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REDH:A database of RNA editome in hematopoietic differentiation and malignancy

Chinese Medical Journal 2024年第3期137卷 283-293页

作者： Jiayue Xu Jiahuan He Jiabin Yang fengjiao wang Yue Huo Yuehong Guo Yanmin Si Yufeng Gao Fang wang Hui Cheng Tao Cheng Jia Yu Xiaoshuang wang Yanni Ma State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemInstitute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical SciencesBeijing 100005China Department of Biochemistry and Molecular Biology Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Institute of Blood Transfusion Chinese Academy of Medical SciencesChengduSichuan 610052China

Background:The conversion of adenosine(A)to inosine(I)through deamination is the prevailing form of RNA editing,impacting numerous nuclear and cytoplasmic transcripts across various eukaryotic species.Millions of high-confidence RNA editing sites have been identified and integrated into various RNA databases,providing a convenient platform for the rapid identification of key drivers of cancer and potential therapeutic targets.However,the available database for integration of RNA editing in hematopoietic cells and hematopoietic malignancies is still lacking.Methods:We downloaded RNA sequencing(RNA-seq)data of 29 leukemia patients and 19 healthy donors from National Center for Biotechnology Information(NCBI)Gene Expression Omnibus(GEO)database,and RNA-seq data of 12 mouse hematopoietic cell populations obtained from our previous research were also used.We performed sequence alignment,identified RNA editing sites,and obtained characteristic editing sites related to normal hematopoietic development and abnormal editing sites associated with hematologic diseases.Results:We established a new database,"REDH",represents RNA editome in hematopoietic differentiation and malignancy.REDH is a curated database of associations between RNA editome and hematopoiesis.REDH integrates 30,796 editing sites from 12 murine adult hematopoietic cell populations and systematically characterizes more than 400,000 edited events in malignant hematopoietic samples from 48 cohorts(human).Through the Differentiation,Disease,Enrichment,and knowledge modules,each A-to-I editing site is systematically integrated,including its distribution throughout the genome,its clinical information(human sample),and functional editing sites under physiological and pathological conditions.Furthermore,REDH compares the similarities and differences of editing sites between different hematologic malignancies and healthy control.Conclusions:REDH is accessible at http://***/.This user-friendly database would aid in understanding the mechanisms of RNA editing in hema

关键词： RNA editing Hematopoietic differentiation Hematopoietic malignancy Database management systems

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Artificial intelligence recognition of pathological T stage and tumor invasion in rectal cancer based on large panoramic pathological sections

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Intelligent Medicine 2022年第3期2卷 141-151页

作者： Yiheng Ju Longbo Zheng Peng Zhao Fangjie Xin fengjiao wang Yuan Gao Xianxiang Zhang Dongsheng wang Yun Lu Department of General Surgery Medical CenterAffiliated Hospital of Qingdao UniversityQingdaoShandong 266000China Department of Pathology Affiliated Hospital of Qingdao UniversityQingdaoShandong 266000China Shandong Key Laboratory of Digital Medicine and Computer Assisted Surgery QingdaoShandong 266071China Hainan Branch of Affiliated Hospital of Qingdao University Lingshui Li Autonomous CountyHainan 572400China

Background The incidence of colorectal cancer is increasing worldwide,and it currently ranks third among all cancers.Moreover,pathological diagnosis is becoming increasingly arduous.Artificial intelligence has demon-strated the ability to fully excavate image features and assist doctors in making decisions.Large panoramic patho-logical sections contain considerable amounts of pathological information.In this study,we used large panoramic pathological sections to establish a deep learning model to assist pathologists in identifying cancerous areas on whole-slide images of rectal cancer,as well as for T staging and prognostic analysis.Methods We collected 126 cases of primary rectal cancer from the Affiliated Hospital of Qingdao University West Coast Hospital District(internal dataset)and 42 cases from Shinan and Laoshan Hospital District(external dataset)that had tissue surgically removed from January to September 2019.After sectioning,staining,and scanning,a total of 2350 hematoxylin-eosin-stained whole-slide images were obtained.The patients in the internal dataset were randomly divided into a training cohort(n=88)and a test cohort(n=38)at a ratio of 7:3.We chose DeepLabV3+and ResNet50 as target models for our experiment.We used the Dice similarity coefficient,accuracy,sensitivity,specificity,receiver operating characteristic(ROC)curve,and area under the curve(AUC)to evaluate the performance of the artificial intelligence platform in the test set and validation set.Finally,we followed up patients and examined their prognosis and short-term survival to corroborate the value of T-staging investigations.Results In the test set,the accuracy of image segmentation was 95.8%,the Dice coefficient was 0.92,the accuracy of automatic T-staging recognition was 86%,and the ROC AUC value was 0.93.In the validation set,the accuracy of image segmentation was 95.3%,the Dice coefficient was 0.90,the accuracy of automatic classification was 85%,the ROC AUC value was 0.92,and the image analysis time was 0.2 s.There was a difference

关键词： Large panoramic pathological sections Rectal cancer Whole-slide imaging Deep learning Survival analysis

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Optimization of Casing Design Parameters to Mitigate Casing Failure Caused by Formation Slippage

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Structural Durability & Health Monitoring 2018年第2期12卷 85-98页

作者： Chaoyang Hu Chi Ai fengjiao wang Northeast Petroleum University DaqingHeilongjiangChina

There has been lack of work efforts on how to optimize cementing and completing parameters in order to prevent casing failure induced by formation slippage in pertroleum industry scope.Once the weak plane fails,the formation will become easily undertaken slippage across a large area along its interface.The plenty of horizontal planes of weakness in reservoir formations,as reported for a number of oilfields,can easily undertaken slippage once it fails.To address the problem,three-dimensional finite element models were established by taking into considerations the elastoplastic mechanical characteristics of both the casing and the near-wellbore rock.Two types of casing impairment scenarios were considered:Casing collapse(that causes tubing stuck in the well)and complete casing shear-off.In this study,the critical slip displacement of casing shear damage under both cemented and un-cemented conditions was calculated,and the critical displacement of casing with various wall thicknesses and steel grades was compared.A new cementing practice for the Daqing oilfield was then proposed by optimizing casing parameters according to API standards,and a new research method was also put forward by proposing new casing materials to effectively mitigate casing failure caused by formation slippage for the future.Modeling results indicate that the stress and deformation associated with casing in the un-cemented condition is more diffused and the critical slippage displacement is larger than that in the cemented condition.Therefore,the un-cemented condition is more effective in preventing casing shear failure and easier for casing repair,for the case of casing damage caused by formation shear slippage.Casing elongation is the key parameter of casing shear failure in the un-cemented condition.Lower grade casing exhibits a larger critical slippage displacement because of its higher elongation capacity under stress.Casing with lower grade and smaller thickness provides more advantages in preventing casing damage in formations abundant

关键词： Finite element casing design formation slippage casing failure

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压驱技术高压降吸附提高采收率机理

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石油学报 2024年第2期45卷 403-411页

作者：王凤娇徐贺刘义坤杜庆龙张栋东北石油大学提高油气采收率教育部重点实验室黑龙江大庆163318 大庆石油管理局博士后工作站黑龙江大庆163453 大庆油田有限责任公司勘探开发研究院黑龙江大庆163712

以大规模压裂为基础的"压驱"技术,应用于特高含水老油田取得了显著的提高采收率效果。为进一步明确压驱技术对压驱剂驱油效率的影响,对高压作用下其在储层多孔介质表面的吸附损耗展开研究。通过开展常压/高压动态吸附实验,对比分析压驱... 详细信息

以大规模压裂为基础的"压驱"技术,应用于特高含水老油田取得了显著的提高采收率效果。为进一步明确压驱技术对压驱剂驱油效率的影响,对高压作用下其在储层多孔介质表面的吸附损耗展开研究。通过开展常压/高压动态吸附实验,对比分析压驱过程压驱剂在岩心表面动态吸附量变化情况;结合常规压汞和扫描电镜测试,阐明了高压降吸附机理;通过反向压驱物理模拟实验,明确了高压降吸附作用对压驱提高采收率的影响。研究表明,压驱剂在岩心表面的动态吸附量随驱替压差升高而呈现降低趋势;驱替压差分别为0.5 MPa、1.0 MPa、1.5 MPa条件下,压驱剂在岩心表面的动态饱和吸附量分别可较驱替压差为0.1 MPa时降低40.67%、62.17%和72.38%;高压作用下岩心孔隙结构发生改变,平均孔隙半径增加,流体渗流阻力降低,渗流速度升高,压驱剂在岩心表面的动态饱和吸附量降低;高压降吸附作用可提高压驱剂驱油效率,为常压条件下的1.96倍;因此,压驱过程中高压作用可有效降低压驱剂在地层内的动态吸附量从而提高驱油效率。研究成果对压驱技术矿场应用阶段进一步提高采收率具有重要的指导意义。

关键词：压驱高压驱替动态吸附量孔隙半径分布提高采收率

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致密储层压驱焖井阶段渗吸机理分子模拟研究

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力学学报 2024年第6期56卷 1624-1634页

作者：王凤娇孟详昊刘义坤徐贺胡超洋东北石油大学提高油气采收率教育部重点实验室黑龙江大庆163318 大庆石油管理局博士后工作站黑龙江大庆163453 东北石油大学三亚海洋油气研究院海南三亚572025

针对致密储层开发中存在的天然地层能量衰减快、驱替相有效波及体积不足等难题,考虑将压驱与焖井相结合的高效开发技术应用于致密储层.基于分子动力学方法从微观作用力角度分析致密储层压驱渗吸机理,进行致密储层压驱过程溶质动态迁移表... 详细信息

针对致密储层开发中存在的天然地层能量衰减快、驱替相有效波及体积不足等难题,考虑将压驱与焖井相结合的高效开发技术应用于致密储层.基于分子动力学方法从微观作用力角度分析致密储层压驱渗吸机理,进行致密储层压驱过程溶质动态迁移表征,并从分子尺度对渗吸阶段进行划分.采用分子模拟方法,构建致密储层壁面-油相-驱替相三相体系,分别从体系弛豫特征、浓度分布及扩散能力和介质间相互作用能等方面分析常规水力压裂后常压驱替条件和压驱高压条件渗吸过程特征性差异,从分子尺度阐释致密储层压驱渗吸机理.研究表明:相对于常规压裂后驱替而言,压驱条件下,驱替相分子扩散系数提高20.06%,与孔隙壁面的相互作用能提高2.3倍;驱替相分子吸附层数增加,油相解吸效果更为明显,渗吸换油效率提高38.73%.此外,渗吸效率随储层温度变化的过程存在峰值,具有先上升后降低的特征;且受到壁面润湿性的影响,壁面亲水性越强渗吸效率越高.从分子尺度将焖井渗吸过程划分为3个阶段:水分子优先靠近壁面;驱替相流体与油相分子竞争吸附,将吸附态油相剥离为游离态,使其远离壁面;压驱液溶质分子进入初始油相范围,进一步置换油相,提高渗吸效率.压驱技术高压注入压驱剂可快速补充地层能量,扩大驱替相流体波及体积并提高洗油效率,在二者的协同作用下可大幅度提高渗吸驱油效率.该项研究可为致密储层高效开发提供理论参考.

关键词：致密储层压驱技术焖井渗吸机理分子动力学

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泄洪雾化现象及对边坡稳定性的影响

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四川水利 2024年第1期45卷 20-23页

作者：王凤娇成都理工大学环境与土木工程学院成都610059

泄洪雾化现象对水利水电工程的安全问题有着重要影响,它不仅会危害到水电枢纽的建筑,还可能诱发岸坡失稳。通过对泄洪雾化及雾化边坡相关文献的归纳,文章论述了泄洪雾化现象产生的原因及机理,总结了研究泄洪雾化现象的方法;并从雾化雨... 详细信息

泄洪雾化现象对水利水电工程的安全问题有着重要影响,它不仅会危害到水电枢纽的建筑,还可能诱发岸坡失稳。通过对泄洪雾化及雾化边坡相关文献的归纳,文章论述了泄洪雾化现象产生的原因及机理,总结了研究泄洪雾化现象的方法;并从雾化雨入渗的特点出发,从两方面阐述了雾化雨诱发边坡失稳的机理;总结了雾化边坡稳定性分析的两种方法——定性分析和定量分析,其中,把定量分析的相关研究凝练为三种方法;总结了用数值模拟计算雾化边坡稳定性的步骤。

关键词：泄洪雾化雾化边坡边坡稳定性数值模拟

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Multiomics comparison among populations of three plant sources of Amomi Fructus

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Horticulture Research 2023年第8期10卷 129-142页

作者： Xinlian Chen Shichao Sun Xiaoxu Han Cheng Li fengjiao wang Bao Nie Zhuangwei Hou Song Yang Jiaojiao Ji Ge Li Yanqian wang Xiaoyu Han Jianjun Yue Cui Li Wei Li Lixia Zhang Depo Yang Li wang School of Pharmaceutical Sciences Sun Yat-Sen University510006 GuangzhouChina Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural Sciences518120 ShenzhenChina Yunnan Key Laboratory of Southern Medicine Utilization Yunnan Branch Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences666100 JinghongChina School of Traditional Dai-Thai Medicine West Yunnan University of Applied Sciences666100 JinghongChina National Center for TCM Inheritance and Innovation Guangxi Botanical Garden of Medicinal Plants530023 NanningChina Kunpeng Institute of Modern Agriculture at Foshan Chinese Academy of Agricultural Sciences528200 FoshanChina

Amomi Fructus(Sharen,AF)is a traditional Chinese medicine(TCM)from three source species(or varieties),including Wurfbainia villosa var.villosa(WVV),W.villosa var.xanthioides(WVX),or W.longiligularis(WL).Among them,WVV has been transplanted from its top-geoherb region,Guangdong,to its current main production area,Yunnan,for>50 years in China.However,the genetic and transcriptomic differentiation among multiple AF source species(or varieties)and between the origin and transplanted populations of WVV is unknown.In our study,the observed overall higher expression of terpenoid biosynthesis genes in WVV than in WVX provided possible evidence for the better pharmacological effect of WVV.We also screened six candidate borneol dehydrogenases(BDHs)that potentially catalyzed borneol into camphor in WVV and functionally verified them.Highly expressed genes at the P2 stage of WVV,Wv05G1424 and Wv05G1438,were capable of catalyzing the formation of camphor from(+)-borneol,(-)-borneol and DL-isoborneol.Moreover,the BDH genes may experience independent evolution after acquiring the ancestral copies,and the following tandem duplications might account for the abundant camphor content in WVV.Furthermore,four populations of WVV,WVX,and WL are genetically differentiated,and the gene flow from WVX to WVV in Yunnan contributed to the greater genetic diversity in the introduced population(WVV-JH)than in its top-geoherb region(WVV-YC),which showed the lowest genetic diversity and might undergo genetic degradation.In addition,terpene synthesis(TPS)and BDH genes were selected among populations of multiple AF source species(or varieties)and between the top-and non-top-geoherb regions,which might explain the difference in metabolites between these populations.Our findings provide important guidance for the conservation,genetic improvement,and industrial development of the three source species(or varieties)and for identifying top-geoherbalism with molecular markers,and proper clinical application of AF.

关键词： herbal among comparison

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公共图书馆未成年人STEM教育的探索与启示——以广州市海珠区图书馆为例

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图书馆学刊 2024年第5期46卷 64-70页

作者：黄子澈王凤姣湘潭大学公共管理学院湖南湘潭411105

调研广州市海珠区图书馆未成年人STEM教育项目的活动内容与活动机制等,提出公共图书馆开展未成年人STEM教育的优化建议:构建立体化服务体系、探索多样化合作模式、发挥图书馆独特优势、打造图书馆优质品牌。

关键词： STEM教育公共图书馆未成年人

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BFRP抗浮锚杆抗拔性能现场试验与荷载传递特性

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岩石力学与工程学报 2024年第6期43卷 1335-1346页

作者：白晓宇吴泽坤王凤姣孙淦张明义闫楠青岛理工大学土木工程学院山东青岛266520

玄武岩纤维增强聚合物(basalt fiber reinforced polymer,BFRP)锚杆具有自重轻、抗拉强度高、耐腐蚀性能好等优点,率先将BFRP锚杆应用于滨海某医院的地下室抗浮中。基于5根不同锚固长度、不同直径的全螺纹BFRP抗浮锚杆的极限抗拔试验,... 详细信息

玄武岩纤维增强聚合物(basalt fiber reinforced polymer,BFRP)锚杆具有自重轻、抗拉强度高、耐腐蚀性能好等优点,率先将BFRP锚杆应用于滨海某医院的地下室抗浮中。基于5根不同锚固长度、不同直径的全螺纹BFRP抗浮锚杆的极限抗拔试验,分析抗浮锚杆的破坏形态,明确锚杆杆体和锚固体的荷载-位移变化规律,探究BFRP抗浮锚杆杆体轴力和剪应力随锚固深度的分布规律,并讨论BFRP锚杆的破坏机制。研究表明:(1)2组BFRP抗浮锚杆的抗拔承载力均超过400 kN,完全满足工程的抗浮要求;(2)随着锚固长度与杆体直径的增加,抗浮锚杆的极限抗拔承载力略有增加,但杆体位移相应增大;(3)BFRP抗浮锚杆轴向应力在孔口处最大,随深度增加而加速降低,轴向应力的传递深度约为锚固长度的2/3,通过增加锚固长度来提升抗浮锚杆的抗拔承载力有限;(4)BFRP抗浮锚杆的剪应力先沿锚固深度迅速增加,在锚固深度0.75 m附近达到峰值后逐渐减小,剪应力峰值随荷载水平的增加而增大。试验结果为BFRP抗浮锚杆的应用奠定了基础。

关键词：岩石力学玄武岩纤维增强聚合物 BFRP抗浮锚杆极限载荷试验荷载传递轴力剪应力

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电力系统控制中智能技术应用研究

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电力设备管理 2024年第10期 201-203页

作者：王风姣谢子楠张荣荣济南金曰公路工程有限公司

电力系统作为一个动态的大系统,其工作的原理十分复杂。在电力系统控制中应用智能技术,有利于优化系统的整体性能,让电力系统能够得到更加科学的控制与运用。本文以本公司变电所综合系统为例,概括了电力系统控制及智能技术,并从多方面... 详细信息

电力系统作为一个动态的大系统,其工作的原理十分复杂。在电力系统控制中应用智能技术,有利于优化系统的整体性能,让电力系统能够得到更加科学的控制与运用。本文以本公司变电所综合系统为例,概括了电力系统控制及智能技术,并从多方面对电力系统控制中智能技术的应用进行了分析。

关键词：电力系统控制智能技术

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