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Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell(cDC1)activation and tumor infiltration

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2804-2818页

作者： fenglian he Zhongen Wu Chenglong Liu Yuanyuan Zhu Yan Zhou Enming Tian Rina Rosin-Arbesfeld Dehua Yang Ming-Wei Wang Di Zhu Department of Pharmacology Minhang Hospitaland Key Laboratory of Smart Drug DeliveryShanghai Engineering Research Center of Immune TherapySchool of PharmacyFudan UniversityShanghai 201203China The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences(CAS)Shanghai 201203China Department of Microbiology and Immunology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources SanyaChina Department of Chemistry School of ScienceThe University of TokyoTokyoJapan Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education School of PharmacyHainan Medical UniversityHaikouChina Shandong Academy of Pharmaceutical Science JinanChina

Conventional type 1 dendritic cells(cDC1)are the essential antigen-presenting DC subset in antitumor *** B-cell lymphoma 9 and B-cell lymphoma 9-like(BCL9/BCL9L)inhibits tumor growth and boosts immune responses against ***,whether oncogenic BCL9/BCL9L impairs antigen presentation in tumors is still not completely ***,we show that targeting BCL9/BCL9L enhanced antigen presentation by stimulating cDC1 activation and infiltration into *** inhibition of BCL9/BCL9L with a novel inhibitor hsBCL9z96 or Bcl9/Bcl9l knockout mice markedly delayed tumor growth and promoted antitumor CD8^(+)T cell ***,targeting BCL9/BCL9L promoted antigen presentation in *** is due to the increase of cDC1 activation and tumor infiltration by the XCL1-XCR1 ***,using single-cell transcriptomics analysis,we found that Bcl9/Bcl9l deficient cDC1 were superior to wild-type(WT)cDC1 at activation and antigen presentation via NF-κB/IRF1 ***,we demonstrate that targeting BCL9/BCL9L plays a crucial role in cDC1-modulated antigen presentation of tumor-derived antigens,as well as CD8^(+)T cell activation and tumor *** BCL9/BCL9L to regulate cDC1 function and directly orchestrate a positive feedback loop necessary for optimal antitumor immunity could serve as a potential strategy to counter immune suppression and enhance cancer immunotherapy.

关键词： immunity Targeting markedly

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Optimization for sound insulation of a sandwich plate with a corrugation and auxetic honeycomb hybrid core

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Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1595-1612页

作者： fenglian LI Yiping WANG Yuxing ZOU School of Mechanical and Electrical Engineering Beijing Information Science and Technology UniversityBeijing 100192China

A sandwich plate with a corrugation and auxetic honeycomb hybrid core is constructed,and its sound insulation and optimization are ***,the motion governing equation of the sandwich plate is established by the third-order shear deformation theory(TSDT),and then combined with the fluid-structure coupling conditions,and the sound insulation is *** theoretical results are validated by COMSOL simulation results,and the effects of the structural parameter on the sound insulation are ***,the standard genetic algorithm is adopted to optimize the sound insulation of the sandwich plate.

关键词： optimization sound insulation hybrid core layer genetic algorithm

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BCL9 regulates CD226 and CD96 checkpoints in CD8^(+)T cells to improve PD-1 response in cancer

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2883-2896页

作者： Mei Feng Zhongen Wu Yan Zhou Zhuang Wei Enming Tian Shenglin Mei Yuanyuan Zhu Chenglong Liu fenglian he Huiyu Li Cao Xie Joy Jin Jibin Dong Dehua Yang Ker Yu Junbin Qian Diether Lambrechts Ming-Wei Wang Di Zhu Department of Pharmacology School of Basic Medical Sciences and School of PharmacyFudan UniversityShanghaiChina School of Pharmacy Fudan UniversityShanghaiChina Key Laboratory of Systems Biology Innovation Center for Cell Signaling NetworkCAS Center for Excellence in Molecular Cell ScienceInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina Clinical Translational Research Center Shanghai Pulmonary HospitalSchool of Life Science and TechnologyTongji UniversityShanghaiChina School of Medicine University of California at San FranciscoSan FranciscoCAUSA Department of Gynecologic Oncology Women's HospitalZhejiang University School of MedicineHangzhouChina VIB Center for Cancer Biology and Laboratory for Translational Genetics Department of Human GeneticsKU LeuvenLeuvenBelgium School of Life Science and Technology ShanghaiTech UniversityShanghaiChina The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences(CAS)ShanghaiChina Shanghai Engineering Research Center of Immune Therapy and Key Laboratory of Smart Drug Delivery Fudan UniversityShanghaiChina

To date,the overall response rate of PD-1 blockade remains unsatisfactory,partially due to limited understanding of tumor immune microenvironment(TIME).B-cell lymphoma 9(BCL9),a key transcription co-activator of the Wnt pathway,is highly expressed in *** genetic depletion and pharmacological inhibition of BCL9 in tumors,we found that BCL9 suppression reduced tumor growth.

关键词： BCL tumor CD226

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1629株医院感染致病菌的构成及对药物敏感性分析

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安徽医科大学学报 2010年第1期45卷 106-108页

作者：赵卉何凤莲安徽医科大学第二附属医院呼吸内科合肥230601

目的探讨1629株医院感染致病菌的构成及对药物敏感性分析,为治疗感染性疾病提供参考依据。方法回顾性分析1629株临床标本病原菌构成及对的敏感性,采用WalkAway-40全自动细菌鉴定及药敏测试仪以及NC31鉴定板进行了分析。结果共检出细菌1... 详细信息

目的探讨1629株医院感染致病菌的构成及对药物敏感性分析,为治疗感染性疾病提供参考依据。方法回顾性分析1629株临床标本病原菌构成及对的敏感性,采用WalkAway-40全自动细菌鉴定及药敏测试仪以及NC31鉴定板进行了分析。结果共检出细菌1629株,革兰阴性杆菌占59.9%,革兰阳性球菌占40.1%,常见病原菌为铜绿假单胞菌(169株)、大肠埃希菌(165株)、表皮葡萄球菌(161株)、肺炎克雷伯菌(151株)、金黄色葡萄球菌(135株)、阴沟肠杆菌(79株)、鲍曼/溶血不动杆菌(76株)、溶血葡萄球菌(86株)和嗜麦芽窄食单胞菌(57株)。细菌对抗生素均呈不同程度耐药,敏感株所占比例极少,但尚未检出耐万古霉素葡萄球菌和肠球菌,革兰阴性杆菌(除嗜麦芽单胞菌外)中对亚胺培南耐药率最低。结论细菌构成与国内其他地区相近,常见细菌对多种抗生素的敏感性均较低,建议临床根据药敏结果选用抗生素,以期减少耐药菌株产生。

关键词：微生物敏感性试验抗药理,微生物交叉感染

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The Characteristics and Driving Factors of the Spatio-temporal Dynamic Evolution of Tourism Ecological Security in the Silk Road Economic Belt

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Journal of Resources and Ecology 2024年第4期15卷 1054-1067页

作者： WANG Shu LIU fenglian YANG Lei CAI Wei Institute of Land&Resources and Sustainable Development Yunnan University of Finance and EconomicsKunming 650221China Institute of Economic Research Yunnan University of Finance and EconomicsKunming 650221China

The exploration of ecological safety in tourism sites can provide a concrete path for sustainable tourism development in a *** on the“Driver-Pressure-State-Impact-Response”(DPSIR)model,we constructed an index system for the evaluation of tourism ecological security(TES)in the Silk Road Economic Belt(SREB)from 2005 to *** index system was used to explore the characteristics of spatial and temporal dynamic evolution with the help of entropy weight TOPSIS method,dynamic index of TES and Markov probability transfer matrix,and a standard deviational ellipse(SDE)model and GM(1,1)model were constructed for spatial pattern analysis and *** results indicate four key aspects of this system.(1)In terms of spatiotemporal evolution,the tourism ecological safety index(TESI)of the SREB increased,the TES levels of the northwestern and southwestern provinces and cities differed significantly,and the quality conditions of TES in the southwestern provinces and cities were better than in the northwest.(2)In terms of dynamic evolutionary characteristics,the speed of change at each level of the SREB was slow,but the level of TES has *** TES level has not shifted by leaps and bounds,and the shifts in the level type show“path dependence”and“self-locking”effects.(3)In terms of spatial and temporal distribution patterns,the spatial pattern of TES in the SREB is a“northwest-southeast”movement trend,and the spatial distribution appeared as“aggregation”from 2005 to *** prediction results show that the center of gravity of TES in the SREB will shift to the southeast from 2025 to 2035,and the spatial spillover effect will be reduced.(4)In terms of driving factors,the number of star-rated hotels,and the amounts of industrial wastewater emissions,tourism foreign exchange earnings,forest coverage,and other parameters are the key factors affecting TES,and the booming tourism industry requires the interconnection and interpenetration of various *** resul

关键词： tourism ecological security spatial-temporal evolution drivers Geo-detector the Silk Road Economic Belt

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Clinical Analysis of Terbutaline and Budesonide Co-Treatment for Chronic Obstructive Pulmonary Disease

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Journal of Clinical and Nursing Research 2024年第4期8卷 311-315页

作者： fenglian Hu Chaoquan Town health Center Feicheng 271614Shandong ProvinceChina

Objective: To analyze the clinical effect of terbutaline combined with budesonide in the treatment of chronic obstructive pulmonary disease. Methods: 500 cases of patients with chronic obstructive pulmonary disease admitted to the hospital from January 2022 to December 2023 were selected and divided into 250 cases in the control group and 250 cases in the observation group by randomization method, both groups received conventional symptomatic treatment, with budesonide added to the control group and terbutaline and budesonide to the observation group, and the lung function indexes, therapeutic effects and adverse drug reactions before and after treatment were compared. Results: After treatment, the level of all lung function indexes of patients in the observation group was higher than that of the control group, and the level of total effective rate of treatment was 96.40%, which was higher than that of the control group (P he difference in the incidence rate of adverse reactions between the two groups was not strong (P > 0.05). Conclusion: In the clinical treatment of chronic obstructive pulmonary disease, the combined use of terbutaline and budesonide can positively improve lung function, with precise effects and few adverse reactions.

关键词： Chronic obstructive pulmonary disease Terbutaline Budesonide

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多发性硬化患者隐匿性损伤的预防性护理

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护士进修杂志 2008年第22期23卷 2052-2053页

作者：何凤莲王玉珍黄鹤宁夏自治区中卫市第二人民医院宁夏中卫751700 兰州大学第二医院甘肃兰州730030

目的回顾分析30例多发性硬化(MS)隐匿性损伤患者的护理体会,评价个性化预防护理对减轻MS隐匿性损伤的价值。方法对30例确诊为MS隐匿性损伤病例,结合临床症状、电生理生化检查及影像学表现,对潜在的隐匿性损伤患者以整体护理为基础,采取... 详细信息

目的回顾分析30例多发性硬化(MS)隐匿性损伤患者的护理体会,评价个性化预防护理对减轻MS隐匿性损伤的价值。方法对30例确诊为MS隐匿性损伤病例,结合临床症状、电生理生化检查及影像学表现,对潜在的隐匿性损伤患者以整体护理为基础,采取个性化预防护理方案措施,评价患者预后。结果27例MS患者整体预后良好,影像、生化及电生理指标趋于稳定或表现正常,视力、肢体运动功能恢复,病情稳定,无复发迹象;所有病例无药物性毒副作用发生,3例患者出现病情的反复、加重。结论临床预防性及综合性个体化护理对减轻MS并发症和隐匿性损伤的程度有现实的指导意义。

关键词：多发性硬化隐匿性损伤护理

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CARD11 serves as a therapeutic biomarker for the drug therapies of ccRCC

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BIOCELL 2024年第5期48卷 817-834页

作者： KAIWEN TIAN HANZHONG CheN QIANQIAN WANG fenglian JIANG CHUNXIANG FENG TENG LI XIAOYONG PU YANLIN TANG JIUMIN LIU Department of Urology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510080China

Background:The incidence of clear cell renal cell carcinoma(ccRCC)is globally high;however,despite the introduction of innovative drug therapies,there remains a lack of effective biomarkers for evaluating treatment ***,Caspase recruiting domain-containing protein 11(CARD11)has garnered attention due to its significant association with tumor development and the immune ***:The expression of CARD11 mRNA and protein in ccRCC were analyzed by public database and *** focus of this study is on the epigenomic modifications of CARD11,its expression of ccRCC immunophenotype,and its correlation with response to immunotherapy and targeted ***,to investigate the mechanism of this molecule’s influence on different biological behaviors of cells,cell tests in vitro have been conducted to observe the impact of its expression ***:CARD11 expression was upregulated which may be mainly modified by body methylation and was correlated with poor prognosis in *** the tumor microenvironment of ccRCC,CARD11 expression was positively correlated with increased T lymphocyte infiltration and increased expression of inhibitory immune ***,ccRCC patients with high CARD11 expression had a better response to immunotherapy and targeted *** knockdown of CARD11 ultimately suppressed the proliferation,migration,and invasion capabilities of ccRCC cells while simultaneously enhancing tumor cell ***:We identified CARD11 as a novel therapeutic biomarker for immunotherapy and targeted therapy in ccRCC.

关键词： Clear cell renal cell carcinoma Tumor microenvironment CARD11 Immune checkpoint inhibitor Tyrosine kinase inhibitor

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Solution processable organic molecule photovoltaic materials containing triphenylamine and with D-A-D structure

Solution processable organic molecule photovoltaic materials...

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The 9th China-Japan Joint Symposium on Conduction and Photoconduction in Organic Solids and Related Phenomena

作者： Chang he Qingguo he fenglian Bai Yongfang Li CAS Key Laboratory of Organic Solids,Center for Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100080,China

Organic and polymer solar cells,based on the blend of organic molecules/polymers as donor and soluble C derivative PCBM as acceptor,have attracted great attentions in recent years due to the importance of utilizing solar energy and their advantages of easy fabrication, low cost and light weight in comparison with their inorganic *** the viewpoints of fabrication cost of the devices and purity control of the materials,development of solution processable organic photovoltaic compounds is important for the organic solar cells（OSCs）.

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类案类判:道德应当还是法律应当

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中州学刊 2024年第3期 64-73页

作者：彭凤莲安庆师范大学安徽安庆246011

类案类判具有法律应当与道德应当的双重属性,将其定位于纯粹的道德应当或法律应当面临诸多困境。因此,我们有必要在理论构造层面构建两者之间的协同实现机制,探求类案类判在司法实践中的实现规程。总体而言,法律应当优先于道德应当是较... 详细信息

类案类判具有法律应当与道德应当的双重属性,将其定位于纯粹的道德应当或法律应当面临诸多困境。因此,我们有必要在理论构造层面构建两者之间的协同实现机制,探求类案类判在司法实践中的实现规程。总体而言,法律应当优先于道德应当是较为现实的选择,也是形式正义的基本要求,但法律应当优先并不当然否定法官道德应当的反思精神。道德应当是实现实质正义必不可少的重要环节,在时势变更、法律修订等特殊情形下,道德应当的地位需优于法律应当。具体而言,在理论构造层面要坚持法律应当优先前提下的道德应当优先的兼顾;在实践层面要坚持道德应当指导下的法律应当制度化推进。

关键词：类案类判案例指导制度道德应当法律应当习近平法治思想

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