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Pulmonary vein antrum isolation of pre-excited atrial fibrillation

Chinese Medical Journal 2013年第14期126卷 2613-2619页

作者： feng Xiang-fei wang Qun-shan SUN Jian ZHANG Peng-pai wang Jun wang Yue-peng LIYi-gang Department of Cardiology Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China

Background Pulmonary vein antrum isolation （PVAI） of pre-excited atrial fibrillation （AF） is controversial. This study aimed to observe the therapeutic effects of PVAI on pre-excited AF. Methods Twenty-nine patients with pre-excited AF were prospectively divided into a PVAI group （group I, 19 cases） and a control group （group II, 10 cases）. To each case in group I, PVAI was performed, and then electroanatomical mapping of accessory pathways （AP） and ablation were constructed on a three-dimensional （3D） map of the valve annulus. Only AP ablation was performed in each case of group II. Results Of the 29 cases, three were found to have dual APs, two had intermittent APs, and the remaining 24 had single APs. All APs were successfully ablated after the procedure. There were no significant statistical differences in the AP procedure duration （（77.4±21.3） minutes vs. （85.3±13.1） minutes）, the AP ablation time （（204±34） seconds vs. （223±62） seconds） and the AP X-ray exposure time （（18.6±4.4） minutes vs. （19.1±4.5） minutes） respectively between groups I and II. As compared with the control group （5 of 10 cases, 50%）, the PVAI group had a significantly lower AF recurrence rate （2 of 19 cases, 11%; P 〈0.05） during follow-up of （20.5±10.0） months. All seven patients who recurred were successfully abolished by a second ablation. Conclusions In patients with pre-excited AF, PVAI is an effective therapeutic approach with a low AF recurrence rate. 3D electroanatomical maps of AP contributed to the high success rate of ablation without significantly prolonging of operational duration and X-ray exposure time.

关键词： pre-excitation atrial fibrillation pulmonary vein antrum isolation 3D map

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XAF1 as a prognostic biomarker and therapeutic target in squamous cell lung cancer

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Chinese Medical Journal 2011年第20期124卷 3238-3243页

作者： CHEN Yong-bing SHU Jian YANG Wen-tao SHI Li GUO Xu-feng wang fei-ge QIAN Yong-yue Department of Cardiothoracic Surgery Second Affiliated HospitalSoochow University Suzhou Jiangsu 215004 China

Background X-linked inhibitor of apoptosis （XlAP）-associated factor 1 （XAF1） is a new tumor suppressor. Low expression of XAF1 is associated with poor prognosis of human cancers. However, the effect of XAF1 on lung cancer remains unknown. In this study, we investigated the expression of XAF1 and its role in squamous cell lung cancer. Methods Cancer tissues, cancer adjacent tissues and normal lung tissues were collected from 51 cases of squamous cell lung cancer. The expression of XAF1 mRNA was determined by reverse transcription-polymerase chain reaction （RT-PCR）. The expression of XAF1 protein was determined by Western blotting and immunohistochemical staining. Ad5/F35-XAF1 virus was generated. Cell proliferation and apoptosis were measured by 3-（4, 5-dimethylthiazol-2-yl）-2, 5-diphenyltetrazolium bromide （MTT） method and flow cytometry （FACS）, respectively. Results The levels of XAF1 protein and mRNA in cancer tissues were significantly lower than those in cancer adjacent and normal lung tissues （P 〈0.05）. The low expression of XAF1 was associated with tumor grade, disease stage, differentiation status and lymph node metastasis in squamous cell lung cancer patients. The restoration of XAF1 expression mediated by Ad5/F35-XAF1 virus significantly inhibited cell proliferation and induced apoptosis in a dose- and time-dependent manner. Conclusion XAF1 is a valuable prognostic marker in squamous cell lung cancer and may be a potential candidate gene for lung cancer therapy.

关键词： XAF1 human lung cancer cell lines cell proliferation apoptosis prognosis, biomarker

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直接力控制导弹的拟人智能自动驾驶仪设计

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系统仿真学报 2008年第22期20卷 6226-6229页

作者：王枫袁飞王青张明廉北京航空航天大学自动化科学与电气工程学院305教研室北京100083

拟人智能控制是一种基于被控对象的物理模型以及人类相应的知识模拟人类处理控制问题的思路和一般方法解决问题的控制方法。基于拟人智能控制思想提出一种针对采用直接力控制导弹的姿态控制的控制逻辑和非线性控制律的设计方法。控制逻... 详细信息

拟人智能控制是一种基于被控对象的物理模型以及人类相应的知识模拟人类处理控制问题的思路和一般方法解决问题的控制方法。基于拟人智能控制思想提出一种针对采用直接力控制导弹的姿态控制的控制逻辑和非线性控制律的设计方法。控制逻辑决定了气动力与直接力两种控制方式的权限分配。然后,利用拟人思想设计定性控制律。利用广义归约的方法将复杂的导弹姿态控制问题分解成若干个可直接解决的本原问题,然后依据各本原问题的主次关系以及耦合关系通过分析导弹的飞行动力学模型设计出非线性控制律结构,最后利用遗传算法将控制律中的各权值优化定量得到定量控制律。所设计出的控制逻辑和控制律在导弹进行大过载机动时保证导弹的稳定性。仿真结果表明复合控制方法可以使导弹具有更高的精度。

关键词：拟人智能控制广义规约遗传算法直接力控制复合控制

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基于企业NPD中知识转移态度对知识共享行为意向影响的研究

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图书馆理论与实践 2017年第9期 61-67页

作者：刘小锋王飞娟新乡医学院图书馆

通过知识管理系统(KMS)研究假设模型演示企业新产品开发(New Product Development,以下简称NPD)内员工知识转移态度对知识共享、知识管理(KM)质量、自我效能和组织情境有间接影响,并基于知识转移态度影响自我效能感角色的角度,构建和研... 详细信息

通过知识管理系统(KMS)研究假设模型演示企业新产品开发(New Product Development,以下简称NPD)内员工知识转移态度对知识共享、知识管理(KM)质量、自我效能和组织情境有间接影响,并基于知识转移态度影响自我效能感角色的角度,构建和研究NPD过程中分享知识模型。本研究将员工知识转移态度作为知识共享管理的一个整体,鼓励员工协同、端正知识转移态度以开展知识转移活动,以此加强自我效能感并创造良好的企业创新气氛,增强自我发现和自我效能感,为企业提供知识转移有效的方案。

关键词：知识转移态度知识共享行为意向 NPD 自我效能感组织情境

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Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong fei Luan Juanjuan Yang feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

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Retrograde approach for the recanalization of coronary chronic total occlusion： preliminary experience of a single center

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Chinese Medical Journal 2010年第7期123卷 857-863页

作者： GE Lei QIAN Ju-ying LIU Xue-bo QIN Qing CUI Shan-jing YAO Kang SHEN Li MA Jian-ying HUANG Dong XU Shi-kun ZHANG feng wang Xiang-fei wang Qi-bing FAN Bing YAN Yan feng Qi wang Hao SHEN An ZHU Ming-hui GE Jun-bo Department of Cardiology Zhongshan Hospital Fudan UniversityShanghai Institute of Cardiovascular Diseases Shanghai 200032China

Background The success rate of antegrade approach for chronic total occlusions （CTO） recanalization has not dramatically increased, especially in complex CTO subset. The retrograde technique may hold great promise. This report aimed to describe our experience of retrograde recanalization for CTO, focusing on its safety and feasibility. Methods We identified 42 patients who underwent revascularization in CTO with retrograde approach from July 2005 to November 2009 in our *** Three kinds of strategy were applied： retrograde as primary strategy （50.0%）, retrograde immediately after antegrade failure （26.2%） and repeat procedure after previous antegrade failure （23.8%）. Septal collaterals were more frequently used as the retrograde access route （92.9%）. Overall success rate was 88.1%. In patients with successful retrograde wire crossing collateral channel to the distal cap of CTO, the success rate of recanalization was 94.1%. In patient with failure to cross the collaterals, the success rate was 62.5%. Eight different kinds of retrograde techniques were used： kissing wire technique （35.3%）, wire trapped and reverse wire trapped technique （17.6%）, back-end balloon and microcatherer reversal technique （14.7%）, controlled antegrade and retrograde subintimal tracking （CART） technique （8.8%）, reverse CART and modified reverse CART technique （8.8%）, retrograde wire crossing technique （2.9%）. There were 4 complications occurred without in-hospital major adverse cardiac events （MACE）. In-hospital MACE was 7.7%. All of them were non-Q wave myocardial infarction. There were no cases of death or target vessel revascularization, either surgery or *** The retrograde approach can be an effective tool for increasing the success rate of recanalization in the very complex CTO. To ensure the success and safety of the approach, careful case selection and device handling by experienced operators is essential.

关键词： chronic total occlusions retrograde collaterals percutaneous coronary intervention

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei feng Jian-Ning Fu Peng Gao Xue-fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang feng-fei wang Guo-Min wang Hai wang Hong-Chi wang Jian wang Jia-Ning wang Jian-Ling wang Jian-Ping wang Jun-Xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang Yue-fei wang You-Fen wang Peng Wei Ming-Zhi Wei Hong Wu Ke-fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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南京城市现代化的战略目标与对策研究

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南京师范专科学校学报 2000年第1期16卷 120-127页

作者：冯年华王飞南京师专.教院副教授南京210017

在江苏现代化进程中 ,南京具有良好的区位优势 ,处于特殊的战略地位。南京城市现代化的目标体系由规划管理、人口素质、生活质量、基础设施、经济结构、社会发展、城市环境七个方面构成 ,实施这一目标则需要从人的现代化建设 ,提升中心... 详细信息

在江苏现代化进程中 ,南京具有良好的区位优势 ,处于特殊的战略地位。南京城市现代化的目标体系由规划管理、人口素质、生活质量、基础设施、经济结构、社会发展、城市环境七个方面构成 ,实施这一目标则需要从人的现代化建设 ,提升中心城市功能 ,调整城市空间结构。

关键词：南京现代化目标对策

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2007至2016年上海市新生儿唇腭裂出生缺陷率发生趋势分析

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中华口腔医学杂志 2018年第5期53卷 301-306页

作者：李丽虞慧婷王旭东周峰王飞王春芳上海交通大学医学院附属第九人民医院口腔颅颌面科上海市口腔医学重点实验室上海市口腔医学研究所国家口腔疾病临床研究中心 200011 上海市疾病预防控制中心信息所 200336 上海市徐汇区疾病预防控制中心 200237

目的分析上海市2007至2016年新生儿唇腭裂的出生缺陷率变化趋势，为唇腭裂的预防、治疗与护理提供参考。方法收集上海市2007年1月至2016年12月出生登记信息，分析新生儿唇腭裂的出生缺陷率、性别比例及与母亲年龄的关系，采用年均变化... 详细信息

目的分析上海市2007至2016年新生儿唇腭裂的出生缺陷率变化趋势，为唇腭裂的预防、治疗与护理提供参考。方法收集上海市2007年1月至2016年12月出生登记信息，分析新生儿唇腭裂的出生缺陷率、性别比例及与母亲年龄的关系，采用年均变化百分比分析时间变化趋势。结果上海市近10年唇腭裂患儿的总出生缺陷率为9.37/万，整体呈下降趋势，比2007年下降28.20%。其中单纯性唇裂总下降率为40.86%，唇裂合并腭裂总下降率为54.60%，单纯性腭裂的出生缺陷率呈上升趋势，总体上升率为14.34%。单纯性腭裂患儿中女性是男性的1.6倍，单纯性唇裂患儿中男性是女性的1.8倍；唇裂合并腭裂患儿中男性是女性的1.5倍。42.01％的新生儿母亲年龄为25- 29岁，在此年龄段新生儿唇腭裂的出生缺陷率最低，为8.53／万。母亲年龄过低或过高均可增加新生儿唇腭裂的发生风险，母亲年龄〈20岁的婴儿唇腭裂出生缺陷率达13.08/万，母亲年龄≥40岁时，其新生儿唇腭裂的出生缺陷率达18.82/万。结论上海市近10年新生儿唇腭裂的总体出生缺陷率呈下降趋势，单纯性唇裂和唇裂合并腭裂明显下降，但是单纯性腭裂有上升趋势。〈20岁或≥40岁的母亲都将增加新生儿唇腭裂出生缺陷的风险。

关键词：唇裂腭裂出生缺陷率趋势分析

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Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-Li Luo Hao-Tong Zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui Guo-Ping Li Yao-Quan Chu Jian-Rong Shi Gang wang Jian-Nan Zhang Zhong-Rui Bai Xiao-Yan Chen feng-fei wang Yan-Xin Guo Jian-Jun Chen Bing Du Xiao Kong Ya-Juan Lei Yin-Bi Li Yi-Han Song Yue Wu Yan-Xia Zhang Xin-Lin Zhou Fang Zuo Peng Du Lin He Wen Hou Yi-Qiao Dong Jian Li Guang-Wei Li Shuang Li Jing Song Yuan Tian Meng-Xin wang Yong-Hui Hou Zhi-Ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Qi Li Yin-Dun Mao Zheng-Hong Tang Qing-Sheng Tao Liang-Ping Tu Da-Qing wang Dan wang Jian-Ping wang Lei wang Shou-Guan wang Shu-Qing wang Ya-Nan wang You wang Yue-fei wang Ming-Zhi Wei Xiang-Xiang Xue Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu De-Hua Yang Shi-Hai Yang Zheng-Qiu Yao Yong Yu Hui Yuan Chao Zhai En-Peng Zhang Jing Zhang Li-Ping Zhang WeiZhang Yong Zhang Zhen-Chao Zhang Ming Zhao Fang Zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

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