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Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway

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Journal of Traditional Chinese Medicine 2024年第2期44卷 268-276页

作者： ZHENG Xueying GUO Liang LAI Siyi LI fengyue LIANG Mingli LIU Wanting MENG Chun LIU Guanghui Department of Bioengineering College of Biological Science and BiotechnologyFuzhou UniversityFuzhou 350104China Eye Institute of Integrated Chinese and Western Medicine Fujian University of Traditional Chinese MedicineFuzhou 350004China Department of Ophthalmology Affiliated People's Hospital(Fujian Provincial People's Hospital)Fujian University of Traditional Chinese MedicineFuzhou 350004China

OBJECTIVE:To investigate the effects of emodin on alkali burn-induced corneal inflammation and ***:The ability of emodin to target vascular endothelial growth factor receptor 2(VEGFR2)was predicted by molecular *** effects of emodin on the invasion,migration,and proliferation of human umbilical vein endothelial cells(HUVEC)were determined by cell counting kit-8,Transwell,and tube formation *** of apoptosis was performed by flow ***31 levels were examined by *** abundance and phosphorylation state of VEGFR2,protein kinase B(Akt),signal transducer and activator of transcription 3(STAT3),and P38 were examined by immunoblot *** alkali burn was performed on 4. *** were divided randomly into two groups,and the alkali-burned eyes were then treated with drops of either 10μM emodin or phosphate buffered saline(PBS)four times a *** microscopy was used to evaluate inflammation and corneal neovascularization(CNV)in all eyes on Days 0,7,10,and *** mice were killed humanely 14.d after the alkali burn,and their corneas were removed and preserved at-80℃ until histological study or protein ***:Molecular docking confirmed that emodin was able to target *** findings revealed that emodin decreased the invasion,migration,angiogenesis,and proliferation of HUVEC in a dose-dependent *** mice,emodin suppressed corneal inflammatory cell infiltration and inhibited the development of corneal neovascularization induced by alkali *** to those of the PBS-treated group,lower VEGFR2 expression and CD31 levels were found in the emodintreated *** dramatically decreased the expression of VEGFR2,p-VEGFR2,p-Akt,p-STAT3,and p-P38 in VEGF-treated ***:This study provides a new avenue for evaluating the molecular mechanisms underlying corneal inflammation and *** might be a promising new therapeutic option for corneal alkal

关键词： alkali burn emodin corneal inflammation corneal neovascularisation vascular endothelial growth factor receptor-2 signal transduction

A warm temperature-released negative feedback loop fine-tunes PIF4.mediated thermomorphogenesis in Arabidopsis

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Plant Communications 2024年第5期5卷 208-224页

作者： Hui Li Mande Xue Huairen Zhang fengyue Zhao Xiaoyi Li Shuancang Yu Danhua Jiang Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Beijing Vegetable Research Center Beijing Academy of Agriculture and Forestry Sciences(BAAFS)BeijingChina National Center for Soybean Improvement State Key Laboratory of Crop Genetics and Germplasm EnhancementCollege of AgricultureNanjing Agricultural UniversityNanjingChina

Plants can sense temperature changes and adjust their growth *** Arabidopsis,high ambient temperatures stimulate stem elongation by activating a key thermoresponsive regulator,PHYTOCHROME INTERACTING FACTOR 4.PIF4..Here,we show that warmth promotes the nighttime transcription of GI,which is necessary for the high temperature-induced transcription of *** analyses suggest that GI prevents excessive thermoresponsive growth by inhibiting PIF4.with this regulatory mechanism be-ing partially reliant on *** transcription is repressed by ELF3 and HY5,which concurrently inhibit PIF4.expression and *** elevation causes the deactivation or degradation of ELF3 and HY5,leading to PIF4.activation and relief of GI transcriptional repression at high *** allows PIF4.to further activate GI transcription in response to elevated ***,in turn,inhibits PIF4.es-tablishing a negative feedback loop thatfine-tunes PIF4.*** addition,we demonstrate that ELF3,HY5,and PIF4.regulate GI transcription by modulating the enrichment of histone variant H2A.Z at the GI ***,ourfindings suggest that thermal release of a negative feedback loopfinely adjusts plant thermomorphogenesis.

关键词： temperature thermomorphogenesis PIF4 GI TOC1 feedback loop

BBX9 forms feedback loops with PIFs and BBX21 to promote photomorphogenic development

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Journal of Integrative Plant Biology 2024年第9期66卷 1934-1952页

作者： Zhaoqing Song Wanying Ye Qing Jiang Huan Lin Qing Hu Yuntao Xiao Yeting Bian fengyue Zhao Jie Dong Dongqing Xu State Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization National Center for Soybean ImprovementCollege of AgricultureNanjing Agricultural UniversityNanjing 210095China Institute of Crop Science College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China

Light is one of the most essential environmental factors that tightly and precisely control various physiological and developmental processes in plants.B-box CONTAINING PROTEINs(BBXs)play central roles in the regulation of light-dependent *** this study,we report that BBX9 is a positive regulator of light ***9 interacts with the red light photoreceptor PHYTOCHROME B(phyB)and transcription factors PHYTOCHROME-INTERACTING FACTORs(PIFs).phyB promotes the stabilization of BBX9 in light,while BBX9 inhibits the transcriptional activation activity of *** turn,PIFs directly bind to the promoter of BBX9 to repress its *** the other hand,BBX9 associates with the positive regulator of light signaling,BBX21,and enhances its biochemical ***21 associates with the promoter regions of BBX9 and transcriptionally up-regulates its ***,this study unveiled that BBX9 forms a negative feedback loop with PIFs and a positive one with BBX21 to ensure that plants adapt to fluctuating light conditions.

关键词： Arabidopsis BBX21 BBX9 light signaling photo-morphogenesis phyB PIF

Embedded high-quality ternary GaAs_(1−x)Sb_(x) quantum dots in GaAs nanowires by molecular-beam epitaxy

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Journal of Semiconductors 2024年第8期45卷 18-24页

作者： Xiyu Hou Lianjun Wen fengyue He Ran Zhuo Lei Liu Hailong Wang Qing Zhong Dong Pan Jianhua Zhao State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

Semiconductor quantum dots are promising candidates for preparing high-performance single photon sources.A basic requirement for this application is realizing the controlled growth of high-quality semiconductor quantum ***,we report the growth of embedded GaAs_(1−x)Sb_(x) quantum dots in GaAs nanowires by molecular-beam *** is found that the size of the GaAs_(1−x)Sb_(x) quantum dot can be well-defined by the GaAs *** dispersive spectroscopy analyses show that the antimony content x can be up to 0.36 by tuning the growth *** GaAs_(1−x)Sb_(x) quantum dots exhibit a pure zinc-blende *** addition,we have developed a new technology to grow GaAs passivation layers on the sidewalls of the GaAs_(1−x)Sb_(x) quantum *** from the traditional growth process of the passivation layer,GaAs passivation layers can be grown simultaneously with the growth of the embedded GaAs_(1−x)Sb_(x) quantum *** spontaneous GaAs passivation layer shows a pure zinc-blende phase due to the strict epitaxial relationship between the quantum dot and the passivation *** successful fabrication of embedded high-quality GaAs_(1−x)Sb_(x) quantum dots lays the foundation for the realization of GaAs_(1−x)Sb_(x)-based single photon sources.

关键词： semiconductor quantum dot nanowire GaAs_(1−x)Sb_(x) molecular-beam epitaxy

Preclinical Evidence and Potential Mechanisms of Electroacupuncture in Regulating Inflammatory Responses After Stroke:A Meta-analysis

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Medicinal Plant 2024年第5期15卷 70-75页

作者： Shilong QI fengyue ZHANG Chunming MA Department of Pre-Rehabilitation Medicine Taihe HospitalHubei University of MedicineShiyan 442000China Department of Neonatology Shiyan Ma-ternal and Child Health HospitalHubei University of MedicineShiyan 442099China

[Objectives]To investigate the evidence-based effect of electroacupuncture on the post stroke inflammatory response and elucidate its potential molecular mechanisms.[Methods]Asystematic electronic search of the Medline,PubMed,and Web of Science databases was initially performed up to June *** risk of bias of the included studies was evaluated using RevMan5.4.software,in accordance with the guidelines set forth in the Cochrane Handbook for Systematic *** random-effects model or fixed-effects models was employed to esti-mate the standardized mean difference(SMD).[Results]A total of 15 studies,comprising a total of 182 rats or mice,were included in this *** pooled analysis of these trials showed a statistically significant reduction in the level of TNF-α(12 studies,SMD=-2.38,[95%CI,-2.86 to-1.90],P4.),and IL-1β(11studies,SMD=-2.4.,[95%CI,-3.32 to-1.50],P4. to 2.70],P=0.008,I^(2)=68).[Conclusions]The findings of this systematic review and meta-analysis dem-onstrate that electroacupuncture stimulation has the potential to regulate the inflammatoryresponses after stroke.

关键词： Electroacupuncture Ischemic stroke Inflammation Meta-analysis Mechanism

The GmSTF1/2–GmBBX4.negative feedback loop acts downstream of blue-light photoreceptors to regulate isoflavonoid biosynthesis in soybean

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Plant Communications 2024年第2期5卷 198-214页

作者： Zhaoqing Song fengyue Zhao Li Chu Huan Lin Yuntao Xiao Zheng Fang Xuncheng Wang Jie Dong Xiangguang Lyu Deyue Yu Bin Liu Junyi Gai Dongqing Xu National Center for Soybean Improvement State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationCollege of AgricultureNanjing Agricultural UniversityNanjing 210095China Beijing Key Laboratory of Environmentally Friendly Management of Fruit Diseases and Pests in North China Institute of Plant and Environment ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Institute of Crop Science College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop ScienceChinese Academy of Agricultural SciencesBeijing 100081China

Isoflavonoids,secondary metabolites derived from the phenylalanine pathway,are predominantly bio-synthesized in legumes,especially soybean(Glycine max).They are not only essential for plant responses to biotic and abiotic stresses but also beneficial to human *** this study,we report that light signaling controls isoflavonoid biosynthesis in ***-light photoreceptors(GmCRY1s,GmCRY2s,GmPHOT1s,and GmPHOT2s)and the transcription factors GmSTF1 and GmSTF2 promote isoflavonoid accumulation,whereas the E3 ubiquitin ligase GmCOP1b negatively regulates isoflavonoid ***1s and GmPHOT2s stabilize GmSTF1/2,whereas GmCOP1b promotes the degradation of these two proteins in ***1/2 regulate the expression of approximately 27.9%of the genes involved in soybean isoflavonoid biosynthesis,including GmPAL2.1,GmPAL2.3,and *** also repress the expression of GmBBX4.a negative regulator of isoflavonoid biosynthesis in *** addition,GmBBX4.physically interacts with GmSTF1 and GmSTF2 to inhibit their transcriptional activation activity toward target genes related to isoflavonoid ***,GmSTF1/2 and GmBBX4.form a negative feedback loop that acts downstream of photoreceptors in the regulation of isoflavonoid *** study provides novel insights into the control of isoflavonoid biosynthesis by light signaling in soybean and will contribute to the breeding of soybean cultivars with high isoflavonoid content through genetic and metabolic engineering.

关键词： photoreceptor light signaling isoflavonoid GmSTF GmBBX4 soybean

产教联合体助力新质生产力发展的逻辑理路和实践路径

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河北师范大学学报（教育科学版） 2024年第4期26卷 101-107页

作者：刘奉越江苏理工学院职业教育学部江苏常州213001

新质生产力是以创新为关键、以质优为核心的生产力形态,是传统生产力的质变与跃升。产教联合体作为产教融合的一种新型组织形态,具有人才培养、技术研发、创新创业以及促进产业经济发展等多种功能,与新质生产力发展密切相关。产教联合... 详细信息

新质生产力是以创新为关键、以质优为核心的生产力形态,是传统生产力的质变与跃升。产教联合体作为产教融合的一种新型组织形态,具有人才培养、技术研发、创新创业以及促进产业经济发展等多种功能,与新质生产力发展密切相关。产教联合体通过塑造新素质劳动者、催生新型劳动对象、拓展劳动资料领域,助力新质生产力发展。在新的时代背景下,产教联合体助力新质生产力发展面临着组织架构运行难度大、企业的办学主体作用亟待加强、对接国家重点产业发展需求不足以及校企契合度不高等诸多挑战。为更好地使产教联合体助力新质生产力发展,应健全保障制度、树立新质人才观、发挥企业的重要主体作用、注重与国家重点产业发展同频共振、推进实体化运行。

关键词：产教联合体新质生产力逻辑理路实践路径

高质量发展下市域产教联合体的构建逻辑及路径

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教育学术月刊 2024年第1期 9-15页

作者：刘奉越江苏理工学院职业教育学部江苏常州213001

市域产教联合体构建不仅是职业教育产教融合的新方向,也是推动职业教育高质量发展的“牛鼻子”,成为近年来国家层面产教融合政策话语的关注点,并且在实践中不断得以持续推进。市域产教联合体作为一种新型产教融合组织形态,是职业教育产... 详细信息

市域产教联合体构建不仅是职业教育产教融合的新方向,也是推动职业教育高质量发展的“牛鼻子”,成为近年来国家层面产教融合政策话语的关注点,并且在实践中不断得以持续推进。市域产教联合体作为一种新型产教融合组织形态,是职业教育产教关系发生新变化的产物,具有组织目标的区域性、治理主体的多样性、组织资源的丰富性和运行机制健全等组织特征,能够更好地服务于区域经济社会发展,促进教育链、人才链与产业链、创新链有机衔接和实现多元共治。市域产教联合体构建遵循一定历史逻辑、理论逻辑和现实逻辑,多重逻辑相统一为其持续发展提供了有益的方法论和理论观。在大力推进职业教育高质量发展的时代背景下,市域产教联合体构建应切实采取以下行动路径,即协调各参与主体利益、明晰法人地位属性、健全组织结构以及加强质量评估。

关键词：高质量发展市域产教联合体价值构建逻辑路径

职业教育产教融合发展水平提升的制度逻辑及优化路径

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现代远距离教育 2024年第2期 84-89页

作者：刘奉越于莎江苏理工学院江苏常州213001 浙江工商职业技术学院浙江宁波315012

组织社会学新制度主义有力地诠释了制度的产生与变迁历程,为人们科学分析制度提供了新的视角。基于组织社会学新制度主义理论,构建了由规制性、规范性和文化-认知性组成的产教融合制度三要素理论分析框架。在职业教育产教融合发展水平... 详细信息

组织社会学新制度主义有力地诠释了制度的产生与变迁历程,为人们科学分析制度提供了新的视角。基于组织社会学新制度主义理论,构建了由规制性、规范性和文化-认知性组成的产教融合制度三要素理论分析框架。在职业教育产教融合发展水平提升的制度逻辑生成中,规制性要素(包括必须遵守的法律、规章以及政策等)提供外部保障;规范性要素(包括价值观和规范性标准)提供制度补充;文化-认知性要素(包括内在性和惯习)是制度建设的核心。正是在上述三种要素的组合作用下,产教融合制度才能够作为一个“连续体”获得内在的合法性,并在实践中发挥持久且稳固的作用。提升职业教育产教融合发展水平,需要加强产教融合立法、构建利益相关者对话交流平台、健全产教融合行为规范、增强产教融合的文化-认知性,继而建立“制度三要素”一体化共同作用的制度体系,以提供良好的制度保障。

关键词：职业教育产教融合规制性规范性文化-认知性