 K.

关键词： thermophysical properties Nimonic 80A resistivity enthalpy heat capacity latent heat

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Accurate energy barriers for catalytic reaction pathways: an automatic training protocol for machine learning force fields

引用

npj Computational materials 2023年第1期9卷 479-488页

作者： Lars L.Schaaf Edvin Fako Sandip De Ansgar Schäfer Gábor Csányi Engineering Laboratory University of CambridgeCB21PZ CambridgeUK BASF SE Carl-Bosch-Straße 3867056 LudwigshafenGermany

We introduce a training protocol for developing machine learning force fields(MLFFs),capable of accurately determining energy barriers in catalytic reaction *** protocol is validated on the extensively explored hydrogenation of carbon dioxide to methanol over indium *** the help of active learning,the final force field obtains energy barriers within 0.05 eV of Density Functional *** to the computational speedup,not only do we reduce the cost of routine in-silico catalytic tasks,but also find an alternative path for the previously established rate-limiting step,with a 40%reduction in activation ***,we illustrate the importance of finite temperature effects and compute free energy *** transferability of the protocol is demonstrated on the experimentally relevant,yet unexplored,top-layer reduced indium oxide *** ability of MLFFs to enhance our understanding of extensively studied catalysts underscores the need for fast and accurate alternatives to direct ab-initio simulations.

关键词： surface catalytic fields

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：