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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei ren-Lin Li Xin-Ran Song Qian-Qian Wan yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Active flow control using machine learning:A brief review

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Journal of Hydrodynamics 2020年第2期32卷 247-253页

作者： feng ren Hai-bao Hu Hui Tang Research Center for Fluid-Structure Interactions Department of Mechanical EngineeringThe Hong Kong Polytechnic UniversityHong KongChina School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an710072China

Nowadays the rapidly developing artificial intelligence has become a key solution for problems of diverse disciplines,especially those involving big *** in these areas also attract researchers from the community of fluid mechanics,especially in the field of active flow control(AFC).This article surveys recent successful applications of machine learning in AFC,highlights general ideas,and aims at offering a basic outline for those who are interested in this specific *** this short review,we focus on two methodologies,i.e.,genetic programming(GP)and deep reinforcement learning(DRL),both having been proven effective,efficient,and robust in certain AFC problems,and outline some future prospects that might shed some light for relevant studies.

关键词： Active flow control(AFC) machine learning genetic programming(GP) deep reinforcement learning(DRL)

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巴西龟代谢性骨病CT诊断病例报告

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动物医学进展 2025年第1期46卷 141-144页

作者：孙嘉徐甘靖宇江蓝刘波俞峰中国农业大学北京100193

代谢性骨病(MBD)是一种因钙缺乏或维生素D 3摄入不足引起的骨骼代谢障碍疾病,其临床表现为骨折、脊椎异常、难产、脱垂等症状。计算机断层扫描(CT)在兽医临床中应用的逐渐增加为龟、鳖类MBD提供了新的诊断方式。该病例中红耳巴西龟血检... 详细信息

代谢性骨病(MBD)是一种因钙缺乏或维生素D 3摄入不足引起的骨骼代谢障碍疾病,其临床表现为骨折、脊椎异常、难产、脱垂等症状。计算机断层扫描(CT)在兽医临床中应用的逐渐增加为龟、鳖类MBD提供了新的诊断方式。该病例中红耳巴西龟血检结果提示其肾脏、肝脏功能损害,钙磷代谢异常。CT扫查提示患龟全身组织大面积矿化、背甲凹陷,定量测量患龟背椎骨、神经骨和胸膜骨3处的骨骼密度远低于正常龟,诊断患龟有严重的MBD。治疗方案为对症治疗、改善饲养管理条件,同时对该龟补充维生素D 3。该病例报告系统陈述了龟鳖MBD的诊疗流程,同时表明了CT扫查可为龟鳖MBD精确诊断、治疗和预后提供新的参考。

关键词：龟代谢性骨病计算机断层扫描骨密度

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Mechanism underpinning effects of Shichangpu(Rhizoma Acori Tatarinowii) on attention deficit hyperactivity disorder

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Journal of Traditional Chinese Medicine 2020年第1期40卷 94-102页

作者： feng Kai Zhao Ying ren Xinxin Chou Yiqian yu Qingyang Li Ling Wang Junhong Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Chengdu University of Traditional Chinese Medicine Chengdu 610075China Shandong University of Chinese Medicine Jinan 250355China Department of Pediatrics Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

OBJECTIVE:To investigate the mechanism underlying the effects of Shichangpu(Rhizoma Acori Tatarinowii)on attention deficit hyperactivity disorder(ADHD).METHODS:A network pharmacology approach integrating ingredients of Shichangpu(Rhizoma Acori Tatarinowii)and target with ADHD,network construction,molecular function interactions and pathway analysis was ***:This approach successfully helped to identify 7 active ingredients of CN,interacting with21 key targets(ADRA1 A,ADRA1 B,ADRA2 A,ADRA2 B,ADRA2 C,ADRB1,ADRB2,CHRM1,CHRM2,CHRM3,PTGS1,SLC6 A2,SLC6 A3,SLC6 A4,DRD1,DRD5,HTR2 A,ADRA1 D,MAOB,GRIA2,HTR1 A).The molecular function interactions among candidate targets mainly consisted of four groups:G-protein coupled amine receptor activity,catecholamine binding,monoamine transmembrane transporter activity and neurotransmitter receptor *** Encyclopedia of Genes and Genomes pathway enrichment analysis indicated that Shichangpu(Rhizoma Acori Tatarinowii)-regulated pathways were mainly classified into signal transduction and monoamine ***:Our investigation revealed that Shichangpu(Rhizoma Acori Tatarinowii)could improve the symptoms of ADHD by regulating neurotransmitter,in multiple types of compounds-target-pathway,which may be implicated in the major pathological processes of ADHD.

关键词： Attention deficit disorder with hyperactivity Shichangpu(Rhizoma Acori Tatarinowii) Plants,medicinal Pharmacology

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The endo-beta mannase MAN7 contributes to cadmium tolerance by modulating root cell wall binding capacity in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2023年第7期65卷 1670-1686页

作者： Qi Wu yu Ting Meng Zhi Hang feng ren Fang Shen Xiao Fang Zhu State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China

The heavy metal cadmium(Cd) is detrimental to crop growth and threatens human health through the food chain. To cope with Cd toxicity,plants employ multiple strategies to decrease Cd uptake and its root-to-shoot translocation. However, genes that participate in the Cd-induced transcriptional regulatory network, including those encoding transcription factors, remain largely unidentified. In this study, we demonstrate that ENDO-BETA-MANNASE 7(MAN7) is necessary for the response of Arabidopsis thaliana to toxic Cd levels. We show that MAN7 is responsible for mannase activity and modulates mannose content in the cell wall, which plays a role in Cd compartmentalization in the cell wall under Cd toxicity conditions. Additionally,the repression of root growth by Cd was partially reversed via exogenous application of mannose,suggesting that MAN7-mediated cell wall Cd redistribution depends on the mannose ***, we identified a basic leucine zipper(bZIP) transcription factor, bZIP44, that acts upstream of MAN7 in response to Cd *** dual-luciferase assays indicated that bZIP44 directly binds to the MAN7 promoter region and activates its transcription. Loss of bZIP44 function was associated with greater sensitivity to Cd treatment and higher accumulation of the heavy metal in roots and ***, MAN7 overexpression relieved the inhibition of root elongation seen in the bzip44mutant under Cd toxicity conditions. This study thus reveals a pathway showing that MAN7-associated Cd tolerance in Arabidopsis is controlled by bZIP44 upon Cd exposure.

关键词： Arabidopsis thaliana bZIP44 cadmium cell wall MAN7 mannose

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Effect of cerium addition on non-metallic inclusions in a high-carbon chromium bearing steel

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Journal of Iron and Steel Research International 2023年第11期30卷 2254-2266页

作者： Hao Li Qiang ren Li-feng Zhang State Key Lab of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004HebeiChina School of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiChina School of Mechanical and Materials Engineering North China University of TechnologyBeijing100144China

Effects of varied levels of cerium(28×10-6,65×10^(-6) and 150×10^(-6))on inclusions in a high-carbon chromium bearing steel at different stages(before adding cerium,after adding cerium for 1,5,10 min and ingot)were studied using laboratory *** automatic scanning electron microscope system with energy-dispersive spectroscopy was used to analyze the amount,composition,size and morphology of inclusions in the steel at different *** the cerium content in the molten steel increased from 0 to 150×10^(-6),the evolution sequence of inclusions was as follows:Al_(2)O_(3)→CeAl11O18→CeAlO_(3)→Ce_(2)O_(2)*** 28×10^(-6) cerium was added,Al_(2)O_(3) inclusions were modified into CeAl_(11)O_(18) inclusions in the molten steel and then were further transformed into Al2O3 and CeAlO3 inclusions in the solid steel during *** the addition of 65×10^(-6) cerium,inclusions in the molten steel were modified into CeAlO_(3) and a small number of Ce2O2S *** the addition amount of cerium increased to 150×10^(-6),inclusions were transformed to Ce_(2)O_(2)*** size of inclusions in the molten steel decreased obviously with cerium *** the other hand,the size of inclusions increased during the cooling process in solid steels of No.1 steel(with 28×10^(-6) cerium)and No.2 steel(with 65×10^(-6) cerium).During the cooling process,unmodified MnS inclusions were precipitated in the solid steel of No.1 steel and wrapped outside the Al2O3 and CeAlO_(3) inclusions to form large complex *** the cooling process of No.2 steel,the inclusion size of CeAlO_(3) increased due to the collision and *** the No.3 steel(with 150×10^(-6) cerium),the average size of inclusions decreased rapidly and remained at a lower size during the cooling process,which was beneficial to improving the fatigue life of the steel.

关键词： Cerium Inclusion Transformation High-carbon chromium bearing steel Modification

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Climate and salinity drive soil bacterial richness and diversity in sandy grasslands in China

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Research in Cold and Arid Regions 2022年第3期14卷 182-195页

作者： ChengChen Pan XiaoYa yu Qi feng yuLin Li ShiLong ren Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhouGansu 730000China School of Tourism and Resource Environment Qiannan Normal University for NationalitiesDuyunGuizhou 558000China Environmental Research Institute Shandong UniversityQingdaoShandong 266237China

Bacteria constitute a large proportion of the biodiversity in soils and control many important processes in terrestrial ***,our understanding of the interactions between soil bacteria and environmental factors remains limited,especially in sensitive and fragile *** this study,geographic patterns of bacterial diversity across four sandy grasslands along a 1,600 km north-south transect in northern China were characterized by high-throughput 16S rRNA gene ***,we analyzed the driving factors behind the patterns in bacterial *** results show that of the 21 phyla detected,the most abundant were Proteobacteria,Actinobacteria,Acidobacteria and Fir‐micutes(average relative abundance>5%).Soil bacterial operational taxonomic unit(OTU)numbers(richness)and Faith's phylogenetic diversity(diversity)were highest in the Otindag Sandy Land and lowest in the Mu Us Sandy *** electrical conductivity(EC)was the most influential factor driving bacterial richness and *** bacterial communities differed significantly among the four sandy grasslands,and the bacterial community structure was signifi‐cantly affected by environmental factors and geographic *** the environmental variables examined,climatic factors(mean annual temperature and precipitation)and edaphic properties(pH and EC)explained the highest propor‐tion of the variation in bacterial community *** factors such as plant species richness and aboveground bio‐mass exhibited weak but significant associations with bacterial richness and *** findings revealed the impor‐tant role of climate and salinity factors in controlling bacterial richness and diversity;understanding these roles is critical for predicting the impacts of climate change and promoting sustainable management strategies for ecosystem services in these sandy lands.

关键词： sandy land soil bacterial diversity biogeography climate change salinity

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Effect of vacuum degree and aeration rate on sludge dewatering behavior with the aeration-vacuum method

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第9期11卷 638-655页

作者： yu-feng GAO Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai University Nanjing 210098 China Geotechnical Research Institute Hohai University Nanjing 210098 China The Science and Technology Division Hohai University Nanjing 210098 China

Due to large-scale dredging operations, a large amount of sludge is inevitably produced. Large areas of land are occupied when the dredged sludge is discarded in the disposal site as waste material. The sludge dewatering with aeration-vacuum (SDAV) method is suit for treating the sludge with high water content and high clay content in the disposal site. The water in the sludge can be discharged out. The volume of the sludge can be reduced quickly, and the recycling of the land can be accelerated by this method. Most importantly, this technique is an efficient way to deal with clogging problems when pumping water from high water content, high clay content dredged sludge. Vacuum degree range tests, the aeration rate range tests, and the influencing factors of sludge dewatering behavior tests were conducted with a self-developed SDAV model test device. Sludge samples were taken from the South-to-North Water Diversion East Line Project in Huai’an White-Horse Lake disposal site, Jiangsu Province, China. The optimal range of vacuum degree and aeration rate were obtained through the test results, and the mechanisms for how the two factors work and how they affect the sludge dewatering behavior were analyzed. The suitable vacuum degree range in SDAV is below 50 kPa, and the suitable aeration rate is about 1.0 m3/h. The low-vacuum degree contributes to reduce the ad-sorption effect of micro-channels on soil particles in filter material and to maintain the arch structures. Aeration has the effects of expansion, disturbance, changing Reynolds number, and dynamic sieve separating. The pump quantity of water per meter of filter tube (m) has different change rules as the vacuum degree changes under different aeration rates. The reason is that the formed arch structures’ conformation and permeability differ greatly under different combined-conditions of vacuum degree and aeration rate. The optimal combined-condition for dewatering the sludge is 35 kPa with 1.0 m3/h.

关键词： High water content dredged sludge Sludge dewatering with aeration-vacuum (SDAV) Vacuum degree Aeration rate Arch structures

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Design, Synthesis and Biological Evaluation of Novel α-Acyloxycarboxamide-Based Derivatives as c-Met Inhibitors

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Chinese Journal of Chemistry 2021年第8期39卷 2241-2250页

作者： yu-juan feng yu-Lin ren Li-Ming Zhao Guo-Qiang Xue Wen-Hao yu Jia-Qi Yang Jun-Wei Liu Northwest Minzu University LanzhouGansu 730030China Department of Public Health The Second Provincial People's Hospital of GansuLanzhouGansu 730030China

Dysregulated HGF/c-Met signalling has been associated with many human cancers,poor clinical outcomes,and even resistance acquisition to some approved targeted *** such,c-Met kinase has emerged as an attractive target ... 详细信息

关键词： 4-(2-Fluorophenoxy)quinoline derivatives c-Met inhibitors Passerini reaction a-Acyloxycarboxamide Biological evaluation

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Sealing reliability modeling of aviation seal based on interval uncertainty method and multidimensional response surface

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Chinese Journal of Aeronautics 2019年第9期32卷 2188-2198页

作者： Baopeng LIAO Bo SUN yu LI Meichen YAN Yi ren Qiang feng Dezhen YANG Kun ZHOU School of Reliability and Systems Engineering Beihang UniversityBeijing 100191China Southwest Technology and Engineering Research Institute Chongqing 400039China

Many variables affect the sealing performance, and their distribution characteristics are difficult to obtain with probabilistic methods owing to the high cost involved. Numerous problems in engineering are similar due to the appearance of small-sample parameters. In this study, the sealing reliability of an aviation seal was defined as the research object, and an interval uncertainty method and multidimensional response surface were proposed to calculate the sealing *** on this, we first analyzed the failure mechanism of the aviation seal and established a leakage rate model. Then, based on the non-probabilistic interval model, an interval uncertainty method was proposed to construct the analytical model. With reference to the limit state equation from the structural reliability theory, the multidimensional response surface was used for fast ***, we chose the single-cylinder gas steering gear used in aircraft as the case study, its sealing reliability in working and non-working statuses were calculated, and the results were verified with the actual maintenance records. By analyzing the sensitivity of some variables, we can improve the sealing reliability of the aviation seal by improving the surface roughness only if the cost ***, we consider that the method proposed in this study realizes the application of smallsample uncertainty analysis in reliability analysis, and could provide a feasible way to solve the similar problems in engineering with multidimensional and small-sample parameters.

关键词： Aviation seal Interval uncertainty method Multidimensional response surface Sealing reliability Small-sample parameters

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