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The effects of autophagy on vascular endothelial cells induced by airborne PM2.5

Journal of Environmental Sciences 2018年第4期30卷 182-187页

作者： Zhixiang Zhou Tong Shao Mengnan Qin Xiaoyan Miao Yu Chang Wang Sheng fengshang wu Yunjiang Yu College of Life Science and Bioengineering Beijing University of Technology State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences South China Institute of Environmental Science Ministry of Environmental Protection

The purpose of this study was to examine the direct toxicity of PM2.5 collected from Beijing on human umbilical vein endothelial cells（HUVEC）. A Cell Counting Kit 8（CCK8） assay demonstrated that PM2.5 exposure decreased the proliferation of HUVECs in a dosedependent manner. We also found that PM2.5 exposure induced autophagy in HUVECs, as evidenced by：（1） an increased number of double-membrane vesicles;（2） enhanced conversion and punctuation of the microtubule-associated protein light chain 3（LC3）; and（3） decreased levels of the selective autophagy substrate p62 in a time-dependent ***, promoting autophagy in PM2.5-exposed HUVECs with rapamycin increased the cell survival rate, whereas inhibiting autophagy via 3-methyladenine significantly decreased cell survival. These results demonstrate that PM2.5 exposure can induce cytotoxicity and autophagy in HUVECs and that autophagy play a protective role against PM2.5-induced cytotoxicity. The findings of the present study imply a direct toxic effect of PM2.5 on HUVECs and provide novel insight into the mechanism of cardiovascular diseases caused by PM2.5 exposure.

关键词： PM2.5 HUVEC Cytotoxicity Autophagy

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浅析司马迁“八书”中体现的宇宙观

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湖南人文科技学院学报 2006年第4期23卷 52-54页

作者：吴象枢吉首大学文学与新闻传播学院湖南吉首416000

在《史记》“八书”中集中体现了司马迁的宇宙思想,全面阐述了天、地、人、阴、阳、五行等原始的宇宙发生因素,“八书”构成了早期的天人宇宙论图式。同时还在《律书》和《历书》中通过阴阳五行八正之气,探究了宇宙由无到有的发展过程,... 详细信息

在《史记》“八书”中集中体现了司马迁的宇宙思想,全面阐述了天、地、人、阴、阳、五行等原始的宇宙发生因素,“八书”构成了早期的天人宇宙论图式。同时还在《律书》和《历书》中通过阴阳五行八正之气,探究了宇宙由无到有的发展过程,在《天官书》、《封禅书》、《河渠书》和《平准书》中阐释了“天地人”的作用和关系,在《礼书》和《乐书》中阐述宇宙的和谐之道。

关键词：司马迁《史记》“八书” 宇宙发生宇宙元素

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