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Mufangji tang ameliorates pulmonary arterial hypertension through improving vascular remodeling,inhibiting inflammatory response and oxidative stress,and inducing apoptosis

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Traditional Medicine Research 2024年第2期9卷 52-65页

作者： Yu-Ming wang Hong-Wei Tao feng-chan wang Ping Han Na Liu Guo-Jing Zhao Hai-Bo Hu Xue-Chao Lu College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Respiratory and Critical Care Medicine Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser hospital)Qingdao 266000China.

Background:Mufangji tang(MFJT)is composed of Ramulus Cinnamomi,Radix Ginseng,Cocculus orbiculatus(Linn.)DC.,and *** clinical settings,MFJT has been effectively employed in addressing a range of respiratory disorders,notably including pulmonary arterial hypertension(PAH).However,the mechanism of action of MFJT on PAH remains ***:In this study,a monocrotaline-induced PAH rat model was established and treated with *** therapeutic effects of MFJT on PAH rat model were *** pharmacology was conducted to screen the possible targets for MFJT on PAH,and the molecular docking between the main active components and the core targets was carried *** key targets identified from network pharmacology were ***:Results showed significant therapeutic effects of MFJT on PAH rat *** of network pharmacology revealed several potential targets related to apoptosis,inflammation,oxidative stress,and vascular *** docking showed that the key components were well docked with the core *** experimental validation results that MFJT treatment induced apoptosis(downregulated Bcl-2 levels and upregulated Bax levels in lung tissue),inhibited inflammatory response and oxdative stress(decreased the levels of IL-1β,TNF-α,inducible NOS,and malondialdehyde,and increased the levels of endothelial nitric oxide synthase,nitric oxide,glutathione and superoxide dismutase),reduced the proliferation of pulmonary arterial smooth muscle cells(downregulated ET-1 andβ-catenin levels and ERK1/2 phosphorylation,increased GSK3βlevels).Conclusion:Our study revealed MFJT treatment could alleviate PAH in rats via induction of apoptosis,inhibition of inflammation and oxidative stress,and the prevention of vascular remodeling.

关键词： Mufangji tang pulmonary arterial hypertension apoptosis inflammatory response oxidative stress vascular remodeling

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How can technology and efficiency alleviate the dilemma of economic growth and carbon emissions in China's industrial economy? A metafrontier decoupling decomposition analysis

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Petroleum Science 2024年第2期21卷 1415-1428页

作者： Miao wang Chao feng School of Business Zhengzhou UniversityZhengzhou450001HenanChina School of Economics and Business Administration Chongqing UniversityChongqing400030China

This paper attempts to explore the decoupling relationship and its drivers between industrial economic increase and energy-related CO_(2) emissions(ICE). Firstly, the decoupling relationship was evaluated by Tapio index. Then, based on the DEA meta-frontier theory framework which taking into account the regional and industrial heterogeneity and index decomposition method, the driving factors of decoupling process were explored mainly from the view of technology and efficiency. The results show that during2000-2019, weak decoupling was the primary state. Investment scale expansion was the largest reason hindering decoupling process of industrial increase from ICE. Both energy saving and production technology achieved significant progress, which facilitated the decoupling process. Simultaneously, the energy technology gap and production technology gap among regions have been narrowed, and played a role in promoting decoupling process. On the contrary, both scale economy efficiency and pure technical efficiency have inhibiting effects on decoupling process. The former indicates that the scale economy of China's industry was not conducive to improve energy efficiency and production efficiency, while the latter indicates that resource misallocation problem may exist in both energy market and product market.

关键词： China's industrial sector Decoupling process Meta-frontier DEA Index decomposition method Driving factors

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Editorial for Multiscale&Multifield Coupling in Geomechanics

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1919-1921页

作者： Min wang Pengzhi Pan Andrew H.C.chan Y.T.feng T-3 Fluid Dynamics and Solid Mechanics Theoretical DivisionLos Alamos National LaboratoryNew MexicoUSA Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhanChina School of Engineering University of TasmaniaTasmaniaAustralia College of Engineering Swansea UniversityWalesUK

We are delighted to serve as guest editors for this special issue in the Journal of Rock Mechanics and Geotechnical *** purpose of this special issue is dedicated to gathering the latest research work on Multiscale&Multifield Coupling in Geomechanics,where we delve into the intricate interplay of various fields and scales that govern the behavior of *** total,30 manuscripts from USA,China,UK,Germany,Canada,India and United Arab Emirates are selected to be included in this issue.

关键词： materials. gathering mechanics

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A novel method for AFRPs burrs removal:Principle of mechanochemo-induced fiber fracture

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Chinese Journal of Aeronautics 2024年第7期37卷 522-538页

作者： Jie XU Bo LI Pingfa feng Qiang wang feng feng Division of Advanced Manufacturing Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China changhe Aircraft Industry(Group)Co.Ltd Jingdezhen 333000China

Burrs generated during the machining of Aramid-Fiber-Reinforced Composites(AFRPs)pose a challenge for the production efficiency of aircraft and helicopter housing *** studies have generally attempted to suppress burrs by referring to delamination suppression *** contrast to stratification,burrs are remediable machining *** such,a mechanochemical method with burrs trimming technological strategy are implemented to effectively combat ***,we clarify the mechanism by which aramid fibers cannot be cut off using analytical and numerical *** addition,the mechanism of fiber fracture with Modified Polyurethane Reactive Polymer(M-PUR),and development of anti-burr devices(thermostatic adhesive sealed generator)are ***,the experimental results show that the reduction rate in burr length is 87%-91%through the mechanochemical *** method not only opens a new avenue to solve the burr problem of aramid fibers but also builds an interdisciplinary bridge between polymer science and composite machining.

关键词： Mechanochemical method Burrs Orthogonal cutting Aramid fiber-reinforced composites Milling

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Derivation of Expanded Isospectral-Nonisospectral Integrable Hierarchies via the Column-vector Loop Algebra

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 778-800页

作者： Hai-feng wang Yu-feng ZHANG School of Science Jimei UniversityXiamen 361021China School of Mathematics China University of Mining and TechnologyXuzhou 221116China

A scheme for generating nonisospectral integrable hierarchies is *** on the method,we deduce a nonisospectral hierarchy of soliton equations by considering a linear spectral *** follows that the corresponding expanded isospectral and nonisospectral integrable hierarchies are deduced based on a 6 dimensional complex linear space ■.By reducing these integrable hierarchies,we obtain the expanded isospectral and nonisospectral derivative nonlinear Schr?dinger *** using the trace identity,the biHamiltonian structure of these two hierarchies are also ***,some symmetries and conserved quantities of the resulting hierarchy are discussed.

关键词： expanded isospectral-nonisospectral integrable hierarchies column-vector loop algebra bi-Hamiltonian structure symmetry

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Can Yin-Chai-Xiao-Du decoction be useful of COVID-19?the mechanism research based on network pharmacology

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Traditional Medicine Research 2020年第4期5卷 188-200页

作者： Lu Yang Ning Li Hai-Bo Hu Bin Yin Guo-Jing Zhao feng-chan wang Xu-Hui wang Hong-Wu wang Xue-Chao Lu Huan-Tian Cui Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China First Clinical Hospital Shandong University of Traditional Chinese MedicineJinan 250000China Department of Pulmonary Disease in Qingdao Hospital of Traditional Chinese Medicine Qingdao 266700China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250000China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology School of Life SciencesShandong UniversityQingdao 250100China

Background:In this study,we preliminarily investigated the mechanism of Yin-Chai-Xiao-Du decoction for the treatment of COVID-19 by the method of network ***:The potential targets and pathways of Yin-Chai-Xiao-Du decoction for the treatment of COVID-19 were examined using network pharmacology;the ingredient and active targets of Yin-Chai-Xiao-Du decoction were collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and PharmMapper databases;the COVID-19-related targets were obtained from the online Mendelian inheritance in man,GeneCards,and GeneMANIA databases;the STRING database and Cytoscape were used to build a protein-protein interaction network,and a Network Analyzer tool was used to perform topology analysis to screen for the key ingredients and targets;the ClueGO and KOBAS 3.0 databases were for the enrichment analysis of gene function(Gene Oncology)and gene pathway(Kyoto Encyclopedia of Genes and Genomes);the herb-ingredient-target-pathway network diagram was constructed by ***:The core herbs screened by the network pharmacological analysis were Jinyinhua(Lonicerae japonicae flos),Lianqiao(Forsythia suspensa),Chaihu(Bupleuri radix),Huangqin(Scutellariae radix),Yinchen(Herba Artemisiae Scopariae),Guanghuoxiang(Pogostemonis herba),Roudoukou(Semen myristicae)and Qinghao(Artemisiae annuae herba).A total of 293 active ingredients were screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,and the key ingredients were quercetin,kaempferol,isorhamnetin,stigmasterol,beta-sitosterol,and ***-Chai-Xiao-Du decoction has 138 COVID-19-related targets,and the key targets were mitogen-activated protein kinase 3,interleukin-6,tumor necrosis factor,vascular endothelial growth factor A,and CC motif ligand *** Encyclopedia of Genes and Genomes analysis revealed 120 enriched gene pathways,and the key pathways were signaling by interleukins,immune system,c

关键词： Coronavirus disease 2019 Bupleuri radix Scutellariae radix Artemisiae annuae herba Cytokine Storm Tumor necrosis factor Interleukin-6

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Efficient Monolithic Perovskite/Silicon Tandem Photovoltaics

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Energy & Environmental Materials 2024年第3期7卷 268-281页

作者： Yong wang Yu wang feng Gao Deren Yang State Key Laboratory of Silicon Materials and School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 310014China Department of Physics Chemistry and Biology(IFM)Linköping UniversityLinköping 58183Sweden

Tunable bandgaps make halide perovskites promising candidates for developing tandem solar cells(TSCs),a strategy to break the radiative limit of 33.7%for single-junction solar *** perovskites with market-dominant crystalline silicon(c-Si)is particularly attractive;simple estimates based on the bandgap matching indicate that the efficiency limit in such tandem device is as high as 46%.However,state-of-the-art perovskite/c-Si TSCs only achieve an efficiency of~32.5%,implying significant challenges and also rich *** this review,we start with the operating mechanism and efficiency limit of TSCs,followed by systematical discussions on wide-bandgap perovskite front cells,interface selective contacts,and electrical interconnection layer,as well as photon management for highly efficient perovskite/c-Si *** highlight the challenges in this field and provide our understanding of future research directions toward highly efficient and stable large-scale wide-bandgap perovskite front cells for the commercialization of perovskite/c-Si TSCs.

关键词： 2-terminal electrical interconnection perovskite/silicon tandem photovoltaics photon management wide-bandgap perovskites

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Advantages and prospects of traditional Chinese medicine in treating COVID-19

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Traditional Medicine Research 2023年第4期8卷 38-48页

作者： feng-chan wang Ping Han Hong Li Hai-Yan Ye Pei-Xia Zhou Wei Tian Yi Xiao Yi Wei Kun wang Xue-Chao Lu Hai-Bo Hu Department of Pulmonary Disease in Qingdao Hospital of Traditional Chinese Medicine Qingdao 266033China Clinical Laboratory in Qingdao Hospital of Traditional Chinese Medicine Qingdao 266033China Department of Internal Medicine in Qingdao Technicians College Qingdao 266229China First Clinical Hospital Shandong University of Traditional Chinese MedicineJinan 250355China

Towards the end of 2019,a novel coronavirus pneumonia(coronavirus disease 19,COVID-19)caused by SARS-CoV-2 infection emerged in *** SARS-CoV-2 virus quickly spread across the globe,seriously affecting public health and economic development of countries ***,antiviral drugs developed for COVID-19 lack strong clinical trial support and the high mutation rate of the virus causes difficulties in vaccine development,thus a complex and delayed large scale role out of an efficacious *** Chinese medicine(TCM)has been used for treating various conditions for thousands of years and has a unique systems *** can be individualized into specific therapeutic regimens according to the patients’physical condition,clinical symptoms,and other distinguishing *** addition,TCM often has different effects at different disease stages,thus contributing to disease prevention,treatment,and *** evidence shows that TCM has efficacy in the treatment of *** active ingredients of TCM have various pharmacological properties,including antiviral,anti-inflammatory,and immunomodulatory activity,with clinical trials showing that these prescriptions reduce symptoms of COVID-19,promote viral clearance,and ultimately improve survival in infected *** article discusses the advantages and mechanisms of TCM in the treatment of COVID-19,hoping to provide a reference platform in the fight against the disease.

关键词： traditional Chinese medicine COVID-19 SARS-CoV-2 benefits

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Mathematics of multi-agent learning systems at the interface of game theory and artificial intelligence

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Science China(Information Sciences) 2024年第6期67卷 445-447页

作者： Long wang feng FU Xingru CHEN Center for Systems and Control College of EngineeringPeking University Center for Multi-Agent Research Institute for Artificial IntelligencePeking University Department of Mathematics Dartmouth College Department of Biomedical Data Science Geisel School of Medicine at Dartmouth School of Science Beijing University of Posts and Telecommunications

Evolutionary game theory (EGT) and artificial intelligence(AI) are two fields that,at first glance,might seem distinct,but they have notable connections and *** former focuses on the evolution of behaviors (or strategies)in a population,where individuals interact with others and update their strategies based on imitation (or social learning).

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Adhesive Contact of Elastic Solids with Self-Affine Fractal Rough Surfaces

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Acta Mechanica Solida Sinica 2024年第2期37卷 265-270页

作者： Xuan-Ming Liang Shi-Wen Chen Si-He wang Zhen-Yuan Gong Jun feng Gang-feng wang Department of Engineering Mechanics SVL and MMMLXi’an Jiaotong UniversityXi’an710049China OPPO Mobile Telecommunications Corporation Ltd. Dongguan523860China

The elastic adhesive contact of self-affine fractal rough surfaces against a rigid flat is simulated using the finite element method. An array of nonlinear springs, of which the force-separation law obeys the Lennard–Jones potential, is introduced to account for the interfacial adhesion. For fractal rough surfaces, the interfacial interaction is generally attractive for large mean gaps, but turns repulsive as the gap continuously shrinks. The interfacial interactions at the turning point corresponding to the spontaneous contact are shown for various surfaces. For relatively smooth surfaces, the probability density distributions of repulsion and attraction are nearly symmetric. However, for rougher surfaces, the simulation results suggest a uniform distribution for attraction but a monotonously decreasing distribution with a long tail for repulsion. The pull-off force rises with increasing ratio of the work of adhesion to the equilibrium distance, whereas decreases for solids with a higher elastic modulus and a larger surface roughness. The current study will be helpful for understanding the adhesion of various types of rough solids.

关键词： Fractal rough surfaces Adhesion Contact mechanics Lennard-Jones potential

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