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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui zhu Li Mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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Modified Liangfu granule exhibits anti-cancer effects in gastric cancer by regulating apoptosis-related proteins and genes

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Journal of Traditional Chinese Medical Sciences 2019年第4期6卷 325-330页

作者： Ya Li Lingqun zhu fengqin Shi Ruibai Li Xinyi Chen Zhi Zheng Bin Qiu Li Hou Department of Oncology and Hematology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Key Laboratory of Chinese Internal Medicine of Educational Ministry and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Environmental Health Sciences Yale School of Public HealthYale UniversityNew HavenCT 06520USA Department of Internal Medicine 5th Division Jiangxi Cancer HospitalJiangxi Cancer CenterNanchang 330029China Department of Pharmacology Yale School of MedicineYale UniversityNew HavenCT 06520USA

Objective:To investigate the anti-cancer effects and mechanism of modified Liangfu granule(MLFG)in BGC-823 gastric cancer ***:The drug serum was extracted from abdominal aorta of Wistar rats treated by cyclophosphamide,dioscin,MLFG(high-,medium-,and low-dose),*** assay was performed to detect the effect of different concentrations of MLFG and dioscin on cell *** effect of MLFG on cellular apoptosis was detected by flow *** blot was used to examine Bcl-2 and Akt in BGC-823 cells treated with *** real-time polymerase chain reaction assay was performed to determine the expression level of caspase-3,E2F1 and E2F3 genes in cells treated by MLFG-and dioscin-containing ***:MLFG-and dioscin-containing serum inhibited the cell proliferation of BGC-823 *** induced gastric carcinoma cell apoptosis and inhibited the expression of Bcl-2 and Akt in a dosedependent *** also significantly induced the gene expression of caspase-3 and downregulated E2F1 and E2F3 gene ***:The effect of MLFG and dioscin on inhibiting cell proliferation and induction of apoptosis of gastric cancer cells might be related to the regulation of Bcl-2 and Akt proteins and the expression of caspase-3,E2F1 and E2F3 genes.

关键词： Modified Liangfu granule Gastric cancer Caspase-3 E2F1 E2F3

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SC-CO2与工业乳化炸药破岩效应的等效试验

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工程科学学报 2025年第2期47卷 249-258页

作者：蒋楠姚颖康朱斌罗学东江汉大学省部共建精细爆破国家重点实验室江汉大学爆破工程湖北省重点实验室中国地质大学(武汉)工程学院

如何定量化核算SC-CO2（超临界二氧化碳）破岩效率是非炸药类破岩技术在实际工程应用时重点关注的内容.本研究基于爆破当量理论计算和现场爆破试验的研究方法，通过工程类比法进行工业乳化炸药等效当量计算，选择典型代表性花岗岩及泥... 详细信息

如何定量化核算SC-CO2（超临界二氧化碳）破岩效率是非炸药类破岩技术在实际工程应用时重点关注的内容.本研究基于爆破当量理论计算和现场爆破试验的研究方法，通过工程类比法进行工业乳化炸药等效当量计算，选择典型代表性花岗岩及泥岩场地，设计进行了SC-CO2与工业炸药破岩效应等效对比现场试验；基于现场破岩等效现场试验测试数据，对比分析试验过程中SC-CO2与工业炸药破岩体积、破岩区域形态、大块率和单耗等破岩区域特征及参量数据.研究结果表明：当SC-CO2破岩体积较大时，其致裂破岩范围的长短轴较长，并且随着剪切片厚度的增加，泥岩场地二氧化碳单耗的下降速率增大，二氧化碳单耗是炸药单耗的6～11倍.SC-CO2破岩技术大块率较高，而炸药爆炸应力波分布均匀，大块率较小.SC-CO2破岩地表振速远小于工业炸药破岩，工业炸药爆破测点合振速值为SC-CO2破岩测点合振速值的9～11倍，SC-CO2破岩对周边环境震动影响较小.SC-CO2破岩测点合应力峰值高于工业炸药破岩，SC-CO2破岩试验中各测点合应力值为炸药破岩试验中对应测点值的1.2～1.6倍.

关键词： SC-CO2 工业炸药等效破岩动力效应破岩体积

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RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao Wang Bang Liu Yang-Pu Jia Zhao-Xiong Zhang Xin Liu Dao-Han Wang Yong-Jia Yan Wei-Hua Fu Feng zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

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FeCrNiCoCu合金疲劳性能及缺陷演变的分子动力学研究

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原子与分子物理学报 2025年第4期42卷 81-86页

作者：朱和军常州工业职业技术学院常州213164

疲劳失效是机械构件的重要失效形式之一,因此本文通过分子动力学模拟方法在应变量ε=0.08下,对高熵合金FeCrNiCoCu合金进行20次循环加载模拟,以探究了高熵合金FeCrNiCoCu合金的疲劳力学性能和组织演变.结果发现,在循环加载过程中,FeCrNi... 详细信息

疲劳失效是机械构件的重要失效形式之一,因此本文通过分子动力学模拟方法在应变量ε=0.08下,对高熵合金FeCrNiCoCu合金进行20次循环加载模拟,以探究了高熵合金FeCrNiCoCu合金的疲劳力学性能和组织演变.结果发现,在循环加载过程中,FeCrNiCoCu模型存在明显的循环软化和循环硬化现象,且循环软化和循环硬化交替出现.通过对模型组织分析发现每个循环周期结束后,有残余位错和层错,这些缺陷直接影响到下一周期的疲劳应力.通过对模型中总能量和无序原子百分比的统计分析可知,模型的总能量呈升高的趋势.模型中无序原子的百分比逐渐升高,最后稳定在0.09左右,无序原子对位错的生成和湮灭有直接的影响,进而影响循环硬化和循环软化.

关键词：循环加载分子动力学疲劳变形微观缺陷演化

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Determining method,conditional factors,traits and applications of nonlinear chemical fingerprint by using dissipative components in samples

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Science China Chemistry 2012年第9期55卷 285-303页

作者： ZHANG TaiMing ZHAO Zhe FANG XuanQi QIAO JunXi XIANG fengqin zhu Rong LIANG YiZeng DING Feng College of Chemistry and Chemical Engineering Central South University Changsha 410083 China Hunan Research Institute for Supervising and Verifying Food Quality Changsha 410002 China

The thermodynamic systems and dynamic model suitable for determining the nonlinear chemical fingerprints of samples were *** results indicated that the damp nonlinear chemical reactions in close systems away from the equilibrium and open systems without the complementarity of the dissipation substances have important significance for the throng characterization and whole content analysis of chemical components in *** factors influencing on nonlinear chemical fingerprint,such as reactant species and their concentrations,electrode types,temperature,stir rate,the sort,dosage and granularity of the sample,*** amply researched by a nonlinear chemistry reaction,namely,damp B-Z oscillation which used acetone and glucose as the main dissipative *** addition,the quantitative information on the whole of chemical components in samples and the traits and applications of the fingerprint were *** method and its important conditions for determining nonlinear chemistry fingerprint used in distinguishing and evaluating complex samples were successfully put forward.

关键词： nonlinear chemical fingerprint dissipative components in samples determining method condition factor authenticityidentification quality evaluation sample

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Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin Qi Huixian zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan Xin Cao Liang Chen Qianxing zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

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MEK1/2抑制剂PD98059对ox-LDL诱导HUVEC损伤的保护机制及对LOX-1表达影响

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重庆医学 2018年第13期47卷 1727-1730页

作者：孙珊胡红玲段晓宇吴钦钦贺映侠卜晓芬明小燕严凤琴朱虹华中科技大学同济医学院附属武汉中心医院综合二科武汉430022

目的探讨MEK1/2抑制剂PD98059对氧化型低密度脂蛋白(ox-LDL)诱导人脐静脉内皮细胞(HUVEC)损伤的保护机制及对低密度脂蛋白受体-1(LOX-1)表达的影响。方法使用ox-LDL诱导HUVEC损伤模型并进行PD98059处理,分阴性对照组、ox-LDL组、阳性对... 详细信息

目的探讨MEK1/2抑制剂PD98059对氧化型低密度脂蛋白(ox-LDL)诱导人脐静脉内皮细胞(HUVEC)损伤的保护机制及对低密度脂蛋白受体-1(LOX-1)表达的影响。方法使用ox-LDL诱导HUVEC损伤模型并进行PD98059处理,分阴性对照组、ox-LDL组、阳性对照组和PD98059+OX-LDL组;检测抑制MEK1/2对ox-LDL诱导HUVEC损伤的影响。结果与阴性对照组比较,ox-LDL组LOX-1、pMEK1/2、RhoA、ROCK1、ROCK2、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的释放增多,细胞增殖能力及培养液中一氧化氮(NO)水平降低(P<0.05);与ox-LDL组比较,阳性对照组和PD98059+ox-LDL组LOX-1、pMEK1/2、RhoA、ROCK1、ROCK2、TNF-α和IL-6的释放减少,细胞增殖能力及NO水平增高(P<0.05)。结论 PD98059抑制MEK1/2信号通路可降低HUVEC中LOX-1的表达以减轻ox-LDL诱导的内皮细胞损伤。

关键词：脂蛋白类 LDL 受体 LDL PD98059 MEK1/2 RhoA/ROCK

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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