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Horticultural Plant Journal 2024年第4期10卷 1035-1048页

作者： Hao Hu fengqun yu Agriculture and Agri-Food Canada Saskatoon Research and Development Centre107 Science PlaceSaskatoonSKS7N OX2Canada

Clubroot disease is a severe threat to Brassica crops globally,particularly in western *** resistance,achieved through pyramiding clubroot resistance(CR)genes with different modes of action,is the most important strategy for managing the ***,studies on the CR gene functions are quite *** this study,we have conducted investigations into the temporal,structural,and interacting features of a newly cloned CR gene,Rcr1,using CRISPR/Cas9 *** temporal functionality,we developed a novel CRISPR/Cas9-based binary vector,pHHIGR-Hsp18.2,to deliver Rcr1 into a susceptible canola line(DH12075)and observed that early expression of Rcr1 is critical for conferring *** structural functionality,several independent mutations in specific domains of Rcr1 resulted in loss-offunction,highlighting their importance for CR *** the study of the interacting features of Rcr1,a cysteine protease gene and its homologous allele in canola were successfully disrupted via CRISPR/Cas9 as an interacting component with Rcr1 protein,resulting in the conversion from clubroot resistant to susceptible in plants carrying intact *** results indicated an indispensable role of these two cysteine proteases in Rcr1-mediated resistance *** study,the first of its kind,provides valuable insights into the functionality of ***,the new vector p HHIGR-Hsp18.2 demonstrated an inducible feature on the removal of add-on traits,which should be useful for functional genomics and other similar research in brassica crops.

关键词： Clubroot resistance Brassica crops Canola Rcr1 CRISPR/Cas9 system Gene knock-out Timing control Non-synonymous mutation Protein-protein interaction

Genetic diversity and population structure of Leptosphaeria maculans isolates in Western Canada

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Journal of Genetics and Genomics 2021年第11期48卷 994-1006页

作者： Qilin Chen Gary Peng Randy Kutcher fengqun yu Saskatoon Research and Development Centre Agriculture and Agri-Food CanadaSaskatoonCanada Department of Plant Sciences Crop Development CentreUniversity of SKSaskatoonSKCanada

Leptosphaeria maculans is a serious concern for canola production *** effective disease management,knowledge of the pathogen’s genetic variability and population structure is a *** this study,whole-genome sequencing was performed for 162 of 1590 *** isolates collected in the years 2007e2008 and 2012e2014 in Western *** variants in genome-wide and specific regions including avirulence(Avr)genes were characterized.A total of 31,870 high-quality polymorphic DNA variants were used to study *** genetic diversity and population *** analysis showed that 150 isolates were clustered into 2 main groups and 4 subgroups by DNA variants located in either Avr or small secreted protein-encoding genes and into 2 main groups and 6 subgroups by genome-wide *** analysis of nucleotide diversity and differentiation also confirmed genetic variation within a population and among *** component analysis with genome-wide variants showed that the isolates collected in 2012e2014 were more genetically diverse than those collected in *** structure analysis discovered three distinct *** isolates from Saskatchewan and Alberta were of similar genetic composition,Manitoba isolates were highly ***-wide association study detected DNA variants in genes AvrLm4-7,Lema_T86300,and Lema_T86310 associated with the years of collection.

关键词： Leptosphaeria maculans DNA variants Blackleg Genetic diversity Population structure

Broadening the genetic base of Brassica juncea by introducing genomic components from *** and *** via digenomic allohexaploid bridging

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The Crop Journal 2022年第3期10卷 672-679页

作者： Jiaqin Mei Jin Liu Fang yue Yangui Chen Jiayi Ming Zhiyong Xiong fengqun yu Jiana Li Wei Qian College of Agronomy and Biotechnology Southwest UniversityChongqing 400716China Academy of Agricultural Sciences Southwest UniversityChongqing 400716China State Cultivation Base of Crop Stress Biology for Southern Mountainous Land of Southwest University Chongqing 400715China Key Laboratory of Herbage and Endemic Crop Biotechnology School of Life SciencesInner Mongolia UniversityHohhot 010070Inner Mongoli1China Agriculture and Agri-Food Canad1 Saskatoon Research and Development Center107 Science PlaceSaskatoonSK S7N 0X2Canada

A narrow genetic base has hindered improvement of Brassica juncea(A^(j)A^(j)B^(j)B^(j)).In this study,large-scale genomic components were introduced from diploid ancestor species into modern *** using a digenomic hexaploid *** hexaploids A^(j)A^(j)A^(r)A^(r)B^(j)B^(j) and A^(j)A^(j)B^(j)B^(j)B^(n)B^(n) were first developed from ***×***(A^(r)A^(r))and ***×***(B^(n)B^(n)),and then crossed with dozens of *** and ***,*** types of hexaploid showed high pollen fertility and moderate seed set throughout the S_(1) to S_(3) generations,and could be crossed with diploid progenitor species under field conditions,in particular for the combination of A^(j)A^(j)B^(j)B^(j)B^(n)B^(n)×*** A^(j)A^(r)B^(n)B^(j)-type and 31 A^(j)A^(r)B^(n)B^(j)-type *** resources were generated,of which the A^(j)A^(r)B^(n)B^(j) type showed higher *** these new-type *** resources,97 individual plants were genotyped with 42 simple sequence repeat markers,together with 16 current *** accessions and 30 hexaploid *** on 180 polymorphic loci,the new-type *** resources and current *** were separated clearly into distinct groups,with large genetic distance between the new-type *** resources and current *** study provides a novel approach to introducing large-scale genomic components from diploid ancestor species into ***.

关键词： Brassica juncea Diploid progenitor species Exotic introgression Genetic diversity Digenomic hexaploid

DP590双相高强钢焊缝在模拟酸雨溶液中的腐蚀行为

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热加工工艺 2017年第17期46卷 187-190页

作者：黄雄朱春东于凤群武汉理工大学材料科学与工程学院湖北武汉430070

研究了DP590双相高强钢CO_2气体保护焊焊缝的组织与腐蚀性能。采用金相显微镜观察了焊缝和母材的微观组织,并用电化学测试、失重试验、腐蚀形貌观察方法研究了高强钢焊缝在不同p H值模拟酸雨中的腐蚀行为。结果表明,母材组织主要为等轴... 详细信息

研究了DP590双相高强钢CO_2气体保护焊焊缝的组织与腐蚀性能。采用金相显微镜观察了焊缝和母材的微观组织,并用电化学测试、失重试验、腐蚀形貌观察方法研究了高强钢焊缝在不同p H值模拟酸雨中的腐蚀行为。结果表明,母材组织主要为等轴铁素体和珠光体组成,组织较均匀;焊缝组织主要是板条状贝氏体、铁素体和残余奥氏体。随着p H值的降低,焊缝和母材的自腐蚀电位均负移,自腐蚀电流密度增大,腐蚀速率加快,且同一p H值下焊缝的耐蚀性差于母材。焊缝较母材的耐蚀性差主要是由于受到明显的电偶腐蚀。

关键词： DP590双相高强钢车身焊缝酸雨环境电化学试验腐蚀

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甘蓝型油菜小孢子胚状体发生的细胞学观察

武汉植物学研究 1998年第3期16卷 197-201页

作者：余凤群傅爱汝刘后利华中农业大学农学系武汉430070

应用甘蓝型油菜DH系保604为材料研究小孢子胚发生过程，结果表明，在小孢子离体培养1～5d内，随培养天数增加，小孢子的存活率迅速下降。部分小孢子培养后出现细胞膨大和分裂，并沿2-细胞、""形3-细胞、多细胞原胚、胚柄球形胚、心形胚... 详细信息

应用甘蓝型油菜DH系保604为材料研究小孢子胚发生过程，结果表明，在小孢子离体培养1～5d内，随培养天数增加，小孢子的存活率迅速下降。部分小孢子培养后出现细胞膨大和分裂，并沿2-细胞、""形3-细胞、多细胞原胚、胚柄球形胚、心形胚最终发育成鱼雷形胚。一般在心形胚阶段，胚柄脱离胚主体部分游离到培养基中。大多数膨大的细胞不能分裂或分裂后停止发育或发育异常。

关键词：甘蓝型油菜小孢子培养胚状体发生细胞学

Silk damping in scalar-induced gravitational waves: a novel probe for new physics

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 79-85页

作者： Yan-Heng yu Sai Wang Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences School of Physics University of Chinese Academy of Sciences

Silk damping is well known in the study of cosmic microwave background（CMB） and accounts for suppression of the angular power spectrum of CMB on large angular multipoles. In this article, we study the effect of Silk damping on the scalar-induced gravitational waves（SIGWs）. Resulting from the dissipation of cosmic fluid, the Silk damping notably suppresses the energydensity spectrum of SIGWs on scales comparable to a diffusion scale at the decoupling time of weakly-interacting particles. The effect offers a novel observable for probing the underlying particle interaction, especially for those mediated by heavy gauge bosons beyond the standard model of particles. We anticipate that pulsar timing arrays are sensitive to gauge bosons with mass ～10～3-10～4 GeV, while space-and ground-based interferometers to those with mass ～10～7-1012GeV, leading to essential complements to on-going and future experiments of high-energy physics.

关键词： scalar-induced gravitational waves Silk damping new physics

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi yu Faith Teo En Ning Chang Liu yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

Attention Eraser and Quantitative Measures for Automated Bone Age Assessment

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Computers, Materials & Continua 2025年第1期82卷 627-644页

作者： Liuqiang Shu Lei yu College of Computer and Information Science Chongqing Normal UniversityChongqing401331China

Bone age assessment(BAA)aims to determine whether a child’s growth and development are normal concerning their chronological *** predict bone age more accurately based on radiographs,and for the left-hand X-ray images of different races model can have better adaptability,we propose a neural network in parallel with the quantitative features from the left-hand bone measurements for *** this study,a lightweight feature extractor(LFE)is designed to obtain the featuremaps fromradiographs,and amodule called attention erasermodule(AEM)is proposed to capture the fine-grained ***,the dimensional information of the metacarpal parts in the radiographs is measured to enhance the model’s generalization capability across images fromdifferent *** is trained and validated on the RSNA,RHPE,and digital hand atlas datasets,which include images from various racial *** model achieves a mean absolute error(MAE)of 4.42 months on the RSNA dataset and 15.98 months on the RHPE *** to ResNet50,InceptionV3,and several state-of-the-art methods,our proposed method shows statistically significant improvements(p<0.05),with a reduction in MAE by 0.2±0.02 years across different racial ***,t-tests on the features also confirm the statistical significance of our approach(p<0.05).

关键词： Bone age assessment attention eraser quantitative feature metacarpal bones

Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist

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Neural Regeneration Research 2025年第10期20卷 2895-2897页

作者： Nicolas Hugues yu Luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA Division of Immunobiology Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOHUSA

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the *** the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

关键词： Figure signature critical

Conversion-type cathode materials for high energy density solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 409-425页

作者： yuhao Ma Shihong Qing Hongyu Liu Chuntao Ma yuan yu Chuang yu Liping Wang School of Materials and Energy University of Electronic Science and Technology of China Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology Zhejiang Sci-Tech University State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic Engineering Huazhong University of Science and Technology

Solid-state lithium batteries （SSLBs） are regarded as an essential growth path in energy storage systems due to their excellent safety and high energy *** particular,SSLBs using conversion-type cathode materials have received widespread attention because of their high theoretical energy densities,low cost,and *** the great progress in research and development of SSLBs based on conversiontype cathodes,their practical applications still face challenges such as blocked ionic-electronic migration pathways,huge volume change,interfacial incompatibility,and expensive processing *** review focuses on the advantages and critical issues of coupling conversion-type cathodes with solid-state electrolytes （SSEs）,as well as state-of-the-art progress in various promising cathodes （e.g.,FeS2,CuS,FeF3,FeF2,and S） in ***,representative research on conversion-type solid-state full cells is discussed to offer enlightenment for their practical ***,the energy density exhibited by the S cathode stands out impressively,while sulfide SSEs and halide SSEs have demonstrated immense potential for coupling with conversion-type ***,perspectives on conversion-type cathodes are provided at the material,interface,composite electrode,and battery levels,with a view to accelerating the development of conversion-type cathodes for high-energy–density SSLBs.

关键词： Sulfur compounds