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Radiotherapy for small cell lung cancer in current clinical practice guidelines

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Journal of the National Cancer Center 2022年第2期2卷 113-125页

作者： Haiyan Zeng Dirk K.M.De Ruysscher Xiao Hu Danyang Zheng Li Yang Umberto Ricardi feng-ming spring kong Lizza E.L.Hendriks Department of Radiation Oncology(Maastro) GROW School for OncologyMaastricht University Medical Center+MaastrichtThe Netherlands Department of Radiation Oncology Zhejiang Cancer HospitalHangzhouChina Department of Clinical Oncology The University of Hong Kong-Shenzhen HospitalShenzhenChina Department of Clinical Oncology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Department of Oncology University of TurinTurinItaly Department of Pulmonary Diseases GROW School for Oncology and Developmental BiologyMaastricht University Medical Center+MaastrichtThe Netherlands

Several guidelines including radiotherapy recommendations exist worldwide for the treatment of small cell lung cancer(SCLC).To evaluate the differences in radiotherapy recommendations we conducted a systematic *** and the sites of medical societies were searched for SCLC guidelines published in either English,Chi-nese,or *** was limited to January 2018 till February 2021 to only include up-to-date *** was extracted and compared regarding the guideline’s development method and radiotherapy *** guidelines were identified(PubMed n=4,societies n=7)from Spain(n=1),Canada(n=1),America(n=3),United Kingdom(n=1),the Netherlands(n=1),and China(n=3),*** guidelines assessed the strength of evidence(SOE)and specified the strength of recommendation(SOR),although methods were *** major radiotherapy recommendations are similar although differences exist in thoracic radiotherapy(TRT)dose,time,and *** areas are TRT in resected stage I-IIA(pN1),prophylactic cranial irradiation(PCI)in resected as well as unresected stage I-IIA,stereotactic body radiation therapy(SBRT)in un-resected stage I-IIA,PCI time,and PCI versus magnetic resonance imaging(MRI)surveillance in stage *** existence of several overlapping guidelines for SCLC treatment indicates that guideline development is(unnec-essarily)repeated by different organizations or *** could be made by better international collaboration to avoid duplicating unnecessary work,which would spare a lot of time and *** should be made to work together on controversial or unknown fields.

关键词： Small cell lung cancer Guideline Radiotherapy

Significance of radiation esophagitis:Conditional survival assessment in patients with non-small cell lung cancer

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Journal of the National Cancer Center 2021年第2期1卷 31-38页

作者： Hao Yu Ka-On Lam Michael D.Green Huanmei Wu Li Yang Weili Wang Jianyue Jin Chen Hu Yang Wang Shruti Jolly feng-ming(spring)kong Biomedical Engineering Shenzhen PolytechnicShenzhenChina BioHealth Informatics School of Informatics and ComputingIUPUIIndianapolisINUSA Department of Clinical Oncology LKS Faculty of Medicinethe University of Hong KongHong KongChina Clinical Oncology Center the University of Hong Kong-Shenzhen HospitalShenzhenChina Radiation Oncology Ann Arbor VA Health CareAnn ArborMIUSA University Hospitals/Cleveland Medical Center Seidman Cancer Center and Case Comprehensive Cancer CenterCase Western Reserve UniversityClevelandOHUSA Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of MedicineBaltimoreMDUSA Radiation Oncology University of MichiganAnn ArborMIUSA

Purpose:This study aimed to examine the effect of radiation esophagitis(RE)and the dynamics of RE on subse-quent survival in non-small cell lung cancer(NSCLC)patients who underwent *** Design:Patients with NSCLC treated with fractionated thoracic radiotherapy enrolled in prospective trials were *** was graded prospectively according to Common Terminology Criteria for Adverse Events(CTCAE)v3.0 per protocol requirement weekly during-RT and 1 month after *** study applied conditional survival assessment which has advantage over traditional survival analysis as it assesses the survival from the event instead of from the baseline.P-value less than 0.05 was considered to be *** primary endpoint is overall ***:A total of 177 patients were eligible,with a median follow-up of 5 *** presence of RE,the maximum RE grade,the evolution of RE and the onset timing of RE events were all correlated with subsequent *** all conditional time points,patients first presented with RE grade1(initial RE1)had significant inferior subsequent survival(multivariable HRs median:1.63,all P-values<0.05);meanwhile those with RE progressed had significant inferior subsequent survival than those never develop RE(multivariable HRs median:2.08,all P-values<0.05).Multivariable Cox proportional-hazards analysis showed significantly higher C-indexes for models with inclusion of RE events than those without(all P-values<0.05).Conclusion:This study comprehensively evaluated the impact of RE with conditional survival assessment and demonstrated that RE is associated with inferior survival in NSCLC patients treated with RT.

关键词： Radiotherapy Radiation esophagitis Conditional survival Non-small cell lung cancer

The role of stereotactic body radiotherapy in hepatocellular carcinoma:guidelines and evidences

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Journal of the National Cancer Center 2022年第3期2卷 171-182页

作者： Yulin Hu Caining Zhao Ren Ji Wenqi Chen Qi Shen CL Chiang Jeff Chan Lingyu Ma Hongwei Yang Tiffany Wong Susannah Ellsworth Chung-Mau Lo Laura A.Dawson feng-ming(spring)kong Graduate School Shenzhen UniversityShenzhenChina Department of Clinical Oncology The University of Hong Kong-Shenzhen HospitalShenzhenChina Department of Clinical Oncology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Division of Hepatobiliary&Pancreatic Surgery Department of SurgeryThe University of Hong Kong-Shenzhen HospitalShenzhenChina Department of Radiation Oncology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina Department of Radiology Division of Interventional RadiologyThe University of Hong Kong-Shenzhen HospitalShenzhenChina Department of Radiation Oncology University of Pittsburgh Medical CenterPittsburghUSA Radiation Medicine Program Princess Margaret HospitalUniversity Health NetworkTorontoCanada Department of Clinical Oncology Queen Mary HospitalHong Kong University Li Ka Shing Faculty of MedicineHong KongChina

Hepatocellular carcinoma(HCC)is a common malignancy with high mortality *** surgery can be curative in early-stage disease,80% of patients cannot undergo surgical *** body radiotherapy(SBRT),an emerging,non-invasive,precision treatment,has shown promising results across various stages of HCC and has thus been adopted in practice to varying degrees around the *** article aims to review current guideline recommendations on SBRT,clinical evidence,and outcome comparisons with other local treatment *** are also made to compare the differences in clinical trials between Asian and Western countries.

关键词： Hepatocellular carcinoma Stereotactic body radiotherapy Guidelines Liver local treatment Local tumor control

放疗联合免疫检查点抑制剂治疗非小细胞肺癌研究进展

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肿瘤综合治疗电子杂志 2019年第4期5卷 1-5,I0002页

作者：刘晓丽李莉袁双虎 feng-ming(spring)kong 于金明山东大学临床医学院济南250117 山东省肿瘤防治研究院(山东省肿瘤医院)山东第一医科大学(山东省医学科学院)放疗科济南250117 济南大学山东省医学科学院医学与生命科学学院济南250022 凯斯西储大学赛德曼癌症中心和病例综合癌症中心放疗科美国俄亥俄州克里夫兰44106

肺癌是世界上常见的致死性癌症之一,其中85%的肺癌为非小细胞肺癌(non-small cell lung cancer,NSCLC)。目前放疗是NSCLC主要的治疗手段之一。随着免疫治疗的发展,免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)已成为部分晚期NS... 详细信息

肺癌是世界上常见的致死性癌症之一,其中85%的肺癌为非小细胞肺癌(non-small cell lung cancer,NSCLC)。目前放疗是NSCLC主要的治疗手段之一。随着免疫治疗的发展,免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)已成为部分晚期NSCLC患者的一线治疗。研究发现放疗与免疫治疗具有协同效应,能够改善NSCLC患者的生存。众多研究探索了放疗联合ICIs治疗NSCLC的安全性及有效性,本文就放疗联合ICIs治疗NSCLC的研究进展做一综述。

关键词：非小细胞肺癌放射治疗免疫治疗免疫检查点抑制剂

Alkaline leaching mechanism of MSWI bottom ash: the pivotal role of Si(Al) chemical bonding environments

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Science China Technological Sciences 2025年

作者： Ningning SHAO Zekun JIAO Weipeng feng Yu JIN Fanlong kong Zhijun DONG Zuotai ZHANG Institute of Technology for Marine Civil Engineering Shenzhen Institute of Information Technology (SZIIT) Guizhou NASH Ecological Technology Co. LTD School of Environmental Science and Engineering Key Laboratory of Municipal Solid Waste Recycling Technology and Management of Shenzhen City Southern University of Science and Technology (SUSTech)

Municipal solid waste incineration bottom ash(MSWIBA) is a complex assemblage of aluminosilicate materials encompassing diverse solid wastes. Thus, its complexity poses great challenges to their resource utilization. For the sake of the alkali activation use of MSWIBA, this work focused on the characterizations and alkaline leaching experiments of various classified MSWIBA after sorting. Among the different categories of MSWIBA, waste glass(BA-G) and other unidentified slags(BA-O) were identified as potential precursors for alkali activation use. The alkaline leaching experiments proved that alkaline concentration, reaction temperature, reaction time, and raw material classification influenced the leaching process and results. Among these, the Si/Al chemical bonding environments from the material type played a pivotal role. When the materials had Qn(n>2) as the primary bonding structure, steric hindrance by the chain frameworks affected the alkali dissolution process, resulting in gradual disintegration from the outer layers inward. For the materials dominated by Q1frameworks, OH-could penetrate the frameworks, leading to their rapid depolymerization and outward dissolution. Overall, the Si/Al bonding environment played a crucial role in alkaline dissolution, providing theoretical guidance for classifying the alkali-activation utilization of MSWIBA and other aluminosilicate solid wastes.

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哌嗪及其衍生物CO_(2)吸收剂的研究进展

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现代化工 2025年第1期45卷 46-50页

作者：孔明梁启晨吴勇刘帅蔡旺锋天津大学化工学院天津300350 安徽兴欣新材料有限公司安徽省企业研发中心安徽池州247260 绍兴兴欣新材料股份有限公司浙江绍兴312300

介绍了哌嗪与CO_(2)反应的机理。总结了单组分哌嗪衍生物、含哌嗪类有机胺的混合胺液吸收剂、哌嗪类有机胺与无机类溶剂混合吸收剂、哌嗪浸渍改性固体类吸附剂捕集CO_(2)的优劣。并对哌嗪类衍生物吸收剂捕集CO_(2)研究提出了展望。

关键词：哌嗪有机胺二氧化碳吸收解吸

Ring-Shaped Jets in Gamma-Ray Bursts

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Chinese Journal of Astronomy and Astrophysics 2008年第4期8卷 411-420页

作者： ming Xu Yong-feng Huang Si-Wei kong Department of Astronomy Nanjing University Nanjing 210093 China

When the axis of a gamma-ray burst （GRB） does not coincide with the spin axis of its source, there may result a ring-shaped jet. Using some refined jet dynamics, we calculate multi-wavelength afterglow light curves for such ring-shaped jets. In the R-band we find an obvious break in the afterglow light curve due to the beaming effect and the break is affected by many parameters, such as the electron energy fraction ζe, the magnetic energy fraction ζB^2, the width of ring △θ and the medium number density n. The overall light curve can be divided into three power-law stages, i.e., an ultra-relativistic stage, an after-break stage and a deep Newtonian stage. For each stage the power-law index is larger in the ring-shaped jet than in the corresponding conical jet.

关键词： gamma rays bursts - ISM jets and outflows

综合理解韧性治理视角下的城市社区洪涝灾害韧性及分析框架

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灾害学 2025年第1期40卷 8-15页

作者：孔锋米胤瑜王一飞中国农业大学人文与发展学院北京100083 北京市科学技术协会防灾减灾专业智库基地北京100089 清华大学应急管理研究基地北京100084 中国气象局气象干部培训学院北京100081

气候变化背景下频发重发的洪涝灾害是人类社会可持续发展面临的重大挑战之一。该文首先从洪涝灾害治理的转变出发,深入探讨了从传统的洪涝风险管理向洪涝风险治理转变的深层含义,并概述了韧性城市发展的关键特征。接着,文章对韧性概念... 详细信息

气候变化背景下频发重发的洪涝灾害是人类社会可持续发展面临的重大挑战之一。该文首先从洪涝灾害治理的转变出发,深入探讨了从传统的洪涝风险管理向洪涝风险治理转变的深层含义,并概述了韧性城市发展的关键特征。接着,文章对韧性概念的发展历程进行了梳理,并对比分析了不同韧性理论及其侧重点。在城市韧性多学科视角下,提出了城市洪涝灾害韧性的主要特征与核心内涵,并回顾了相关研究进展,同时指出了社区韧性评价的主要聚焦点。再次,论述了城市社区在面对洪涝灾害时的稳健性、适应性和可转换性特征。最后,从韧性治理的角度,构建了“制度-网络-能力”的分析框架,并详细阐释了城市社区洪涝灾害韧性分析的五个维度:制度韧性、组织韧性、社会韧性、基础设施韧性和技术韧性,以及这些维度之间的内容特征和逻辑联系。

关键词：灾害韧性脆弱性社区洪涝灾害治理气候变化灾害治理的复杂性工程韧性生态韧性演进韧性

A Bayesian expectation maximization algorithm for state estimation of intelligent vehicles considering data loss and noise uncertainty

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Science China Technological Sciences 2025年

作者： Yan WANG feng TIAN Jianqiang WANG Keqiang LI Department of Industrial and Systems Engineering The Hong Kong Polytechnic University School of Vehicle and Mobility Tsinghua University

Sideslip angle, yaw rate, and vehicle velocity are essential for intelligent vehicle control. Since these vehicle states are not measured directly, some Kalman-based approaches have been developed to estimate these states using in-vehicle sensors. However, the existing studies seldom account for the influence of sensor data loss on estimation accuracy. In addition,the process and measurement noise change during the estimation process because of the various driving conditions. To address these problems, an expectation-maximization robust extended Kalman filter (EMREKF) is proposed. Firstly, a robust extended Kalman filter (REKF) is developed to deal with the impact of missing measurements. Then, an improved expectation maximization (EM) algorithm that considers data loss is presented to update the noise parameter of the REKF dynamically. Finally,the improved EM is fused with the REKF to form the EMREKF to estimate vehicle state. The experimental results demonstrate that the EMREKF outperforms EKF, REKF, and maximum correntropy criterion EKF for various degrees of data loss and the proposed algorithm has a strong adaptive ability to different driving conditions.

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