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Spatiotemporal characteristics and Monte Carlo simulationbased human health risk of heavy metals in soils from a typical coal-mining city in eastern China

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Frontiers of Environmental Science & Engineering 2024年第10期18卷 61-74页

作者： Xiangyue Pan Xinrui Weng Lingyu zhang Fang Chen Hui Li Yunhua zhang Anhui Province Key Laboratory of Farmland Ecological Conservation and Pollution Prevention College of Resources and EnvironmentAnhuiAgricultural UniversityHefei 230026China Agricultural Products Quality and Safety Center Xuancheng 242000China

Mining activities typically discharge considerable amounts of heavy metals into the environment,raising concerns about soil metal pollution,environmental security,and human ***,a systematic regional-scale investigation of soil heavy metal pollution in mining areas is necessary for soil *** this study,5817 soil samples from the Huainan coal mining area collected for studies conducted from 2000 to 2021 were compiled to quantify the pollution level and spatiotemporal variation of heavy metals(Cu,Pb,Zn,Cr,Cd,As,Hg,Ni,and Mn).The associated ecological health risk of heavy metals in soil was assessed using the Hakanson ecological hazard index,Monte Carlo simulation in conjunction with the total hazard quotient,and the hazard *** was the top contaminant,followed by *** terms of spatial distribution,heavy metal contamination was more severe in the eastern area of fengtai and Datong districts,because these districts of Anhui Province are significant industrial *** addition,the results of the Monte Carlo evaluation of human health risks showed that the total noncarcinogenic risk of heavy metals in soil is below the acceptable level,while the carcinogenic risk was 5.97% for adults and 15.53% for *** accounted for 57.4% of noncarcinogenic risk,Cr contributed 36.1%of carcinogenic *** with adults,children are more vulnerable to the carcinogenic and noncarcinogenic risks posed by heavy metals,with oral consumption being the primary exposure *** research can provide useful details for protecting the environment and managing soil in a coal mining area.

关键词： Heavy metals Spatiotemporal distribution Ecological health risk assessment Monte Carlo simulation Coal mining area

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Repetitive transcranial magnetic stimulation improves consciousness disturbance in stroke patients A quantitative electroencephalography spectral power analysis

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Neural Regeneration Research 2012年第31期7卷 2465-2472页

作者： Ying Xie Tong zhang Capital Medical University School of Rehabilitation Medicine Department of Rehabilitation Electric Power Teaching Hospital of CapitalMedical University Beijing 100073 China Department of Neurology and Rehabilitation Capital Medical University School of Rehabilitation Medicine China Rehabilitation ResearchCenter Beijing 100068 China

Repetitive transcranial magnetic stimulation is a noninvasive treatment technique that can directly alter cortical excitability and improve cerebral functional activity in unconscious patients. To investigate the effects and the electrophysiological changes of repetitive transcranial magnetic stimulation cortical treatment, 10 stroke patients with non-severe brainstem lesions and with disturbance of consciousness were treated with repetitive transcranial magnetic stimulation. A quantitative electroencephalography spectral power analysis was also performed. The absolute power in the alpha band was increased immediately after the first repetitive transcranial magnetic stimulation treatment, and the energy was reduced in the delta band. The alpha band relative power values slightly decreased at 1 day post-treatment, then increased and reached a stable level at 2 weeks post-treatment. Glasgow Coma Score and JFK Coma Recovery Scale-Revised score were improved. Relative power value in the alpha band was positively related to Glasgow Coma Score and JFK Coma Recovery Scale-Revised score. These data suggest that repetitive transcranial magnetic stimulation is a noninvasive, safe, and effective treatment technology for improving brain functional activity and promoting awakening in unconscious stroke patients.

关键词： repetitive transcranial magnetic stimulation consciousness disturbance stroke quantitative electroencephalography nervous excitation consciousness neuroregenerative disease regeneration neural regeneration

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基于机器学习方法建立慢性阻塞性肺疾病合并肺癌风险的预测模型

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中国呼吸与危重监护杂志 2022年第11期21卷 782-789页

作者：李梦琪贺丰泰吴雅楠张尽晖王琪大连医科大学附属第二医院呼吸内科辽宁大连116023 大连医科大学附属第二医院放射科辽宁大连116023 东北大学医学与生物信息工程学院辽宁沈阳110819

目的建立基于机器学习的慢性阻塞性肺疾病(简称慢阻肺)患者合并肺癌风险的预测模型,探索慢阻肺患者罹患肺癌的高风险因素,为早期发现慢阻肺患者肺癌发病风险提供智能预警奠定基础。方法回顾分析2010年—2021年就诊于大连医科大学附属... 详细信息

目的建立基于机器学习的慢性阻塞性肺疾病(简称慢阻肺)患者合并肺癌风险的预测模型,探索慢阻肺患者罹患肺癌的高风险因素,为早期发现慢阻肺患者肺癌发病风险提供智能预警奠定基础。方法回顾分析2010年—2021年就诊于大连医科大学附属第二医院的共154例患者,其中慢阻肺组99例,慢阻肺合并肺癌组55例。患者均进行胸部高分辨率电子计算机断层扫描(high resolution computed tomography,HRCT)及肺功能测试。主要分析:(1)两组患者的年龄、体重指数(body mass index,BMI)、吸烟指数等基本信息、实验室检查结果、肺功能及胸部HRCT定量参数之间的差异是否具有统计学意义;(2)使用单因素和二元logistic回归方法分析慢阻肺患者患肺癌的高风险因素指标;(3)使用logistic回归和Gaussian过程等机器学习方法建立慢阻肺患者合并肺癌风险的预测模型。结果基于统计学和logistic回归方法分析,BMI下降、全肺气肿指数增大、全肺平均密度增高、用力肺活量及凝血酶原时间百分比活动度增加是慢阻肺患者合并肺癌的危险因素。基于慢阻肺患者合并肺癌的机器学习风险预测模型,使用凝血酶原时间百分比活动度、全肺气肿指数、全肺平均密度、用力肺活量联合神经元特异性烯醇化酶和细胞角蛋白19的可溶性片段为特征,得到logistic回归和Gaussian过程的受试者工作特征曲线下面积均为0.88。结论使用机器学习的方法建立慢阻肺患者合并肺癌风险的预测模型,可用于早期发现罹患肺癌高风险的慢阻肺患者。

关键词：肺癌慢性阻塞性肺疾病卷积神经网络机器学习

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Comparative characterization of antibody responses induced by Ad5-vectored spike proteins of emerging SARS-CoV-2 VOCs

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Signal Transduction and Targeted Therapy 2022年第8期7卷 3126-3138页

作者： Busen Wang Jinghan Xu Shipo Wu Zhe zhang Zhenghao Zhao Jun zhang Ling Fu Xiaodong Zai Yudong Wang Guanying zhang ZhengShan Chen Yi Chen Hancong Sun Xiaohong Song Jinlong zhang Lianhui Zhu Lihua Hou Wei Chen Beijing Institute of Biotechnology No.20 Dongdajie StreetFengtai District100071 BeijingChina

Highly divergent SARS-CoV-2 variants have continuously emerged and spread around the world,and updated vaccines and innovative vaccination strategies are urgently needed to address the global SARS-COV2 ***,we established a series of Ad5-vectored SARS-CoV-2 variant vaccines encoding multiple spike proteins derived from the Alpha,Beta,Gamma,Epsilon,Kappa,Delta and Omicron lineages and analyzed the antibody immune responses induced by single-dose and prime-boost vaccination strategies against emerging SARS-CoV-2 variants of concern(VOCs).Single-dose vaccination with SARS-CoV-2 variant vaccines tended to elicit the optimal self-matched neutralizing effects,and Ad5-B.1.351 produced more broad-spectrum cross-neutralizing antibodies against diverse *** contrast,prime-boost vaccination further strengthened and broadened the neutralizing antibody responses against highly divergent SARS-CoV-2 *** heterologous administration of Ad5-B.1.617.2 and Ad5-B.1.429 to Ad5-WT-primed mice resulted in superior antibody responses against most *** particular,the Omicron spike could only stimulate self-matched neutralizing antibodies with infrequent cross-reactivities to other variants used in single-dose vaccination strategies;moreover,with prime-boost regimens,this vaccine elicited an optimal specific neutralizing antibody response to Omicron,and prompted cross-antibody responses against other VOCs that were very similar to those obtained with Ad5-WT ***,this study delineated the unique characteristics of antibody responses to the SARS-CoV-2 VOC spikes with the single-dose or prime-boost vaccination strategies and provided insight into the vaccine development of next SARS-CoV-2 VOCs.

关键词： neutral optimal matched

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Neural network mapping of gelastic behavior in children with hypothalamus hamartoma

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World Journal of Pediatrics 2024年第7期20卷 735-745页

作者： Zhi‑Hao Guo Jian‑Guo zhang Xiao‑Qiu Shao Wen‑Han Hu Lin Sang Zhong Zheng Chao zhang Xiu Wang Chun‑De Li Jia‑Jie Mo Kai zhang Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityNo.119 South 4th Ring West RoadFengtai DistrictBeijing 100070China Department of Neurosurgery Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Beijing Fengtai HospitalBeijingChina

Background Hypothalamus hamartomas(HHs)are rare,congenital,tumor-like,and nonprogressive malformations resulting in drug-resistant epilepsy,mainly affecting *** seizures(GS)are an early hallmark of epilepsy with *** aim of this study was to explore the disease progression and the underlying physiopathological mechanisms of pathological laughter in *** We obtained clinical information and metabolic images of 56 HH patients and utilized ictal semiology evaluation to stratify the specimens into GS-only,GS-plus,and no-GS subgroups and then applied contrasted trajectories inference(cTI)to calculate the pseudotime value and evaluate GS *** logistic regression was performed to identify neuroimaging-clinical predictors of GS,and then voxelwise lesion network-symptom mapping(LNSM)was applied to explore GS-associated brain *** cTI inferred the specific metabolism trajectories of GS progression and revealed increased complexity from GS to other seizure *** was further validated via actual disease duration(Pearson R=0.532,P=0.028).Male sex[odds ratio(OR)=2.611,P=0.013],low age at seizure onset(OR=0.361,P=0.005),high normalized HH metabolism(OR=−1.971,P=0.037)and severe seizure burden(OR=−0.006,P=0.032)were significant neuroimaging clinical *** revealed that the dysfunctional cortico-subcortico-cerebellar network of GS and the somatosensory cortex(S1)represented a negative *** This study sheds light on the clinical characteristics and progression of GS in children with *** identified distinct subtypes of GS and demonstrated the involvement of specific brain regions at the cortical–subcortical–cerebellar *** valuable results contribute to our understanding of the neural correlates of GS.

关键词： Contrasted trajectories inference Gelastic seizure Hypothalamus hamartoma Lesion network-symptom mapping Neural basis

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Characterization of flavor fingerprinting of red sufu during fermentation and the comparison of volatiles of typical products

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Food Science and Human Wellness 2019年第4期8卷 375-384页

作者： Peng Wang Xiaoran Ma Wenping Wang Dandan Xu Xin zhang Jian zhang Yong Sun Beijing Academy of Food Sciences No.70YangqiaoFengtai DistrictBeijing 100068People’s Republic of China Beijing Food Brewing Institute No.4Luchang StreetXicheng DistrictBeijing 100050People’s Republic of China

Traditional Chinese red sufu is a popular condiment,and typical flavor is an important indicator of sensory qualities in commercial *** this study,the volatile aroma analysis of Wangzhihe red sufu(WRS)from different fermentation stages and four typical red sufu products from different locations was carried out by gas chromatography-mass spectrometry(GC–MS),gas chromatography-mass spectrometry/olfactory(GC–MS/O),electronic nose(E-nose)and sensory *** showed that 106 volatile compounds were identified in Wangzhihe red sufu during fermentation process,in which phenolics and alcohols were dominant at molded and salted phetze stages,while esters and alcohols became predominate at post-fermentation *** volatile aroma substances varied at each fermentation ***,86 volatiles,including 16 aroma-active compounds,were detected in four typical red sufu *** multivariate analysis results showed the difference in samples from different fermentation stages and typical red sufu products according to GC–MS and E-nose *** with flavor omics,discriminant model was established for effective discrimination of samples from different fermentation stages and locations,as well as references to sufu maturity *** study presented a new strategy for quality evaluation of red sufu,which could be the supplement to quality evaluation standards.

关键词： Red sufu Fermentation process Volatile compounds HS-SPME-GC-MS Flavor omics

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RDX/AP配比对HTPB复合推进剂低压燃烧性能的影响

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推进技术 1988年第6期 48-53页

作者：张仁胡景发王锐鑫王凤泰

本文研究了RDX/AP配比对其HTPB复合推进剂爆温(T_v)、燃烧产物中HCl含量、燃速和燃速压力指数的影响.探索了叔丁基二茂铁、铬酸铅等添加剂对RDX/AP丁羟推进剂燃速的催化效果.应用单幅摄影、中止燃烧和扫描电镜等实验技术对其结果作了初... 详细信息

本文研究了RDX/AP配比对其HTPB复合推进剂爆温(T_v)、燃烧产物中HCl含量、燃速和燃速压力指数的影响.探索了叔丁基二茂铁、铬酸铅等添加剂对RDX/AP丁羟推进剂燃速的催化效果.应用单幅摄影、中止燃烧和扫描电镜等实验技术对其结果作了初步的分析.

关键词：端羟基聚丁二烯推进剂硝铵推进剂推进剂燃烧性能

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Characteristics of PM_(2.5) pollution in Beijing after the improvement of air quality

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Journal of Environmental Sciences 2021年第2期33卷 1-10页

作者： Xiaojuan Huang Guiqian Tang Junke zhang Baoxian Liu Chao Liu Jin zhang Leilei Cong Mengtian Cheng Guangxuan Yan Wenkang Gao Yinghong Wang Yuesi Wang Plateau Atmosphere and Environment Key Laboratory of Sichuan Province School of Atmospheric SciencesChengdu University of Information TechnologyChengdu 610225China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry(LAPC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Faculty of Geosciences and Environmental Engineering Southiuest Jiaotong UniversityChengdu 611756China Beijing Municipal Environmental Monitoring Centre Beijing 100048China fengtai District Ecology and Environment Bureau Beijing 100071China School of Environment Henan Normal UniuersityKey Laboratory Jor YellouRiuer and Huai Riuer Water Environment and Pollution ControlMinistry of EducationHenan Key Laboratory/or EnvironmentaI Pollution ControlXinxiang 453007China

Following the implementation of the strictest clean air policies to date in Beijing,the physicochemical characteristics and sources of PM_(2.5) have changed over the past few *** improve pollution reduction policies and subsequent air quality further,it is necessary to explore the changes in PM_(2.5) over *** this study,over one year(2017-2018)field study based on filter sampling(TH-150C;Wuhan Tianhong,China)was conducted in fengtai District,Beijing,revealed that the annual average PM_(2.5) concentration(64.8±43.1μg/m^3)was significantly lower than in previous years and the highest PM_(2.5) concentration occurred in spring(84.4±59.9μg/m^3).Secondary nitrate was the largest source and accounted for 25.7%of the measured PM_(2.5).Vehicular emission,the second largest source(17.6%),deserves more attention when considering the increase in the number of motor vehicles and its contribution to gaseous *** addition,the contribution from coal combustion to PM_(2.5) decreased *** weekends,the contribution from EC and NO3−increased whereas the contributions from SO4^2−,OM,and trace elements decreased,compared with *** the period of residential heating,PM_(2.5) mass decreased by 23.1%,compared with non-heating period,while the contributions from coal combustion and vehicular emission,and related species *** the aggravation of pollution,the contribution of vehicular emission and secondary sulfate increased and then decreased,while the contribution of NO3−and secondary nitrate continued to increase,and accounted for 34.0%and 57.5%of the PM_(2.5) during the heavily polluted days,respectively.

关键词： PM_(2.5) Seasonal variations Chemical composition Source apportionment Pollution evolution

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A rapid chemometrics model for antioxidant substance mining of Chinese dwarf cherry[Cerasus humilis(Bge.)Sok.]based on polyphenol profile and antioxidant capacity of 30 germplasms

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Food Bioscience 2023年第3期53卷 2991-3000页

作者： Yushi zhang Qingyu Cui Chang-e Guo Xiaobing zhang Shupeng Liu Xiaoxue Wang Jinjiang Zhao Zihan Zhao Weidong Li School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488PR China Pharmaron Beijing Co. Ltd.Beijing 100176PR China Beijing fengtai District Hospital of Chinese Medicine Nanyuan HospitalBeijing 100076PR China

Chinese dwarf cherry(Ouli)is a native shrub in northwest China with high ecological value,but the nutritive potential remains to be *** this study,the total content of polyphenols,flavonoids,proanthocyanidins,and anthocyanins of Ouli from 30 germplasms were measured,and the antioxidant activities were evaluated by FRAP and ABTS *** polyphenol profile was determined by ultra-high-performance liquid chromatography-high resolution mass *** relational analysis and partial least squares were utilized to build chemometrics models for selecting antioxidant *** contents of total flavonoids,proanthocyanidins,phenols and total anthocyanidins of 30 germplasms of Ouli were 119.92-668.76 mg/100 g fresh weight(FW),90.81-555.44 mg/100 g FW,148.42-390.43 mg/100 g FW,0.02-17.26 mg/100 g FW,respectively.A total of 61 compounds were identified,including 40 flavonoids(26 flavonols,4 anthocyanins,6 dihydroflavonols,2 dihydrochalcones,and 2 flavones),12 proanthocyanidins,6 phenolic acids,and 3 types of other class compounds(one stilbene and two phenols).The proanthocyanidin compounds in Ouli contributes most to the total antioxidant capacity with the antioxidant rank that procyanidin trimer>tetramer>dimer≈*** and procyanidin B1 were the most abundant compounds and were 18.45-162.50μg/g FW and 30.52-149.42μg/g FW,***(SX)2 and SX10 could be considered as potential germplasms,and proanthocyanidins could be chosen as a characteristic nutrient evaluation index of *** study not only takes a key step to lay the groundwork for further research of Ouli but also provides a reference for the discovery of the functional ingredients of other foods.

关键词： Antioxidant capacity Chinese dwarf cherry(Ouli) Polyphenol Proanthocyanidin Ultra-high-performance liquid chromatography-high resolution mass spectrometry Chemometrics

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Multicenter evaluation of a simple and sensitive nucleic acid self-testing for SARS-CoV-2

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Virologica Sinica 2023年第4期38卷 620-626页

作者： Xin-Xin Shen Feng-Yu Li Meng Qin Guo-Hao zhang Meng-Yi zhang Hong Liu Xiu-Li Sun Zhen-Jiang Xin Xue-Jun Ma NHC Key Laboratory of Medical Virology and Viral Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China Hebei Medical University Shijiazhuang050031China fengtai District Center for Disease Control and Prevention of Beijing Beijing100071China Beijing Baicare Biotechnology Co. Ltd.Beijing102206China Shandong University of Technology School of Life Sciences and MedicineZibo255000China

A rapid and accurate COVID-19 diagnosis is a prerequisite for blocking the source of infection as soon as possible and taking the appropriate medical ***,we developed GeneClick,a device for nucleic acid self-testing of SARS-CoV-2,consisting of three modules:a sampling kit,a microfluidic chip-based disposable cartridge,and an amplification *** addition,we evaluated the clinical performance of GeneClick using 2162 nasal swabs collected at three medical institutions,using three commercial RT-qPCR kits and an antigen self-test as *** to RT-qPCR,the sensitivity and specificity of the GeneClick assay were 97.93%and 99.72%,respectively,with a kappa value of 0.979(P<0.01).Of the 2162 samples,2076 were also tested for SARS-CoV-2 *** the 314 positive samples identified by GeneClick assay,63 samples were undetected by antigen ***,the GeneClick nucleic acid self-test demonstrated higher accuracy than the antigen-based *** on the additional features,including simple operation,affordable price,portable device,and reliability of smartphone APP-driven sampling and result reporting,GeneClick offers a powerful tool for field-based SARS-CoV-2 detection in primary healthcare institutions or at-home use.

关键词： Nucleic acid self-testing SARS-CoV-2 RT-qPCR Antigen-test

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