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Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex promotes intestinal development as a new iron supplement

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Science China Life Sciences 2025年第1期 219-231页

作者： Yingying feng Yuying Wu Jialu Wang Zhenglin Dong Qian Yu Shuangshuang xia Chunxue liu Haihua Wang Xin Wu Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of Sciences ANYOU Biotechnology Group Co.Ltd Qingdao Seawin Biotech Group Co. LTD

Iron is a crucial micronutrient, and its deficiency can have detrimental effects on the health of infants. Dietary polysaccharide-iron(Ⅲ) complexes(PICs) are promising for addressing iron deficiency due to their minimal adverse reactions and high iron absorption rate. This study aimed to investigate the effects of dietary Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex(EP-Fe) on newborns, using 3-day weaned piglets as the iron-deficiency model. Results showed that EP-Fe improved iron levels and promoted intestinal development in piglets. Transcriptome sequencing revealed that EP-Fe increased the survival of intestinal epithelial cells under hypoxia by upregulating the expression of genes that promote the development of the vascular system. Additionally, EP-Fe enhanced the mucosal barrier functions by inhibiting myosin light chain kinase(MLCK)/phosphorylated myosin light chain(p-MLC) signaling pathway to increase the expression of intestinal tight junction proteins. Furthermore, the 16S r RNA gene sequencing of gut microbiota showed that EP-Fe promoted the enrichment of Bacteroides＿fragilis and other gut microbes that can metabolize carbohydrates. In conclusion, EP-Fe is an effective iron supplement for newborns, and it can be developed as a comprehensive nutritional supplement.

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Deep learning-based software engineering: progress,challenges, and opportunities

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Science China(Information Sciences) 2025年第1期68卷 57-144页

作者： xiangping CHEN Xing HU Yuan HUANG He JIANG Weixing JI Yanjie JIANG Yanyan JIANG Bo liu Hui liu xiaochen LI xiaoli LIAN Guozhu MENG Xin PENG Hailong SUN Lin SHI Bo WANG Chong WANG Jiayi WANG Tiantian WANG Jifeng XUAN Xin xia Yibiao YANG Yixin YANG Li ZHANG Yuming ZHOU Lu ZHANG School of Journalism and Communication Sun Yat-sen University School of Software Technology Zhejiang University School of Software Engineering Sun Yat-sen University School of Software Dalian University of Technology School of Computer Science and Technology Beijing Institute of Technology Key Laboratory of High Confidence Software Technologies (Peking University) Ministry of EducationSchool of Computer Science Peking University State Key Laboratory for Novel Software Technology Nanjing University School of Computer Science and Engineering Beihang University Institute of Information Engineering Chinese Academy of Sciences School of Computer Science Fudan University State Key Laboratory of Complex & Critical Software Environment (CCSE) School of Software Beihang University School of Computer and Information Technology Beijing Jiaotong University School of Computer Science and Technology Harbin Institute of Technology School of Computer Science Wuhan University Huawei Technologies

Researchers have recently achieved significant advances in deep learning techniques, which in turn has substantially advanced other research disciplines, such as natural language processing, image processing, speech recognition, and software engineering. Various deep learning techniques have been successfully employed to facilitate software engineering tasks, including code generation, software refactoring, and fault localization. Many studies have also been presented in top conferences and journals, demonstrating the applications of deep learning techniques in resolving various software engineering tasks. However,although several surveys have provided overall pictures of the application of deep learning techniques in software engineering,they focus more on learning techniques, that is, what kind of deep learning techniques are employed and how deep models are trained or fine-tuned for software engineering tasks. We still lack surveys explaining the advances of subareas in software engineering driven by deep learning techniques, as well as challenges and opportunities in each subarea. To this end, in this study, we present the first task-oriented survey on deep learning-based software engineering. It covers twelve major software engineering subareas significantly impacted by deep learning techniques. Such subareas spread out through the whole lifecycle of software development and maintenance, including requirements engineering, software development, testing, maintenance, and developer collaboration. As we believe that deep learning may provide an opportunity to revolutionize the whole discipline of software engineering, providing one survey covering as many subareas as possible in software engineering can help future research push forward the frontier of deep learning-based software engineering more systematically. For each of the selected subareas,we highlight the major advances achieved by applying deep learning techniques with pointers to the available datasets i

关键词： deep learning software engineering software benchmark software artifact representation survey

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不同干燥方法对黄精干燥特性和品质的影响

食品工业科技 2018年第7期39卷 158-161,167页

作者：衡银雪郑旭煦殷钟意边凤霞刘丹丹重庆工商大学环境与资源学院重庆400067

研究微波真空干燥法、自然晒干法、微波干燥法、真空干燥法和热风干燥法5种不同干燥方法对黄精干燥曲线和黄精多糖、总酚、总皂苷、5-羧甲基糠醛含量及多糖抗氧化活性的影响。分别采用超声波辅助法提取黄精中的黄精多糖、总酚、总皂苷... 详细信息

研究微波真空干燥法、自然晒干法、微波干燥法、真空干燥法和热风干燥法5种不同干燥方法对黄精干燥曲线和黄精多糖、总酚、总皂苷、5-羧甲基糠醛含量及多糖抗氧化活性的影响。分别采用超声波辅助法提取黄精中的黄精多糖、总酚、总皂苷、5-羟甲基糠醛,并运用文献介绍的方法测定其含量。同时用FRAP和超氧阴离子自由基检测法检测黄精多糖抗氧化活性。结果表明,微波真空干燥法干燥速率最大,所用干燥时间最短,黄精干燥产品中多糖、总酚、总皂苷含量损失最少,5-羧甲基糠醛生成量较小,其干燥品中黄精多糖含量达(63.59±1.25)mg·g-1,且其20 mg·m L-1多糖溶液对超氧阴离子自由基的抑制率达(30.01%±1.30%)。说明微波真空干燥法更适于得到高品质的黄精干燥产品。

关键词：微波真空干燥干燥曲线黄精多糖抗氧化活性

Some Ergodic Theorems for a Parabolic Anderson Model

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Acta Mathematica Sinica,English Series 2012年第12期28卷 2443-2462页

作者： Yong liu LMAM feng xia YANG School of Mathematical Sciences and Institute of Mathematicsand Center for Statistical SciencePeking University LMAM School of Mathematical SciencesPeking University

In this paper, we study some ergodic theorems of a class of linear systems of interacting diffusions, which is a parabolic Anderson model. First, under the assumption that the transition kernel a = （a（i,j））i,j∈s is doubly stochastic, we obtain the long-time convergence to an invariant probability measure Vh starting from a bounded a-harmonic function h based on self-duality property, and then we show the convergence to the invariant probability measure Uh holds for a broad class of initial distributions. Second, if （a（i, j））i,j∈s is transient and symmetric, and the diffusion parameter c remains below a threshold, we are able to determine the set of extremal invariant probability measures with finite second moment. Finally, in the case that the transition kernel （a（i,j））i,j∈s is doubly stochastic and satisfies Case I （see Case I in [Shiga, T.： An interacting system in population genetics. J. Math. Kyoto Univ., 20, 213-242 （1980）]）, we show that this parabolic Anderson model locally dies out independent of the diffusion parameter c.

关键词： Linear system of interacting diffusion parabolic Anderson model ergodic invariant measures clustering phenomena

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中小学学科德育实施的内在逻辑与有效路径

北京教育学院学报 2025年第1期39卷 41-46页

作者：刘霞江苏省教育科学研究院德育与心理健康教育研究所江苏南京210013

落实立德树人根本任务、建立高质量的学校德育工作体系、培育学生核心素养要求必须深入实施学科德育。学科德育是学科知识和德育要素的内在耦合,是学科学习与道德养成的同向同构。实施中小学学科德育要遵循学科逻辑和德育逻辑,通过课堂... 详细信息

落实立德树人根本任务、建立高质量的学校德育工作体系、培育学生核心素养要求必须深入实施学科德育。学科德育是学科知识和德育要素的内在耦合,是学科学习与道德养成的同向同构。实施中小学学科德育要遵循学科逻辑和德育逻辑,通过课堂教学主渠道,完成公共知识向个人能力和素养的转译,达成学科德育目标。因此,要坚持从道德价值的角度深度解读教材的育人价值,从道德养成的角度选择适合的教学方式,从道德评价的角度引领课程作业和评价改革,优化学科德育实施路径,提升育人效果。

关键词：立德树人学科德育核心素养学科实践

Metallographic etching and microstructure characterization of NiCrMoV rotor steels for nuclear power

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International Journal of Minerals,Metallurgy and Materials 2013年第12期20卷 1164-1169页

作者： Peng liu feng-gui Lu xia liu Yu-lai Gao School of Materials Science and Engineering Shanghai University School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai Turbine Plant

The grain size of prior austenite has a distinct influence on the microstructure and final mechanical properties of steels. Thus, it is significant to clearly reveal the grain boundaries and therefore to precisely characterize the grain size of prior austenite. For NiCrMoV rotor steels quenched and tempered at high temperature, it is really difficult to display the grain boundaries of prior austenite clearly, which limits a further study on the correlation between the properties and the corresponding microstructure. In this paper, an effective etchant was put forward and further optimized. Experimental results indicated that this agent was effective to show the details of grain boundaries, which help analyze fatigue crack details along the propagation path. The optimized corrosion agent is successful to observe the microstructure characteristics and expected to help analyze the effect of microstructure for a further study on the mechanical properties of NiCrMoV rotor steels used in the field of nuclear power.

关键词： metallography etching austenite grain size and shape etchants nuclear power plants

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三峡水库微塑料与悬沙的聚集特性及作用机制

湖泊科学 2025年第1期37卷 149-158页

作者：刘洁张智超李霞朱丽帆蒋晖重庆交通大学国家内河航道工程技术研究中心重庆400074 重庆交通大学河海学院重庆400074

本文依据三峡库区悬沙矿物组成和泥沙级配为依据配置沙样,选择长江上游典型微塑料PMMA和PS,在自制大型水箱中开展水流剪切作用下微塑料和泥沙异质聚集实验,分析微泥絮团的形态特征和聚集机制。结果表明在水流紊动剪切作用下,相比泥沙同... 详细信息

本文依据三峡库区悬沙矿物组成和泥沙级配为依据配置沙样,选择长江上游典型微塑料PMMA和PS,在自制大型水箱中开展水流剪切作用下微塑料和泥沙异质聚集实验,分析微泥絮团的形态特征和聚集机制。结果表明在水流紊动剪切作用下,相比泥沙同质聚集的絮团粒径,微泥异质聚集的絮团粒径更大,且每毫升样品中微泥絮团上的微塑料吸附数量随水流剪切率增大而迅速增加。扫描电镜和能谱分析结果表明,在水动力条件下泥沙与PMMA、PS微球发生异质聚集,聚集过程中存在电子转移和化学态的转变,并产生不饱和键(C C)。由于PMMA官能团的结合能变化比PS大,此过程失电子更多、表面电荷更大,更容易与泥沙发生聚集。

关键词：微塑料悬沙微泥絮团形貌聚集机制三峡水库

Evaluation of the therapeutic significance of Glehniae Radix polysaccharides on the ulcerative colitis through DSS-induced rat model

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Food Science and Human Wellness 2025年

作者： Jie liu Xufang Geng Yuxin Yang Jiao Xu Haoran feng Tianshuo Zhang Guangzhao Zhou Man Wang Changshun Wang Dongsheng Jia Yuting Chen Bin Cong Ding Zhao The Postdoctoral Mobile Station of Basic Medicine， Hebei Medical University The Department of Pharmacognosy， School of Pharmacy， Hebei Medical University Hebei Key Laboratory of Forensic Medicine， College of Forensic Medicine， Hebei Medical University

Glehniae Radix has a wide range of pharmaceutical applications， and research on its main components has mainly focused on coumarins， alkaloids， lignans， and flavonoids， while neglecting the research on polysaccharides. Literature reports and our previous studies have shown that polysaccharides have certain therapeutic significance in immune regulation， antioxidant， anti-inflammatory and other aspects. Herein， the rat model of ulcerative colitis (UC) was established to evaluate the anti-inflammatory efficacy of the prepared Glehniae Radix polysaccharide (GLP) from the perspectives of inflammatory factors， intestinal tissue morphology， and microflora changes. The polysaccharides are mainly composed of galacturonic acid， rhamnose， glucose， galactose， and arabinose in molar ratios of 1.4:9.2:33.3:2.5:2.9， and GLP could downregulate the expression pro-inflammatory factors (interleukin-6， tumor necrosis factor-α， and interferon-γ) and significantly upregulate the expression of anti-inflammatory factor (interleukin-10). In addition， Glehniae Radix aqueous extract (GLA)， GLP with low dosage (GLPL) and GLP with high dosage (GLPH) could increase the number of goblet cells， enhance the integrity of crypt structure， and reverse the status of inflammatory infiltrating cells. Moreover， GLA and GLPH could upregulate Lactobacillus and Lachnoclostridium in UC rats， and appropriately downregulate Lachnospiraceae＿NK4A136＿group， thereby optimizing the proportion of bacterial flora and improving the intestinal microbial environment. Our findings not only be valuable as theoretical materials for the further clinical applications of GLP， but the identified biomarkers and metabolic pathways also provide new clues for the diagnosis of UC.

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Study of 4-t-octylphenol degradation and microbial community in granular sludge

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Journal of Environmental Sciences 2008年第2期20卷 167-171页

作者： liu Yi WANG feng xia Siqing ZHAO Jianfu State Key Laboratory of Pollution Control and Resource Reuse Key Laboratory Yangtze River Water Environment Ministry of Education School of Environmental Science and Engineering Tongji University Shanghai 200092 China

In this study, the authors have investigated the effects of various factors on both aerobic and anaerobic degradation of 4-t-octylphenol （4-t-OP） in granular sludge. In comparison, the aerobic degradation rate was much higher than that of anaerobic degradation. The optimal pH values for 4-t-OP degradation in granular sludge were 9 and 7 under aerobic and anaerobic conditions, respectively. And the degradation rate decreased with an increase in the initial 4-t-OP concentration. Addition of yeast extract or homologous compounds such as phenol also enhanced the 4-t-OP degradation, especially under the aerobic condition. To investigate the bacterial community in this study, the denaturing gradient gel electrophoresis （DGGE） method was applied, based on the primers, for the 16S rDNA V3 region of bacteria, γ-proteobacteria and bacillus were identified as the major species of sludge.

关键词： aerobic degradation anaerobic degradation 4-t-octylphenol (4-t-OP) granular sludge DGGE