检索结果-南通市图书馆

Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： Hua Bai Xiao-feng feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,Lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

Frequency Weighting Filter Design for Automotive Ride Comfort Evaluation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2016年第4期29卷 727-738页

作者： du feng School of Mechanical and Automotive Engineering South China University of Technology

Few study gives guidance to design weighting filters according to the frequency weighting factors,and the additional evaluation method of automotive ride comfort is not made good use of in some *** on the regularities of the weighting factors,a method is proposed and the vertical and horizontal weighting filters are *** whole frequency range is divided several times into two parts with respective *** each division,a parallel filter constituted by a low-and a high-pass filter with the same cutoff frequency and the quality factor is utilized to achieve section *** cascading of these parallel filters obtains entire *** filters own a high ***,low order filters are preferred in some *** bilinear transformation method and the least P-norm optimal infinite impulse response（IIR） filter design method are employed to develop low order filters to approximate the weightings in the *** addition,with the window method,the linear phase finite impulse response（FIR） filter is designed to keep the signal from distorting and to obtain the staircase *** the same case,the traditional method produces 0.330 7 m · s^–2 weighted root mean square（r.m.s.） acceleration and the filtering method gives 0.311 9 m · s^–2 *** fourth order filter for approximation of vertical weighting obtains 0.313 9 m · s^–2 *** factors of the acceleration signal weighted by the weighting filter and the fourth order filter are 3.002 7 and 3.011 1,*** paper proposes several methods to design frequency weighting filters for automotive ride comfort evaluation,and these developed weighting filters are effective.

关键词： frequency weighting ride comfort evaluation least P-norm optimal method bilinear transformation weighting filter design

序题创新与“因文立体”:论明代文学总集《文章辨体汇选》的辨体批评观

在线全文

学校读者我要写书评

暂无评论

南都学坛 2025年第1期45卷 44-54页

作者：肖锋杜莹中国传媒大学人文学院北京100024

“辨体”是贯穿贺复征《文章辨体汇选》的主要批评方法。他采取“省略”“改写”“补充”等方式,对“序题”进行经典化构建,形成新的序题模式。在选文编次上,不拘泥于辨析文体的体裁、形式等外在要素,而依次遵循“体—时—人”的层级结... 详细信息

“辨体”是贯穿贺复征《文章辨体汇选》的主要批评方法。他采取“省略”“改写”“补充”等方式,对“序题”进行经典化构建,形成新的序题模式。在选文编次上,不拘泥于辨析文体的体裁、形式等外在要素,而依次遵循“体—时—人”的层级结构,既继承“原释选敷”的辨体法,又独创了“四部整合”“选己入集”“裁篇摘句”的辨体法,这充分体现了其对“因文立体”的灵活使用。其“尊体”观集中表现在对“文章以体制为先”的继承与发扬上,其“破体”观则以变体为常态,以别体为创体,因此深化并完善了辨体批评的实践路径和目标,具有辨文体价值、析文体风格变化、见文体演变轨迹、示文体写作范例的重要意蕴,使《文章辨体汇选》成为明代具有集大成意义的文体总集。

关键词：序题 “因文立体” 贺复征《文章辨体汇选》辨体批评观

Effects of vacancies on interwall spacings of multi-walled carbon nanotubes

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第10期11卷 714-721页

作者： ming-du MA Jefferson Zhe LIU Li-feng WANG Lu-ming SHEN Quan-shui ZHENG Department of Engineering Mechanics Tsinghua University Beijing 100084 China Department of Mechanical and Aerospace Engineering Monash University Clayton Victoria 3168 Australia Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA School of Civil Engineering University of Sydney NSW 2006 Australia

We use molecular dynamics (MD) simulations to study the effects of vacancies on tube diameters and interwall spacings of multi-walled carbon nanotubes (MWCNTs). Two types of vacancies, double vacancy and three dangling-bond (3DB) single vacancy, are identified to have opposite effects on the tube size change, which explains the inconsistency of the experimentally measured interwall spacings of MWCNTs after electron beam irradiation. A theoretical model to quantitatively predict the shrunk structures of the irradiated MWCNTs is further developed. We also discuss the fabrications of prestressed MWCNTs, in which reduced interwall spacings are desired to enhance the overall elastic modulus and strength.

关键词： Multi-walled carbon nanotubes (MWCNTs) Noise carbon nanotubes Electron beam irradiation Defects

Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng Jie Shen Jinxing Lu Chuqiang Huang Zhuoyuan Chen feng Peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

Study and Application of Heat Treat ment of Multi-Element Wear-Resistant Low-Alloy Steel

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2006年第1期13卷 57-61页

作者： JIANG Zhi-qiang du Jian-ming feng Xi-lan Department of Industrial Engineering Zhengzhou Institute of Aeronautics Zhengzhou 450015 Henan China School of Engineering and Technology Shenzhen University Shenzhen 518060 Guangdong China

The effects of heat treatment on the properties of multi element wear-resistant low-alloy steel （MLAWS） which is used to make the liner of rolling mill torus were researched. The results show that when quenching temperature is lower than 900℃, the hardness increases with the increase of temperature, and when quenching temperature is higher than 900℃, the hardness decreases with the increase of temperature. As quenching temperature is lower than 920℃, the effect of quenching temperature on the impact toughness is not obvious. When quenching temperature is higher than 920℃ , impact toughness decreases with the increase of temperature. When tempering temperature is higher than 450 ℃ , the hardness begins to decrease obviously. After tempering at 350℃, the best wear resistance was obtained. According to the service condition of rolling mill torus liner, the MLAWS is quenched from 900-920 ℃ and tempered at 350-370℃.

关键词： rolling mill torus liner heat treatment mechanical property wear resistance

Derivation of Oridonin with Bioreduction-Responsive Disulfide Bond

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2014年第5期32卷 448-453页

作者： ming du Qisang Guo Hua feng Guolin Lu Xiaoyu Huang Obstetrics&Gynecology Hospital Shanghai Medical College of Fudan UniversityShanghai 200011China Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

A novel oridonin derivative substituted with 3-((2,3-dihydroxypropyl)dithio)-propionyl group at 14-O position was synthesized through a two-step procedure:Esterification of oridonin with 3-(2-pyridyldithio)propanoic acid and the subsequent thiol-disulfide exchange reaction with 3-mercapto-1,*** bioreduction-responsive di-sulfide bond in the compound leads to high leaving ability of the 14-O acyl moiety when treated with glutathione as monitored by reverse phase high-performance liquid chromatography.

关键词： oridonin disulfide esterification 3-mercapto-1,2-propanediol glutathione

Si/TiO_(2) carbon fiber core encapsulated in hierarchical multiple MXene@Co-MoS_(2) shells for constructing a free-standing anode of lithium storage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4222-4233页

作者： Xian-ping du Ying Huang Jia-ming Wang Zhen-he feng Xu Sun MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary Conditions School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Shanghai Institute of Space Power-Sources Shanghai 200245China Ningbo Institute of Northwestern Polytechnical University Ningbo 315103China

Silicon-based(Si-based) materials offer more possibilities for generating new portable electronic devices due to their high specific capacities. However, their inferior electrical conductivity and volume expansion during cycling seriously limit their development. The optimum solution is to select specific materials to establish an exceptionally conductive and volume buffer structure,which can assist Si materials in developing their excellent lithium storage properties. In this study, Si particles were confined in TiO_(2)carbon fibers(TiO_(2)CFs) via electrospinning, after which they were encapsulated with MXene and Co-MoS_(2)(CMS) nanosheets to fabricate hierarchical ST-2@MXene@CMS films. TiO_(2)CF, MXene and CMS were employed to establish a coherent conductive network with one-, two-and three-dimensional electronic pathways to permit the unimpeded flow of electrons inside the electrode material. TiO_(2)CF, MXene and CMS acted precisely as multilayered buffers to ameliorate the volume change of Si particles during cycling. In addition, the CMS nanosheets were involved in lithium storage, contributing to the final electrochemical performance. Ultimately, the ST-2@MXene@CMS films served as free-standing electrodes, avoiding the impact of inactive interfaces on the electrochemical performance and fulfilling the lightweight requirement for new energy storage devices.

关键词： Si particles MXene Co-MoS_(2)nanosheets Hierarchical structure Lithium-ion batteries

Recent progress in electrochemical synthesis of carbon-free hydrogen carrier ammonia and ammonia fuel cells:A review

在线全文

学校读者我要写书评

暂无评论

Materials Reports(Energy) 2022年第4期2卷 3-18页

作者： feng du Wei Sun Hui Luo Chang ming Li Institute of Materials Science and Devices School of Materials Science and EngineeringSuzhou University of Science and TechnologySuzhou215011PR China College of Chemistry and Chemical Engineering Hainan Normal UniversityHaikou571158PR China

Ammonia(NH3)is a cornerstone widely used in the modern agriculture and industry,the annual global production gradually increases to almost 200 million *** 80%of the produced NH3 is used in the fertilizer industry and is essential for the development of global agriculture and consequently for maintaining population ***,NH3 can power hydrogen(H2)fueled devices,such as H2 fuel cells(FC),to use the interconversion between chemical energy and electric energy of nitrogen(N2)cycle,which can effectively alleviate the intermittent problems of renewable ***,the problems faced by NH3 in storage and release still restrict its ***,this review introduces the latest research and development of electrochemical NH3 synthesis and direct NH3 FC,as well as outlines the technical challenges,possible improvement measures and development perspectives.N2 reduction reaction(NRR)and nitrate reduction reaction(NO3RR)are two potential approaches for electrochemical NH3 ***,the existing research foundation still faces challenges in achieving high selectivity and *** NH3 FC are easy to transport and are expected to be widely used in mobile energy consuming equipment,but also limited by the lack of highly active and stable NH3 oxidation *** perspectives of ammonia fuel cells as an alternative green energy are discussed.

关键词： Electrocatalysis Nitrogen reduction reaction(NRR) Nitrate reduction reaction(NO3RR) Carbon-free hydrogen carrier Ammonia fuel cells