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Painful intervertebral disc degeneration and inflammation:from laboratory evidence to clinical interventions

Bone Research 2021年第1期9卷 1-14页

作者： feng-juan lyu Haowen Cui Hehai Pan Kenneth MC Cheung Xu Cao James C.Iatridis Zhaomin Zheng School of Medicine South China University of TechnologyGuangzhouChina Department of Spine Surgery The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Orthopedics&Traumatology The University of Hong KongHong KongSARChina Department of Orthopedic Surgery Johns Hopkins UniversityBaltimoreMDUSA Leni and Peter W.May Department of Orthopedics Icahn School of Medicine at Mount SinaiNew YorkNYUSA Pain Research Center Sun Yat-sen UniversityGuangzhouChina

Low back pain(LBP),as a leading cause of disability,is a common musculoskeletal disorder that results in major social and economic *** research has identified inflammation and related signaling pathways as important factors in the onset and progression of disc degeneration,a significant contributor to *** mediators also play an indispensable role in discogenic *** suppression of LBP is a primary goal of clinical practice but has not received enough attention in disc research ***,an overview of the advances in inflammation-related pain in disc degeneration is provided,with a discussion on the role of inflammation in IVD degeneration and pain *** models,mechanical models,and spontaneous models as the main animal models to study painful disc degeneration are discussed,and the underlying signaling pathways are ***,potential drug candidates,either under laboratory investigation or undergoing clinical trials,to suppress discogenic LBP by eliminating inflammation are *** hope to attract more research interest to address inflammation and pain in IDD and contribute to promoting more translational research.

关键词： degeneration eliminating enough

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Simplified liver imaging reporting and data system for the diagnosis of hepatocellular carcinoma on gadoxetic acid-enhanced magnetic resonance imaging

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2439-2448页

作者： Rong lyu Wei-juan Hu Di Wang Jiao Wang Yu-Bing Ye Ke-feng Jia Department of Radiology Tianjin Third Central HospitalTianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesArtificial Cell Engineering Technology Research CenterTianjin 300170China

BACKGROUND The liver imaging reporting and data system(LI-RADS)diagnostic table has 15 cells and is too *** diagnostic performance of LI-RADS for hepatocellular carcinoma(HCC)is not satisfactory on gadoxetic acid-enhanced magnetic resonance imaging(EOB-MRI).AIM To evaluate the ability of the simplified LI-RADS(sLI-RADS)to diagnose HCC on *** A total of 331 patients with 356 hepatic observations were retrospectively *** diagnostic performance of sLI-RADS A-D using a single threshold was evaluated and compared with LI-RADS v2018 to determine the optimal *** algorithms of sLI-RADS A-D are as follows:The single threshold for sLI-RADS A and B was 10 mm,that is,classified observations≥10mm using an algorithm of 10-19 mm observations(sLI-RADS A)and≥20 mm observations(sLI-RADS B)in the diagnosis table of LI-RADS v2018,respectively,while the classification algorithm remained unchanged for observations0.999).With HBP hypointensity as an MF,the sensitivity of F-sLI-RADS was greater than that of LI-RADS v2018(93.0%vs 87.0%,P<0.001)and sLI-RADS D(93.0%vs 89.8%,P=0.016),without a lower specificity(86.5%vs 90.1%,P=0.062;86.5%vs 89.4%,P=0.125).Compared with that of LI-RADS v2018,the time to classif

关键词： Hepatocellular carcinoma Magnetic resonance imaging Liver Diagnosis Contrast agent

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Attractor for the Extensible Beam Equation with Nonlocal Weak Damping on Time–Dependent Space

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1115-1126页

作者： Chun Xiang ZHAO feng juan MENG Institute of Applied System Analysis Jiangsu UniversityZhenjiang 212013P.R.China School of Mathematics and Physics Jiangsu University of TechnologyChangzhou 213001P.R.China

In this article,we consider the long-time behavior of extensible beams with nonlocal weak damping:ε(t)u_(tt)+Δ^(2)u-m(‖▽u‖^(2))Δu+‖u_(t)‖^(p_(u_(t)))+f(u)=h,whereε(t)is a decreasing function vanishing at *** the theory of process on time-dependent spaces,we investigate the existence of the time-dependent attractor by using the Condition(C_(t))method and more detailed *** results obtained essentially improve and complete some previous works.

关键词： Time-dependent attractor extensible beams equation nonlocal weak damping

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Uncertainties of ENSO-related Regional Hadley Circulation Anomalies within Eight Reanalysis Datasets

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Advances in Atmospheric Sciences 2024年第1期41卷 115-140页

作者： Yadi LI Xichen LI juan feng Yi ZHOU Wenzhu WANG Yurong HOU International Center for Climate and Environment Sciences(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 101408China College of Global Change and Earth System Science(GCESS) Beijing Normal UniversityBeijing 100875China

El Nino-Southern Oscillation(ENSO),the leading mode of global interannual variability,usually intensifies the Hadley Circulation(HC),and meanwhile constrains its meridional extension,leading to an equatorward movement of the jet *** studies have investigated the response of HC to ENSO events using different reanalysis datasets and evaluated their capability in capturing the main features of ENSO-associated HC ***,these studies mainly focused on the global HC,represented by a zonal-mean mass stream function(MSF).Comparatively fewer studies have evaluated HC responses from a regional perspective,partly due to the prerequisite of the Stokes MSF,which prevents us from integrating a regional *** this study,we adopt a recently developed technique to construct the three-dimensional structure of HC and evaluate the capability of eight state-of-the-art reanalyses in reproducing the regional HC response to ENSO *** show that all eight reanalyses reproduce the spatial structure of HC responses well,with an intensified HC around the central-eastern Pacific but weakened circulations around the Indo-Pacific warm pool and tropical *** spatial correlation coefficient of the three-dimensional HC anomalies among the different datasets is always larger than ***,these datasets may not capture the amplitudes of the HC responses *** uncertainty is especially large for ENSO-associated equatorially asymmetric HC anomalies,with the maximum amplitude in Climate Forecast System Reanalysis(CFSR)being about 2.7 times the minimum value in the Twentieth Century Reanalysis(20CR).One should be careful when using reanalysis data to evaluate the intensity of ENSO-associated HC anomalies.

关键词： regional Hadley circulation ENSO atmosphere-ocean interaction reanalysis data

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Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 687-698页

作者： juan Lin Zhu-feng Chen Guo-Dong Guo Xin Chen Shengli Clinical Medical College Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Pathology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Internal Medicine Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND The Alcian blue(AB)and periodic acid Schiff(PAS)stains are representative mucus markers in gastric signet ring cell carcinoma(SRCC).They are low-cost special staining methods used to detect acidic mucus and neutral mucus,***,the clinical importance of the special combined AB and PAS stain is *** To investigate AB expression,PAS expression and the AB-to-PAS(A/P)ratio in gastric SRCC patients and to assess patient *** Paraffin-embedded sections from 83 patients with gastric SRCC were stained with AB and PAS,and signet ring cell positivity was assessed ***-histochemical staining for Ki67,protein 53(P53)and human epidermal growth factor receptor 2(HER2)was performed *** cancer-specific survival(CSS)rate was estimated via Kaplan-Meier *** proportional hazards models were used for univariate and multivariate survival *** Kaplan-Meier survival analysis revealed that the 3-year CSS rate was significantly greater in the high-PAS-expression subgroup than in the low-PAS-expression subgroup(P0.5 group(P=0.042).Univariate Cox regression analysis revealed that the factors affecting prognosis included tumor diameter,lymph node metastasis,vessel carcinoma embolus,tumor stage,the A/P ratio and the expression of Ki67,P53 and the *** multivariate regression analysis confirmed that low PAS expression[hazard ratio(HR)=3.809,95%confidence interval(CI):1.563-9.283,P=0.003]and large tumor diameter(HR=2.761,95%CI:1.086-7.020,P=0.033)were independent risk factors for poor *** A/P>0.5 is potentially a risk factor for prognosis,and low PAS expression is an independent risk factor in the prognosis of gastric *** expression and the A/P ratio could help in predicting the clinical prognosis of patients with SRCC.

关键词： Alcian blue Periodic acid-Schiff Prognosis Gastric Signet ring cell carcinoma

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A multi-stream network for retrosynthesis prediction

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Frontiers of Computer Science 2024年第2期18卷 231-233页

作者： Qiang ZHANG juan LIU Wen ZHANG feng YANG Zhihui YANG Xiaolei ZHANG Institute of Artificial Intelligence School of Computer ScienceWuhan UniversityWuhan 430072China College of Informatics Huazhong Agricultural UniversityWuhan 430072China

1 Introduction Retrosynthesis aims to predict a set of reactants for producing given molecules[1],which plays a significant part in the biochemistry field,such as molecular pathway design and drug *** existing methods perform better in solving this problem,most of these methods[2,3]only describe the molecules from one kind of perspective,such as they use Simplified Molecular Input Line Entry System(SMILES)strings[4]to represent the atomic components and the relationship between atoms of molecules or leverage Extended Connectivity Fingerprints(ECFPs)represent the information of the molecular sub-structure composition via binary vectors[5].

关键词： synthesis reactant hough

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Carbon preservation in sedimentary deposits: Beyond mineral protection

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The Innovation 2024年第2期5卷 5-6页

作者： Yunpeng Zhao juan Jia Chengzhu Liu Xiaojuan feng State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

The deposition and preservation of organic carbon(OC)in sedimentary environments(including soils and sediments)play major roles in mediating the global carbon *** than 90%of OC burial in the ocean occurs in continental margin sediments,which contributes to the evolution of the Earth’s atmosphere,such as oxygen content,over geological timescales.1 However,how OC escapes mineralization and persists in such sedimentary deposits has long been a *** protection through physicochemical associations of organic matter with minerals and cations is considered to be one of the primary mechanisms contributing to the environmental persistence of sedimentary OC.

关键词： sedimentary mineralization environments

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Climate-driven changes in drought metrics across the Yellow River Basin based on Coupled Model Intercomparison Project Phase 6

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Journal of Geographical Sciences 2024年第9期34卷 1841-1856页

作者： LIU Jiayuan LIU Xianfeng LIANG juan feng Yu School of Geography and Tourist Shaanxi Normal UniversityXi'an 710119China Ningbo Institute of Digital Twin Eastern Institute for Advanced StudyNingbo 315200ZhejiangChina

Recent climate change has accelerated the global hydrological cycle, substantially affecting drought metrics such as drought duration and drought propagation;however, knowledge of drought patterns in these metrics remains limited. Here, we aimed to address the evolution and influencing factors of major drought metrics under past and future climate scenarios within the Yellow River Basin(YRB) based on Coupled Model Intercomparison Project Phase 6(CMIP6). Accordingly, we investigated the changes in drought duration for meteorological drought and agricultural drought across the YRB and identified the variability in drought propagation time from meteorological drought to agricultural drought by using a standardized precipitation/soil moisture index and run theory. Meteorological and agricultural drought duration, and propagation time, increased from 1850 to 2014, decreased significantly from 2015 to 2100 with change trends of –0.0027, –0.0197, and –0.002 month/year, respectively. Drought duration had a negative sensitivity to humidification, and agricultural drought was more sensitive than meteorological drought. Propagation time exhibited a greater sensitivity to meteorological humidification than agricultural humidification. The results also suggest that precipitation, evapotranspiration, and soil moisture are the main drivers of drought metric changes, with air temperature and crop cover exhibiting a strong indirect effect on drought metrics in the YRB. Decreased propagation time from meteorological to agricultural drought and decreased duration provide evidence for the accelerated occurrence and increased impact of drought, highlighting the importance of a more comprehensive understanding of drought metric changes under rapid climate change.

关键词： drought duration drought propagation climate change humidification Yellow River Basin CMIP6

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Comparative DNA methylation reveals epigenetic adaptation to high altitude in snub-nosed monkeys

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Zoological Research 2024年第5期45卷 1013-1026页

作者： Ling Wang Wei-Qiang Liu juan Du Meng Li Rui-feng Wu Ming Li Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

DNA methylation plays a crucial role in environmental ***,using whole-genome bisulfite sequencing,we generated comprehensive genome-wide DNA methylation profiles for the high-altitude Yunnan snub-nosed monkey(Rhinopithecus bieti)and the closely related golden snub-nosed monkey(***).Our findings indicated a slight increase in overall DNA methylation levels in golden snub-nosed monkeys compared to Yunnan snub-nosed monkeys,suggesting a higher prevalence of hypermethylated genomic regions in the *** genomic methylation analysis demonstrated that genes associated with differentially methylated regions were involved in membrane fusion,vesicular formation and trafficking,hemoglobin function,cell cycle regulation,and neuronal *** results suggest that the high-altitude-related epigenetic modifications are extensive,involving a complete adaptation process from the inhibition of single Ca^(2+)channel proteins to multiple proteins collaboratively enhancing vesicular function or inhibiting cell differentiation and *** assays demonstrated that overexpression or down-regulation of candidate genes,such as SNX10,TIMELESS,and CACYBP,influenced cell viability under stress ***,this research suggests that comparing DNA methylation across closely related species can identify novel candidate genomic regions and genes associated with local adaptations,thereby deepening our understanding of the mechanisms underlying environmental adaptations.

关键词： Snub-nosed monkeys Whole-genome bisulfite sequencing DNA methylation High-altitude adaptation

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Allosteric regulation of Keap1 by 8b-hydroxy-acyclocostunolide for the treatment of acute lung injury

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4174-4178页

作者： juan Zhang Min Zhang Qi-Meng Zhu Xin-Rong Xu Yan-Li feng Sheng Lin feng Qiu Cheng-Peng Sun School of Chinese Materia Medic1 Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

To the Editor:Acute lung injury(ALI)is a debilitating lung disease characterized by pulmonary edema,diffuse alveolar damage,and uncontrolled neutrophil *** cases of ALI can potentially lead to the development of acute respiratory distress syndrome(ARDS),which can lead to impaired respiratory function,multiorgan dysfunction,and an extremely high mortality *** may be caused by various factors,including aspiration,severe pneumonia,sepsis,trauma,fatty embolism,pancreatitis,and blood *** clinical approaches to treating ALI/ARDS include mechanical ventilation,extracorporeal membrane oxygenation(ECMO),and other supportive therapies5,***,ALI/ARDS is an urgent problem that needs to be addressed in the field of respiratory critical care and innovative mechanisms and therapies6.

关键词： Macrophage overactivation Keap1 8b-Hydroxy-a-cyclocostunolide Nrf2 Acute lung injury

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