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Synthesis of 3-Methylthio-benzo[b]furans/Thiophenes via Intramolecular Cyclization of 2-Alkynylanisoles/Sulfides Mediated by DMSO/DMSO-d_(6) and SOCl_(2)

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Chinese Journal of Chemistry 2021年第4期39卷 887-895页

作者： Beibei Zhang Xiaoxian Li Xuemin Li fengxia sun Yunfei Du Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin300072 China College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyHebei Research Center of Pharmaceutical and Chemical EngineeringShijiazhuangHebei050018 China

Main observation and conclusion The reaction of 2-alkynylanisoles/sulfides with SOCl_(2) and DMSO was conducted to conveniently furnish the biologically interesting 3-(methylthio)-benzo[b]furans/thiophenes via intramolecular cyclization.DMSO acts as a solvent as well as a sulfur source and can also be replaced with DMSO-d_(6),enabling the incorporation of the SCD3 moiety of DMSO-d_(6) to the 3-position of the heterocyclic frameworks.

关键词： 3-Methylthio-benzo[b]furans/Thiophenes 2-Alkynylanisoles/Sulfides DMSO/DMSO-d_(6)SOCl_(2) Interrupted pummerer process

Sequential neoadjuvant chemotherapy using pegylated liposomal doxorubicin and cyclophosphamide followed by taxanes with complete trastuzumab and pertuzumab treatment for HER2-positive breast cancer: A phase Ⅱ single-arm study

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Chinese Journal of Cancer Research 2024年第1期36卷 55-65页

作者： Yaping Yang Liang Jin Yudong Li Nanyan Rao Chang Gong Shunrong Li Jiannan Wu Jinghua Zhao Linxiaoxiao Ding fengxia Gan Jun Zhang Ruifa Feng Zhenzhen Liu Qiang Liu Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene RegulationGuangzhou 510120China Department of Thyroid and Breast Surgery Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000China Breast and Thyroid Surgery Guilin Medical College Second Affiliated HospitalGuilin 541199China Department of Breast Disease Henan Breast Cancer Centerthe Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008China

Objective: Despite cardiotoxicity overlap, the trastuzumab/pertuzumab and anthracycline combination remains crucial due to significant benefits. Pegylated liposomal doxorubicin(PLD), a less cardiotoxic anthracycline, was evaluated for efficacy and cardiac safety when combined with cyclophosphamide and followed by taxanes with trastuzumab/pertuzumab in human epidermal growth factor receptor-2(HER2)-positive early breast cancer(BC).Methods: In this multicenter, phase II study, patients with confirmed HER2-positive early BC received four cycles of PLD(30-35 mg/m^(2)) and cyclophosphamide(600 mg/m^(2)), followed by four cycles of taxanes(docetaxel,90-100 mg/m^(2) or nab-paclitaxel, 260 mg/m^(2)), concomitant with eight cycles of trastuzumab(8 mg/kg loading dose,then 6 mg/kg) and pertuzumab(840 mg loading dose, then 420 mg) every 3 weeks. The primary endpoint was total pathological complete response(tp CR, yp T0/is yp N0). Secondary endpoints included breast p CR(bp CR),objective response rate(ORR), disease control rate, rate of breast-conserving surgery(BCS), and safety(with a focus on cardiotoxicity).Results: Between May 27, 2020 and May 11, 2022, 78 patients were treated with surgery, 42(53.8%) of whom had BCS. After neoadjuvant therapy, 47 [60.3%, 95% confidence interval(95% CI), 48.5%-71.2%] patients achieved tp CR, and 49(62.8%) achieved bp CR. ORRs were 76.9%(95% CI, 66.0%-85.7%) and 93.6%(95% CI,85.7%-97.9%) after 4-cycle and 8-cycle neoadjuvant therapy, respectively. Nine(11.5%) patients experienced asymptomatic left ventricular ejection fraction(LVEF) reductions of ≥10% from baseline, all with a minimum value of >55%. No treatment-related abnormal cardiac function changes were observed in mean N-terminal pro-BNP(NT-pro BNP), troponin I, or high-sensitivity troponin.Conclusions: This dual HER2-blockade with sequential polychemotherapy showed promising activity with rapid tumor regression in HER2-positive BC. Importantly, this regimen showed an acceptable safety profile,especially a low risk of cardiac events,

关键词： Breast cancer HER2-positive breast cancer dual HER2 blockade neoadjuvant therapy sequential therapy

护理人员导管相关感染防控护理实践知识现况调查

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中国护理管理 2024年第1期24卷 14-18页

作者：孙众马晶淼翁峰霞蔡虻首都医科大学附属北京中医医院院感办北京市100010 天津医科大学总医院妇科浙江大学医学院附属第一医院外科监护室北京医院医院感染管理处/疾病预防控制处

目的:调查护理人员对导管相关感染防控护理实践知识的掌握现况,以期为提高护理人员导管相关感染防控知识水平提供参考。方法 :于2023年7月12日至8月12日,采用自行设计的导管相关感染防控相关知识问卷,通过中华护理学会医院感染管理专业... 详细信息

目的:调查护理人员对导管相关感染防控护理实践知识的掌握现况,以期为提高护理人员导管相关感染防控知识水平提供参考。方法 :于2023年7月12日至8月12日,采用自行设计的导管相关感染防控相关知识问卷,通过中华护理学会医院感染管理专业委员会平台向临床护士、护理管理者及专业为护理的感控专职人员发放问卷。结果 :知识问卷11题中回答正确人数比例达到50%的有5题,达到80%的仅有3题。正确率最高的是输液接头消毒方法(97.49%),正确率较低是吸痰前稀释痰液方式(19.80%)、留置尿管的清洁消毒(19.06%)、气管插管患者不要定时气囊放气(15.51%)、拔出尿管前膀胱无需功能锻炼(9.97%)等。不同级别医院、不同工作年限、职称及所在岗位的护理人员比较,回答正确率差异具有统计学意义(P<0.05)。结论 :护理人员导管相关感染防控护理实践知识掌握水平有待提升,需要加强循证能力及相关知识培训。

关键词：导管相关感染护理实践现况调查医院感染与控制

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嗜热蓝细菌高温适应机制及生物技术应用

生物工程学报 2024年第6期40卷 1752-1775页

作者：张婷孙绘梨齐凤霞毛绍名栾国栋吕雪峰中南林业科技大学生命科学与技术学院湖南长沙410004 中南林业科技大学林业生物技术湖南省重点实验室湖南长沙410004 中国科学院青岛生物能源与过程研究所山东省合成生物学重点实验室山东青岛266101 山东能源研究院山东青岛266101 青岛新能源山东省实验室山东青岛266101

嗜热蓝细菌是一类具有独特耐热特征的蓝细菌,可以作为研究光合生物高温适应机制的模式生物。系统解析嗜热蓝细菌的高温适应机制,有助于深入理解光合生物及其他微生物响应和适应高温环境的分子机理,同时还具有指导耐热作物培育和构建微... 详细信息

嗜热蓝细菌是一类具有独特耐热特征的蓝细菌,可以作为研究光合生物高温适应机制的模式生物。系统解析嗜热蓝细菌的高温适应机制,有助于深入理解光合生物及其他微生物响应和适应高温环境的分子机理,同时还具有指导耐热作物培育和构建微生物耐热细胞工厂的潜在应用前景。本文全面综述了嗜热蓝细菌的相关研究进展,包括其生态分布、形态特征、组学研究和耐热机制挖掘等多个方面;此外,还对嗜热蓝细菌在生物技术领域的应用前景与未来研究方向进行了展望。本文为深入了解蓝细菌光合生理与代谢特点,特别是嗜热蓝细菌在高温适应机制方面的研究提供了参考。

关键词：嗜热蓝细菌高温适应机制光合微生物抗逆资源组学特征

Biodegradation of organochlorine pesticide endosulfan by bacterial strain Alcaligenes faecalis JBW4

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Journal of Environmental Sciences 2013年第11期25卷 2257-2264页

作者： Lingfen Kong Shaoyuan Zhu Lusheng Zhu Hui Xie Kunchang Su Tongxiang Yan Jun Wang Jinhua Wang Fenghua Wang fengxia sun Key Laboratory of Agricultural Environment in Universities of Shandong National Engineering Laboratory for Efcient Utilization of Soil and Fertilizer Resources College of Resources and Environment Shandong Agriculture University College of Marine Life Sciences Ocean University of China

The recently discovered endosulfan-degrading bacterial strain Alcaligenesfaecalis JBW4 was isolated from activated sludge. This strain is able to use endosulfan as a carbon and energy source. The optimal conditions for the growth of strain JBW4 and for biodegradation by this strain were identified, and the metabolic products of endosulfan degradation were studied in detail. The maximum level of endosulfan biodegradation by strain JBW4 was obtained using broth at an initial pH of 7.0, an incubation temperature of 40℃ and an endosulfan concentration of I00 mg/L. The concentration of endosulfan was determined by gas chromatography. Strain JBW4 was able to degrade 87.5% of α-endosulfan and 83.9% of β-endosulfan within 5 days. These degradation rates are much higher than the previously reported bacterial strains. Endosulfan diol and endosulfan lactone were the major metabolites detected by gas chromatography-mass spectrometry; endosulfan sulfate, which is a persistent and toxic metabolite, was not detected. These results suggested that A. faecalis JBW4 degrades endosulfan via a non-oxidative pathway. The biodegradation of endosulfan by A. faecalis is reported for the first time. Additionally, the present study indicates that strain JBW4 may have potential for the biodegradation of endosulfan residues.

关键词： bacterial biodegradation endosulfan Alcaligenesfaecalis optimal conditions endosulfan diol non-oxidative pathway

基于核酸扩增-侧流层析试纸的食源性致病菌快速检测研究进展

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食品工业科技 2024年第5期45卷 412-425页

作者：贠紫光魏勇张建崔双双李灿孙凤霞农业农村部特色农产品加工与质量安全控制重点实验室(部省共建) 石河子大学食品学院新疆石河子832000 食品营养与安全控制兵团重点实验室石河子大学食品学院新疆石河子832000 新疆天润乳业股份有限公司新疆乌鲁木齐830063

食源性致病菌严重危害食品安全。传统的致病菌检测方法费时耗力,难以应对现代食品安全检测快速、简便的需求。分子生物学检测方法,如聚合酶链式反应法、等温核酸扩增法以及基于规律成簇间隔短回文重复序列的核酸检测技术等,已被广泛应... 详细信息

食源性致病菌严重危害食品安全。传统的致病菌检测方法费时耗力,难以应对现代食品安全检测快速、简便的需求。分子生物学检测方法,如聚合酶链式反应法、等温核酸扩增法以及基于规律成簇间隔短回文重复序列的核酸检测技术等,已被广泛应用于食源性致病菌检测,为保障食品安全发挥了重要作用。近年来,联用核酸扩增检测技术和免疫层析技术成为食源性致病菌快速检测的研究热点。本文总结了核酸扩增和侧流层析试纸联用快速检测食源性致病菌的研究进展,重点讨论了其优缺点,并展望其未来发展方向,以期为食源性致病菌的检测和防控提供参考。

关键词：食源性致病菌核酸扩增侧流层析试纸快速检测

青皮核桃采后病害生防菌贝莱斯芽胞杆菌XRD006全基因组分析及防治效果研究

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微生物学报 2024年第1期64卷 303-322页

作者：席飞汤静吕凤霞孙佩馨张国华肖红梅南京农业大学食品科技学院江苏南京210095 山东五康轩现代农林发展有限公司山东邹城273519

【目的】探究生防菌贝莱斯芽胞杆菌(Bacillus velezensis)XRD006对青皮核桃采后病害的生防能力及其贮藏保鲜效果,解析菌株的基因特性和次级代谢产物,了解菌株的抑菌机制。【方法】通过抑菌试验确定XRD006对青皮核桃采后病原菌的抑制能... 详细信息

【目的】探究生防菌贝莱斯芽胞杆菌(Bacillus velezensis)XRD006对青皮核桃采后病害的生防能力及其贮藏保鲜效果,解析菌株的基因特性和次级代谢产物,了解菌株的抑菌机制。【方法】通过抑菌试验确定XRD006对青皮核桃采后病原菌的抑制能力。利用活体抑菌及贮藏试验探究生防菌对青皮核桃采后病原菌的抑制能力及对青皮核桃贮藏品质的影响。以全基因组测序了解菌株XRD006的基因组特征及潜在抑菌相关基因;利用antiSMASH软件预测XRD006的次级代谢产物;结合比较基因组学分析XRD006和贝莱斯芽胞杆菌标准株FZB42、SQR9之间的共线性关系和次级代谢产物基因簇差异。利用高效液相色谱(high performance liquid chromatography,HPLC)和质谱鉴定XRD006次级代谢产物并通过牛津杯法测定其抑菌能力。【结果】抑菌试验表明菌株XRD006对青皮核桃采后病原菌隐秘刺盘孢(Colletotrichum aenigma)、暹罗炭疽菌(Colletotrichum siamense)、葡萄座腔菌(Botryosphaeria dothidea)和藤仓镰刀菌(Fusarium fujikuroi)的抑菌率分别为49.22%、50.61%、53.83%和58.71%。活体抑菌试验表明,XRD006在果实上能有效抑制病原菌的侵染与生长。贮藏试验显示,XRD006发酵上清液可以显著延缓果实的失重、减少微生物的生长,降低过氧化物酶(peroxidase,POD)和多酚氧化酶(polyphenol oxidase,PPO)酶活变化的同时,保持核仁品质。全基因组测序显示XRD006基因组长4371975 bp,GC含量为46.07%,含蛋白编码基因4362个,具有胞外水解酶、生物膜等抑菌促生相关基因;antiSMASH预测显示XRD006分别含有9种已知和5种未知的次级代谢产物的编码基因簇。菌株XRD006与FZB42和SQR9亲缘关系密切,三者有8种相同的次级代谢产物基因簇,但是基因簇的位置和编码基因有差异。次级代谢产物鉴定显示,XRD006可以产生伊枯草菌素(iturin)和丰原素(fengycin)两种脂肽家族;抑菌试验表明,相比于C13-iturin、C14-iturin、C15-iturin和C17-fengycin C,fengycin家族的C16-fengycin B对暹罗炭疽菌(C.siamense)HT12的抑菌效果最好。【结论】贝莱斯芽胞杆菌XRD006对青皮核桃采后病害具有良好生防能力,具备实际应用潜力。

关键词：生防菌贮藏品质全基因组比较基因组学次级代谢产物

Earthquake geochemical scientific expedition and research

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Earthquake Research Advances 2023年第4期3卷 58-64页

作者： Chang Lu Xiaocheng Zhou Zhi Chen Zhaofei Liu Le Hu fengxia sun Giovanni Martinelli Ying Li Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing100036China State Key Laboratory of Geological Processes and Mineral Resources School of Earth Science and ResourcesChina University of Geosciences(Beijing)Beijing100083China INGV-National Institute of Geophysics and Volcanology Dept.of Palermo Palermo90146Italy

Large earthquakes can cause both casualties and economic losses, but they also provide invaluable opportunities for earthquake scientific research. Geofluids, due to their wide distribution, sensitive response to underground conditions, and ease of observation, are widely applied in field investigations after earthquakes. Analyzing the origin of fluids, energy transfer processes, temperature/pressure conditions, and the spatial-temporal evolution of geofluids can provide valuable information concerning the mechanism of earthquake precursor anomalies, shortterm prediction methods, identification of the seismogenic faults, determination of earthquake risk, and the environmental impact of post-earthquake fluids. This article details post-earthquake scientific expeditions and research on fluid geochemistry in China and abroad, aimed at providing ideas and guidance for future scientific expedition work and geochemistry-related earthquake studies.

关键词： Geofluids Geochemistry Earthquake investigation

A first-principles study of helium diffusion in quartz and coesite under high pressure up to 12GPa

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Geoscience Frontiers 2021年第2期12卷 1001-1009页

作者： Hong Liu Lingling Wang Shuchen Li Yaochun Yang Hua Tian fengxia sun Chaowen Xu Lei Liu Yi Li Yueju Cui Ying Li Jijun Zhao United Laboratory of High-Pressure Physics and Earthquake Science Key Laboratory of Earthquake PredictionInstitute of Earthquake ForecastingCEABeijing 100036China Key Laboratory of Materials Modification by Laser Ion and Electron Beams(Dalian University of Technology)Ministry of EducationDalian 116024China College of Information Engineering and Computer Science(Tai Yuan University of Technology) Taiyuan 030024China

Helium diffusion in mantle minerals is crucial for understanding mantle structure and the dynamic processes of Earth's degassing.In this paper,we report helium incorporation and the mechanism of its diffusion in perfect crystals of quartz and coesite.The diffusion pathways,activation energies(Ea),and frequency factors of helium under ambient and high pressure conditions were calculated using Density Functional Theory(DFT)and the climbing image nudged elastic band(CI-NEB)method.The calculated diffusive coefficients of He in the quartz in different orientations are:D[100]=1.24×10^(−6)exp.(−26.83 kJ/mol/RT)m^(2)/s D[010]=1.11×10^(−6)exp.(−31.60 kJ/mol/RT)m^(2)/s.and in the coesite:D[100]=3.00×10^(−7)exp.(−33.79 kJ/mol/RT)m^(2)/s D[001]=2.21×10^(−6)exp.(−18.33 kJ/mol/RT)m^(2)/s.The calculated results indicate that diffusivity of helium is anisotropic in both quartz and coesite and that the degree of anisotropy is much more pronounced in coesite.Helium diffusion behavior in coesite under high pressures was investigated.The activation energies increased with pressure:Ea[100]increased from 33.79 kJ/mol to 58.36 kJ/mol,and Ea[001]increased from 18.33 kJ/mol to 48.87 kJ/mol as pressure increased from0 GPa to 12 GPa.Our calculations showed that helium is not be quantitatively retained in silica at typical surface temperatures on Earth,which is consistent with the findings from previous studies.These results have implications for discussion of the Earth's mantle evolution and for recognition thermal histories of ultra-high pressure(UHP)metamorphic terranes.

关键词： Helium Diffusion Quartz Coesite High pressure