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Lactoferrin-Conjugated Polylactic Acid Nanobubbles Encapsulated Perfluoropentane as a Contrast Agent for Ultrasound/Magnetic Resonance Dual-Modality Imaging

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Journal of Renewable Materials 2022年第3期10卷 767-780页

作者： Liqiong Ding Pingsheng Li Liu He fengnan xu Jieqiong Ding Binhua Luo School of Pharmacy Hubei University of Science and TechnologyXianning437100China Pharmacy Department of the Second Affiliated Hospital Hubei University of Science and TechnologyXianning437100China School of Basic Medical Sciences Hubei University of Science and TechnologyXianning437100China

The development of contrast agents that can be activated by multiple modes is of great significance for tumor *** this study,the lactoferrin(Lf)-conjugated polylactic acid(PLLA)nanobubbles(Lf-PLLA NBs)were used to encapsulate liquid perfluoropentane(PFP)with the double emulsion method,creating PFP loaded(PFP/Lf-PLLA)NBs for the ultrasound/magnetic resonance dual-modality imaging of subcutaneous *** parti-cle diameter and stability of nanobubbles were investigated by photon correlation *** biocompat-ibility of nanobubbles was preliminarily evaluated by cell proliferation and migration assay,hemolysis rate,and blood biochemistry analysis.A B-mode clinical ultrasound real-time imaging system was used to perform ultra-sonic imaging in *** resonance imaging in vivo was applied with a clinical 3.0 T magnetic resonance imaging(MRI)scanner *** mean particle diameter of PFP/Lf-PLLA NBs was 320.2±4.1 nm with a low polydispersity index(PDI,0.145±0.025),and the NBs were negatively charged(−11.4±0.4 mV).The transmis-sion electron microscopy(TEM)results showed that PFP/Lf-PLLA NBs exhibited highly monodispersed and pos-sessed an obvious spherical structure of *** had good stability at 4°*** concentrations of the PFP/Lf-PLLA NBs solution had no effect on the cell in cytotoxicity and cell migration,and the results of hemolysis rate and blood biochemistry assay also indicated the good biocompatibility of *** the ultrasound/magnetic resonance imaging of tumor-bearing mice,PFP/Lf-PLLA NBs showed signifi-cantly enhanced contrast ability of tumor ***,PFP/Lf-PLLA NBs had great potential to be a contrast agent for tumor dual-modality imaging in vivo.

关键词： Lactoferrin polylactic acid nanobubbles contrast agent ultrasound/magnetic resonance imaging

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反渗透系统浓水回用的工厂实践

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上海环境科学 2024年第5期43卷 210-213页

作者：徐冯楠上海海立电器有限公司上海201206

工厂除盐水制取过程中会产生反渗透(RO)浓排水。基于RO浓水特点及水质情况,分析了收集后进入反渗透膜制成除盐水及再处理后用于盥洗冲厕、水处理药剂配制、以及洗衣房、班车、车间和厂区地面清洁等的可能性。结合生产长期的考核运行,发... 详细信息

工厂除盐水制取过程中会产生反渗透(RO)浓排水。基于RO浓水特点及水质情况,分析了收集后进入反渗透膜制成除盐水及再处理后用于盥洗冲厕、水处理药剂配制、以及洗衣房、班车、车间和厂区地面清洁等的可能性。结合生产长期的考核运行,发现反渗透系统浓排水回用于制成除盐水未造成管道结垢,在降低用水成本的同时可减少废水的排放,实现节水减排。

关键词：反渗透浓排水回用水处理

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酸-菌-酶法处理黄姜皂素生产废渣的工艺

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西北农业学报 2010年第7期19卷 196-201页

作者：李美秀呼世斌王燕洁徐冯楠西北农林科技大学资源环境学院陕西杨凌712100 西北农林科技大学理学院陕西杨凌712100

通过正交试验,考察了酸-菌-酶法共降解黄姜皂素生产废渣的最佳糖化工艺条件。结果表明,皂素生产废渣先进行酸水解,再利用黄孢原毛平革菌对其中的木质素进行降解,最后进行酒精酶水解,得到这种酸-菌-酶法糖化工艺的最优条件为,蒸汽处理后... 详细信息

通过正交试验,考察了酸-菌-酶法共降解黄姜皂素生产废渣的最佳糖化工艺条件。结果表明,皂素生产废渣先进行酸水解,再利用黄孢原毛平革菌对其中的木质素进行降解,最后进行酒精酶水解,得到这种酸-菌-酶法糖化工艺的最优条件为,蒸汽处理后的废渣先经液固比20∶1、稀硫酸(w=4%)、100℃的条件下酸水解120 min;再于30℃、pH6、加菌量100 mL.L-1的培养条件下利用黄孢原毛平革菌(Phanerochaete chry-sosporium)降解4 d;最后在酶用量0.9 mL、温度为50℃、pH4.8的工艺条件下酶解100 min。黄姜皂素废渣经该条件处理后,木质素去除率达42.82%,还原糖得率最高达59.72%,比采用酸-酶法水解后的还原糖得率提高了25.62%。这种酸-菌-酶法结合工艺可以更有效地降解皂素生产废渣,得到较高的还原糖量。

关键词：皂素生产废渣酸-菌-酶法糖化还原糖

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生活服务类App界面的适老化设计研究

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艺术与设计（理论版） 2024年第8期 42-44页

作者：张天爽许枫楠沈阳建筑大学设计艺术学院沈阳110000

生活服务类App为我们的生活带来便利。近年来由于人口老龄化的加剧,大龄用户使用生活服务类App的比例逐渐增高,由于老年人的生理、思维特点不同于青年人,操作手机App一直是困扰大龄用户的难题,UI设计适老化改造逐渐引起广泛重视。美团... 详细信息

生活服务类App为我们的生活带来便利。近年来由于人口老龄化的加剧,大龄用户使用生活服务类App的比例逐渐增高,由于老年人的生理、思维特点不同于青年人,操作手机App一直是困扰大龄用户的难题,UI设计适老化改造逐渐引起广泛重视。美团等生活服务类App也推出了长辈版操作界面,但只限于外卖板块,功能板块的不完整使得大龄用户暂时无法享用平台的全部服务,导致大龄用户在使用其他板块上不得不启用App的常规版本去进行操作。文章针对此类问题,试图在UI设计的设计配色、文字排版、控件图标、交互结构4个方面切入,通过社会调研,根据大龄用户自身特点、操作难点,对生活服务类App新版块开发的UI设计提出新思路和优化方案,从而实现产品功能与大龄用户的进一步适配。

关键词：老年人 UI设计生活服务类App 适老化

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Enantio-divergent C–H borylation with two different ligands from a single chiral source

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Science China Chemistry 2025年第1期68卷 226-232页

作者： Rongrong Du Senmiao xu State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University of Chinese Academy of Sciences

Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

关键词： asymmetric catalysis C–H borylation all-carbon quaternary stereocenters synthetic methods

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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-Fu xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia Rui Mao Xiang Cao Yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Applications of in-situ solid-state nuclear magnetic resonance in methanol to olefins reaction

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Science China Chemistry 2025年第1期68卷 134-151页

作者： Jing Niu Shutao xu Yingxu Wei Zhongmin Liu National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of Sciences State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

The methanol-to-olefins（MTO） reaction offers an alternative pathway for the production of low-carbon olefins from non-oil feedstocks. Fundamental research has been impeded by a lack of comprehensive understanding of its underlying mechanism,despite the significant progress made in industry. In-situ solid-state nuclear magnetic resonance（ss NMR） spectroscopy has emerged as a pivotal tool, offering crucial insights into key species under real-time operando conditions. Furthermore, the host–guest interaction between zeolites or surface species residing on zeolites and the reactant/active intermediates is revealed by the combination of in-situ13C MAS NMR and 2D correlation spectroscopy. Moreover, recent technological advancements in hyperpolarization（HP） methods, including HP129Xe NMR and dynamic nuclear polarization（DNP）, have significantly improved the sensitivity of ss NMR, enabling detailed structural and kinetic analysis as well as the detection of trace species. In this feature article, we summarized recent advancements in（in-situ） ss NMR spectroscopy applied to MTO reaction processes,encompassing mechanistic investigations at various stages and the intricate host–guest interactions. These theoretical insights into the dynamic evolution of MTO reactions lay a solid foundation for the optimization of catalytic processes and the development of efficient catalysts, thereby advancing the techniques towards more sustainable and economical production route for olefins.

关键词： MTO zeolites in-situ ssNMR reactive intermediates reaction mechanism

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高效石油降解菌的筛选及其降解性能研究

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生物技术通报 2010年第7期26卷 221-226页

作者：徐冯楠冯贵颖马雯王军玲李美秀王燕洁呼世斌西北农林科技大学资源与环境学院杨凌712100 西北农林科技大学理学院杨凌712100 西北农林科技大学生命科学学院杨凌712100

从长期被石油污染的土壤中驯化筛选、分离出2株高效石油降解菌Y-7和Y-9,通过形态学特征的观察和生理生化试验对其进行初步鉴定,鉴定结果分别为假单胞菌属(Pseudomonas sp.)和芽孢杆菌属(Bacillus sp.)。同时,研究并分析了不同pH、温度... 详细信息

从长期被石油污染的土壤中驯化筛选、分离出2株高效石油降解菌Y-7和Y-9,通过形态学特征的观察和生理生化试验对其进行初步鉴定,鉴定结果分别为假单胞菌属(Pseudomonas sp.)和芽孢杆菌属(Bacillus sp.)。同时,研究并分析了不同pH、温度、初始石油浓度、接种量、吐温80等条件对菌体生长和石油降解率的影响。结果表明,在试验条件下,2株优势菌在初始pH为7左右,对石油的降解率可分别高达68.7%,74.5%,偏酸或偏碱的环境均不利于菌体的生长;培养温度对2株菌体生长和石油降解率的影响较大,最佳温度为35℃,降解率达到最大,分别为73.1%和69.6%;石油初始浓度大于0.4g/L时,Y-7降油率从69%降到49%,Y-9基本变化不大,控制石油物质浓度在0.4g/L,有利于对石油的生物处理;最佳接种量为2mL/L;吐温80对石油的降解促进作用有待进一步分析与研究。

关键词：石油降解菌筛选假单胞菌芽孢杆菌

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