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Unlocking the potential:How acupuncture reshapes the liver-centered lipid metabolism pattern to fight obesity

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Journal of Integrative Medicine 2024年第5期22卷 523-532页

作者： Shu-rui Yang Li Chen Dan Luo Ya-yuan Wang feng-xia liang College of Acupuncture and Orthopedics Hubei University of Chinese MedicineWuhan 430061Hubei ProvinceChina Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion Wuhan 430061Hubei ProvinceChina Hubei Shizhen Laboratory Wuhan 430060Hubei ProvinceChina Hubei International Science and Technology Cooperation Base of Preventive Treatment by Acupuncture and Moxibustion Wuhan 430061Hubei ProvinceChina Acupuncture and Moxibustion Department Affiliated Hospital of Hubei University of Chinese Medicine(Hubei Provincial Hospital of Traditional Chinese Medicine)Wuhan 430060Hubei ProvinceChina

Obesity,a widespread global health issue,is frequently linked to disrupted lipid metabolism,resulting in excessive accumulation of adipose tissue and associated health ***,a traditional Chinese medical modality,has exhibited potential as a viable intervention for addressing *** underlying mechanism proposed involves the stimulation of specific acupoints to exert a regulatory influence on hepatic *** liver has a central role in lipid metabolism,including processes such as lipid synthesis,storage and *** is believed to enhance the liver’s efficiency in processing lipids,thereby reducing lipid accumulation and improving metabolic *** indicates that acupuncture can influence the expression of certain genes and proteins involved in lipid metabolism in the *** includes upregulating genes that promote lipid breakdown and oxidation,and downregulating those involved in lipid ***,acupuncture has been shown to improve insulin sensitivity,which is crucial for the regulation of lipid ***,the potential anti-inflammatory effects of acupuncture may play a significant role in its efficacy for the treatment of *** presence of chronic inflammation has been strongly associated with metabolic disorders such as *** its ability to mitigate inflammation,acupuncture can potentially aid in the restoration of lipid metabolism and the reduction of body ***,the amelioration of hepatic oxidative stress represents another mechanism by which acupuncture may contribute to the reduction of lipid ***,the liver,being the primary site of lipid metabolism,maintains communication with various organs including the brain,adipose tissue,skeletal muscle and *** perspective opens new avenues for the treatment of obesity,emphasizing the importance of holistic approaches in managing complex metabolic disorders.

关键词： Acupuncture Obesity Liver-centered lipid metabolism pattern

Effectiveness of Acupuncture for Alzheimer's Disease: An Updated Systematic Review and Meta-analysis

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Current Medical Science 2019年第3期39卷 500-511页

作者： Qi HUANG Dan LUO Li CHEN feng-xia liang Rui CHEN Department of Acupuncture and Moxibustion Hubei University of Chinese Medicine Wuhan 430061China Department of Integrated TCM and Western Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Acupuncture has reportedly improved memory and cognitive impairment in both animal and clinical studies. It may be an effective treatment for Alzheimer's disease (AD). The purpose of this meta-analysis was to review the effectiveness of acupuncture for the treatment of AD. Eight databases were searched for articles published up to and including July 2017, and 13 studies fulfilling the inclusion criteria were identified. The main outcomes assessed were clinical efficacy rate, Mini-Mental State Examination score, Ability of Daily Living Scale score, Alzheimer's Disease Assessment Scale-Cognition score, Hasegawa's Dementia Scale (HDS) score, and adverse events. The methodological quality of the articles was assessed using Cochrane's risk of bias. All the studies compared the efficacy of acupuncture with that of medication, and were published in Chinese journals. Meta-analysis revealed that acupuncture yielded positive results as determined via all the indexes scored except the HDS (95% CI -0.26 to 0.90, Z=0.35, P=0.73). Only one of the studies reported adverse events associated with acupuncture and medication. The rate of adverse events in the medication group was 13%. In most of the studies assessed in the current metaanalysis, acupuncture alone was better than conventional western medicines for the treatment of AD.

关键词： acupuncture medication meta-analysis systematic review

Is Acupuncture Effective for Improving Insulin Resistance?A Systematic Review and Meta-analysis

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Current Medical Science 2018年第6期38卷 1109-1116页

作者： Ai-qun SONG Yang-pu ZHANG Rui CHEN feng-xia liang Department of Acupuncture and Moxibustion Hubei University of Chinese MedicineWuhan 430061China Department of Physical Medicine and Rehabilitation Hubei Provincial Hospital of lntegrated Chinese and Western Medicine Wuhan 430015China Department of Traditional Chinese Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

This study aimed to evaluate the clinical efficacy of acupuncture for intervening insulin resistance (IR)by meta-analysis of related randomized controlled trials (RCTs).Studies published prior to 31 January 2018 were searched on Pubmed,Medline,Cochrane Library, Embase databases and Chinese *** RCTs,which examined acupuncture as the sole or adjunctive treatment for IR-related diseases,were *** primary outcome was homeostasis model assessment for insulin resistance (HOMA-IR).The secondary outcomes consisted of fasting blood glucose (FBG),fasting insulin (FINS)and 2-h postprandial blood glucose (2h-PBG).The differences between groups were reported as mean differences (MD).All statistical analyses were performed using RevMan software *** carefully screening relevant studies,9 RCTs involving 562 patients (279 in experimental group and 283 in control group)were enrolled in this *** pooled results showed that acupuncture had significant effects on HOMA-IR (MD 0.70,95%CI 0.04 to 1.35,P=-0.040.05).The present meta-analysis indicated that acupuncture can help to improve IR to a certain extent,which remains to be confirmed by further high-quality RCTs.

关键词： acupuncture insulin resistance randomized controlled trials meta-analysis

Mesenchymal stem cell-derived extracellular vesicles:A promising therapeutic strategy in diabetic osteoporosis

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World Journal of Diabetes 2024年第12期15卷 2399-2403页

作者： Ya-Jing Yang Xi-Er Chen Xu-Chang Zhou feng-xia liang Department of Acupuncture and Moxibustion Hubei University of Chinese MedicineWuhan 430065Hubei ProvinceChina College of Sports Medicine Wuhan Sports UniversityWuhan 430079Hubei ProvinceChina School of Sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China Preventive Treatment of Acupuncture and Moxibustion of Hubei Provincial Collaborative Innovation Center College of Acupuncture-Moxibustion and Orthopaedics of Hubei University of Chinese MedicineWuhan 430065Hubei ProvinceChina

Diabetic osteoporosis(DOP)is a serious complication of diabetes *** is urgent to explore efficient clinical treatment strategies for *** has been found that mesenchymal stem cell-derived extracellular vesicles(MSC-EVs),as an emerging cell-free therapy,show great potential in DOP ***-EVs can effectively promote bone formation,inhibit bone resorption,and modulate the inflammatory microenvironment by delivering cargoes of microRNAs,long non-coding RNAs,and proteins to target cells,thereby ameliorating bone loss in ***,there are limited reports on the treatment of DOP with *** evoke more attention to this potential strategy,this article summarised the extant literature on MSC-EVs for DOP to provide new directions for further research and to promote the application of MSC-EVs in the clinical management of DOP.

关键词： Bone marrow mesenchymal stem cells Adipose-derived mesenchymal stem cells extracellular vesicles MicroRNAs Long non-coding RNAs Diabetic osteoporosis

Non-ultrawide bandgap CsPbBr_(3) nanosheet for sensitive deep ultraviolet photodetection

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Journal of Materials Science & Technology 2023年第28期159卷 251-257页

作者： Chun-Yan Wu Yu-Xuan Le Li-Yan liang Jing-Yue Li feng-xia liang Shi-Rong Chen xiao-Ping Yang Yu-Xue Zhou Lin-Bao Luo School of Microelectronics Hefei University of TechnologyHefei 230009China College of Physical Science and Technology Yangzhou UniversityYangzhou 225002China

In this study,we report the fabrication of a sensitive deep ultraviolet(DUV)photodetector by using CsPbBr_(3) nanosheets synthesized through confined-space growth at room *** peak pho-toresponse of the device upon illumination blueshifts with decreasing thickness and a 68 nm CsPbBr_(3) nanosheet based device displays a peak response to 265 nm illumination,showing responsivity and spe-cific detectivity of 85 mA/W and 4.05×1011 Jones at 3 V bias,*** simulation re-veals that the blueshift is associated with the wavelength-dependent absorption coefficient of CsPbBr_(3) nanosheet:incident light with shorter wavelengths can be absorbed on the superficial surface,while long-wavelength light has a larger penetration depth,leading to dominant DUV absorption in thinner CsPbBr_(3) *** work will shed light on the facile and cost-effective fabrication of DUV photode-tectors from non-ultrawide bandgap(UWBG)all-inorganic perovskite materials.

关键词： Non-ultrawide bandgap semiconductors CsPbBr_(3)nanosheet Wavelength-dependent absorption coefficient Sensitive DUV photodetector

TWO DIMENSIONAL PROPERTIES OF REVERSED DUCKWEED AMPHIPHILIC POLYMER

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Chinese Chemical Letters 1993年第10期4卷 939-940页

作者： Jin WANG Rui feng ZHANG Yue xia liang Jia Cong SHEN Department of Chemistry,JiLin University Changchun 130023

The surface pressure-Area isotherms of Reversed Duckweed amphiphili polymer were examined in view of their chemical structure and two- dimentional properties of polymer monolayer were studied.

关键词： Poly TWO DIMENSIONAL PROPERTIES OF REVERSED DUCKWEED AMPHIPHILIC POLYMER

SYNTHESIS OF A NEW KIND OF AMPHIPHILIC COPOLYMER AND CHARACTERIZATION OF THEIR LB FILMS

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Chinese Chemical Letters 1993年第11期4卷 1003-1006页

作者： Jin WANGRui feng ZHANG Yue xia liang De Jun WANG Jia Cong SUEN Department of Chemistry, Jinlin University, Changchun 130023

A new kind of amphiphilic copolymer was synthesized with azo bond functional side chains, and elementary studies about formation of I,B film, UV-visible spectra and photoelectrical properties of multilayers of this ki... 详细信息

关键词： In SYNTHESIS OF A NEW KIND OF AMPHIPHILIC COPOLYMER AND CHARACTERIZATION OF THEIR LB FILMS LB

Efficient OpenMP Based Z-curve Encoding and Decoding Algorithms

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Computers, Materials & Continua 2025年第1期82卷 1313-1327页

作者： Zicheng Zhou Shaowen Sun Teng liang Mengjuan Li fengling xia School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China School of Communications Information Engineering Yunnan Communications Vocational and Technical CollegeKunming650500China Library Yunnan Normal UniversityKunming650500China Faculty of Civil Aviation and Aeronautics Kunming University of Science and TechnologyKunming650500China

Z-curve’s encoding and decoding algorithms are primely important in many Z-curve-based *** bit interleaving algorithm is the current state-of-the-art algorithm for encoding and decoding *** simple,its efficiency is hindered by the step-by-step coordinate shifting and bitwise *** tackle this problem,we first propose the efficient encoding algorithm LTFe and the corresponding decoding algorithm LTFd,which adopt two optimization methods to boost the algorithm’s efficiency:1)we design efficient lookup tables(LT)that convert encoding and decoding operations into table-lookup operations;2)we design a bit detection mechanism that skips partial order of a coordinate or a Z-value with consecutive 0s in the front,avoiding unnecessary iterative *** propose order-parallel and point-parallel OpenMP-based algorithms to exploit the modern multi-core *** results on discrete,skewed,and real datasets indicate that our point-parallel algorithms can be up to 12.6×faster than the existing algorithms.

关键词： Z-curve lookup table OpenMP bit detection mechanism

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan Guo Hong-Bo Jin Cong-feng Qiao Yue-liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries