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Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus

Animal Models and Experimental Medicine 2024年第4期7卷 433-443页

作者： Xin-Yue Liu Han-Wen Zheng feng-zhong wang Tul-Wahab Atia Bei Fan Qiong wang Institute of Food Science and Technology Chinese Academy of Agricultural SciencesBeijingChina Sino-Portugal TCM International Cooperation Center the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhouChina Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachiPakistan

In traditional Chinese medicine(TCM),based on various pathogenic symptoms and the‘golden chamber’medical text,Huangdi Neijing,diabetes mellitus falls under the category‘collateral disease’.TCM,with its wealth of experience,has been treating diabetes for over two *** antidiabetic Chinese herbal medicines re-duce blood sugar,with their effective ingredients exerting unique *** well as a glucose lowering effect,TCM also regulates bodily functions to prevent diabetes associated complications,with reduced side effects compared to western synthetic *** herbal medicine is usually composed of polysaccharides,saponins,al-kaloids,flavonoids,and *** active ingredients reduce blood sugar via various mechanism of actions that include boosting endogenous insulin secretion,enhancing insulin sensitivity and adjusting key enzyme activity and scavenging free *** actions regulate glycolipid metabolism in the body,eventually achiev-ing the goal of normalizing blood *** different animal models,a number of molecular markers are available for the detection of diabetes induction and the molecular pathology of the disease is becoming ***,there is a dearth of scientific data about the pharmacology,dose-effect relationship,and structure-activity relationship of TCM and its *** research into the efficacy,toxicity and mode of action of TCM,using different metabolic and molecular markers,is key to developing novel TCM antidiabetic formulations.

关键词： animal model Chinese herbal medicine diabetes mellitus evaluation index mechanism of action

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Synthesis and Optoelectronic Properties of Donor-acceptor Molecules Containing Pyromellitic Diimide Chromophore

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Chemical Research in Chinese Universities 2013年第6期29卷 1083-1088页

作者： ZHANG Qian LU Xue-feng wang zhong-sheng ZHOU Gang Laboratory of Advanced Materials Department of ChemistryFudan University Shanghai 200438 P.R.China

Three donor-acceptor molecules containing pyromellitic diimide chromophore were designed and synthe- sized. The synthetic route towards the target compounds was systematically investigated and discussed in detail. The resulted organic semiconductors have shown promising optoelectronic properties as further revealed by UV-Vis ab- sorption spectroscopy, cyclic voltammetry, and theoretic calculation.

关键词： Pyromellitic diimide Donor-acceptor Charge transfer

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NUMERICAL SIMULATION OF FLOW FIELDS IN A NATURAL DRAFT WET-COOLING TOWER

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Journal of Hydrodynamics 2007年第6期19卷 762-768页

作者： YANG Xiang-liang SUN feng-zhong wang Kai SHI Yue-tao wang Nai-hua Heze Power Plant China Guodian Coporation Heze 274000 China School of Power and Energy Engineering Shandong University Jinan 250061 China

The flow field in the hyperbolic natural draft wet-cooling tower, which has great effects on the economy and security of power plant, was studied through numerical simulation. The mathematical model was established and analyzed in order to optimize the cooling-tower and to evaluate its efficiency. Various working conditions were considered and compared with each other, such as the circulating water flux, air temperature and tower resistance. It is concluded that when the cooling-tower runs without wind, there is a vacuum region inside the tower and the pressure rises with the increase of the tower height. Meanwhile, the inner flow field is axisymmetrical. The air velocity achieves its climax at the axis. It is also found that the effect of circulating water temperature is equivalent to that of the water flux.

关键词： cooling tower flow field circulation water flux circulation water temperature numerical simulation

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Extraction(DSX) from Erigeron breviscapus modulates outward potassium currents in rat retinal ganglion cells

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1101-1106页

作者： Shuo Yin zhong-feng wang Jun-Guo Duan Lu Ji Xue-Jing Lu Key Laboratory for Visual Function and Ophthalmopathy Chengdu University of Traditional Chinese Medicine Institutes of Brain Science Fudan University

AIMTo investigate the effect of DSX, an active component extracted from Erigeron breviscapus, on the voltage-gated outward K+ channel currents in rat retinal ganglion cells (RGCs) by using electrophysiological method, and to explore the possible mechanisms of DSX on optic nerve *** K+ currents were recorded by using whole-cell patch-clamp techniques on acutely isolated rat RGCs. Outward K+ currents were induced by a series of depolarizing voltage pulses from a holding potential of -70 mV to +20 mV in an increment of 10 *** application of DSX voltage-dependently suppressed both the steady-state and peak current amplitudes of outward K+ currents in rat RGCs. Furthermore, DSX reversibly and dose-dependently inhibited the amplitudes of outward K+ currents of the cells. At +20 mV membrane potential DSX at the concentrations of 0.02 g/L and 0.05 g/L showed no significant effects on the currents. In contrast, DSX at higher concentrations (0.1 g/L, 0.2 g/L and 0.5 g/L) significantly suppressed the current *** results suggest that DSX reversibly and dose-dependently suppress outward K+ channel currents in rat RGCs, which may be one of the possible mechanisms underlying Erigeron breviscapus prevents vision loss and RGC damage caused by glaucoma.

关键词： Erigeron breviscapus retinal ganglion cells potassium channel

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L-and T-type Ca^(2+)channels dichotomously contribute to retinal ganglion cell injury in experimental glaucoma

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Neural Regeneration Research 2023年第7期18卷 1570-1577页

作者： Hong-Ning wang Wen-Jing Qian Guo-Li Zhao Fang Li Yan-Ying Miao Bo Lei Xing-Huai Sun zhong-feng wang State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghaiChina Institutes of Neuroscience and Third Affiliated Hospital Henan Provincial People’s HospitalHenan Eye InstituteHenan Eye HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute and Department of Ophthalmology Eye&ENT HospitalNHC Key Laboratory of MyopiaShanghai Key Laboratory of Visual Impairment and RestorationFudan UniversityShanghaiChina

Retinal ganglion cell apoptotic death is the main pathological characteristic of glaucoma,which is the leading cause of irreversible *** of Ca^(2+)homeostasis plays an important role in ***-gated Ca^(2+)channel blockers have been shown to improve vision in patients with ***,whether and how voltage-gated Ca^(2+)channels are involved in retinal ganglion cell apoptotic death are largely *** this study,we found that total Ca^(2+)current densities in retinal ganglion cells were reduced in a rat model of chronic ocular hypertension experimental glaucoma,as determined by whole-cell patch-clamp electrophysiological *** analysis showed that L-type Ca^(2+)currents were downregulated while T-type Ca^(2+)currents were upregulated at the later stage of *** blot assay and immunofluorescence experiments confirmed that expression of the Ca_(V)1.2 subunit of L-type Ca^(2+)channels was reduced and expression of the Ca_(V)3.3 subunit of T-type Ca^(2+)channels was increased in retinas of the chronic ocular hypertension *** tumor necrosis factor-α,an important inflammatory factor,inhibited the L-type Ca^(2+)current of isolated retinal ganglion cells from control rats and enhanced the T-type Ca^(2+)*** changes were blocked by the tumor necrosis factor-αinhibitor XPro1595,indicating that both types of Ca^(2+)currents may be mediated by soluble tumor necrosis factor-α.The intracellular mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and nuclear factor kappa-B signaling pathway mediate the effects of tumor necrosis factor-α.TUNEL assays revealed that mibefradil,a T-type calcium channel blocker,reduced the number of apoptotic retinal ganglion cells in the rat model of chronic ocular *** results suggest that T-type Ca^(2+)channels are involved in disrupted Ca^(2+)homeostasis and apoptosis of retinal ganglion cells in glaucoma,and application of T-type

关键词： apoptosis CaV1.2 CaV3.3 chronic ocular hypertension extracellular signal-regulated kinase mitogen-activated protein kinase nuclear factor-kappa B patch-clamp retina tumor necrosis factor-α

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Research of multilayers in EUV, soft X-ray and X-ray

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光学精密工程 2005年第4期13卷 512-518页

作者： wang Zhan-shan wang feng-li ZHANG zhong wang Hong-chang WU Wen-juan ZHANG Shu-min XU Yao GU zhong-xiang CHENG Xin-bin L1 Cun-xia WU Yong-rong wang Bei QIN Shu-jin CHEN Ling-yan Institute of Precision Optical Engineering Department of Physics Tongji University Shanghai 200092 China

To develop beam splitters for soft X-ray laser Michelson interferometer at 13.9 nm, Mo/Si multilayers of 100 nm thickness deposited on both sides of silicon nitride were fabricated by using DC magnetron sputtering. Initial evaluation of their reflectivity and transmission showed that reflectivity and transmission were above 10% and 25%. The broadband analyzers have been designed, fabricated and characterized for 13～20 nm polarization measurements. The measured results are in good agreement with the design. The supermirrors with different angular intervals at 0.154 nm have been designed, fabricated and characterized.

关键词： EUV X射线多层性激光宽带光纤

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Highly efficient expression of human extracellular superoxide dismutase(rhEcSOD)with ultraviolet-B-induced damage-resistance activity in transgenic silkworm cocoons

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Insect Science 2024年第4期31卷 1150-1164页

作者： feng wang Ri-Yuan wang De-Bin zhong Ping Zhao Qing-You Xia Integrative Science Center of Germplasm Creation in Western China(CHONGQING)Science City Biological Science Research CenterSouthwest UniversityChongqingChina Century Legend Biotechnology Research Institute(Chongqing)Co. Ltd.ChongqingChina

Extracellular superoxide dismutase(EcSOD)protects tissues from oxidative stress,and thus is considered as a therapeutic agent for many diseases such as atherosclerosis,hypertension,and ***,cost-effective production of bioactive recombinant human EcSOD(rhEcSOD)remains a ***,we developed an efficient strategy for producing active rhEcSOD by transgenic *** was successfully synthesized as homodimers and homotetramers in the middle silk gland and spun into the cocoons with a concentration of 9.48±0.21 mg/*** of rhEcSOD from the cocoons could be conveniently achieved with a purity of 99.50%and a yield of 3.5±0.5 mg/***,N-glycosylation at the only site of N89 in rhEcSOD with 10 types were *** purified rhEcSOD gained the potent enzymatic activity of 4162±293 U/mg after Cu/Zn ions *** importantly,rhEcSOD was capable of penetrating and accumulating in the nuclei of cells to maintain cell morphology and attenuate ultraviolet B-induced cell apoptosis by eliminating reactive oxygen species and inhibiting the C-Jun N-terminal kinase signaling *** results demonstrated that the transgenic silkworm could successfully produce rhEcSOD with enzymatic and biological activities for biomedical applications.

关键词： antioxidant human extracellular superoxide dismutase recombinant expression silkworm silk gland

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Cure of experimental botulism and antibotulismic effect of toosendanin

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Acta Pharmacologica Sinica 2004年第6期25卷 137-146页

作者： Yu-liang SHI2, zhong-feng wang Key laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy ofScience, Shanghai200031, China Key laboratory of Neurobiology Shanghai Institutes for Biological Sciences Chinese Academy of Science Shanghai 200031 Chin

Botulinum neurotoxins (BoNTs), a group of bacterial proteins that comprise a light chain disulfide linked a heavy chain, are the most lethal biotoxins known to mankind. By inhibiting neurotransmitter release, BoNTs cause severe neuroparalytic disease, botulism. A series of important findings in the past 10 years which displayed the molecular targets of BoNTs and hence proposed a four-step action mechanism to explain BoNT intoxication greatly advanced the study of antibotulismic drug. In this article, we reviewed these progresses and anti-botulismic compounds found in recent years. These compounds function due to their facilitation on neurotransmitter release or to their interference on the binding, internalization, translocation, and endopeptidase activity of the toxins. Toosendanin is a triterpenoid derivative extracted from a digestive tract-parasiticide in Chinese traditional medicine. Chinese scientists have found that the compound is a selective prejunctional blocker. In spite of sharing some similar action with BoNT, toosendanin can protect botulism animals that have been administrated with lethal doses of BoNT/A or BoNT/B for several hours from death and make them restore normal activity. The neuromuscular junction preparations isolated from the rats that have been injected with toosendanin tolerate BoNT/A challenge. Toosendanin seems to have no effect on endopeptidase activity of BoNT, but blocks the toxin approach to its enzymatic substrate.

关键词： toosendanin botulinum toxins botulism synaptic transmission neurotransmitter triterpene Chinese traditional medicine

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Microfluidic-based isolation of circulating tumor cells with high-efficiency and high-purity

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Chinese Chemical Letters 2024年第8期35卷 101-111页

作者： feng Wu Xuemin Kong Yixuan Liu Shuli wang zhong Chen Xu Hou Fujian Engineering Research Center for Solid-State Lighting Department of Electronic ScienceSchool of Electronic Science and EngineeringXiamen UniversityXiamen 361005China College of Physics and New Energy Xuzhou University of TechnologyXuzhou 221018China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Physical Science and Technology Xiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China

The isolation of circulating tumor cells(CTCs)from complex biological samples is of paramount signifi-cance for advancing cancer diagnosis,prognosis,and ***,the low concentration of CTCs and nonspecific adhesion of white blood cells(WBCs)present challenges that hinder the efficiency and purity of captured ***-based strategies utilize precise fluid control at the micron level to incorporate specific micro/nanostructures or recognition molecules,enabling effective CTCs ***,by employing surface modification designs that exhibit exceptional anti-adhesion properties against WBCs,the purity of isolated CTCs can be further *** review offers an in-depth explo-ration of recent advancements,challenges,and opportunities associated with microfluidic-based CTCs iso-lation from biological ***,we will comprehensively introduce the microfluidic-based strate-gies for achieving high-efficiency CTCs isolation,which includes the morphological design of microchan-nels for physical force-based CTCs isolation and the specific modification of microchannel surfaces for affinity-based CTCs ***,a review of recent research advances in microfluidic-based high-purity CTCs isolation is presented,focusing on strategies that decrease the nonspecific adhesion of WBCs through surface micro-/nanostructure construction or chemical and biological ***,we will summarize the article by providing the prospective opportunities and challenges for the future development of microfluidic-based CTCs isolation.

关键词： Microfluidics Isolation Circulating tumor cells High-efficiency High-purity

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An Active Deception Defense Model Based on Address Mutation and Fingerprint Camouflage

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China Communications 2024年第7期21卷 212-223页

作者： wang Shuo Chu Jiang Pei Qingqi Shao feng Yuan Shuai zhong Xiaoge State Key Laboratory of Astronautic Dynamics Xi’an Satellite Control CenterXi’an 710043China State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710071China Shaanxi Key Laboratory of Blockchain and Secure Computing Xidian UniversityXi’an 710071China

The static and predictable characteristics of cyber systems give attackers an asymmetric advantage in gathering useful information and launching *** reverse this asymmetric advantage,a new defense idea,called Moving Target Defense(MTD),has been proposed to provide additional selectable measures to complement traditional ***,MTD is unable to defeat the sophisticated attacker with fingerprint tracking *** overcome this limitation,we go one step beyond and show that the combination of MTD and Deception-based Cyber Defense(DCD)can achieve higher performance than either of *** particular,we first introduce and formalize a novel attacker model named Scan and Foothold Attack(SFA)based on cyber kill ***,we develop probabilistic models for SFA defenses to provide a deeper analysis of the theoretical effect under different defense *** models quantify attack success probability and the probability that the attacker will be deceived under various conditions,such as the size of address space,and the number of hosts,attack analysis ***,the experimental results show that the actual defense effect of each strategy almost perfectly follows its probabilistic ***,the defense strategy of combining address mutation and fingerprint camouflage can achieve a better defense effect than the single address mutation.

关键词： address mutation deception defense fingerprint camouflage moving target defense probabilistic model

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