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Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries

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Bioactive Materials 2021年第3期6卷 638-654页

作者： Lihua Luo Yan He Ling Jin Yanni Zhang Fernando P.Guastaldi Abdullkhaleg A.Albashari fengting hu Xiaoyan Wang Lei Wang Jian Xiao Lingli Li Jianming Wang Akon Higuchi Qingsong Ye School and Hospital of Stomatology Wenzhou Medical UniversityWenzhouZhejiangChina Tianyou Hospital Wuhan University of Science and TechnologyWuhan430064China Skeletal Biology Research Center Massachusetts General Hospital and Harvard School of Dental MedicineBostonMA02114USA Wenzhou Institute of Biomaterials and Engineering WenzhouZhejiang Province325000China Molecular Pharmacology Research Center School of PharmacyWenzhou Medical UniversityWenzhou325035China School of Ophthalmology and Optometry Eye HospitalWenzhou Medical UniversityWenzhouZhejiang325027China Department of Biliary and Pancreatic Surgery/Cancer Research Center Affiliated Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Center of Regenerative Medicine Renmin Hospital of Wuhan UniversityWuhan430060China

Due to the limitations in autogenous nerve grafting or Schwann cell transplantation,large gap peripheral nerve injuries require a bridging strategy supported by nerve *** based therapies provide a novel treatment for peripheral nerve *** this study,we first experimented an optimal scaffold material synthesis protocol,from where we selected the 10%GFD formula(10%GelMA hydrogel,recombinant human basic fibroblast growth factor and dental pulp stem cells(DPSCs))to fill a cellulose/soy protein isolate composite membrane(CSM)tube to construct a third generation of nerve regeneration conduit,*** this CSM-GFD conduit was applied to repair a 15-mm long defect of sciatic nerve in a rat *** 12 week post implant surgery,at histologic level,we found CSM-GFD conduit could regenerate nerve tissue like neuron and Schwann like nerve cells and myelinated nerve *** physical level,CSM-GFD achieved functional recovery assessed by a sciatic functional index *** both levels,CSM-GFD performed like what gold standard,the nerve autograft,could ***,we unveiled that almost all newly formed nerve tissue at defect site was originated from the direct differentiation of exogeneous DPSCs in *** conclusion,we claimed that this third-generation nerve regeneration conduit,CSM-GFD,could be a promising tissue engineering approach to replace the conventional nerve autograft to treat the large gap defect in peripheral nerve injuries.

关键词： Dental pulp stem cells human basic fibroblast growth factor Gelatin methacrylate Large gap Peripheral nerve injuries Nerve graft

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健身瑜伽在新时代高校体育中的体育价值

衡水学院学报 2022年第1期24卷 97-101页

作者：胡凤婷曹文玲高杰云南民族大学中印瑜伽学院云南昆明650000 衡水学院体育学院河北衡水053000

健身瑜伽所特有的呼吸法、体位法、冥想结合的运动形式和以身心双修为目标的内涵特征,使其与其他体育项目有所不同。健身瑜伽以人为本、健身育人以及终身体育的价值取向,在很大程度上满足了新时代大学生对高校体育的多元化价值需求。健... 详细信息

健身瑜伽所特有的呼吸法、体位法、冥想结合的运动形式和以身心双修为目标的内涵特征,使其与其他体育项目有所不同。健身瑜伽以人为本、健身育人以及终身体育的价值取向,在很大程度上满足了新时代大学生对高校体育的多元化价值需求。健身瑜伽在新时代高校体育中的体育价值主要体现在三个方面:一是健身育体,瑜伽练习对增强大学生身体素质,特别是对减肥以及塑形等均具有显著效果;二是促进心理健康,健身瑜伽在多个方面可以改善大学生心理素质,增进大学生心理健康水平,促进大学生人格的健全发展;三是休闲体育价值,健身瑜伽在一定程度上补充和拓展了高校体育价值,对提升大学生生活品质,帮助学生在体育锻炼中享受乐趣,促进大学生健康成长具有积极意义。

关键词：瑜伽健身瑜伽新时代高校体育价值

Selective electroreduction of nitrate to ammonia via NbWO_(6)perovskite nanosheets with oxygen vacancy

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Chinese Chemical Letters 2023年第5期34卷 385-388页

作者： Tao Feng fengting Li Xiaojun hu Ying Wang School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai 201418China State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Electrocatalytic nitrate reduction to ammonia(NRA)under ambient conditions is significant for carbonneutral synthetic ***,the lack of efficient electrocatalysts with tunable nanostructure for NRA remains a grand ***,Nb WO_(6)nanosheets with oxygen vacancy(NbWO_(6-x))was demonstrated via thermal treatment and exfoliation with NH_(3)selectivity of 86.8%and Faradaic efficiency of85.7%toward NRA.^(1)H nuclear magnetic resonance spectra coupled with^(15)N isotope labeling experiments proved that NH_(3)originated from NO_(3)^-.The function of oxygen vacancy was revealed by computational studies in ***,the reaction mechanism and pathway of NRA could be deduced based on the results of online differential electrochemical mass spectrometry(DEMS).This work provides a selective NH_(3)generation strategy to decarbonize the energy-chemical sector,bridging the gap between batteries and biofuels.

关键词： Nitrate reduction Ammonia generation NbWO_(6-x)nanosheets Oxygen vacancy Adsorption energy

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含氧杂环化合物合成研究

广东化工 2024年第11期51卷 18-19,74页

作者：纪凤婷胡祎波彭林邵阳学院食品与化学工程学院湖南邵阳422000

含氧杂环化合物广泛存在于天然产物中,在医药、食品等领域有广泛研究及应用,是天然活性物质的重要组成部分。本研究利用磷酸催化剂作用于α,β-不饱和酮类化合物,催化关环,利用迈克尔加成机理得到十三元含氧杂环化合物。本文在以6-庚炔... 详细信息

含氧杂环化合物广泛存在于天然产物中,在医药、食品等领域有广泛研究及应用,是天然活性物质的重要组成部分。本研究利用磷酸催化剂作用于α,β-不饱和酮类化合物,催化关环,利用迈克尔加成机理得到十三元含氧杂环化合物。本文在以6-庚炔-1-醇为起始原料经过烷基化、戴斯马丁氧化、witting反应、迈克尔加成等一系列的条件温和、操作简单的反应成功合成了含氧杂环化合物。为含氧杂环化合物的人工合成提供了一定的参考。

关键词：磷酸催化含氧杂环化合物迈克尔加成

Functional Hyperbranched Polythioamides Synthesized from Catalyst-free Multicomponent Polymerization of Elemental Sulfur

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Chinese Journal of Chemistry 2022年第6期40卷 725-733页

作者： Shangrun Liu fengting Li Wenxia Cao Rongrong hu Ben Zhong Tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSouth China University of TechnologyGuangzhouGuangdong 510640China Shenzhen Institute of Molecular Aggregate Science and Engineering School of Science and EngineeringThe Chinese University of Hong KongShenzhen CityGuangdong 518172China AIE Institute GuangzhouGuangdong 510530China Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science&TechnologyClear Water BayKowloonHong KongChina

Hyperbranched polymers with unique topological structures,large number of branching sites and terminal groups have attracted much attention,and are expected to possess advanced functionalities compared with their linear polymer *** devel-opment of hyperbranched polymers is hence highly desired but challenging,especially for sulfur-containing polymers which are at-tractive metal absorbents,optical materials,dielectric materials,and self-healing *** this work,six hyperbranched polythi-oamides with various topological structures,well-defined repeating units,satisfying yields(up to 99%),and high molecular weights(up to 101400 g/mol)were successfully designed and synthesized from the catalyst-free multicomponent polymerization of ele-mental sulfur,aromatic alkynes and aliphatic amines,through different monomer combination strategies based on the designed three-or four-functional alkyne and amine *** hyperbranched polythioamides possess unique luminescence property,and strong affinity toward Hg^(2+),which can be utilized in the fluorescence detection of Hg^(2+),as well as mercury removal from aque-ous solutions with high efficiency of 99.99%and low mercury residue of 0.1 *** polythioamides with unique struc-tures may be developed to a group of fascinating materials and find their potential applications as metal absorbents and optoelec-tronic materials.

关键词： Hyperbranched polymer Polythioamide Polymerization Sulfur Mercury

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干细胞外泌体在再生医学中的研究与应用

口腔疾病防治 2020年第1期28卷 1-10页

作者：叶青松胡凤婷罗丽花 Maria Troulis 澳大利亚昆士兰大学牙学院温州医科大学口腔医学院干细胞与组织工程研究所哈佛大学麻省总医院哈佛大学牙学院口腔颌面外科

干细胞是一类具有高度自我更新以及快速增殖能力的未分化多能细胞。在特定的条件下,干细胞可向人体其他组织细胞如骨骼肌细胞、心肌细胞、成骨细胞以及神经样细胞等进行诱导分化。近年来,随着组织工程与再生医学的发展,干细胞作为优秀... 详细信息

干细胞是一类具有高度自我更新以及快速增殖能力的未分化多能细胞。在特定的条件下,干细胞可向人体其他组织细胞如骨骼肌细胞、心肌细胞、成骨细胞以及神经样细胞等进行诱导分化。近年来,随着组织工程与再生医学的发展,干细胞作为优秀的种子细胞被广泛应用于再生医学各个领域,但依然存在着移植后细胞存活率和再生能力下降、出现免疫排斥、伦理监管等问题,因此很难普遍而安全地使用干细胞银行来进行再生医学应用。干细胞的旁分泌作用自被发现以来,受到了极大的关注,越来越多的证据支持干细胞以旁分泌方式活动的观点,尤其是外泌体的分泌对其生物学功能起着至关重要的作用。外泌体是一类纳米级胞外囊泡,内含RNA、蛋白质等生物活性分子,与干细胞有着相类似的功能,在细胞通讯、免疫应答、修复组织损伤等方面有着不可忽略的作用。目前在骨/软骨组织修复、神经组织再生、肝肾组织再生、肌肉组织修复、血管组织再生、味蕾再生、牙再生等领域也已开展了关于干细胞外泌体在组织工程与再生医学方面的临床前期研究。本文将从外泌体的组成、形成释放、鉴定等方面详细地介绍外泌体,并阐述不同干细胞来源的外泌体在组织工程与再生医学中的研究现况,对其广阔的应用前景进行展望。

关键词：干细胞外泌体胞外囊泡组织工程再生医学骨再生软骨再生牙再生血管再生临床前研究

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手性磷酸不对称催化合成四氢吡喃杂环化合物

当代化工研究 2024年第12期 172-174页

作者：纪凤婷彭林邵阳学院食品与化学工程学院湖南422000

四氢吡喃环结构广泛存在于天然活性物质中。四氢吡喃环类化合物及其衍生物有良好的降糖、抗菌、抗炎、抗肿瘤等药理学活性。本文以4-戊炔-1-醇为起始原料,经烷基化、Dess-Martin氧化、Witting反应、脱保护基、Diels-Alder反应等利用手... 详细信息

四氢吡喃环结构广泛存在于天然活性物质中。四氢吡喃环类化合物及其衍生物有良好的降糖、抗菌、抗炎、抗肿瘤等药理学活性。本文以4-戊炔-1-醇为起始原料,经烷基化、Dess-Martin氧化、Witting反应、脱保护基、Diels-Alder反应等利用手性磷酸催化剂不对称催化合成含有四氢吡喃环单元的六元骈六元环化合物,并且产物有良好的对映选择性(93%ee)。

关键词：手性磷酸催化四氢吡喃环不对称催化含氧杂环化合物

Corrigendum to‘Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries’[Bioactive Mater.6(3)(2021)638-654]

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Bioactive Materials 2022年第1期7卷 2-2页

作者： Lihua Luo Yan He Ling Jin Yanni Zhang Fernando P.Guastaldi Abdullkhaleg A.Albashari fengting hu Xiaoyan Wang Lei Wang Jian Xiao Lingli Li Jianming Wang Akon Higuchi Qingsong Ye School and Hospital of Stomatology Wenzhou Medical UniversityWenzhouZhejiangChina Tianyou Hospital Wuhan University of Science and TechnologyWuhan430064China Skeletal Biology Research Center Massachusetts General HospitalHarvard School of Dental MedicineBostonMA02114USA Wenzhou Institute of Biomaterials and Engineering WenzhouZhejiang Province325000China Molecular Pharmacology Research Center School of PharmacyWenzhou Medical UniversityWenzhou325035China School of Ophthalmology and Optometry Eye HospitalWenzhou Medical UniversityWenzhouZhejiang325027China Department of Biliary and Pancreatic Surgery Cancer Research CenterAffiliated Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Center of Regenerative Medicine Renmin Hospital of Wuhan UniversityWuhan430060China

The authors regret that the author(A.H.)was removed as an agreement could not be reached between the two affiliations of the *** authors would like to apologise for any inconvenience caused.

关键词： injuries removed repair

含马来酰亚胺结构单元的含氮杂环化合物的合成研究

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当代化工研究 2024年第12期 181-183页

作者：李磊纪凤婷彭林邵阳学院食品与化学工程学院湖南422000

马来酰亚胺结构单元广泛存在于具有生物活性的天然产物和药物中。本文利用N-苯基马来酰亚胺烯与偶氮二甲酸酯作为反应底物合成含马来酰亚胺骨架的含氮杂环化合物,对反应条件进行了系统优化。结果表明,反应溶剂1,4-二氧六环,温度75℃时,2... 详细信息

马来酰亚胺结构单元广泛存在于具有生物活性的天然产物和药物中。本文利用N-苯基马来酰亚胺烯与偶氮二甲酸酯作为反应底物合成含马来酰亚胺骨架的含氮杂环化合物,对反应条件进行了系统优化。结果表明,反应溶剂1,4-二氧六环,温度75℃时,20 mol%K_(2)CO_(3)催化物料配比为1.5:1的马来酰亚胺烯烃与偶氮二甲酸二叔丁酯,得到最佳产率94%。

关键词：马来酰亚胺偶氮二甲酸酯含氮杂环化合物