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Chinese Chemical Letters 2008年第2期19卷 249-252页

作者： Xing Cui guo Zhang feng qin guo Fu Wang Jian guo Wang State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences P.O. Bx 165 Taiyuan Shanxi 030001 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

Critical temperatures and pressures of nominal reacting mixture in synthesis of dimethyl carbonate （DMC） from methanol and carbon dioxide （quaternary mixture of carbon dioxide ＋ methanol ＋ water ＋ DMC） were measured using a high-pressure view cell. The results suggested that the critical properties of the reacting mixture depended on the reaction extent as well as its initial composition （initial ratio of carbon dioxide to methanol）. Such information is essential for determining the reaction conditions when one intends to carry out the synthesis of DMC with CO2 and methanol under supercritical conditions.

关键词： Critical properties Reacting mixture Supercritical fluid Dimethyl carbonate Synthesis Methanol Carbon dioxide

Alterations in microbial community during the remediation of a black-odorous stream by acclimated composite microorganisms

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Journal of Environmental Sciences 2022年第8期34卷 181-193页

作者： feng Shi Zongli Liu Jialin Li Huiwang Gao Song qin Jingjing guo Key Lab of Coastal Biology and Biological Resource Conservation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China qingdao HOOH Environmental Protection Technology Co.Ltd.qingdao 266073 China

Microbial application is an efficient, economical, and ecofriendly method for remediating black-odorous rivers. In this study, the field treatment effect and microbial community changes were monitored during remediation by the acclimated complex microorganisms of a typical black-odorous stream. After the treatment, the total phosphorus and ammonia contents decreased by 74.0% and 76.3% and the concentrations of dissolved oxygen increased from 1.65 to 4.90 mg/L, indicating the effectiveness of the acclimated composite microorganisms. The proportion of Bacteroidetes decreased significantly by 48.1% and that of Firmicutes increased by 2.23% on average, and the microbial diversity index first increased and then tended to be uniform. Redundancy analysis demonstrated that the pH,dissolved oxygen, and oxidation-reduction potential together determined the composition of the microbial communities(p < 0.05). These findings showed that the acclimated composite microorganisms can effectively remediate the black odor.

关键词： Black-odorous water Composite microorganisms Microbial community Environmental impact factors In-siu bioremediation

2001年湖北地区381株肠球菌的耐药性分析

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中华全科医师杂志 2003年第2期2卷 104-106页

作者：李杰李霞张银旺付有荣冯国琴郭清莲武汉大学中南医院检验科 430071

目的研究肠球菌的临床分布特征,并测试其对美国临床实验室标准化委员会(NCCLS)推荐抗生素的敏感性,以便合理用药。方法对湖北地区2001年1月～12月间分离出的381株肠球菌进行纸片扩散法药敏试验和β-内酰胺酶测定。结果 381株肠球菌中... 详细信息

目的研究肠球菌的临床分布特征,并测试其对美国临床实验室标准化委员会(NCCLS)推荐抗生素的敏感性,以便合理用药。方法对湖北地区2001年1月～12月间分离出的381株肠球菌进行纸片扩散法药敏试验和β-内酰胺酶测定。结果 381株肠球菌中粪肠球菌占78.0％、屎肠球菌占19.4％、坚忍肠球菌占1.6％、鸟肠球菌占0.53％、空肠肠球菌与孤独肠球菌各占0.3％;产β-内酰胺酶的肠球菌占3.2％。在检出肠球菌的标本中源于泌尿道和生殖道者占首位,为46.5％,可能与部分资料来源于泌尿专科医院有关;其次为呼吸系统,占35.4％。对抗生素的耐药率由低到高依次为:万古霉素(5.8％)、替考拉宁(7.9％)、呋喃妥因(11.0％)、氨苄西林(24.7％)、青霉素(26.8％)、环丙沙星(38.6％)、氯霉素(54.6％)、高浓度庆大霉素(54.6％)、高浓度链霉素(52.5％)、四环素(79.3％)。结论分离出的肠球菌中以粪肠球菌、屎肠球菌为主;检出肠球菌的标本中主要来源于泌尿生殖系统及呼吸系统;屎肠球菌的耐药性明显高于粪肠球菌;

关键词： 2001年湖北地区肠球菌耐药性抗生素药敏试验

Fracture mechanism of inclusions in thick plate center under tensile loading

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Journal of Iron and Steel Research International 2024年第5期31卷 1196-1209页

作者： Lei Hu Li-qin Zhang feng Hu guo-hong Zhang Kuan Zheng Collaborative Innovation Center for Advanced Steels Wuhan University of Science and TechnologyWuhan430081HubeiChina Department of Applied Physics Wuhan University of Science and TechnologyWuhan430081HubeiChina Analysis and Testing Center Wuhan University of Science and TechnologyWuhan430081HubeiChina

Segregation of solute atoms in the center of thick plates of the tempered steel can cause an inhomogeneous structural transformation and generate micron-sized inclusions,which leads to lamellar tearing of thick plate and decreases the plasticity and *** formation and fragmentation mechanisms of micron-sized inclusions,like MnS and(Nb,Ti)C,in the center of thick plates were investigated by using thermodynamic calculations,finite element simulations,and electron backscatter diffraction characterization *** results show that micron-sized inclusions nucleate and grow in the liquid phase,and under tensile loading,they exhibit three fragmentation *** local stress during the fragmentation of inclusions is lower than the critical fracture stress of adjacent grains,and phase boundaries can effectively impede crack propagation into the *** existence of a low proportion of high-angle grain boundaries(58.1%)and high Kernel average misorientation value(0.534°)in the segregation band promotes inclusions fragmentation and crack *** difference in crack initiation and propagation direction caused by the morphology of inclusions and physical properties,as well as different matrix arrest abilities,is the main reasons for the diversity of inclusion fragmentation.

关键词： Thick plate Inclusion Finite element simulation Critical fracture stress Fracture mechanism

Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-Hua Wan Hong-Wei Zhang Xiao guo Hua guo Shou-feng Jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-feng Zhang qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

盆腔器官脱垂患者耻骨宫颈筋膜中转化生长因子-β_1和结缔组织生长因子的表达及其意义

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中华妇幼临床医学杂志（电子版） 2011年第5期7卷 356-360页

作者：戚小英洪莉郭凤琴任艳李秉枢武汉大学人民医院妇产科武汉430060

目的探讨盆腔器官脱垂（POP）患者耻骨宫颈筋膜中转化生长因子（TGF）-β1和结缔组织生长因子（CTGF）表达的作用。方法选取2009年5月至12月，30例因POP在本院行阴式子宫全切除术患者的耻骨宫颈筋膜组织纳入POP组，再按照盆腔器官垂定量... 详细信息

目的探讨盆腔器官脱垂（POP）患者耻骨宫颈筋膜中转化生长因子（TGF）-β1和结缔组织生长因子（CTGF）表达的作用。方法选取2009年5月至12月，30例因POP在本院行阴式子宫全切除术患者的耻骨宫颈筋膜组织纳入POP组，再按照盆腔器官垂定量（P0p-Q）将其分为POP—QⅡ°组（n=10）、POP—QⅢ°组（n=10）和POP—QIV。组（n=10）。选择20例同期在本院行阴式子宫全切除术的非POP患者的耻骨宫颈筋膜组织纳入对照组。应用免疫组化法和蛋白免疫印迹技术检测上述4组患者的耻骨宫颈筋膜组织中TGF-β1和CTGF的表达情况，分析二者之间及与POP及其分度的关系。POP组与对照组患者均已婚，绝经，无其他结缔组织疾病，无盆腔手术病史，无急、慢性盆腔炎病史，术前3个月内未服用雌激素类药物，术后病理学检查证实无雌激素相关性疾病。两组患者年龄、分娩次数、体重指数（BMD及其他与POP相关病史（慢性便秘、慢性咳嗽等）比较，差异无统计学意义（P〉0．05）（本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准，得到该委员会批准）。结果①免疫组化检测结果显示：TGF-β1和CTGF呈阳性染色，主要定位于成纤维细胞的细胞质内。POP组TGF-β1和CTGF的阳性染色很弱，甚至缺失，阳性表达率分别为46．7％（14／30）和50．0％（15／30）。其中，POP—QⅡ°组阳性表达率分别为70．0％（7／10）和80．0％（8／10），POP—QⅢ°组分别为50．0％（5／10）和60．0％（6／10），POP—QⅣ°组分别为20．0％（2／10）和10．0％（1／10），均低于对照组[90．0％（18／20）和85．0％（17／20）]，且差异均有统计学意义（x2=27．242，x2=23．958；P〈0．05）。TGF-β1和CTGF表达与POP—Q分度呈负相关（r=-0．409，-0．572；P〈0．05）；而TGF-β1和CTGF两者之间的表达呈正相关性（r=0．401，P〈0．05）。②蛋白免疫印迹法检测对照组、POP—QⅡ°组、POP—QⅢ°组和POP—QⅣ°组耻骨宫颈筋膜组织中TGF-β1和CTGF的相对表达量分别为0．4344±0．097，0．2441±0．060，0．1844±0．041，0．1345±0．033和1．2732±0．180，0．2132±0．028，0．1045±0．023，0．0034±0．001。POP—QⅡ°～POP—QⅣ°组TGF1的表达量，均显著低于对照组，且差异均有统计学意义（P=0．000）；而POP-QⅡ°～POP—QⅣ°组之间除POP-QⅡ°组显著高于POp-QⅣ°组，差异均有统计学意义（P=0．001）外，POP—QⅡ°组与POP—QⅢ°。组及POP—QⅢ°组与POP—QⅣ°组比较，差异无统计学意义（P—o．068，0．126）。POP—QⅡ°～POp-QⅣ°组CTGF表达量均显著低于对照组，差异均有统计学意义（P=0．000）；POP—QⅡ°～POP—QⅣ°组间比较，差异亦有统计学意义（P=0．000）。结论POP患者耻骨宫颈筋膜组织中TGF-β1和CTGF表达下降，与POP的发病和临床分度有关。

关键词：盆腔脏器脱垂转化生长因子-β1 结缔组织生长因子

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan guo Hong-Bo Jin Cong-feng Qiao Yue-Liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

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Shotgun proteomic analysis of Bombyx mori brain： emphasis on regulation of behavior and development of the nervous system

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Insect Science 2016年第1期23卷 15-27页

作者： guo-Bao Wang qin Zheng Yun-Wang Shen Xiao-feng Wu College of Animal Science Zhejiang University Hangzhou China

The insect brain plays crucial roles in the regulation of growth and develop- ment and in all types of behavior. We used sodium dodecyl sulfate polyacrylamide gel electrophoresis and high-performance liquid chromatography - electron spray ionization tandem mass spectrometry （ESI-MS/MS） shotgun to identify the proteome of the silkworm brain, to investigate its protein composition and to understand their biological functions. A total of 2210 proteins with molecular weights in the range of 5.64-1539.82 kDa and isoelectric points in the range of 3.78-12.55 were identified. These proteins were anno- tated according to Gene Ontology Annotation into the categories of molecular function, biological process and cellular component. We characterized two categories of proteins： one includes behavior-related proteins involved in the regulation of behaviors, such as locomotion, reproduction and learning; the other consists of proteins related to the devel- opment or function of the nervous system. The identified proteins were classified into 283 different pathways according to KEGG analysis, including the PI3K-Akt signaling path- way which plays a crucial role in mediating survival signals in a wide range of neuronal cell types. This extensive protein profile provides a basis for further understanding of the physiological functions in the silkworm brain.

关键词： behavior Bombyx mori brain nervous system proteomics shotgun

Dynamic Bandwidth Allocation and Rate Coordination for DiffServ Environment

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 248-252页

作者： CHEN Gang WU guo-xin ZHANG San-feng YOU feng-qin Department of Computer Science and Engineering Southeast University Nanjing 210096 Jiangsu China Key Laboratory of Computer Network and Information Integration of MOE Southeast University Nanjing 210096Jiangsu China

This paper presents a novel model for dynamic bandwidth allocation and rate coordination based on DiffServ and a bandwidth broker（BB）. In this model, assignment of bandwidth was made according to a periodic trace of network characteristics per application. And adjustment of transfer rate was accomplished through negotiation with applications by a bandwidth agent. This model was evaluated using network simulator 2 （NS-2）, and distinct improvements were found in respects of delay and packet loss of overall network and single flow. Finally, the model was suggested to be leveraged to multimedia applications with properties of lower delay and lower packet loss.

关键词： QoS bandwidth broker(BB) dynamic bandwidth allocation rate coordination

Structural reliability analysis using enhanced cuckoo search algorithm and artificial neural network

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Journal of Systems Engineering and Electronics 2018年第6期29卷 1317-1326页

作者： qin Qiang feng Yunwen LI feng Aerospace Science and Industry Corporation Defense Technology Research and Test Center Beijing 100854China School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China CASIC Space Engineering Development Co. LtdBeijing 100854China

The present study proposed an enhanced cuckoo search(ECS) algorithm combined with artificial neural network(ANN) as the surrogate model to solve structural reliability problems. In order to enhance the accuracy and convergence rate of the original cuckoo search(CS) algorithm, the main parameters namely, abandon probability of worst nests paand search step sizeα0 are dynamically adjusted via nonlinear control equations. In addition, a global-best guided equation incorporating the information of global best nest is introduced to the ECS to enhance its exploitation. Then, the proposed ECS is linked to the well-trained ANN model for structural reliability analysis. The computational capability of the proposed algorithm is validated using five typical structural reliability problems and an engineering application. The comparison results show the efficiency and accuracy of the proposed algorithm.

关键词： structural reliability enhanced cuckoo search(ECS) artificial neural network(ANN) cuckoo search(CS) algorithm