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Additive manufacturing of degradable metallic scaffolds for material-structure-driven diabetic maxillofacial bone regeneration

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Bioactive Materials 2024年第6期36卷 413-426页

作者： Wencheng Song Danlei Zhao fengyuan Guo Jiajia wang Yifan wang Xinyuan wang Zhengshuo Han Wenjie Fan Yijun Liu Zhi xu Lili Chen Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration WuhanChina Department of Mechanical Engineering The University of Hong KongHong KongChina

The regeneration of maxillofacial bone defects associated with diabetes mellitus remains challenging due to the occlusal loading and hyperglycemia ***,we propose a material-structure-driven strategy through the additive manufacturing of degradable Zn-Mg-Cu gradient *** in situ alloying of Mg and Cu endows Zn alloy with admirable compressive strength for mechanical support and uniform degradation mode for preventing localized *** scaffolds manifest favorable antibacterial,angiogenic,and osteogenic modulation capacity in mimicked hyperglycemic microenvironment,and Mg and Cu promote osteogenic differentiation in the early and late stages,*** addition,the scaffolds expedite diabetic maxillofacial bone ingrowth and regeneration by combining the metabolic regulation effect of divalent metal cations and the hyperboloid and suitable permeability of the gradient *** sequencing further reveals that RAC1 might be involved in bone formation by regulating the transport and uptake of glucose related to GLUT1 in osteoblasts,contributing to cell function *** by bone healing and structural cues,this study offers an essential understanding of the designation and underlying mechanisms of the material-structure-driven strategy for diabetic maxillofacial bone regeneration.

关键词： Additive manufacturing Degradable metallic scaffolds Material-structure-driven Diabetes mellitus Maxillofacial bone regeneration

Cooperative effect between copper species and oxygen vacancy in Ce_(0.7−x)Zr_(x)Cu_(0.3)O_(2) catalysts for carbon monoxide oxidation

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Frontiers of Chemical Science and Engineering 2021年第6期15卷 1524-1536页

作者： Shan wang xuelian xu ping Xiao Junjiang Zhu Xinying Liu Institute for the Development of Energy for African Sustainability College of ScienceEngineering and TechnologyUniversity of South AfricaJohannesburg1710South Africa Hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile UniversityWuhan430200China

The effects of Zr doping on the existence of Cu and the catalytic performance of Ce_(0.7−x)Zr_(x)Cu_(0.3)O_(2)for CO oxidation were *** characterization results showed that all samples have a cubic structure,and a small amount of Zr doping facilitates Cu^(2+) ions entering the CeO2 lattice,but excessive Zr doping leads to the formation of surface CuO crystals ***,the number of oxygen vacancies caused by the Cu^(2+) entering the lattice(e.g.,Cu^(2+)-□-Ce^(4+);□:oxygen vacancy),and the amount of reducible copper species caused by CuO crystals,varies with the Zr *** CO oxidation tests indicated that the oxygen vacancy and the reducible copper species were the adsorption and activation sites of O_(2)and CO,respectively,and the cooperative effects between them accounted for the high CO oxidation ***,the samples x=0.1 and 0.3,which possessed the most oxygen vacancy or reducible copper species,showed the best activity for CO oxidation,with full CO conversion obtained at 110℃.The catalyst is also stable and has good resistance to water during the reaction.

关键词： Ce-Zr-Cu-O CO oxidation reducible copper species oxygen vacancy cooperative effect

Heat distribution model under hydrogen-rich low-carbon conditions in blast furnace

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Journal of Iron and Steel Research International 2024年第3期31卷 584-594页

作者： Gang wang Jun xu Kun He Zhong-ping Zou Hao Bai School of Metallurgy and Ecological Engineering University of Science and Technology BeijingBeijing 100083China CISDI Low-Carbon Blast Furnace Research Office MCC Low-Carbon Technology Research InstituteChongqing 401122China

Low carbon development of blast furnaces is one of the key technological directions in the current development of *** to the differences in the physical and chemical properties of hydrogen and carbon,hydrogen-rich media entering a blast furnace will change the heat distribution,thus affecting the stability of ***,a heat distribution model was proposed to study the temperature distribution in a blast furnace,simultaneously considering gas-solid heat exchange,slag and iron melting,and chemical *** model was used to analyze the temperature distribution of a 2300 m^(3) blast furnace and was verified via comparison with actual production ***,the effects of the injection rate of hydrogen-rich media,H2 concentration,and oxygen enrichment rate of the blast on the temperature distribution were *** indicated that the increase in the injection rate of the hydrogen-rich media decreased the amount of direct reduction and led to an increase in the furnace ***,an increase in the oxygen enrichment rate led to a decrease in the furnace temperature,but could reduce the solid fuel ratio,while the change in H2 concentration had less effect on the temperature *** combination of hydrogen-rich media injection and the increase in the oxygen enrichment rate would help to adjust the temperature distribution to the same level as the conventional blast furnace conditions.

关键词： Heat distribution Blast furnace Low-carbon condition Hydrogen enrichment Calculation model

Anti-rheumatoid arthritic effect of volatile components in notopterygium incisum in rats via anti-inflammatory and anti-angiogenic activities

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Chinese Journal of Natural Medicines 2018年第12期16卷 926-935页

作者： BI Jian-ping LI ping xu Xi-Xi wang Ting LI Fei Shandong Provincial Traditional Chinese Medical Hospital Affricated Hospital of Shandong University of Traditional Chinese MedicineJinan 250000China Center for Drug Safety Evaluation and Research of Zhejiang University Hangzhou 310000China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210000China Key Laboratory for the Research of Aromatic Chinese Medicine in Yunnan College of Pharmaceutical ScienceYunnan University of Traditional Chinese MedicineKunming 650000China School of Pharmacy Xinjiang Medical UniversityUrumqi 830001China

Notopterygium incisum(QH) has been used for the treatment of rheumatoid arthritis(RA), and volatile oils may be its mainly bioactive constituents. The present study was designed to analyze the volatile compounds in QH and to determine the anti-arthritic capacity of Notopterygium volatile oils and the potential mechanism of action. The volatile compounds analysis was conducted by GC-MS. The anti-arthritic capacity test of the volatile oils was conducted on adjuvant-induced arthritis(AIA) rats. The anti-inflammatory property was tested in NO release model in RAW 264.7 cells. Endothelial cells were used to evaluate the anti-proliferative and anti-tube formative effects. 70 compounds were analyzed by GC-MS in the volatile oils. Notopterygium volatile oils weakened the rat AIA in a dose-dependent manner(2, 4, and 8 g crude drug/kg). The NO production by RAW 264.7 was decreased by more than 50% in Notopterygium volatile oils(5, 15, and 45 μg·mL^(-1)) pretreated groups. Notopterygium volatile oils also inhibited EAhy926 cell proliferation and further delayed EAhy926 cell capillary tube formation in a concentration-dependent manner. The anti-NO productive, anti-proliferative, and anti-tube formative effects of Notopterygium volatile oils strongly suggested that the therapeutic effect of QH in AIA might be related to the potent anti-inflammatory and anti-angiogenic capacities of the volatile oils.

关键词： Notopterygium incisum Volatile oil Adjuvant-induced arthritis NO production Endothelial tube formation

Crystal structures of N-terminal WRKY transcription factors and DNA complexes

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Protein & Cell 2020年第3期11卷 208-213页

作者： Yong-ping xu Hua xu Bo wang Xiao-Dong Su State Key Laboratory of Protein and Plant Gene Research and Biomedical Pioneering Innovation Center(BIOPIC)Peking UniversityBeijing 100871China

Dear Editor,Plant-specific WRKY transcription factors(TFs)are among the largest families of TFs in higher plants;they are also found in the unicellular eukaryote Giardia lamblia and the slime mold Dictyostelium discoideum(Ulker and Somssich,2004),but not in *** TFs participate in diverse developmental and physiological processes in plants,such as disease resistance,abiotic stress responses,senescence,seed and trichome development,as well as additional developmental and hormone-controlled processes(Agarwal et al.,2011).

关键词： complexes families Crystal

A model for carbon isotope distribution of methane duringdiagenesis

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Chinese Science Bulletin 1998年第7期43卷 576-578页

作者： ping Guan Yongchang xu Wenhui Liu Darui wang Peking Univ Dept Geol Beijing 100871 Peoples R China Chinese Acad Sci Lanzhou Inst Geol Lanzhou 730000 Peoples R China Res Inst Petr Explorat & Dev Beijing 100083 Peoples R China

The evolution of methane carbon isotope with depth has been discussed based on diagenetic reaction kinetics and isotopic Rayleigh fractionational theory. A mathematical model to describe data of methane carbon isotope... 详细信息

关键词： methane carbon isotope maturity Rayleigh fractionation.

Knowledge-enhanced semantic communication system with OFDM transmissions

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Science China(Information Sciences) 2023年第7期66卷 266-282页

作者： Xiaodong xu Huachao XIONG Yining wang Yue CHE Shujun HAN Bizhu wang ping ZHANG State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Department of Broadband Communication Peng Cheng Laboratory

As a promising technology to enable effective multi-modal transmission over wireless channels,semantic communication has attracted a lot of attention from academics and industries. Different from Shannon’s information theory, based on common background knowledge provided by the knowledge base, the goal of semantic communication is transmitting intended useful information from the transmitter and recovered by the receiver at the semantic level. However, the existing studies on semantic communication rarely emphasize the essence and the usage of the knowledge base. In this paper, we propose a knowledge-enhanced semantic communication(KESC) system, where the knowledge base is cloud-edge-device collaborative cached. To solve the problem that float-type symbols are difficult to transmit directly through a radio frequency(RF)system, we adopt orthogonal frequency division multiplexing(OFDM) to transmit semantic vectors directly without some traditional signal processing techniques in semantic information transmission, and the semantic pilot is designed to assist semantic reception. Furthermore, we formulate a multi-encoder transformer based neural network model for the KESC system to support text transmission(KESC-T), where the decoder is implemented with a knowledge graph to enhance the performance of semantic decoding. Besides, we define knowledge-enhanced efficiency(KEE) to measure the gain in semantic recovery accuracy brought by per unit of knowledge. Simulation results demonstrate that the recovery accuracy of our proposed KESC outperforms the compared scheme, especially in low signal-to-noise ratio(SNR) or resource-constrained scenarios.

关键词： semantic communication knowledge graph OFDM transformer deep learning

Record of Early-Stage Rodingitization from the Purang Ophiolite Complex,Western Tibet

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Journal of Earth Science 2019年第6期30卷 1108-1124页

作者： Songjie wang xu-ping Li Wenyong Duan Fanmei Kong Zeli wang Shandong Key Laboratory of Depositional Mineralization and Sedimentary Minerals Shandong University of Science and Technology

Rodingitization,commonly coupled with serpentinization of ultramafic rocks,bears significant information for fluid-rock interactions and element transfer from sea-floor to subduction zone *** outcrops of rodingites are exposed along the Yarlung Zangbo suture zone(YZSZ)of southern Tibet,providing us an excellent opportunity to probe the petrogenetic processes,and unravel their implications for regional tectonic *** studies have been performed on rodingites from the eastern to central portions of the YZSZ,whereas limited work has ever been conducted on rodingitized rocks from the western segment of the YZSZ,precluding a comprehensive understanding of this lithological *** this paper,we present detailed studies of petrology,mineral,whole-rock geochemistry and phase equilibrium modeling on a suite of newly recognized rodingites within the Purang ophiolite massif in the southwestern part of the *** rodingites have a major metasomatic mineral association of chlorite,clinozoisite,amphibole and minor amounts of plagioclase,representing products of an early-stage *** generally present compositions of low SiO2(48.89 wt.%–53.57 wt.%),Fe2O3^T(3.77 wt.%–5.56 wt.%),Na2O(1.31 wt.%–1.93 wt.%),Al2O3(4.78 wt.%–8.84 wt.%),moderate CaO(9.69 wt.%–11.23 wt.%),and high MgO(24.11 wt.%–26.08 wt.%)concentrations with extremely high Mg^# values[Mg^#=100×Mg/(Mg+Fe^2+)molar]of 89–***-rock recalculation reveals that the rodingites have a protolith of mantle-derived olivine gabbro or *** have low rare earth element compositions(∑REE=2.4 ppm–6.5 ppm)and are characterized by flat LREE and slightly enriched HREE patterns with positive Eu anomalies;they also exhibit positive anomalies in Sr,U and Pb and negative anomalies in high-field strength elements,including Nb,P and Ti,suggesting for a subduction-zone *** equilibrium modeling shows that the rodingitization did take place at P<2 kbar and T=~350–400℃,consiste

关键词： Purang ophiolite complex early-stage rodingitization geochemistry phase equilibrium modeling western Tibet

Early apoptosis in intestinal and diffuse gastric carcinomas

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World Journal of Gastroenterology 2000年第6期6卷 898-901页

作者： Hong ping Zhou xu wang Nan Zheng Zhang Institute of Oncology Xuzhou Medical CollegeXuzhou 221002Jiangsu ProvinceChina Department of Oncology the PLA 97th HospitalXuzhou 221004Jiangsu ProvinceChina

INTRODUCTIONApoptosis,described by Kerr in 1972,plays a keyrole in all types of regulated cellular processes inmulticellular,*** is defined as amorphologic change,including fragmentation of theDNA,cell shrinkage,dilat... 详细信息

关键词： stomach neoplasms/pathology apoptosis flow cytometry Bcl-2 protein phosphatidylserines