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IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

Genes & Diseases 2024年第1期11卷 464-478页

作者： Mengtian fan Nana Geng Xingyue Li Danyang Yin Yuyou Yang Rong Jiang Cheng Chen Naibo Feng Li Liang Xiaoli Li fengtao Luo Huabing Qi Qiaoyan Tan Yangli Xie Fengjin Guo Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Laboratory of Stem Cells and Tissue Engineering School of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Department of Orthopedics The 1st Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Wound Repair and Rehabilitation Medicine State Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes,in which the Indian hedgehog(IHH)and parathyroid hormone-related protein-parathyroid hormone-1 receptor(PTHrP-PTH1R)feedback loop is crucial.The inositol-requiring enzyme 1a/X-box-binding protein-1 spliced(IRE1α/XBP1s)branch of the unfolded protein response(UPR)is essential for normal cartilage development.However,the precise role of ER stress effector IRE1α,encoded by endoplasmic reticulum to nucleus signaling 1(ERN1),in skeletal development remains unknown.Herein,we reported that loss of IRE1α accelerates chondrocyte hypertrophy and promotes endochondral bone growth.ERN1 acts as a negative regulator of chondrocyte proliferation and differentiation in postnatal growth plates.Its deficiency interrupted PTHrP/PTH1R and IHH homeostasis leading to impaired chondrocyte hypertrophy and differentiation.XBP1s,produced by p-IRE1α-mediated splicing,binds and up-regulates PTH1R and IHH,which coordinate cartilage development.Meanwhile,ER stress cannot be activated normally in ERN1-deficient chondrocytes.In conclusion,ERN1 deficiency accelerates chondrocyte hypertrophy and cartilage mineralization by impairing the homeostasis of the IHH and PTHrP/PTH1R feedback loop and ER stress.ERN1 may have a potential role as a new target for cartilage growth and maturation.

关键词： Cartilage development ER stress ERN1 IHH PTHrP/PTH1R

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Tip-induced directional charge separation on one-dimensional BiVO4 nanocones for asymmetric light absorption

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Journal of Energy Chemistry 2022年第9期31卷 326-332,I0009页

作者： Nengcong Yang Ruotian Chen Chenwei Ni Dongfeng Li Qi Sun Lifang Liu Yu Qi Shengye Jin Xiuli Wang fengtao fan Can Li Fuxiang Zhang State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsDalian National Laboratory for Clean EnergyChinese Academy of SciencesDalian 116023LiaoningChina State Key Laboratory of Molecular Reaction Dynamics and Dynamics Research Center for Energy and Environmental Materials Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

One dimensional(1D)semiconductor is a class of extensively attractive materials for many emerging solar energy conversion technologies.However,it is still of shortage to assess the impact of 1D structural symmetry on spatial charge separation and understand its underlying mechanism.Here we take controllably-synthesized 1D BiVO_(4)nanocones and nanorods as prototypes to study the influence of 1D symmetry on charge separation.It is found that the asymmetric BiVO_(4)nanocones enable more effective charge separation compared with the symmetric nanorods.The unexpected spatial charge separation on the nanocones is mainly ascribed to uneven light absorption induced diffusion-controllable charge separation due to symmetry breaking of 1D nanostructure,as evidenced by spatial and temporal resolved spectroscopy.Moreover,the promotion effect of charge separation on the nanocones was quantitatively evaluated to be over 20 times higher than that in BiVO_(4)nanorods.This work gives the first demonstration of the influence of 1D structural symmetry on the charge separation behavior,providing new insights to design and fabricate semiconductor materials for efficient solar energy conversion.

关键词： Charge separation Tip-enhanced light absorption Surface photovoltage BiVO4 Photocatalysis

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Visualizing the role of applied voltage in non-metal electrocatalysts

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National Science Review 2023年第9期10卷 46-55页

作者： Ziyuan Wang Jun Chen Chenwei Ni Wei Nie Dongfeng Li Na Ta Deyun Zhang Yimeng Sun Fusai Sun Qian Li Yuran Li Ruotian Chen Tiankai Bu fengtao fan Can Li Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of Sciences 2. Department of ChemistryCollaborative Innovation Center of Chemistry for Energy Materials (iChEM)College of Chemistry and Chemical Engineering Xiamen University Energy College University of Chinese Academy of Sciences Department of Materials Imperial College London

Understanding how applied voltage drives the electrocatalytic reaction at the nanoscale is a fundamental scientific problem,particularly in non-metallic electrocatalysts,due to their low intrinsic carrier concentration.Herein,using monolayer molybdenum disulfide(MoS2) as a model system of non-metallic catalyst,the potential drops across the basal plane of MoS2(△Vsem) and the electric double layer(△Vedl)are decoupled quantitatively as a function of applied voltage through in-situ surface potential microscopy.We visualize the evolution of the band structure under liquid conditions and clarify the process of EFkeeping moving deep into Ec, revealing the formation process of the electrolyte gating effect.Additionally,electron transfer(ET) imaging reveals that the basal plane exhibits high ET activity,consistent with the results of surface potential measurements.The potential-dependent behavior of kfand nsin the ET reaction are further decoupled based on the measurements of △Vsemand △Vedl.Comparing the ET and hydrogen evolution reaction imaging results suggests that the low electrocatalytic activity of the basal plane is mainly due to the absence of active sites,rather than its electron transfer ability.This study fills an experimental gap in exploring driving forces for electrocatalysis at the nanoscale and addresses the long-standing issue of the inability to decouple charge transfer from catalytic processes.

关键词： non-metal electrocatalyst surface potential electron transfer hydrogen evolution reaction mapping

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Formation of multifaceted nano-groove structure on rutile TiO_(2) photoanode for efficient electron-hole separation and water splitting

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Journal of Energy Chemistry 2022年第2期31卷 19-25页

作者： Xiaoyi Zhan Yaling Luo Ziyu Wang Yao Xiang Zheng Peng Yong Han Hui Zhang Ruotian Chen Qin Zhou Hongru Peng Hao Huang Weimin Liu Xin Ou Guijun Ma fengtao fan fan Yang Can Li Zhi Liu State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Photoelectrochemical(PEC)water-splitting using solar energy holds great promise for the renewable energy future,and a key challenge in the development of industry viable PEC devices is the unavailability of high-efficient photoanodes.Herein,we designed a TiO_(2) model photocatalyst with nano-groove pattern and different surface orientation using low-energy Ar+irradiation and photoetching of TiO_(2),and significantly improved the intrinsic activity for PEC water oxidation.High-resolution transmission electron microscopy directly manifests that the grooves consist of highly stepped surface withsteps and well-crystallized.Transient absorption spectroscopy reveals the groove surface that allows for increased recovery lifetime,which ensures promoted electron-hole separation efficiency.Surface photovoltage directly shows the carrier separation and transportation behaviors,verified by selective photodeposition,demonstrating the groove surface on TiO_(2) contributes to electron-hole separation.This work proposes an efficient and scalable photoanode strategy,which potentially can open new opportunities for achieving efficient PEC water oxidation performance.

关键词： TiO_(2)nano-grooves Oxygen vacancies Photoetching Water oxidation

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Light-driven directional ion transport for enhanced osmotic energy harvesting

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National Science Review 2021年第8期8卷 178-185页

作者： Kai Xiao Paolo Giusto Fengxiang Chen Ruotian Chen Tobias Heil Shaowen Cao Lu Chen fengtao fan Lei Jiang Max Planck Institute of Colloids and Interfaces Department of Colloid Chemistry Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang University State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile University State Key Laboratory of Catalysis 2011-iChEMDalian National Laboratory for Clean Energy (DNL)Dalian Institute of Chemical Physics(DICP)Chinese Academy of Sciences State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

Light-driven ion(proton) transport is a crucial process both for photosynthesis of green plants and solar energy harvesting of some archaea. Here, we describe use of a TiO2/C3N4semiconductor heterojunction nanotube membrane to realize similar light-driven directional ion transport performance to that of biological systems. This heterojunction system can be fabricated by two simple deposition steps. Under unilateral illumination, the TiO2/C3N4heterojunction nanotube membrane can generate a photocurrent of about 9 μA/cm~2, corresponding to a pumping stream of ～5500 ions per second per nanotube. By changing the position of TiO2and C3N4, a reverse equivalent ionic current can also be realized. Directional transport of photogenerated electrons and holes results in a transmembrane potential, which is the basis of the light-driven ion transport phenomenon. As a proof of concept, we also show that this system can be used for enhanced osmotic energy generation. The artificial light-driven ion transport system proposed here offers a further step forward on the roadmap for development of ionic photoelectric conversion and integration into other applications, for example water desalination.

关键词： ion pump ion transport nanofluidic porous membrane carbon nitride

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Probing of coupling effect induced plasmonic charge accumulation for water oxidation

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National Science Review 2021年第6期8卷 160-168页

作者： Yuying Gao Feng Cheng Weina fang Xiaoguo Liu Shengyang Wang Wei Nie Ruotian Chen Sheng Ye Jian Zhu Hongyu An Chunhai fan fengtao fan Can Li State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyCollaborative Innovation Center of Chemistry for Energy Materials (i Ch EM)Dalian Institute of Chemical PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences School of Chemistry and Chemical Engineering and Institute of Molecular MedicineRenji HospitalSchool of MedicineShanghai Jiao Tong University

A key issue for redox reactions in plasmon-induced photocatalysis, particularly for water oxidation, is the concentration of surface-accumulating charges(electrons or holes) at a reaction site for artificial photosynthesis. However, where plasmonic charge accumulated at a catalyst’s surface, and how to improve local charge density at active sites, remains unknown because it is difficult to identify the exact spatial location and local density of the plasmon-induced charge, particularly with regard to holes. Herein, we show that at the single particle level, plasmon-coupling-induced holes can be greatly accumulated at the plasmonic Au nanoparticle dimer/Ti O2 interface in the nanogap region, as directly evidenced by the locally enhanced surface photovoltage. Such an accumulation of plasmonic holes can significantly accelerate the water oxidation reaction(multi-holes involved) at the interfacial reaction site, with nearly one order of magnitude enhancement in photocatalytic activities compared to those of highly dispersed Au nanoparticles on Ti O2. Combining Kelvin probe force microscopy and theoretical simulation, we further clarified that the local accumulated hole density is proportional to the square of the local near-field enhancement. Our findings advance the understanding of how charges spatially distribute in plasmonic systems and the specific role that local charge density at reaction sites plays in plasmonic photocatalysis.

关键词： plasmonic photocatalysis coupling effect charge separation surface photovoltage spatial distribution

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Solvent-Free Synthesis of ITQ-12, ITQ-13, and ITQ-17 Zeolites

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Chinese Journal of Chemistry 2017年第5期35卷 572-576页

作者： Qinming Wu Xiaolong Liu Longfeng Zhu Xiangju Meng Feng Deng fengtao fan Zhaochi Feng Can Li Stefan Maurer Mathias Feyen Ulrich Muller Feng-Shou Xiao Key Lab of Applied Chemistry of Zhejiang Province Department of Chemistry Zhejiang University Hangzhou Zhejiang 310007 China State Key Laboratory of Magnetic Resonance andAtomic and Molecular Physics Wuhan Center for Magnetic Resonance Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan Hubei 430071 China College of Biological Chemical Sciences and Engineering Jiaxing University Jiaxing Zhejiang 314001 China State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian Liaoning 116023 China BASF Catalysts (Shanghai) Co. Ltd. 239 Luqiao Road Jinqiao Export Process Zone Pudong New District Shanghai 201206 China Process Research and Chemical Engineering BASF SE 67056 Ludwigshafen Germany

Development of the sustainable routes for synthesis of ITQ-family zeolites is very important because of their unique structures and excellent catalytic and adsorptive properties.The burden of costly raw materials and low efficiency of synthesis put a strong challenge for their widespread commercial application.Here,we show an alternative and simple route for synthesis of ITQ-12,ITQ-13,and ITQ-17 zeolites using commercially available organic templates by a facile grinding process of anhydrous starting raw solids,followed by heating at 140-180 ℃.Compared with the conventional hydrothermal synthesis,this approach has obvious advantages such as employment of low-cost organic templates with very high effectiveness,high yield of zeolite products,short crystallization time,and relatively simple procedures.This methodology might open a pathway to synthesize ITQ zeolites with more sustainable manner.

关键词： zeolite sustainable route solvent-free synthesis low-cost organic template ITQ-family

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Size dependent photogenerated charge separation in single domain ferroelectric PbTiO3 nanoparticles

Size dependent photogenerated charge separation in single do...

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中国化学会第二十次全国电化学大会

作者： Yong Liu Huanwang Jing fengtao fan Can Li State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian National Laboratory for Clean Energy College of Chemistry and Chemical Engineering Lanzhou University

Ferroelectric materials have drawn a lot of attention in photovoltage and photocatalysis due to intensive ferroelectric internal field. Because of lacking detailed knowledge on the ferroelectric fields in ferroelectric particles, utilization and improvement of ferroelectric field remain a challenge at present stage. Herein,

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A Semantic-Aware Method for Polymorphic Signature Generation

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Wuhan University Journal of Natural Sciences 2012年第6期17卷 494-498页

作者： GUO fan TU fengtao YU Min College of Computer Information Engineering Jiangxi Normal UniversityNanchang 330022JiangxiChina

It is difficult for security experts to generate polymorphic signatures by using traditional string mining and matching techniques.A semantic-aware method is presented to generate a kind of two-level signature that includes both polymorphic semantics and string patterns.It first analyzes the characteristics of polymorphic engines and categorizes the data flows into different clusters and then uses static data flow methods to extract invariable semantic instructions.And then,it combines traditional string methods to generate the signature.In comparison with other methods,experimental results show that it may effectively reduce false positives and false negatives.

关键词： string pattern polymorphism attack signature semantic aware

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Hydrophobic and Magnetic Reduced Graphene Oxide Nanocomposite for Emulsified Oil Removal

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中国炼油与石油化工：英文版 2017年第3期19卷 48-58页

作者： fan fengtao Li Xufei Liu fang Jiang Guofei Sui Linlin Zhao Chaocheng State Key Laboratory of Petroleum Pollution Control College of Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580

Magnetic reduced graphene oxide(MRGO) nanocomposite was prepared by the chemical coprecipitation method and applied as adsorbent for removing emulsified oil from oily wastewater. SEM, TEM, XRD, FT-IR, VSM and other analytical methods were utilized to characterize the prepared MRGO. The adsorption performance of MRGO was evaluated under different initial adsorbate concentration, MRGO dosage, temperature, and pH value of the solution. The adsorption kinetics and isotherms were investigated. In addition, the MRGO repeatability was also tested. It was found that almost 65%of emulsified oil were removed by MRGO in the first 15 min. The MRGO adsorption capacity and efficiency for removal of adsorbate reached 335.85 mg/g and 92.52% within 60 min, respectively. The adsorption capacity reduced with an increasing MRGO dosage, while increased with the increase of emulsified oil concentration. The adsorption performance of MRGO in the alkaline environment was lower than that in the acidic environment. The adsorption data could well fit to the pseudosecondorder model. The Langmuir model could well describe the isotherm data. The MRGO adsorption capacity was still more than 236.1 mg/g at the sixth regeneration cycle.

关键词： magnetic reduced graphene oxide nanocomposites adsorption emulsified oil

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