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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li Jiang Xiong-Ying Ji feng-Ying zhang Ping zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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石英玻璃的高温介电特性研究

四川大学学报（自然科学版） 2005年第S1期42卷 393-398页

作者：王仪财吴孟强许峰云张树人电子科技大学微电子与固体电子学院成都610054

基于克劳休斯-莫索缔方程和德拜理论,建立了石英玻璃的介电模型,分析了石英玻璃的高温介电及损耗性质.本文讨论了高温下析晶行为对石英玻璃介电常数的影响,并着重分析了石英玻璃介电损耗的来源,指出了在高温下石英玻璃的损耗主要是电导... 详细信息

基于克劳休斯-莫索缔方程和德拜理论,建立了石英玻璃的介电模型,分析了石英玻璃的高温介电及损耗性质.本文讨论了高温下析晶行为对石英玻璃介电常数的影响,并着重分析了石英玻璃介电损耗的来源,指出了在高温下石英玻璃的损耗主要是电导损耗,并得出了石英玻璃介电损耗的温度特性.

关键词：石英玻璃极化损耗析晶高温

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论一阶量词及其语义解释

外语学刊 2025年第1期 106-112页

作者：张力锋南京大学哲学系南京210023

一阶量词具有极大的普遍性,可以统一地处理由于论域变化造成的无限多日常量词。基于一阶语言公式的严格递归构造,重叠量化式归根结底可诉诸原子句和逻辑常项(特别是量词)的意义,得到准确的理解。代入解释挑战标准的量词解释,将量化语句... 详细信息

一阶量词具有极大的普遍性,可以统一地处理由于论域变化造成的无限多日常量词。基于一阶语言公式的严格递归构造,重叠量化式归根结底可诉诸原子句和逻辑常项(特别是量词)的意义,得到准确的理解。代入解释挑战标准的量词解释,将量化语句的真还原为相应去量化语句的代入实例的真,而代入实例被规定或设定为真未必是在存在论意义上,从而既能刻画一阶推理的有效性,又可确保量词作为逻辑常项的本体论中立性。但量化语句并未因代入量词的本体论中立而在语言实践中被剥夺存在含意,它的存在含意下沉至名字及命名关系;克里普克建构的代入量化语义佐证了以上论点,可以驳斥将代入量化看作一种特殊对象量化的误读,代入量化只表明量化语句的真值条件是某些代入实例为真,而不是将量化语句翻译或还原为那个代入实例。

关键词：量词满足代入解释本体论承诺真值条件名字

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指向课程协同育人的跨学科主题学习路径设计

教学与管理 2025年第2期 24-28页

作者：殷凤张慧上海市浦东教育发展研究院上海200127 上海市浦东新区高桥镇小学上海200137

核心素养体系本身关注的是综合性素养,以落实“培养什么人”的教育目标。加强课程综合,注重关联,开展跨学科主题学习,强化课程协同育人功能,是新一轮课程改革的重要指向。以关联内容结构、融通核心素养、创设进阶活动、落实以评促学作... 详细信息

核心素养体系本身关注的是综合性素养,以落实“培养什么人”的教育目标。加强课程综合,注重关联,开展跨学科主题学习,强化课程协同育人功能,是新一轮课程改革的重要指向。以关联内容结构、融通核心素养、创设进阶活动、落实以评促学作为跨学科学习设计的路径,精准把握跨学科学习的取向,避免学科间的简单“拼盘”,从而真正实现课程的协同育人。

关键词：跨学科主题学习协同育人核心素养

Coseismic surface ruptures of MW7.8 and MW7.5 earthquakes occurred on February 6, 2023, and seismic hazard assessment of the East Anatolian Fault Zone, Southeastern Türkiye

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Science China Earth Sciences 2025年

作者： Peng LIANG Yueren XU Xiaocheng ZHOU Ying LI Qinjian TIAN Huiping zhang Zhikun ren Jingxing YU Chuanyou LI Zheng GONG Shiguang WANG Aixia DOU Zifa MA Junjie LI Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake Administration China Earthquake Disaster Prevention Center State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake Administration Institute of Geophysics China Earthquake Administration

On February 6, 2023, southeastern Türkiye experienced a devastating earthquake doublet along the East Anatolian Fault（EAF）, with moment magnitude（MW） values of 7.8 and 7.5. These strong earthquakes resulted in at least 50,000 deaths and severe economic losses. Systematic research on coseismic surface ruptures induced by these events is vital for assessing the cascade rupture behaviors of plate boundary faults and future seismic hazards in the region. Interpretation of high-resolution post-earthquake satellite images and field investigations yielded the following results:（1） the two strong earthquakes had separate rupture zones. The first earthquake generated an approximately 280 km coseismic surface rupture along the southwestern segment of the main EAF, with 241 left-lateral displacements reaching up to 6.8±0.68 m, particularly 40 km northeast of the epicenter. The second earthquake produced a roughly 110 km surface rupture on an east-west branch of the EAF, with maximum displacements of 7.2±0.72 m.（2） The MW7.8 earthquake resulted in a cascading rupture across multiple segments of the southwestern section of the main EAF, with significantly variable displacements. The northeastern and southwestern parts of the main EAF and Malatya Fault remain at risk of strong earthquakes in the future.（3） The EAF rupture zone is densely populated, and due to the site amplification effect of loose sediments on foreland alluvial fans, foundation failures of buildings in the populated areas are common. Therefore, it is crucial to enhance the future seismic fortification capabilities in urban and rural areas along the EAF.

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H型试剂对于大直径泥水盾构泥水分离处理的影响与应用

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岩土工程学报 2025年第1期47卷 153-163页

作者：张箭任国平尹义豪钟小春张春雷梁禹河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210098 中铁十四局集团大盾构工程有限公司江苏南京211800 河海大学环境学院江苏南京210098 中山大学土木工程学院广东珠海519082

针对广东湛江湾海底隧道施工中出现的盾构废弃泥浆脱水速率慢、泥渣含水率高与废浆排放污染等问题,研发了一种新型H型脱水试剂。通过絮凝脱水试验、微观机理试验以及现场生产试验,揭示了泥浆泥水分离体积比/上清液浊度/粒径分布和Zeta... 详细信息

针对广东湛江湾海底隧道施工中出现的盾构废弃泥浆脱水速率慢、泥渣含水率高与废浆排放污染等问题,研发了一种新型H型脱水试剂。通过絮凝脱水试验、微观机理试验以及现场生产试验,揭示了泥浆泥水分离体积比/上清液浊度/粒径分布和Zeta电位等变化规律,综合评价H型试剂与3种聚丙烯酰胺(PAM)在泥浆脱水效果方面的差异。结果表明:H型试剂与泥浆作用的最优添加量为0.5%;与PAM相比,H型试剂前期沉降速度较慢,但脱水后的泥渣含水率降低了约18.1%,且上清液非常清澈,7.8的pH值符合直接外排条件;H型试剂兼具了较好的桥网作用与电中和作用,使粒径<10μm的细粒更容易聚集成50μm以上的大颗粒,加快了泥浆的絮凝速度。H型试剂营造了渗水性更强的Ca排水通道,降低泥浆的黏滞性,提高泥浆压滤脱水的效率;与原脱水试剂相比,现场使用0.1%的H型试剂,可提高30.5%的脱水泥样含固率,降低20%的工程成本。

关键词：泥水盾构泥水分离絮凝脱水机理研究现场试验

Non-equilibrium steady structures of confined liquid crystals driven by a dynamic boundary

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Science China(Physics,Mechanics & Astronomy) 2019年第11期62卷 115-124页

作者： RuiFen zhang ChunLai ren JiaWei feng YuQiang Ma National Laboratory of Solid State Microstructures and Department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing University

Steady structures originating from dynamic self-assembly have begun to show their advantages in new generation materials, and pose challenges to equilibrium self-assembly. In view of the important role of confinement in self-assembly, here, we propose a new type of confinement leading to dynamic steady structures, which opens a new window for the conventional *** our model, we consider the self-assembly of ellipsoids in 2D circular confinement via the boundary performing periodically stretching and contracting oscillation. Langevin dynamics simulations reveal the achievement of non-equilibrium steady structures under appropriate boundary motions, which are novel smectic structures with stable topological defects. Different from the confinement with a static boundary, ellipsoids close to the boundary have variable orientations depending on the boundary ***-order structural transitions, accompanied by the symmetry change and varied defect number, occur with the change of oscillating amplitude and/or frequency of the boundary. Slow and fast dynamics are distinguished according to whether structural rearrangements and energetic adjustment happen or not. The collective motion of confined ellipsoids, aroused by the work performed on the system, is the key factor determining both the structure and dynamics of the self-assembly. Our results not only achieve novel textures of circular confined liquid crystals, but also inspire us to reconsider the self-assembly within the living organisms.

关键词： dynamic self-assembly confined liquid crystals steady structure collective motion Langevin dynamics simulation

Distribution of TiN inclusions in Ti-stabilized ultra-pure ferrite stainless steel slab

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Journal of Iron and Steel Research International 2019年第9期26卷 962-972页

作者： Hao-jian Duan Ying zhang Ying ren Li-feng zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

In order to clarify and control the silver defect on surface of cold-rolled sheet of the Ti-stabilized ultra-pure ferrite stainless steel, the distribution of TiN inclusions on the cross section of hot-rolled plate was studied using automated scanning electron microscopy/energy-dispersive X-ray spectroscopy inclusion analysis (ASPEX 1020 system). It was found that the number density decreases sharply from the surface to the center of the hot-rolled plate, whereas the average size increases. Then, the distribution of TiN inclusions on the cross section of continuously cast slab was investigated. Similarly, numerous small-sized TiN inclusions were generated at the subsurface of the slab. The average size rapidly increased and the number density dramatically decreased from the subsurface to 1/4 thickness, while from 1/4 thickness to 1/2 thickness, the increase in average size and the decrease in number density were slight. Thermodynamics results showed that TiN inclusion was formed below the liquidus temperature, which indicated that TiN inclusions could not be formed during secondary refining. Considering the microsegregation of solute elements and the equilibrium of TiN formation during solidification, TiN precipitated in the mushy zone when the solid fraction was close to 0.2. The growth of TiN was analyzed based on the diffusion-controlled growth model. With the increase in cooling rate, the time for TiN growth decreased and the size of TiN inclusions was diminished, which revealed the size distribution of TiN inclusions in the cast slab qualitatively.

关键词： TiN inclusion Ti-stabilized ultra-pure ferrite stainless steel Distribution in slab Thermodynamics Diffusion-controlled growth model

Dynamic mass variation and multiphase interaction among steel, slag, lining refractory and nonmetallic inclusions: Laboratory experiments and mathematical prediction

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International Journal of Minerals,Metallurgy and Materials 2021年第8期28卷 1298-1308页

作者： Ju-jin Wang Li-feng zhang Gong Cheng Qiang ren Ying ren School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China

The mass transfer among the multiphase interactions among the steel, slag, lining refractory, and nonmetallic inclusions during the refining process of a bearing steel was studied using laboratory experiments and numerical kinetic prediction. Experiments on the system with and without the slag phase were carried out to evaluate the influence of the refractory and the slag on the mass transfer. A mathematical model coupled the ion and molecule coexistence theory, coupled-reaction model, and the surface renewal theory was established to predict the dynamic mass transfer and composition transformation of the steel, the slag, and nonmetallic inclusions in the steel. During the refining process,Al_(2)O_(3) inclusions transformed into Mg O inclusions owing to the mass transfer of [Mg] at the steel/refractory interface and(Mg O) at the slag/refractory interface. Most of the aluminum involved in the transport entered the slag and a small part of the aluminum transferred to lining refractory, forming the Al_(2)O_(3) or Mg O·Al_(2)O_(3). The slag had a significant acceleration effect on the mass transfer. The mass transfer rate(or the reaction rate) of the system with the slag was approximately 5 times larger than that of the system without the slag. In the first 20 min of the refining, rates of magnesium mass transfer at the steel/inclusion interface, steel/refractory interface, and steel/slag interface were x, 1.1 x, and 2.2 x,respectively. The composition transformation of inclusions and the mass transfer of magnesium and aluminum in the steel were predicted with an acceptable accuracy using the established kinetic model.

关键词： mass transfer steel slag lining refractory nonmetallic inclusions kinetic model