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Expression of IL-26 predicts prognosis of patients with hepatocellular carcinoma after surgical resection

Hepatobiliary & Pancreatic Diseases International 2019年第3期18卷 242-248页

作者： Zhi-feng Xi Seogsong Jeong Chen-Chen Wang Hong-Jie Li Han Guo Jie Cai Jia-Xin Li xiao-Ni Kong Ying Tong Qiang Xia Department of Liver Surgery Renji Hospital School of Medicine Shanghai Jiao Tong University

Background: There is no data regarding prognostic impact of interleukin(IL)-26 on outcomes of patients with hepatocellular carcinoma(HCC). The present study aimed to evaluate the prognostic impact of IL-26 on HCC patients undergoing liver resection. Methods: From 2003 to 2008, 122 patients with HCC who received surgical curative resection were enrolled. Patients were stratified into IL-26-upper and-lower groups according to the median expression level from immunohistochemical staining of resected specimens. Prognostic impact of IL-26 was estimated using Kaplan–Meier curves. Univariate and multivariate analyses were performed to evaluate timedependent prognostic impact and independency of IL-26. Demographic and clinical factors that were associated with IL-26 were comprehensively identified. Results: Prognosis of the patients with high level of IL-26 revealed to be significantly unfavorable in both cumulative recurrence-free survival( P < 0.001) and overall survival( P = 0.002). Upper expression of IL-26(HR: 1.643;95% CI: 1.021 to 2.644;P = 0.041) and microvascular invasion(HR: 3.303;95% CI: 1.255 to 8.696;P = 0.016) were identified as significant independent prognostic factors for overall survival in the multivariable analysis. Conclusions: IL-26 is a novel prognostic factor for HCC after resection. Evaluation of IL-26 expression may be potentially valuable in clinical therapy when planning individualized follow-up schedule and evaluating candidates for prophylactic adjuvant treatment to prevent recurrence.

关键词： Interleukin 26 Hepatocellular carcinoma Surgical resection Prognostic factors

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The transcription factor PU.1 promotes alternative macrophage polarization and asthmatic airway inflammation

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Journal of Molecular Cell Biology 2015年第6期7卷 557-567页

作者： feng Qian Jing Deng Yong Gyu Lee Jimmy Zhu Manjula Karpurapu Sangwoon Chung Jun-Nian Zheng Lei xiao Gye Young Park John W.Christman School of Pharmacy Engineering Research Center of Cell&Therapeutic AntibodyMinistry of EducationShanghai Jiao Tong UniversityShanghaiChina Department of Internal Medicine Section of PulmonaryAllergyCritical Careand Sleep MedicineThe Ohio State UniversityColumbusUSA Department of Physiology and Biophysics College of MedicineUniversity of Illinois at ChicagoChicagoUSA Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer InstituteXuzhou Medical CollegeXuzhouChina Department of Medicine Section of PulmonaryCritical Careand Sleep MedicineUniversity of Illinois at ChicagoChicagoUSA

The transcription factor PU.1 is involved in regulation of macrophage differentiation and ***,the role of PU.1 in alternatively activated macrophage(AAM)and asthmatic inflammation has yet been *** we report that PU.1 serves as a critical regulator of AAM polarization and promotes the pathological progress of asthmatic airway *** response to the challenge of DRA(dust mite,ragweed,and Aspergillus)allergens,conditional PU.1-deficient(PU/ER(T)^(+/-))mice displayed attenuated allergic airway inflammation,including decreased alveolar eosinophil infiltration and reduced production of IgE,which were associated with decreased mucous glands and goblet cell *** reduced asthmatic inflammation in PU/ER(T)^(+/-) mice was restored by adoptive transfer of IL-4-induced wild-type(WT)***,after treating PU/ER(T)^(+/-) mice with tamoxifen to rescue PU.1 function,the allergic asthmatic inflammation was significantly *** vitro studies demonstrate that treatment of PU.1-deficient macrophages with IL-4 attenuated the expression of chitinase 3-like 3(Ym-1)and resistin-like molecule alpha 1(Fizz-1),two specific markers of AAM *** addition,PU.1 expression in macrophages was inducible in response to IL-4 challenge,whichwas associated with phosphorylation of signal transducer and activator of transcription 6(STAT6).Furthermore,DRAchallenge in sensitized mice almost abrogated gene expression of Ym-1 and Fizz-1 in lung tissues of PU/ER(T)^(+/-) mice compared with WT *** data,all together,indicate that PU.1 plays a critical role in AAM polarization and asthmatic inflammation.

关键词： PU.1 alternatively activated macrophage asthmatic inflammation Th2 IL-4

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厚壁圆筒的载荷特征与变形规律研究

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计算力学学报 2013年第S1期30卷 41-45页

作者：寿列枫浦锡锋田宙雷鸣西北核技术研究所西安710024

为了研究厚壁圆筒在受到相同冲量但载荷特征不同时材料的变形规律,分别采用解析解、LS-DYNA软件和有限元计算程序对厚壁圆筒在受到内压作用下的力学响应进行了计算比较,在得到基本一致的结果后,利用有限元计算程序对冲量相同时四种加载... 详细信息

为了研究厚壁圆筒在受到相同冲量但载荷特征不同时材料的变形规律,分别采用解析解、LS-DYNA软件和有限元计算程序对厚壁圆筒在受到内压作用下的力学响应进行了计算比较,在得到基本一致的结果后,利用有限元计算程序对冲量相同时四种加载方式下厚壁圆筒的动力学响应进行了计算,计算结果表明冲量相同时,不同载荷特征的载荷作用下的应变是不同的,应变与载荷作用时间和大小相关.

关键词：厚壁筒载荷特征变形规律有限元计算

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State transfer and entanglement between two-and four-level atoms in a cavity

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Chinese Physics B 2023年第10期32卷 522-530页

作者：李思吾冯田峰胡骁龙周晓祺 School of Physics Sun Yat-Sen UniversityGuangzhou 510275China

Qudits with a large Hilbert space to host quantum information are widely utilized in various applications, such as quantum simulation and quantum computation, but the manipulation and scalability of qudits still face challenges. Here, we propose a scheme to directly and locally transfer quantum information from multiple atomic qubits to a single qudit and vice versa in an optical cavity. With the qubit–qudit interaction induced by the cavity, our scheme can transfer quantum states efficiently and measurement-independently. In addition, this scheme can robustly generate a high-dimensional maximal entangled state with asymmetric particle numbers, showing its potential in realizing an entanglement channel. Such an information interface for qubits and qudit may have enlightening significance for future research on quantum systems in hybrid dimensions.

关键词： quantum state transfer quantum entanglement cavity quantum eletrodynamics

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Synthesis, Crystal Structure and Fungicidal Activity of Ethyl 2-(3-(4-Fluorobenzamido)phenyl)-4-((4-fluorobenzoyl)oxy)thiazole-5-carboxylate

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Chinese Journal of Structural Chemistry 2019年第6期38卷 923-929页

作者： GUO xiao-feng SU Han-Xiang FAN Zhi-Jin SUN Xue-Wen SUN Yao-Zheng QIN Zhong-Xiang State Key Laboratory of Elemento-organic Chemistry College of Chemistry Nankai University

The target compound, ethyl 2-（3-（4-fluorobenzamido）phenyl）-4-（（4-fluorobenzoyl）oxy） thiazole-5-carboxylate, was synthesized by four-step procedures including N-protection, thionation, cyclization and acylation. Its structure was characterized by 1 H NMR, 13C NMR, HRMS and single-crystal X-ray diffraction. The target compound crystallizes as monoclinic crystal system, space group C2/c with a = 9.6097（19）, b = 14.246（3）, c = 33.070（7） ?, V = 4515.1（16） ?3, Z = 8, Dc = 1.496 Mg/m3, F（000） = 2096 and μ = 0.203 mm-1. There are 21864 reflections measured（4.94≤2θ≤55.96°）, of which 5357 were unique（Rint = 0.1418） and used in all calculations. The final R = 0.0581（I > 2σ（I）） and wR = 0.1453（reflections）. The target compound showed over 50% of growth inhibition against Physalospora piricola, Rhizoctonia cerealis and Sclerotinia sclerotiorum.

关键词： thiazole synthesis crystal structure fungicidal activity

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Identification and validation of novel loci associated with wheat quality through a genome-wide association study

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Journal of Integrative Agriculture 2022年第11期21卷 3131-3147页

作者： PU Zhi-en YE Xue-ling LI Yang SHI Bing-xin GUO Zhu DAI shou-fen MA Jian LIU Ze-hou JIANG Yun-feng LI Wei JIANG Qian-tao CHEN Guo-yue WEI Yu-ming ZHENG You-liang College of Agronomy Sichuan Agricultural UniversityChengdu 611130P.R.China Triticeae Research Institute Sichuan Agricultural UniversityWenjiang 611130P.R.China Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs/College of Food and Biological EngineeringChengdu UniversityChengdu 610106P.R.China Crop Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066P.R.China

Understanding the genetic basis of quality-related traits contributes to the improvement of grain protein concentration(GPC),grain starch concentration(GSC),and wet gluten concentration(WGC)in *** this study,a genome-wide association study(GWAS)based on a mixed linear model(MLM)was performed on 236 wheat accessions,including 160 cultivars and 76 landraces,using a 55K single nucleotide polymorphism(SNP)array in multiple environments.A total of 12 stable QTL/SNPs that control different quality traits in this populations in at least two environments under stripe rust stress were *** these 12,three,seven and two QTLs associated with GPC,GSC and WGC were characterized,respectively,and they were located on chromosomes(chr)1B,1D,2A,2B,2D,3B,3D,5D,and 7D with the phenotypic variation explained(PVE)ranging from 4.2 to 10.7%.Compared with the previously reported QTLs/genes,five QTLs(***-1BL,***-1DS,***-2DL.1,***-2DL.2,and ***-5DL)were potentially *** markers for the SNPs AX-108770574 and AX-108791420 on chr5D associated with wet gluten concentration were successfully *** phenotypes of the cultivars containing the A-allele in AX-108770574and the T-allele in AX-108791420 were extremely significantly(P<0.01)higher than those of the landraces containing the G-or C-allele with respect to the wet gluten concentration in each of the *** KASP markers developed and validated in this study could be utilized in molecular breeding aimed at improving the quality of wheat.

关键词： cultivars landraces grain protein concentration(GPC) grain starch concentration(GSC) wet gluten concentration(WGC) 55K SNP validation

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Hydrodynamic Effect of the Regulation Project of Yangtze River Deepwater Channel Downstream of Nanjing

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China Ocean Engineering 2013年第6期27卷 767-779页

作者：杨东利窦希萍张新周罗小峰 College of Harbor Coastal and Offshore Engineering Hohai University President's Office Nanjing Hydraulic Research Institute Key Laboratory of Port Waterway & Sedimentation Engineering MOC Nanjing Hydraulic Research Institute

A two-dimensional flow numerical model of the tidal reaches, which total length is more than 700 km, is established from Datong to the Yangtze River estuary. The tidal levels, velocities, diversion ratios and dynamic axes before and after the separate regulation of each reach and combined regulation of all reaches are obtained. The comparative analysis shows that the regulation project of a separate reach basically has no impact on velocity distributions and variations of diversion ratios of upper and lower reaches, the variations of dynamic axes are only within the local scope of the project. The regulation project of a separate reach also has less impact on the water level in the lower adjacent reaches, but will make the water levels in the upper reaches rise. After the implementation of the regulation projects for all reaches, the rise of water level in the upstream reaches will have a cumulative impact.

关键词： Yangtze River deepwater channel regulation project numerical model

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The Relationship Between TMT Characteristics and R&D Investment:Empirical Analysis of Chinese Manufacture Listed Firms on GEM

浙商研究

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浙商研究 2012年 212-222页

作者： Yuan An-fu Wang xiao-feng Huang Jia

Abstract:Based on Shenzhen GEM listed company data in June,2012,combining the Upper Echelons Theory in TMT study with the CEM in diversity research,this paper studies empirically with Stata 10.0 software to explore the relationship between TMT characteristics and R&D *** results show that TMT with younger members and rich working experiences tends to invest more on R&D;however,the average age and gender diversity do not have significant *** results verify the proposition in CEM,which states that the elaboration of task-relevant information and perspectives is an important mediating variable between group diversity and organization innovation performance.

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甲状腺功能亢进合并腹膜播散性平滑肌瘤病、乳腺腺病1例

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中国CT和MRI杂志 2025年第1期23卷 205-206页

作者：张志强姚纯万翠霞陈湘光陈小凤杨志企梅州市人民医院放射科广东梅州514031

患者,女性,37岁,8个月前发现左下腹部包块并渐进性增大,无伴月经周期及量改变。体格检查示左侧附件区一实性肿物,边界清,表面不平,质硬,活动度欠佳,无压痛。患者于2008年在外院诊断为甲状腺功能亢进,现予丙硫氧嘧啶100mg每天两次治疗。2... 详细信息

患者,女性,37岁,8个月前发现左下腹部包块并渐进性增大,无伴月经周期及量改变。体格检查示左侧附件区一实性肿物,边界清,表面不平,质硬,活动度欠佳,无压痛。患者于2008年在外院诊断为甲状腺功能亢进,现予丙硫氧嘧啶100mg每天两次治疗。2013年因子宫平滑肌瘤在外院行腹腔镜下肌瘤剔除术。实验室检查示促甲状腺激素减低,甲状腺球蛋白抗体、甲状腺过氧化酶抗体、雌二醇、促黄体生成素、催乳素增高。

关键词：腹膜播散性平滑肌瘤病乳腺腺病甲状腺功能亢进

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土工织物散体桩桩体单轴压缩试验

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中国公路学报 2018年第6期31卷 181-187页

作者：陈建峰曾岳冯守中李丽华同济大学土木工程学院上海200092 武汉广益交通科技股份有限公司湖北武汉430074 常州泰勒思达新材料有限公司江苏常州213021

土工织物散体桩是一种新型的复合地基桩基,为了研究其在轴向荷载下的强度和变形特性,并探讨桩体强度和模量的确定方法,选用了3种相对密度(Dr=0.42,0.62,0.78)的碎石和4种筋材强度(T=33,43,52,65kN·m-1)的无接缝聚丙烯土工编织布套筒,... 详细信息

土工织物散体桩是一种新型的复合地基桩基,为了研究其在轴向荷载下的强度和变形特性,并探讨桩体强度和模量的确定方法,选用了3种相对密度(Dr=0.42,0.62,0.78)的碎石和4种筋材强度(T=33,43,52,65kN·m-1)的无接缝聚丙烯土工编织布套筒,制备成12组直径为300mm,高度为600mm的大尺寸土工织物散体桩桩体试样,对试样进行单轴压缩试验至破坏。研究结果表明:单轴压缩下土工织物散体桩桩体应力-应变曲线在加载初期因碎石受到初始压密而上凹,而后近似线性增长至桩体强度,随后应力随应变减小呈现应变软化特性;当加载接近至桩体强度时,编织布套筒中间部位明显鼓胀,该处横向筋丝逐根断裂直至桩体失效,故横向筋丝的强度对桩体的强度起控制作用,在实际应用中可加强横向筋丝的强度以进一步提高桩体的竖向承载力;土工织物散体桩桩体强度与碎石相对密度无相关关系,而与筋材强度呈较好的线性统计关系,可以通过筋材强度确定土工织物散体桩的桩体强度;土工织物散体桩桩体模量随筋材强度或碎石密实度的增大而明显增大,在同一碎石密实度下,桩体模量随筋材强度呈线性增长关系;建立了土工织物散体桩桩体模量理论计算公式,并采用试验值对理论公式进行修正,修正系数κ=2.4,修正后的结果与试验值吻合很好。

关键词：道路工程土工织物散体桩单轴压缩试验聚丙烯土工编织布桩体强度桩体模量

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