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A Novel Design of a Pre-separation Panel Structure to Protect Against the Impact of an Explosion in an Aircraft Plenum Chamber

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Acta Mechanica Solida Sinica 2024年第1期37卷 166-180页

作者： Zongxing liu Xiang Yang jun liu School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China COMAC Shanghai Aircraft Design and Research Institute Shanghai 201210China

To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast ***,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage ***,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation ***,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact *** calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the *** residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged *** results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.

关键词： Pre-separation panel structure Explosive response Residual strength Aircraft plenum chamber Least risk bomb location

Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells

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Asian Journal of Andrology 2024年第2期26卷 165-174页

作者： Hai-Wei feng Yu Zhao Yan-Ling Gao Dong-Teng liu Li-jun Huo Key Laboratory of Agricultural Animal Genetics Breeding and ReproductionEducation Ministry of ChinaCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterThe University of Hong Kong-Shenzhen HospitalShenzhen 518053China Maternal-Fetal Medicine Institute Department of Obstetrics and GynaecologyShenzhen Baoan Women's and Children's HospitalJinan UniversityShenzhen 518100China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various *** mitochondrial protease complex(ClpXP),which consists of caseinolytic mitochondrial matrix peptidase X(ClpX)and caseinolytic protease P(ClpP)and mediates the degradation of misfolded,damaged,and oxidized proteins,is essential for maintaining mitochondrial *** has been implicated in meiosis regulation,but its precise role is currently *** this study,we engineered an inducible male germ cell-specific knockout caseinolytic mitochondrial matrix peptidase X(Clpx^(cKO))mouse model to investigate the function of ClpX in *** found that disrupting Clpx in male mice induced germ cell apoptosis and led to an absence of sperm in the ***,it caused asynapsis of homologous chromosomes and impaired meiotic recombination,resulting in meiotic arrest in the zygotene-to-pachytene transition *** loss of ClpX compromised the double-strand break(DSB)repair machinery by markedly reducing the recruitment of DNA repair protein RAD51 homolog 1(RAD51)to DSB *** dysfunction may be due to an insufficient supply of energy from the aberrant mitochondria in Clpx^(cKO) spermatocytes,as discerned by electron ***,ubiquitination signals on chromosomes and the expression of oxidative phosphorylation subunits were both significantly attenuated in Clpx^(cKO) *** together,we propose that ClpX is essential for maintaining mitochondrial protein homeostasis and ensuring homologous chromosome pairing,synapsis,and recombination in spermatocytes during meiotic prophase I.

关键词： ClpX homologous chromosome meiosis mitochondrial recombination synapsis

Recent Advances in Deciphering the Mechanisms and Biological Functions of DNA Demethylation

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Chinese Journal of Chemistry 2024年第6期42卷 645-651页

作者： Yang feng Sheng-jun Chen Bi-feng Yuan Key Laboratory of Aquatic Product Processing Ministry of Agriculture and Rural AffairsNational R&D Center for Aquatic Product ProcessingSouth China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong510300 China School of Public Health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhanHubei430071 China

5-Methylcytosine (5mC) is a dynamic and reversible epigenetic modification in genomic DNA of higher *** has been well-established that the demethylation of 5mC occurs through the ten-eleven translocation (TET)-mediated oxidation of 5mC followed by thymine DNA glycosylase (TDG)-initiated base excision repair (BER).Recent findings also have identified an alternative pathway of DNA *** this pathway,TET enzymes directly oxidize 5mC to form 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC).These modified bases can undergo direct deformylation or decarboxylation,***,DNA demethylation can also occur through the deamination of 5mC and 5hmC,resulting in the production of thymine and 5-hydroxymethyluracil (5hmU),*** DNA demethylation pathways possess critical functional implications and roles in biological *** Recent Advances article will focus on the studies of mechanisms and biological functions of DNA demethylation,shedding light on the reversible nature of the epigenetic modification of 5mC.

关键词： Epigenetics DNA DNA methylation 5-Methylcytosine Demethylation Mechanisms Biological functions C—C bond cleavage Mass spectrometry

Self-Triggered Set Stabilization of Boolean Control Networks and Its Applications

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1631-1642页

作者： Rong Zhao jun-e feng Dawei Zhang the School of Mathematics Shandong UniversityShandong UniversityJinan 250100China

Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.

关键词： Boolean control networks(BCNs) output regulation self-triggered control semi-tensor product of matrices set stabilization synchronization

Thermoelectric transport properties of p-type Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3) high entropy compounds

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Rare Metals 2024年第7期43卷 3415-3421页

作者： feng Jiang Cheng-Liang Xia Yong-Bin Zhu jun Li Yue Chen Wei-Shu liu Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

The introduction of entropy concept into thermoelectric materials recently has attracted broad ***,we showed the phase diagram of the ternary systems of Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3).Among the high entropy compounds (HECs),we have identified an intrinsic p-type region near our previously reported Bi_(0.8)Sb_(0.8)In_(0.4)Se_(3) in the phase diagram.

关键词： entropy (3) compounds

Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

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Rare Metals 2024年第3期43卷 1207-1221页

作者： Shun Xing Dong-Hui Wang Hai-feng Zhang Li-Dan liu Cheng-Ce Li Chao Wei jun-Yu liu Nai-Jian Ge Xuan-Yong liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Intervention Center Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai200438China School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjin300130China

Malignant obstruction makes gallbladder cancer have a high mortality ***-titanium alloy(nitinol)stents are commonly used as a local intervention to maximize patient survival time,but the stents lack antitumor and antibacterial capacity and are vulnerable to secondary ***-based drugs show good therapeutic promise against gallbladder *** meet clinical *** layered double hydroxides(LDHs)film is constructed on the nitinol,whose arsenite loading amounts rose by 60%after simple heat treatment compared with the conventional anion-exchange *** addition,calcination promotes the dissolution of nickel ions from the LDHs lattice,resulting in a powerful synergistic killing effect on tumor cells together with the released *** importantly,the calcined arsenic-loaded LDHs are sensitive to the acidic microenvironment of tumor tissues,which presents a much lower arsenic and nickel release amount in the normal tissues,guaranteeing its ***,the vertically sharp LDHs nanosheets can synergize with arsenic to achieve effective physical cleavage and chemical killing of adherent and planktonic *** short,we attempt to use arsenic drugs for local interventions and reasonably avoid their toxic side effects,which provides a new design idea for nitinol stents applied in the treatment of gallbladder cancer.

关键词： Nitinol Layered double hydroxides Arsenic Gallbladder cancer

Unlocking the potential of thin-film composite reverse osmosis membrane performance:Insights from mass transfer modeling

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Chinese Chemical Letters 2024年第5期35卷 66-76页

作者： Kexin Yuan Yulei liu Haoran feng Yi liu jun Cheng Beiyang Luo Qinglian Wu Xinyu Zhang Ying Wang Xian Bao Wanqian Guo jun Ma State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China College of Architecture and Environment Sichuan UniversityChengdu 610065China School of Municipal and Environmental Engineering Shandong Jianzhu UniversityJi’nan 250101China College of Water Conservancy and Hydropower Engineering Sichuan Agricultural UniversityYaan 625014China

Thin-film composite(TFC)reverse osmosis(RO)membranes have attracted considerable attention in water treatment and desalination processes due to their specific separation ***,the trade-off effect between water flux and salt rejection poses huge challenges to further improvement in TFC RO membrane *** research works have been dedicated to optimizing membrane fabrication and modification for addressing this *** the meantime,several reviews summarized these ***,the existing reviews seldom analyzed these methods from a theoretical perspective and thus failed to offer effective optimization directions for the RO process from the root *** this review,we first propose a mass transfer model to facilitate a better understanding of the entire process of how water and solute permeate through RO membranes in detail,namely the migration process outside the membrane,the dissolution process on the membrane surface,and the diffusion process within the ***,the water and salt mass transfer behaviors obtained from model deduction are comprehensively analyzed to provide potential guidelines for alleviating the trade-off effect between water flux and salt rejection in the RO ***,inspired by the theoretical analysis and the accurate identification of existing bottlenecks,several promising strategies for both regulating RO membranes and optimizing operational conditions are proposed to further exploit the potential of RO membrane *** review is expected to guide the development of high-performance RO membranes from a mass transfer theory standpoint.

关键词： Reverse osmosis Mass transfer model Trade-off effect Membrane performance Optimization strategies

Achieving a remarkable low-temperature tensile ductility in a high-strength tungsten alloy

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Tungsten 2024年第1期6卷 150-161页

作者： Xiang Cheng Zhuo-Ming Xie Xue-feng Xie Long-Fei Zeng Rui liu jun-feng Yang Xue-Bang Wu Xian-Ping Wang Chang-Song liu Qiang-feng Fang Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China

Hot-swaging yields a high ultimate tensile strength of 712 MPa but a limited tensile ductility with the total elongation of3.6%at a testing temperature of 200℃in a representative W-0.5wt.%ZrC *** this work,the evolution of Vickers microhardness with annealing temperatures is investigated in detail,which contributes to a rough index chart to guide the search for an optimized post-annealing *** the post-annealing around 1300℃,an outstanding tensile ductility at200℃,including a uniform elongation of 14%and a total elongation of~25%,has been achieved without the sacrifice of its *** evolution of dislocations and grain structures with the annealing temperatures accessed through backscattered scanning electron microscope and transmission electron microscope analysis reveals that the improved low-temperature tensile ductility has resulted from the reduction of residual dislocations and dislocation tanglement via the static recovery,which provides more room to accommodate dislocations,and hence stronger strain hardening ability and tensile ductility.

关键词： Tungsten Low-temperature ductility Annealing Dislocations

Glide symmetry for mode control and significant suppression of coupling in dual-strip SSPP transmission lines

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Advanced Photonics 2021年第2期3卷 68-77页

作者： Xiao Tian Yan Wenxuan Tang jun feng liu Meng Wang Xin Xin Gao Tie jun Cui Southeast University School of Information Science and EngineeringState Key Laboratory of Millimeter WavesNanjingChina Southeast University Institute of Electromagnetic SpaceNanjingChina

Glide symmetry,which is one kind of higher symmetry,is introduced in a special type of plasmonic metamaterial,the transmission lines(TLs)of spoof surface plasmon polaritons(SSPPs),in order to control the dispersion characteristics and modal fields of the *** show that the glide-symmetric TL presents merged pass bands and mode degeneracy,which lead to broad working bandwidth and extremely low coupling between neighboring ***-conductor SSPP TLs with and without glide symmetry are arranged in parallel as two channels with very deep subwavelength separation(e.g.,λ0∕100 at 5 GHz)for the application of integrated circuits and *** coupling between the hybrid channels is analyzed using coupled mode theory and characterized in terms of scattering parameters and near-field *** demonstrate theoretically and experimentally that the hybrid TL array obtains significantly more suppressed crosstalk than the uniform array of two nonglide symmetric ***,it is concluded that the glide symmetry can be adopted to flexibly design the propagation of SSPPs and benefit the development of highly compact plasmonic circuits.

关键词： glide symmetry spoof surface plasmon polaritons dispersion control mode degeneracy coupling suppression