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World Journal of Clinical Cases 2024年第11期12卷 1967-1973页

作者： Guang-Di Zhou qin Li Affiliated to Shanghai Jiao Tong University School of Medicine Xinhua HospitalShanghai 200092China Department of Obstetrics and Gynecology Shanghai Changhai HospitalShanghai 200433China

BACKGROUND Ovarian cancer is the most common malignant tumor of the female reproductive system,and the survival rate of patients with relapsed and refractory ovarian cancer is very low.CASE SUMMARY Here,we report a case of high-grade serous papillary adenocarcinoma of the ovary that was successfully treated with immunotherapy.Radical surgery and adjuvant chemotherapy for the 56-year-old patient were successful;however,her tumor relapsed.Subsequent second-line chemotherapy,targeted agents,and other treatments were ineffective,as the tumor continued to recur and metastasize.Anti-programmed cell death-1(PD-1)monotherapy(tislelizumab)completely alleviated the tumor,and the multiple metastatic tumors disappeared.To date,the patient has used anti-PD-1 for 32 months,experiencing no disease progression and maintaining good health without additional treatment.CONCLUSION This case suggests that anti-PD-1 immunotherapy may have long-term positive effects on outcomes in some refractory recurrent solid tumors.Further research is needed to identify patients most likely to respond to anti-PD-1 therapy.

关键词： Anti-programmed cell death-1 Tislelizumab Ovarian cancer Relapsed cancer treatment Immunotherapy Case report

Apatite Fission-Track Thermochronology in the Tamusu Area,Bayingobi Basin,NW China,and its Geological Significance

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 585-601页

作者： TONG qinlong qin Mingkuan YE Fawang CNNC Beijing Research Institute of Uranium Geology National Key Laboratory of Remote Sensing Information and Image Analysis TechnologyBeijing 100029China

The Bayingobi basin is located in the middle of Central Asia Orogenic Belt,at the intersection of Paleo-Asian Ocean and Tethys Ocean,as well as the junction of multiple tectonic plates.This unique tectonic setting underpins the basin's intricate history of tectonic activity.To unravel the multifaceted tectono-thermal evolution within the southwestern region of the basin and to elucidate the implications of sandstone-hosted uranium mineralization,granitic and clastic rock samples were collected from the Zongnai Mts.uplift and Yingejing depression,and apatite fission track(AFT)dating and thermal history simulation analysis were performed.AFT dating findings reveal that the apparent ages of all samples fall within the range of 244 Ma to 112 Ma.In particular,the bedrock of the Zongnai Mts.and Jurassic detrital apatite fission tracks have undergone complete annealing,capturing the uplift-cooling age.Meanwhile,the AFT ages of Cretaceous detrital rocks are either equivalent to or notably exceed the age of sedimentary strata,signifying the cooling age of the provenance.A comprehensive examination of AFT ages and palaeocurrent direction analyses suggests that the Cretaceous source in the Tamusu area predominantly originated from the central and southern sectors of the Zongnai Mts.uplift.However,at a certain juncture during the Late Early Cretaceous,the Cretaceous provenance expanded to include the northern part of the Zongnai Mts.uplift.Based on the results of thermal history simulations and previous studies,it is considered that the Tamusu area has undergone four distinct tectonic uplift events since the Late Paleozoic.The first is the Late Permian to Early Triassic(260-240 Ma),which is associated with the closure of the Paleo-Asian Ocean and the accretionary orogeny within the Alxa region.The second uplift event took place in the Early Jurassic(190-175 Ma)and corresponded to intraplate orogeny following the closure of the Paleo-Asian Ocean.The third uplift event is the Late Jurassic to Early Cretaceous(160-120 Ma),which

关键词： apatite fission-track tectono-thermal history sandstone-hosted uranium deposit Bayingobi basin Central Asian Orogenic Belt

SHARP POINTWISE-IN-TIME ERROR ESTIMATE OF L1 SCHEME FOR NONLINEAR SUBDIFFUSION EQUATIONS

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Journal of Computational Mathematics 2024年第3期42卷 662-678页

作者： Dongfang Li Hongyu qin Jiwei Zhang School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Modeling and Scientific Computing Huazhong University of Science and TechnologyWuhan 430074China School of Mathematics and Statistics Wuhan UniversityWuhan 430072China

An essential feature of the subdiffusion equations with theα-order time fractional derivative is the weak singularity at the initial time.The weak regularity of the solution is usually characterized by a regularity parameterσ∈(0,1)∪(1,2).Under this general regularity assumption,we present a rigorous analysis for the truncation errors and develop a new tool to obtain the stability results,i.e.,a refined discrete fractional-type Grönwall inequality(DFGI).After that,we obtain the pointwise-in-time error estimate of the widely used L1 scheme for nonlinear subdiffusion equations.The present results fill the gap on some interesting convergence results of L1 scheme onσ∈(0,α)∪(α,1)∪(1,2].Numerical experiments are provided to demonstrate the effectiveness of our theoretical analysis.

关键词： Sharp pointwise-in-time error estimate Ll scheme Nonlinear subdiffusion equations Non-smooth solutions

On entire solutions of some Fermat type differential-difference equations

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 69-88页

作者： LONG Jian-ren qin Da-zhuan School of Mathematical Sciences Guizhou Normal UniversityGuiyang 550025China

On one hand,we study the existence of transcendental entire solutions with finite order of the Fermat type difference equations.On the other hand,we also investigate the existence and growth of solutions of nonlinear ... 详细信息

关键词： entire solutions differential-difference equations existence finite order

A Tri-mode of Mock-Walker Cells

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Advances in Atmospheric Sciences 2024年第4期41卷 671-679页

作者： Han qin Ji NIE Zhiyong MENG Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China China Meteorological Administration Tornado Key Laboratory Foshan 528061China

This work uses cloud-resolving simulations to study mock-Walker cells driven by a specified sea surface temperature(SST).The associated precipitation in the mock-Walker cells exhibits three different modes,including a single peak of precipitation over the SST maximum(mode 1),symmetric double peaks of precipitation straddling the SST maximum(mode 2),and a single peak of precipitation on one side of the SST maximum(mode 3).The three modes are caused by three distinct convective activity center migration traits.Analyses indicate that the virtual effect of water vapor plays an important role in differentiating the three modes.When the SST gradient is large,the virtual effect may be strong enough to overcome the temperature effect,generating a low-level low-pressure anomaly below the ascending branch of the Walker cell off the center.The results here highlight the importance of the virtual effect of water vapor and its interaction with convection and large-scale circulation in the Walker circulation.

关键词： Walker circulation cloud-resolving simulation virtual effect

Deep Video Harmonization by Improving Spatial-temporal Consistency

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Machine Intelligence Research 2024年第1期21卷 46-54页

作者： Xiuwen Chen Li Fang Long Ye qin Zhang Key Laboratory of Media Audio and Video Ministry of Education Communication University of ChinaBeijing 100024China

Video harmonization is an important step in video editing to achieve visual consistency by adjusting foreground appear-ances in both spatial and temporal dimensions.Previous methods always only harmonize on a single scale or ignore the inaccuracy of flow estimation,which leads to limited harmonization performance.In this work,we propose a novel architecture for video harmoniza-tion by making full use of spatiotemporal features and yield temporally consistent harmonized results.We introduce multiscale harmon-ization by using nonlocal similarity on each scale to make the foreground more consistent with the background.We also propose a fore-ground temporal aggregator to dynamically aggregate neighboring frames at the feature level to alleviate the effect of inaccurate estim-ated flow and ensure temporal consistency.The experimental results demonstrate the superiority of our method over other state-of-the-art methods in both quantitative and visual comparisons.

关键词： Harmonization temporal consistency video editing video composition nonlocal similarity

Parallelization strategies for resolved simulations of fluid-structure-particle interactions

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 857-872页

作者： Jianhua qin Fei LIAO Guodan DONG Xiaolei YANG The State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China Interdisciplinary Center for Fundamental and Frontier Sciences Nanjing University of Science and TechnologyJiangyin 214443Jiangsu ProvinceChina School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China School of Engineering Sciences University of Chinese Academy of SciencesBeijing 100049China

Fluid-structure-particle interactions in three spatial dimensions happen in many environmental and engineering flows.This paper presents the parallel algorithms for the hybrid diffuse and sharp interface immersed boundary(IB)method developed in our previous work.For the moving structure modeled using the sharp interface IB method,a recursive box method is developed for efficiently classifying the background grid nodes.For the particles modeled using the diffuse interface IB method,a‘master-slave’approach is adopted.For the particle-particle interaction(PPI)and particle-structure interaction(PSI),a fast algorithm for classifying the active and inactive Lagrangian points,which discretize the particle surface,is developed for the‘dry’contact approach.The results show that the proposed recursive box method can reduce the classifying time from 52seconds to 0.3 seconds.Acceptable parallel efficiency is obtained for cases with different particle concentrations.Furthermore,the lubrication model is utilized when a particle approaches a wall,enabling an accurate simulation of the rebounding phenomena in the benchmark particle-wall collision problem.At last,the capability of the proposed computational framework is demonstrated by simulating particle-laden turbulent channel flows with rough walls.

关键词： particle-resolved direct numerical simulation particle-laden flow complex geometry resolved fluid-structure-particle interaction(RFSPI) immersed boundary(IB)method

Inorganic ionic polymerization:From biomineralization to materials manufacturing

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Nano Research 2024年第2期17卷 550-569页

作者： Yanhua Sang Kexin qin Ruikang Tang Zhaoming Liu Department of Chemistry Zhejiang UniversityHangzhou 310058China

Biomineralization process regulates the growth of inorganic minerals by complex molecules,proteins,and cells,endowing bio-materials with marvels structures and excellent properties.The intricate structures and compositions found in biominerals have inspired scientists to design and synthesize numerous artificial biomimetic materials.The methodology for controlling the formation of inorganics plays a pivotal role in achieving biomimetic structures and compositions.However,the current approach predominantly relies on the classical nucleation theory,which hinders the precise preparation of inorganic materials by replicating the biomineralization strategy.Recently,the development of“inorganic ionic polymerization”strategy has enabled us to regulate the arrangement of inorganic ions from solution to solid phase,which establishes an artificial way to produce inorganic materials analogous to the biomineralization process.Based on inorganic ionic polymerization,a series of achievements have been realized for the biomimetic preparation,including moldable construction of inorganic materials,hard tissue regeneration,and high-performance biomimetic materials.Moreover,the utilization of inorganic ionic polymerization has also facilitated the production of numerous advanced materials,including novel structures that exceed the current knowledge of materials science.The inorganic ionic polymerization system provides new artificial strategies and methodologies for the controllable synthesis of inorganics,which mimics the biomineralization process,paving the way for the future development of more high-performance materials.

关键词： biomineralization inorganic ionic polymerization biomimetic materials crystal growth synthetic methodology

Capturability-based Fuzzy Footstep Planner for a Biped Robot with Centroidal Compliance

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Journal of Bionic Engineering 2024年第1期21卷 84-100页

作者： Zihan Xu qin Fang Yong Ren Chengju Liu Robot and Artificial Intelligence Lab(RAIL) College of Electronic and Information EngineeringTongji UniversityShanghai 201804China Applied Technology College Soochow UniversitySuzhou 215000China

Compliance motion and footstep adjustment are active balance control strategies from learning human subconscious behaviors.The force estimation without direct end-actuator force measurement and the optimal footsteps based on complex analytical calculation are still challenging tasks for elementary and kid-size position-controlled robots.In this paper,an online compliant controller with Gravity Projection Observer(GPO),which can express the external force condition of perturbations by the estimated Projection of Gravity(PoG)with estimation covariance,is proposed for the realization of disturbance absorption,with which the robustness of the humanoid contact with environments can be maintained.The fuzzy footstep planner based on capturability analysis is proposed,and the Model Predictive Control(MPC)is applied to generate the desired steps.The fuzzification rules are well-designed and give the corresponding control output responding to complex and changeable external disturbances.To validate the presented methods,a series of experiments on a real humanoid robot are conducted.The results verify the effectiveness of the proposed balance control framework.

关键词： Biped walking Centroidal compliance Gravity projection observer Fuzzy footstep planner

Constitutive modelling of concrete material subjected to low-velocity projectile impact:insights into damage mechanism and target resistance

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第2期25卷 161-182页

作者： Shen LIU Xieping HUANG Xiangzhen KONG qin FANG Center for Hypergravity Experiment and Interdisciplinary Research Zhejiang UniversityHangzhou310058China Institute of Geotechnical Engineering Zhejiang UniversityHangzhou310058China State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing210007China

This paper presents a numerical study to improve the understanding of the complex subject of penetration and perforation of concrete targets impacted by low-velocity projectiles.The main focus is on the damage mechanisms and the major factors that account for the target resistance of the concrete.An improved continuous surface cap model recently proposed was employed.The model was first equipped with element erosion criteria and was adequately validated by comparisons with ballistic experiments.Comprehensive numerical simulations were carried out where the individual influence of tensile,shear,and volumetric behaviors(pore collapse)of a concrete target on its ballistic performance was investigated.Results demonstrated that cratering on the front face and scabbing on the rear face of the concrete target were mainly dominated by its tensile behavior.The major target resistance came from the second tunneling stage which was primarily governed by the shear and volumetric behaviors of the concrete.Particularly,this study captured the pore collapse-induced damage phenomenon during the high-pressure tunneling stage,which has been extensively reported in experiments but has usually been neglected in previous numerical investigations.

关键词： Penetration Perforation Damage mechanism Target resistance Projectile impact Pore collapse