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Chinese Chemical Letters 2006年第7期17卷 853-856页

作者： Ye WANG Zhan Zhu LIU Ye feng TANG Shi zhi chen Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100050

Two functionalized pentacyclic compounds 12a, 12b were constructed via a highly efficient synthetic route, employing a tricyclic amino aldehyde as the key intermediate. The crucial steps involved coupling of two segme... 详细信息

关键词： Ecteinascidin saframycin tetrahydroisoquinoline Pictet-Spengler reaction.

Combination of low-energy shock-wave therapy and bone marrow mesenchymal stem cell transplantation to improve the erectile function of diabetic rats

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Asian Journal of Andrology 2017年第1期19卷 26-33页

作者： Hai-Tao Shan Hai-Bo Zhang Wen-Tao chen feng-zhi chen Tao Wang Jin-Tai Luo Min Yue Ji-Hong Lin An-Yang Wei Department of Urology Medical Center for Overseas Patients Nanfang Hospital Southern Medical University Guangzhou China Department of Urology Shawan People's Hospital Panyu District Guangzhou China Shenzhen Hyde Medical Equipment Co. Ltd. Shenzhen China Department of Urology Longjiang HospitalShunde District Foshan China Laboratory Animals Center Southern Medical University Guangzhou China.

Stem cell transplantation and low-energy shock-wave therapy （LESWT） have emerged as potential and effective treatment protocols for diabetic erectile dysfunction. During the tracking of transplanted stem cells in diabetic erectile dysfunction models, the number of visible stem cells was rather low and decreased quickly. LESWT could recruit endogenous stem cells to the cavernous body and improve the microenvironment in diabetic cavernous tissue. Thus, we deduced that LESWT might benefit transplanted stem cell survival and improve the effects of stem cell transplantation. In this research, 42 streptozotocin-induced diabetic rats were randomized into four groups： the diabetic group （n = 6）, the LESWT group （n = 6）, the bone marrow-derived mesenchymal stem cell （BMSC） transplantation group （n = 15）, and the combination of LESWT and BMSC transplantation group （n = 15）. One and three days after BMSC transplantation, three rats were randomly chosen to observe the survival numbers of BMSCs in the cavernous body. Four weeks after BMSC transplantation, the following parameters were assessed： the surviving number of transplanted BMSCs in the cavernous tissue, erectile function, real-time polymerase chain reaction, and penile immunohistochemical assessment. Our research found that LESWT favored the survival of transplanted BMSCs in the cavernous body, which might be related to increased stromal cell-derived factor-1 expression and the enhancement of angiogenesis in the diabetic cavernous tissue. The combination of LESWT and BMSC transplantation could improve the erectile function of diabetic erectile function rats more effectively than LESWT or BMSC transplantation performed alone.

关键词： bone marrow mesenchymal stem cell diabetes mellitus erectile function low-energy shock-wave therapy

Investigation of PM_(2.5) pollution during COVID-19 pandemic in Guangzhou,China

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Journal of Environmental Sciences 2022年第5期34卷 443-452页

作者： Luyao Wen Chun Yang Xiaoliang Liao Yanhao Zhang Xuyang Chai Wenjun Gao Shulin Guo Yinglei Bi Suk-Ying Tsang zhi-feng chen Zenghua Qi Zongwei Cai Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyRm 510Engineering Facility Building No.3Guangzhou 510006China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongChina Guangzhou Meteorological Public Service Center Guangzhou Meteorological ServiceGuangzhou 510006China School of Life Sciences The Chinese University of Hong KongHong KongChina

The COVID-19 pandemic has raised awareness about various environmental issues,includ-ing PM_(2.5) ***,PM_(2.5) pollution during the COVID-19 lockdown was traced and an-alyzed to clarify the sources and factors influencing PM_(2.5) in Guangzhou,with an emphasis on heavy *** lockdown led to large reductions in industrial and traffic emissions,which significantly reduced PM_(2.5) concentrations in ***,the trend of PM_(2.5) concentrations was not consistent with traffic and industrial emissions,as minimum concentrations were observed in the fourth period(3/01-3/31,22.45 μg/m^(3))of the ***,the concentrations of other gaseous pollutants,e.g.,SO_(2),NO_(2) and CO,were corre-lated with industrial and traffic emissions,and the lowest values were noticed in the sec-ond period(1/24-2/0_(3))of the *** correlation analysis revealed that the decreased PM_(2.5) concentrations during COVID-19 can be mainly attributed to decreased in-dustrial and traffic emissions rather than meteorological *** meteorological factors were included in the PM_(2.5) composition and backward trajectory analyses,we found that long-distance transportation and secondary pollution offset the reduction of primary emissions in the second and third stages of the ***,industrial PM_(2.5) emis-sions from western,southern and southeastern Guangzhou play an important role in the formation of heavy pollution *** results not only verify the importance of control-ling traffic and industrial emissions,but also provide targets for further improvements in PM_(2.5) pollution.

关键词： PM_(2.5)pollution COVID-19 pandemic PM_(2.5)composition Meteorological analysis Source appointment

Measurement of Neutron Fluxes and Spectra during the NT-TBM Operation of CN HCSB

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Southwestern Institute of Physics Annual Report

Southwestern Institute of Physics Annual Report 2004年第1期 97-100页

作者： YANG Jinwei feng Kaiming chen zhi

Neutronics measurement system provides neutron fluxes and spectra at the locations of beryllium multiplier and tritium breeder during the operation of the NT-TBM （D-D and D-T phase in ITER）. This is important for studying and assessing capabilities of beryllium multiplier and tritium breeder in the China helium cooled solid breeder （CNHCSB）. A special neutron diagnostic system has been proposed that allows to measure neutron fluxes and spectra without interrupt the operation of ITER. This system includes encapsulated foil activation analysis, micro-fission chamber detectors （MFC）, and a compact neutron spectrometer using natural diamond detector （NDD）.

关键词： NT-TBM MFC NDD

Research on Fault Tolerant Scheduling Algorithms of Web Cluster Based on Probability

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Wuhan University Journal of Natural Sciences 2005年第1期10卷 70-74页

作者： LIUAn-feng chenzhi-gang LONGGuo-Ping CollegeofInformationScienceandEngineering CentralSouthUniversityChangsha410083HunanChina

Aiming at the soft real-lime fault tolerant demand of critical webapplications at present, such as E-commerce, a new fault tolerant scheduling algorithm based onprobability is proposed. To achieve fault tolerant scheduling, the primary/slave backuptechnology isapplied on the basis of task's self similar accessing characteristics, when the primary taskcompleted successfully, the resources allocated for the slave task are reclaimed, thus advancingsystem's efficiency. Experimental results demonstrate on the premise of satisfying system's certainfault tolerant probability, task's schcdulabi-listic probability is improved, especially, the highertask's self similar degree is, the more obviously the utilization of system resources is enhanced.

关键词： soft real-time system faull tolerant scheduling probabilistic analysis self similar sehedulabilistk probability

Erlotinib as a salvage treatment for patients with advanced non-small cell lung cancer after failure of gefitinib treatment

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Chinese Medical Journal 2011年第15期124卷 2279-2283页

作者： SONG Zheng-bo YU Yong-feng chen zhi-wei LU Shun Shanghai Lung Tumor Clinical Medical Center Chest Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200030 China

Background Several clinical trials showed that erlotinib was effective after the failure of gefitinib in advanced non-small cell lung cancer （NSCLC）. The aim of this study was to evaluate the feasibility of erlotinib treatment after the failure of gefitinib based on the data from our hospital. Methods The clinical data of 20 patients with advanced NSCLC who were admitted to Shanghai Chest Hospital from August 2007 to December 2008 were retrospectively analyzed. All of the patients were given erlotinib treatment after the failure of gefitinib. Survival analysis was made by Kaplan-Meier method. The Cox regression model was performed to analyze the relationship between the influential factors and the erlotinib progression-free survival （PFS）. Results Five patients had a partial response （PR）, nine patients had stable disease （SD） and six patients had progressive disease （PD） with gefitinib treatment. The median PFS was 277 days （95% CI 0-566）. No patient had a PR, seven had SD and fourteen PD with the erlotinib therapy. The median PFS was 31 days （95% CI 9.1-52.9）. The response rate （RR） was 0, and the disease control rate （DCR） was 35% （7/20）. Cox regression analysis demonstrated that sex （P=0.96）, age （P=0.89）, smoking history （P=0.78）, performance status （PS）（P=0.98）, gefitinib efficacy （P=-0.90） and whether chemotherapy was applied between using the two drugs （P=-0.45） had no significant correlation with erlotinib PFS. Fifteen patients had epidermal growth factor receptor （EGFR） mutation status determined. There were five cases got SD with the erlotinib treatment in ten mutation negative （wild-type） patients. No SD was recorded in the five mutation positive patients. Conclusions The efficacy of erlotinib treatment after gefitinib failure was limited. However, the patients who are EGFR mutation negative can probably benefit from erlotinib treatment after gefitinib failure.

关键词： non-small cell lung cancer erlotinib gefitinib efficacy epidermal growth factor receptor mutation

Research and Development of SWITRIM Code and Its Applications

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Southwestern Institute of Physics Annual Report

Southwestern Institute of Physics Annual Report 2005年第1期 108-110页

作者： DENG Baiquan HUANG Jinhua feng Kaiming chen zhi

The ftrst numerical simulation code package WITRIM has been developed to calculate the tritium inventory distribution and time-evolution in all sub-systems of FEB fusion reactor. The applications during recent six years indicate that it is reasonable and fully admitted by colleagues abroad. Some creative papers with new concept are published. For instance, we first time pointed out a new phenomenon of ＂tritium well depth and tritium well time＂ during the fusion reactor start-up phase. This is somewhat similar to, but quite different from the ＂iodine well depth and iodine well time＂ poisoning problem during restart-up process of a fission reactor. The authors not only proposed but also numerically solved this new phenomenon. The combination of the SWITRIM code package, user＇s guide, and application example are briefly introduced in this article.

关键词： SWITRIM code Tritium inventory

Calorimetric investigation on the thermal stability of the tertiary structure of Zika xrRNA1

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Calorimetric investigation on the thermal stability of the t...

Thermal stability of the subgenomic flavivirus RNAs with XRN1 degradation resistance

中国化学会第七届全国热分析动力学与热动力学学术会议

作者： zhi-feng chen Jia-Xin Dong School of Chemistry and Pharmaceutical Sciences Guangxi Normal University

Zika virus is one of the *** flavivirus are (+)-sense single-stranded mosquito-borne RNA *** has been found that there are some RNA elements that can resist to the degradation of intracellular exonuclease XRN1 in the 3’UTR of flavivirus,which are named as *** crystal structure of ZIKV xrRNA1 has been solved (Fig 1A and B).It is speculated that the mechanism of its XRN1 resistance is that the 5’ end of sfRNA is fixed and protected by aspecific pseudoknot *** structure makes it have a mechanical stability that the 5’end of it cannot approach to the active center of *** order to study the stability of this tertiary structure (pseudoknot),the thermal denaturation process of ZIKV xrRNA1 and its mutants (Fig.1C) were measured by DSC [2](MicroCalVP-CapillaryDSC).The structural fact or saff ecting the tertiary structure stabilityof ZIKV xrRNA1 were discussed.

关键词： ZIKV xrRNA1 Differential Scanning Calorimetry Thermal Stability

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Thermal stability of the subgenomic flavivirus RNAs with XRN...

Epidural fentanyl decreases the minimum local analgesic concentration of epidural lidocaine

中国化学会第七届全国热分析动力学与热动力学学术会议

作者： zhi-feng chen Jia-Xin Dong School of Chemistry and Pharmaceutical Sciences Guangxi Normal University

Flaviviruses(FVs) are a growing global health threat,and their incidence and spread are *** pathogenicity and cytopathology of these single-stranded RNA viruses may be influenced by the noncoding subgenomic flaviviruses RNAs(sfRNAs),which are produced by resisting the degradation by the 5’→3’ exonuclease XRN1 in host cell through a complex RNA structure-based mechanism .

关键词： Thermal stability Subgenomic flaviviruses RNAs Differential scanning calorimetry

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Chinese Medical Journal 2012年第22期125卷 3977-3980页

作者： ZHANG Jian ZHENG Yue-ying feng zhi-ying chen Chao-qin ZHU Sheng-mei Department of Anesthesiology First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310003China

Background Epidural lidocaine can be used when regional anesthesia needs to be established quickly, but the effect of co-administering epidural fentanyl on the minimum local analgesic concentration （MLAC） of lidocaine is not known. We compared the MLAC of epidural lidocaine in combination with different doses of fentanyl for epidural anesthesia in adults. Methods One hundred and twenty patients requiring epidural analgesia were randomly allocated to receive 20 ml of one of four solutions： lidocaine, or lidocaine plus fentanyl 1 pg/ml, 2 pg/ml, or 3 pg/ml. The first patient in each group was administered 1% lidocaine weight by volume; subsequent patients received a concentration determined by the response of the previous patient to a higher or lower concentration according to up and down sequential allocation in 0.1% increments. Efficacy was assessed using a visual analog pain scale, and accepted if this was 〈10 mm on a 100 mm scale within 30 minutes. The extent of motor block and of nausea and vomiting were recorded at 30 minutes after administration of the epidural solution and two hours after surgery, respectively. Results The MLAC of lidocaine in those receiving lidocaine alone was 0.785% （95%C/0.738-0.864）. A significant dose-dependent reduction was observed with the addition of fentanyl： the MLAC of lidocaine with fentanyl at 2 pg/ml was 0.596% （95%C/0.537-0.660） and 0.387% with fentanyl at 3 pg/ml （95%C/0.329-0.446, P 〈0.001）. Conclusion Epidural fentanyl significantly reduces the dose of lidocaine required for effective epidural analgesia in adults without causing adverse side effects. （Chi CTR-TRC-11001559）

关键词： epidural anesthesia fentanyl lidocaine minimum local analgesic concentration