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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 74-79页

作者： Chao Zhang Ya-Ping Tian Yue Wang feng-hua guo Jun-Fang Qin Hong Ni Tianjin Medical University General Hospital Department of Clinical Biochemistry General Hospital of PLA Nankai University College of Medicine

BACKGROUND:The human telomerase reverse transcriptase(hTERT) gene encodes the catalytic subunit of telomerase,which mediates pleiotropic effects,including the regulation of senescence and proliferation and plays an important role in *** study attempts to clarify the genetic predisposition to hepatocellular carcinoma(HCC),focusing on the hTERT gene rs2736098 ***:Four hundred patients with HCC and 400 noncancer controls were genotyped to elucidate the potential association between hTERT rs2736098 polymorphism and HCC ***:Compared with the controls,the patients with HCC had a lower frequency of G/G genotype(33.3% vs 44.3%,P=0.001) and a higher frequency of G/A(51.5% vs 39.5%,P=0.001).Allele genotypic frequencies in the patients differed from those of the controls(P=0.040).The data of this study rs2736098[A] allele contributed significantly to HCC risk in female patients(OR=1.78,95% CI,1.17-2.72,P=0.007),patients with HCV infection(OR=2.89,95% CI,1.08-7.70,P=0.031),non-drinker patients(OR=1.32,95% CI,1.06-1.65,P=0.015),and patients not affected by HBV(OR=1.77,95% CI,1.30-2.40,P<0.001).CONCLUSIONS:rs2736098[A] may be an independent hereditary parameter in HCC,but some risk factors would cover up the association by more powerful *** results are important guidance for further studies in detecting HCC-associated single nucleotide polymorphisms.

关键词： human telomerase reverse transcriptase single nucleotide polymorphism hepatocarcinogenesis hereditary susceptibility

Cross-reactivity of anti-H pylori antibodies with membrane antigens of human erythrocytes

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World Journal of Gastroenterology 2007年第27期13卷 3742-3746页

作者： feng-hua guo Xiao-Mei Yan Chun-Xiang Fan Fei Zhao Yuan Hu Di Xiao Xun Zeng Mao-Jun Zhang Li-hua He Fan-Ling Meng Jian-Zhong Zhang National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention PO Box 5 Changping Beijing 102206 China

AIM： To investigate whether anti-H pylori antibodies have cross-reaction with antigens of erythrocyte membrane. METHODS： Blood samples were collected from 14 volunteers （8 positive and 6 negative for Hpylori detected by ^13C-urea breath test） of the general population. Erythrocyte membrane proteins of the subjects were examined by Western blot using anti-H pylori serum. The proteins related to the positive bands were identified by mass spectrum analysis. RESULTS： Anti-Hpylori antibodies had cross-reaction with the proteins of about 50 kDa of erythrocyte membranes in all samples independent of H pylori infection. One protein in the positive band was identified as Chain S, the crystal structure of the cytoplasmic domain of human erythrocyte Band-3 protein. CONCLUSION： Anti-HpyloH antibodies cross-react with some antigens of human erythrocyte membrane, which may provide a clue for the relationship between Hpylori infection and vascular disorders.

关键词： H pylori Antibodies Erythrocyte Crossreactivity

HIV incidence among men who have sex with men using geosocial networking smartphone application in Beijing, China: an open cohort study

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Infectious Diseases of Poverty 2021年第2期10卷 14-24页

作者： guo-Dong Mi Bin-Bin Zhang Fei Yu Xian-Long Ren Jason JOng Ya-Qi Fan feng-hua guo Chun-Jun Li Mian-Zhi Zhang Min-Ying Zhang Danlan Beijing Media Limited BeijingChina School of Medicine Nankai University94Weijin RoadTianjin 300071China Beijing Center for Diseases Control and Prevention BeijingChina Central Clinical School Monash UniversityMelbourneAustralia Departm ent of Clinical Research London School of Hygiene and Tropical MedicineLondonU K. Tianjin People's 2Hospital TianjinChina Dongfang Hospital Beijing University of Chinese MedicineBeijingChina.

Background:Sexual transmission among men who have sex with men(MSM)is the dominant route of HIV transmission in *** use of geosocial networking(GSN)smartphone application(app)has dramatically changed the pattern of sexual behaviors and HIV risk among MSM;but data on HIV incidence and the changing risk behaviors of GSN app-using MSM are *** aims to assess the HIV incidence and its correlates among gay GSN app-using MSM in ***:We constructed an open cohort which was initiated and maintained using a GSN app to assess the HIV incidence among app-using MSM,recruited from June 2017 to December *** completed an online questionnaire on their sociodemographic characteristics,sexual behaviors,recreational drug use and sexually transmitted infections *** each man had an HIV test,and those tested negatives were enrolled into the *** completed follow-ups with additional HIV tests though the app during the study period,and were censored at HIV seroconversion or study end *** incidence was calculated by dividing the sum of observed HIV seroconversions by the observed ***(Chi-square test and Fisher's exact test)and multivariate(proportional hazards regression)analyses were used to examine correlates of HIV ***:A total of 6957 HIV negative MSM were enrolled in the open cohort,37 seroconversions occurred among 1937 men contributing 1065 observed person-years:HIV incidence was 3.47 per 100 person-years[95%confidence interval(Cl):2.37-4.57].More than five sexual partners[hazard ratio(HR)=2.65,95%Cl:1.04-6.67],and sex with HIV positive partners(HR=3.82,95%Cl:1.16-12.64)in the preceding six months were positively associated with HIV *** condom use for anal sex(HR=0.27,95%Cl:0.07-0.96),and reporting insertive anal sex only(HR=0.23,95%Cl:0.08-0.62)in the preceding six months were protective factors for HIV ***:Tailored interventions targeting app-usin

关键词： Men who have sex with men Geosocial networking application HIV Incidence Sexual risk behavior

Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

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World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： hua Bai Xiao-feng feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,Lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

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使用多光谱手段研究熔石英断裂机理

光谱学与光谱分析 2017年第11期37卷 3327-3331页

作者：胡锐峰韩敬华冯国英韩伟朱启华王竹萍古琼琼四川大学电子信息学院四川成都610064 中国工程物理研究院激光聚变研究中心四川绵阳621900

熔石英玻璃是高能激光系统中不可缺少的光学材料,其损伤问题一直是限制系统能量提升的瓶颈之一。通过纳秒激光脉冲诱导熔石英玻璃样品产生断裂,并使用多光谱手段对断裂前后样品进行检测,从而在实验和理论上了解了样品断裂形貌及内部相... 详细信息

熔石英玻璃是高能激光系统中不可缺少的光学材料,其损伤问题一直是限制系统能量提升的瓶颈之一。通过纳秒激光脉冲诱导熔石英玻璃样品产生断裂,并使用多光谱手段对断裂前后样品进行检测,从而在实验和理论上了解了样品断裂形貌及内部相变结构成因,并从宏观到微观上统一解释了断裂形貌和相变结构的关系。在激光等离子冲击波作用下,熔石英发生断裂,且冲击波作用过程中在玻璃内部产生了推动裂纹扩展的尖端环向应力。在尖端环向应力作用下,不同损伤区域形成了不同扩展速度和长度的裂纹,按照裂纹形貌特性差异可以将断裂区分为雾化区、羽毛区、镜面区三个部分。使用透射光谱、能量散射光谱检测损伤前后样品,发现裂纹的产生引起了玻璃透过率和带隙的下降,且断裂区出现氧原子游离或缺失;使用Raman光谱检测样品损伤前后不同形貌区,发现等离子冲击波使熔石英中Si—O—Si键断裂并发生重组,导致镜面区、羽毛区、雾化区三元拓扑环和四元拓扑环宏观上对应的斯石英相和柯石英相的相对含量依次升高,破坏了材料的固有原子结构特性,使材料断裂区向高密度相转变。氧游离的发生会在玻璃内部产生的大量缺陷,从而使得玻璃透过率及带隙下降,严重影响了玻璃的性能。

关键词：熔石英玻璃激光诱导损伤相变拉曼光谱

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基于加权最小二乘法的多舰定位算法

北京理工大学学报 2005年第11期25卷 971-974页

作者：倪忠德冯国华马宝华北京理工大学机电工程学院北京100081 中船工业集团船舶系统工程部北京100036

针对双舰定位存在的定位态势要求高、定位精度低等,提出了基于加权最小二乘法的多舰定位算法.该算法的实质是基于多舰侦察设备的测向角度、位置信息,利用纯方位交叉定位原理,建立非线性观测方程;通过泰勒展开将非线性系统转化为线性系统... 详细信息

针对双舰定位存在的定位态势要求高、定位精度低等,提出了基于加权最小二乘法的多舰定位算法.该算法的实质是基于多舰侦察设备的测向角度、位置信息,利用纯方位交叉定位原理,建立非线性观测方程;通过泰勒展开将非线性系统转化为线性系统;利用最小二乘原理并考虑测向精度的权重因素,提出了多舰的定位模型.仿真结果表明,定位结果与测向精度和初始态势有关.

关键词：最小二乘法定位多舰定位

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期 272-283页

作者： Yuwei hua Yizhi Zhang Zhenming guo Shan Bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

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十大孔兑综合治理与黄河内蒙古段度汛安全

中国水土保持 2008年第4期 8-10页

作者：冯国华张庆琼内蒙古自治区水利厅内蒙古呼和浩特010020

十大孔兑是黄河内蒙古段由南向北汇流的10条相邻的一级支流,多年平均向黄河输沙2 711万t,近年来向黄河输沙呈增加态势,洪水泥沙对黄河及下游造成了极大的危害。针对十大孔兑泥沙来源于上中游的特点,应在孔兑上游实施沟道、坡面综合治理... 详细信息

十大孔兑是黄河内蒙古段由南向北汇流的10条相邻的一级支流,多年平均向黄河输沙2 711万t,近年来向黄河输沙呈增加态势,洪水泥沙对黄河及下游造成了极大的危害。针对十大孔兑泥沙来源于上中游的特点,应在孔兑上游实施沟道、坡面综合治理工程,在孔兑中游进行防沙治沙,在孔兑中下游引洪澄地,缓洪减沙,保障黄河内蒙古段的度汛安全。

关键词：水土流失综合治理十大孔兑黄河内蒙古段

基于LSB检测的JPEG隐写分析特征增强方法

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应用科学学报 2016年第6期34卷 670-676页

作者：郑国华冯国瑞余江程航张新鹏上海大学通信与信息工程学院上海200444

隐写分析构造共生矩阵特征时因截断而导致部分信息丢失,于是提出基于DCT系数最低有效位面的特征扩展方法,增加对截断处嵌入信息的描述.对DCT系数平面取模生成最低有效位平面,通过统计相邻位置的取值,生成二阶、三阶共生矩阵.为进一步增... 详细信息

隐写分析构造共生矩阵特征时因截断而导致部分信息丢失,于是提出基于DCT系数最低有效位面的特征扩展方法,增加对截断处嵌入信息的描述.对DCT系数平面取模生成最低有效位平面,通过统计相邻位置的取值,生成二阶、三阶共生矩阵.为进一步增强特征的性能,引入Zigzag扫描,获得重新排列的DCT系数平面,在此基础上提取相应特征.通过上述方法,在原有LIU特征的基础上构造508维特征.结果表明,在对抗DCT系数最低有效位嵌入的隐写中,所提方法能有效提高对隐写图像的检测率.

关键词： JPEG隐写分析 LSB平面 Zigzag扫描

Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang guo Di Lan Zirui Jia Zhenguo Gao Xuetao Shi Mukun He hua guo Guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection