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A mixed blessing for liver transplantation patients—Rapamycin

Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 14-21页

作者： Guang-Han Fan Chen-Zhi Zhang feng-qiang gao Xu-Yong Wei Sun-Bin Ling Kai Wang Jian-Guo Wang Shu-Sen Zheng Mehrdad Nikfarjam Xiao Xu Department of Hepatobiliary and Pancreatic Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University CancerGuangzhou 510060China Westlake Laboratory of Life Sciences and Biomedicine Hangzhou 310024China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 310000China NHC Key Laboratory of Combined Multi-Organ Transplantation Hangzhou 310003China Department of Surgery University of MelbourneAustin HealthHeidelbergVIC 3084Australia

Background:Liver transplantation(LT)is an effective treatment option for end-stage liver disease.Mammalian target of rapamycin(m TOR)inhibitors,such as rapamycin,are widely used post LT.Data sources:In this review,we focused on the anti-cancer activities and metabolic side effects of rapamycin after LT.The literature available on Pub Med for the period of January 1999-September 2022 was reviewed.The key words were rapamycin,sirolimus,liver transplantation,hepatocellular carcinoma,diabetes,and lipid metabolism disorder.Results:Rapamycin has shown excellent effects and is safer than other immunosuppressive regimens.It has exhibited excellent anti-cancer activity and has the potential in preventing hepatocellular carcinoma(HCC)recurrence post LT.Rapamycin is closely related to two long-term complications after LT,diabetes and lipid metabolism disorders.Conclusions:Rapamycin prevents HCC recurrence post LT in some patients,but it also induces metabolic disorders.Reasonable use of rapamycin benefits the liver recipients.

关键词： Liver transplantation Rapamycin Metabolic disease Hepatocellular carcinoma Tumor recurrence

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Spatial diversion and coordination of flood water for an urban flood control project in Suzhou, China

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Water Science and Engineering 2024年第2期17卷 108-117页

作者： Yu Xu You-peng Xu qiang Wang Yue-feng Wang Chao gao Department of Geography and Spatial Information Techniques Ningbo UniversityNingbo 315211China State Key Laboratoryof Hydology Water Resources and Hydraulic Enginering Nanjing Hydraulic Research InstitueNanjing 210029China Laboratory of Sustainable Urban Drainage Ningbo UniversityNingbo 31521lChina Schol of Gegraphical and Oceanographic Sciences Nanjing UniversiyNanjing 210023China School of Geography and Tourism Chongqing Normal UniversityChongqing 401331China

Suzhou City,located in the Yangtze River Delta in China,is prone to flooding due to a complex combination of natural factors,including its monsoon climate,low elevation,and tidally influenced position,as well as intensive human activities.The Large Encirclement Flood Control Project(LEFCP)was launched to cope with serious floods in the urban area.This project changed the spatiotemporal pattern of flood processes and caused spatial diversion of floods from the urban area to the outskirts of the city.Therefore,this study developed a distributed flood simulation model in order to understand this transition of flood processes.The results revealed that the LEFCP effectively protected the urban areas from floods,but the present scheduling schemes resulted in the spatial diversion of floods to the outskirts of the city.With rainstorm frequencies of 10.0%to 0.5%,the water level differences between two representative water level stations(Miduqiao(MDQ)and fengqiao(FQ))located inside and outside the LEFCP area,ranged from 0.75 m to 0.24 m and from 1.80 m to 1.58 m,respectively.In addition,the flood safety margin at MDQ and the duration with the water level exceeding the warning water level at FQ ranged from 0.95 m to 0.43 m and from 4 h to 22 h,respectively.Rational scheduling schemes for the hydraulic facilities of the LEFCP in extreme precipitation cases were developed ac-cording to food simulations under seven scheduling scenarios.This helps to regulate the spatial flood diversion caused by the LEFCP during extreme precipitation.

关键词： Urban flooding Urban flood control project Rainstorm fregue ncy Flood simulation model Suzhou City

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Formation mechanism of fault accommodation zones under combined stress in graben basin:Implications from geomechanical modeling

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Petroleum Science 2024年第1期21卷 54-76页

作者： Qi-qiang Ren Jin-Liang gao Rong-Tao Jiang Jin Wang Meng-Ping Li Jian-Wei feng Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Jianghan Oilfield Oil and Gas Production Capacity Construction Management Center Chongqing408000China Sinopec Chongqing Fuling Shale Gas Exploration and Development Company Chongqing408000China College of Energy Chengdu University of TechnologyChengdu 610059SichuanChina School of Geoscience China University of Petroleum(East China)Qingdao 266580ShandongChina

A fault accommodation zone is a type of structure that is defined as regulating displacement and strain between faults structure.Increasing numbers of fault accommodation zones are being identified in graben basins,indicating the potential exploration target and petroleum accumulation areas.This study aims to analyze the formation mechanism and development of fault accommodation zones under combined stress by a numerical simulation method considering geomechanical modeling.Using three-dimensional(3-D)seismic interpretation and fractal dimension method,exampled with the Dongxin fault zone,the fault activity and fault combination pattern were conducted to quantitatively characterize the activity difference in fault accommodation zones.Combined with mechanical experiment test,a geomehcanical model was established for fault accommodation zones in a graben basin.Integrating the paleostress numerical simulations and structural physical simulation experiment,the developmental characteristics and genetic mechanism of fault accommodation zones were summarized.Influenced by multi movements and combined stresses,three significant tectonic evolution stages of the Dongxing Fault Zone(DXFZ)were distinguished:During the E_(s)^(3)sedimentary period,the large difference in the stress,strain,and rupture distribution in various faults were significant,and this stage was the key generation period for the prototype of the DXFZ,including the FAZ between large-scale faults.During the E_(s)^(2)sedimentary period,the EW-trending symmetric with opposite dipping normal faults and the NE-SW trending faults with large scale were furtherly developed.The junction area of two secondary normal faults were prone to be ruptured,performing significant period for inheriting and developing characteristics of fault accommodation zones.During the Es1 sedimentary period,the high-order faults in the DXFZ exhibited the obvious fault depressions and strike-slip activity,and the fault accommodation zones were furtherly inherited and developed.This stage was

关键词： Fault accommodation zone Graben basin Fault activity Tectonic physical simulation experiment Finite element numerical simulation Dongxin fault zone

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Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 186-194页

作者： Meng-Xiao feng Hua Zou Yuan-qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and pharmaceuticals.However,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide poisoning in humans.This study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide poisoning.Methods:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning from June 2022 to July 2022.The entire course of the incidents was described in detail.Blood 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass spectrometer.Hema-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic mitophagy.Results:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective measures.The typical course of 2-amino-5-chloro-N,3-dimethylbenzamide poisoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical evolution.Rash and fever may be the important premonitory symptoms for further organ injuries.The chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and micro-circulation.Three patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive treatments.One patient survived by liver transplantation.The postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual hepatocytes.Conclusions:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning.The chemical enter

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide Poisoning Clinical characteristics Liver injury

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Efficient second and third harmonic generation in dual-layer lithium niobate microdisk resonator

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 33-38页

作者： Zhenzhong Hao Xiao Wu qiang Luo Zhang Li Rui Ma Fang Bo feng gao Guoquan Zhang Jingjun Xu MOE Key Laboratory of Weak-Light Nonlinear Photonics TEDA Institute of Applied Physics and School of PhysicsNankai UniversityTianjin 300457China

Lithium niobate thin film frequency doubler has extensive applications in the preparation of classical and quantum sources.In this study,we successfully fabricated microdisk resonators with a quality factor of 2.2×10^(5) in reverse-polarization dual-layer x-cut lithium niobate for the first time.Based on the modal phase matching condition,efficient second harmonic generation with a record normalized conversion efficiency of~56000%W-1 and cascaded third harmonic generation with an efficiency of~6500%W-2 were obtained in the microdisk resonator.Compared with the periodically poled lithium niobate microcavity,the complex domain structure preparation processes are avoided.Our work provides a scheme for achieving highly efficient second-order nonlinear effects in non-periodically poled microcavities.

关键词： harmonic lithium niobate

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Global output feedback control of feedforward nonlinear time-delay systems with unknown growth rate and unknown measurement sensitivity

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Control Theory and Technology 2024年第1期22卷 122-134页

作者： Weiyong Yu Keao gao Hongbing Zhou qiang Liu Academy of Artificial Intelligence Beijing Institute of Petrochemical TechnologyBeijing102617China School of Mathematics and Statistics Nanyang Normal UniversityNanyang473061HenanChina

This paper discusses the problem of global state regulation via output feedback for a class of feedforward nonlinear time-delay systems with unknown measurement sensitivity. Different from previous works, the nonlinear terms are dominated by upper triangular linear unmeasured (delayed) states multiplied by unknown growth rate. The unknown growth rate is composed of an unknown constant, a power function of output, and an input function. Furthermore, due to the measurement uncertainty of the system output, it is more difficult to solve this problem. It is proved that the presented output feedback controller can globally regulate all states of the nonlinear systems using the dynamic gain scaling technique and choosing the appropriate Lyapunov–Krasovskii functionals.

关键词： Adaptive control Dynamic gain controllers Feedforward time-delay systems Measurement sensitivity Output feedback

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Lufengpithecus inner ear provides evidence of a common locomotor repertoire ancestral to human bipedalism

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The Innovation 2024年第2期5卷 122-129页

作者： Yinan Zhang Xijun Ni qiang Li Thomas Stidham Dan Lu feng gao Chi Zhang Terry Harrison Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China University of Chinese Academy of Sciences Beijing 100049China Yunnan Institute of Cultural Relics and Archeology Kunming 650118China Center for the Study of Human Origins Department of AnthropologyNew York UniversityNew YorkNY 10003USA

Various lines of evidence have been used to infer the origin of human bipedalism,but the paucity of hominoid postcranial fossils and the diversity of inferred locomotor modes have tended to confound the reconstruction of ancestral morphotypes.Examination of the bony labyrinth morphology of the inner ear of extinct and living hominoids provides independent evidence for inferring the evolution of hominoid locomotor patterns.New computed tomography data and morphometric analyses of the Late Miocene ape Lufengpithecus indicate that it and other stem great apes possess labyrinths similar to one another and show that hominoids initially evolved from a positional repertoire that included orthogrady,below-branch forelimb suspension and progression,above-branch bipedalism,climbing,clambering,and leaping(hylobatid-like)to one that comprised above-branch quadrupedalism,below-branch forelimb suspension,vertical climbing,limited leaping,terrestrial quadrupedal running and walking,possibly with knuckle walking,and short bouts of bipedalism(chimpanzee-like).The bony labyrinth morphology of Lufengpithecus indicates that it probably conforms more closely to the last common ancestors of crown hominoids and hominids in its locomotor behavior than do other Miocene hominoids.Human bipedalism evolved from this common archetypal Lufengpithecus-like locomotor repertoire.The low evolutionary rate of semicircular canal morphology suggests that Lufengpithecus experienced a relative stasis in locomotor behavior,probably due to the uplift of the Tibetan Plateau,which created a stable environment in the Miocene of southwestern China.

关键词： China probably uplift

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Love wave propagation in one-dimensional piezoelectric quasicrystal multilayered nanoplates with surface effects

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 619-632页

作者： Xin feng Liaoliang KE Yang gao College of Science China Agricultural UniversityBeijing 100083China School of Mechanical Engineering Tianjin UniversityTianjin 300350China

The exact solutions for the propagation of Love waves in one-dimensional(1D)hexagonal piezoelectric quasicrystal(PQC)nanoplates with surface effects are derived.An electro-elastic model is developed to investigate the anti-plane strain problem of Love wave propagation.By introducing three shape functions,the wave equations and electric balance equations are decoupled into three uncorrelated problems.Satisfying the boundary conditions of the top surface on the covering layer,the interlayer interface,and the matrix,a dispersive equation with the influence of multi-physical field coupling is provided.A surface PQC model is developed to investigate the surface effects on the propagation behaviors of Love waves in quasicrystal(QC)multilayered structures with nanoscale thicknesses.A novel dispersion relation for the PQC structure is derived in an explicit closed form according to the non-classical mechanical and electric boundary conditions.Numerical examples are given to reveal the effects of the boundary conditions,stacking sequence,characteristic scale,and phason fluctuation characteristics on the dispersion curves of Love waves propagating in PQC nanoplates with surface effects.

关键词： piezoelectric quasicrystal(PQC)material multilayered plate dispersion characteristic surface effect

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Micromechanics of Thermal Conductive Composites:Review,Developments and Applications

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Acta Mechanica Solida Sinica 2024年第2期37卷 215-237页

作者： Guannan Wang Yulin Huang Mengyuan gao qiang Chen Department of Civil Engineering Zhejiang UniversityHangzhou310058China Center for Balance Architecture Zhejiang UniversityHangzhou310007China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an710049China

Micromechanics investigations of composites with fiber-shaped reinforcement are extensively applied in the engineering design and theoretical analysis of thermal composites in the aerospace engineering and high-tech industry.In this paper,a critical review of various classical micromechanics approaches is provided based on the classification framework and the development of micromechanics tools.Several numerical micromechanics tools have been developed to overcome limitations through exactly/approximately solving the internal governing equations of microstructures.The connections and limitations of those models are also investigated and discussed,based on which three recently developed numerical or semi-analytical models are explained,including finite-element micromechanics,finite-volume direct averaging micromechanics,and locally exact homogenization theory,as well as machine learning tools.Since it is almost inevitable to mention the interfacial effects on thermal behavior of fibrous composites,we review the new mathematical relations that interrupt the original continuity conditions due to the existence of interphase/interface within unit cells.Generally speaking,the interphase/interface is demonstrated to play a significant role in influencing the effective coefficients and localized thermal fields.The present work also briefly reviews the application of micromechanics tools in emerging engineered woven composites,natural fibrous composites,and ablative thermal protection composites.It is demonstrated that sophisticated micromechanics tools are always demanded for investigating the effective and localized responses of thermal fibrous composites.

关键词： Micromechanics models Thermal fibrous composites Microstructural detail-free models Semi-analytical and numerical methods Interfacial effects Woven composites Natural composites

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High Dynamic Bounding and Jumping Motion of Quadruped Robot Based on Stable Optimization Control

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Journal of Bionic Engineering 2024年第1期21卷 101-111页

作者： Sai Gu Fei Meng Botao Liu Junyao gao qiang Huang School of Mechatronical Engineering Beijing Institute of Technology100081 BeijingChina Key Laboratory of Biomimetic Robots and Systems Ministry of EducationBeijing 100081China

Aiming at the environment such as ravines and obstacles that may be encountered in the actual movement,this paper proposes a method for optimizing the bounding and jumping motion based on the ground touching force trajectory and the air motion trajectory of the quadruped robot.The method of optimizing the ground reaction force according to the speed of the demand and the height of the jump,and adjusting the stance and swing time according to the relationship of dynamics and momentum conservation.At the same time,under the constraints of dynamics and energy consumption of the robot system,considering the jumping distance and height,a method for optimizing the air trajectory of bounding and jumping is proposed.State switching and landing stability control are also added.Finally,the experimental results show that the quadruped robot has strong bounding and jumping ability,and has achieved stable bounding movement and forward jump movement of 0.8 m.

关键词： Quadruped robot High dynamic motion control-Periodic limit cycle Trajectory optimization

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