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Punicalagin protects bovine endometrial epithelial cells against lipopolysaccharide-induced inflammatory injury

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第6期18卷 481-491页

作者： An LYU Jia-jia CHEN Hui-chuan WANG Xiao-hong YU Zhi-cong ZHANG Ping GONG Lin-shu JIANG feng-hua liu Beijing Key Laboratory for Dairy Cow Nutrition College of Animal Science and TechnologyBeijing University of AgricultureBeijing 102206China

Objective：Bovine endometritis is one of the most common reproductive disorders in *** aim of this study was to investigate the anti-inflammation potential of punicalagin in lipopolysaccharide（LPS）-induced bovine endometrial epithelial cells（bE ECs）and to uncover the underlying ***：bE ECs were stimulated with different concentrations（1,10,30,50,and 100μg/ml）of LPS for 3,6,9,12,and 18 *** assay was used to assess cell viability and to identify the conditions for inflammatory injury and effective concentrations of *** real-time polymerase chain reaction（q RT-PCR）was used to assess gene expression of pro-inflammatory *** blotting was used to assess levels of inflammation-related ***：Treatment of b EECs with 30μg/ml LPS for 12 h induced cell injury and reduced cell ***（5,10,or 20μg/ml）pretreatment significantly decreased LPS-induced productions of interleukin（IL）-1β,IL-6,IL-8,and tumor necrosis factor-α（TNF-α）in bE *** research showed that punicalagin inhibited the activation of the upstream mediator nuclear factor-κB（NF-κB）by suppressing the production of inhibitorκBα（IκBα）and phosphorylation of *** also indicated that punicalagin can suppress the phosphorylation of mitogen-activated protein kinases（MAPKs）including p38,c-Jun N-terminal kinase（JNK）,and extracellular signal-regulated kinase（ERK）.Conclusions：Punicalagin may attenuate LPS-induced inflammatory injury and provide a potential option for the treatment of dairy cows with Escherichia coli endometritis.

关键词： Bovine endometrial epithelial cell Cytokine Inflammatory injury Punicalagin

The optimal choice of chemotherapy regimens for patients with relapsed platinum-resistant epithelial ovarian cancer/primary peritoneal/fallopian tube cancer - protocol for a systematic review and network meta-analysis

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TMR Integrative Medicine 2017年第1期1卷 30-36页

作者： feng-hua liu Xiao-Li Zhou Hui-Ting Xiao Jin-Hui Tian Quan Hao Yong Tang National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Medical University Cancer institute and hospital Tianjin China Tianjin center for disease control and prevention Tianjin Medical University Cancer institute and hospital Tianjin China Department of gynecology Cancer TianjinMedical University Cancer institute and hospital Tianjin China Evidence-Based Medicine Center School ofBasic Medical Sciences Lanzhou University Lanzhou China Department of pancreatic cancer Tianjin MedicalUniversity Cancer institute and hospital Tianjin China

Objective： Debulking surgery （residual disease of less than 1 cm） followed by platinum-taxane chemotherapy isthe current standard therapy for patients with epithelial ovarian cancer, primary peritoneal carcinoma and primaryfallopian cancer. But the prognosis remains poor. Several chemotherapy regimens could be selected for patientswith recrudescent cancer. However, the standard second chemotherapy regimen remains a subject of debate. Thepurpose of our study is to carry out a systematic review and network meta-analysis to compare the efficacy andsafety of different regimens for recurrent platinum-resistant ovarian cancer based on existing randomized controlledtrials （RCTs）. Methods and analysis： Medline, EMBASE, Cochrane Library and Cochrane Library databases,Science Citation Index Expanded, Conference Proceedings Citation Index-Science and *** will besystematically searched for eligible studies. Randomized controlled trials （RCT） on chemotherapy, immune therapy,biological therapy, targeted therapy for recurrent platinum-resistant ovarian cancer with multiple outcome measureswill be included. The Cochrane Risk of Bias Tool will be used to assess the quality of included studies. The primaryoutcomes are overall survival and median survival time. The secondary outcomes include the safety and side effectsof these regimens. Direct meta-analysis and network meta-analysis （NMA） will be conducted to compare differentregimens. Conclusion： The results of this network meta-analysis will provide direct and indirect evidence oftreatments for recurrent platinum-resistant ovarian cancer, and it may provide a ranking of the chemotherapyregimens for patients and gynecological oncologists to help them select the best option.

关键词： Epithelial ovarian cancer Chemotherapy Network meta-analysis Protocol

Magnolol pretreatment attenuates heat stress-induced IEC-6 cell injury

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第6期17卷 413-424页

作者： Chen MEI Sha-sha HE Peng YIN Lei XU Ya-ran SHI Xiao-hong YU An LYU feng-hua liu Lin-shu JIANG Beijing Key Laboratory for Dairy Cow Nutrition College of Animal Science and Technology Beijing University of Agriculture College of Veterinary Medicine China Agricultural University (CAU)

Objective： Heat stress （HS） is an important environmental stressor that adversely influences livestock during the summer. The aim of this study was to investigate whether magnolol protects against HS-induced intestinal epithelial cell injury. Materials and methods： An intestinal epithelial cell line （IEC-6） was subjected to HS at 42℃, with and without magnolol pretreatment. Cell injury was detected by monitoring lactate dehydrogenase （LDH） release. MTS （3-（4,5-dimethyithiazol-2-yl）-5-（3-carboxymethoxyphenyl）-2-（4-sulfophenyl）-2H-tetrazolium） assay was used to as- sess cell proliferation and viability, including identifying effective concentrations of magnolol. Flow cytometry confirmed Gl-phase cell-cycle arrest and its alleviation by magnolol. Active DNA synthesis was measured by incorporation of nucleic acid 5-ethynyl-2＇-deoxyuridine （EdU）. Gl-phase cell-cycle-related gene expression was assessed by real-time reverse transcription polymerase chain reaction （RT-PCR） and levels of Gl-phase-related proteins by Western blotting Results： HS induced IEC-6 cell injury and decreased cell viability, as demonstrated by data from LDH and MTS assays respectively. Based on a number of criteria, IEC-6 cells subjected to HS were arrested in the G1 phase Of the cell cycle. Magnolol pretreatment decreased HS-induced cell injury through relief of this cell-cycle arrest. Conclusions： Magnolol pretreatment attenuates HS-induced injury in IEC-6 cells. Magnolol is potentially promising as a protective strategy for HS in livestock.

关键词： Cell-cycle arrest Cell injury Heat stress IEC-6 cell line Magnolol

Yimu San improves obstetric ability of pregnant mice by increasing serum oxytocin levels and connexin 43 expression in uterine smooth muscle

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第11期18卷 986-993页

作者： Qi-huan WANG Shuang ZHANG Li-meng QIN Wen-jun ZHANG feng-hua liu Jian-qin XU Yun-fei MA Ke-dao TENG College of Veterinary Medicine China Agricultural University College of Animal Science and Technology Beijing University of Agriculture

Prolonged farrowing remains one of the critical challenges in intensive pig farming. This study aims to explore the effects and mechanism of Yimu San （YMS）, a Chinese veterinary medicine micro mist, on delivery ability with mouse models. Thirty-two pregnant mice were randomly divided into a control group and Iow-YMS, med-YMS, and high-YMS groups. The labor process time and stillbirth rate were recorded, the levels of serum oxytocin and prostaglandin E2 （PGE2） were measured with enzyme-linked immunosorbent assay （ELISA）. Contractility measure- ments of the isolated uterus and the expression of connexin 43 （Cx43） in uterine smooth muscle were evaluated. The results showed that compared with the control group, the birth process time and stillbirth rate in the med-YMS and high-YMS groups were remarkably lower. The in vitro uterine contractions, levels of oxytocin, PGE2, and Cx43 in the med-YMS and high-YMS groups were significantly higher than those in the control group. The differences of the above measurements between the Iow-YMS group and the control group were not obvious. It can be speculated that YMS could significantly promote labor in pregnant mice by enhancing the levels of oxytocin, Cx43, and PGE2.

关键词： Yimu San Delivery ability Uterine contraction Oxytocin Prostaglandin 52 Connexin 43

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian feng hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

Synthesis and Characterization of Unsymmetrical (10,11), (26,27)- Dimide-2,19-disulfonic acid Phthalocyanine Zinc Dipotassium Salt

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有机化学 2003年第Z1期23卷 71-71页

作者： PENG Yi-Ru LIN Zhi-Peng huaNG feng-hua liu Li-Zheng Institution of Chemistry & Materials Fujian Normal Unversity Fuzhou 350007 Institution of Chemistry & Materials Fujian Normal Unversity Fuzhou 350007 Institution of Chemistry & Materials Fujian Normal Unversity Fuzhou 350007 Institution of Chemistry & Materials Fujian Normal Unversity Fuzhou 350007

　　Metallophthalocyanines (MPcs) are generally obtained by templated reaction using metal salts and aromatic ortho-dinitrile or dicarboxylic anhyrides. [1] Published routes for preparing amphiphilic phthalocyanine mostly involve one of two methods: "in a plot" reaction and in situ reaction, [2] i. e. condensation of two different substituted precursors in appropriate statistical rate. The first method unavoidably leads to a product with much more complicated mixture, so that it needs tedious separation. While the second method in which the synthesis of amphiphilic phthalocyine is performed by mixed condensation of two types of precursors (hydrophic and lipophilic) which differ substantially in their physical properties and reactivities require arduously selection of optimal reaction conditions.……

关键词： physical properties in situ reaction selection of

Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

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World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： hua Bai Xiao-feng feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,Lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

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响应面分析法优化芋头多糖的脱色工艺

食品研究与开发 2018年第16期39卷 115-120页

作者：都凤华刘楠楠吉林农业大学食品科学与工程学院吉林长春130118

为研究芋头多糖的脱色工艺条件,以多糖脱色率和多糖保留率为考察指标,比较柱状活性炭、颗粒活性炭、白陶土3种脱色剂的脱色效果,确定最优脱色剂,并通过单因素和响应面试验,优化脱色条件。结果表明,白陶土脱色效果优于其他两种脱色剂。... 详细信息

为研究芋头多糖的脱色工艺条件,以多糖脱色率和多糖保留率为考察指标,比较柱状活性炭、颗粒活性炭、白陶土3种脱色剂的脱色效果,确定最优脱色剂,并通过单因素和响应面试验,优化脱色条件。结果表明,白陶土脱色效果优于其他两种脱色剂。以白陶土作为芋头多糖的脱色剂,其最佳工艺条件为:白陶土添加量5.8%,脱色温度50℃,脱色时间27.5 min,在最佳工艺下,多糖脱色率为87.66%,而多糖保留率可达96.98%。

关键词：芋头多糖脱色工艺白陶土响应面法

一种车辆模型辅助的MEMS-SINS导航方法

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中国惯性技术学报 2017年第2期25卷 209-215页

作者：王美玲冯国强李亚峰于华超刘彤北京理工大学自动化学院北京100081

针对城市环境中GNSS因遮挡导致MEMS-SINS精度快速降低的问题,在车辆运动学约束的基础上,结合四通道ABS轮速传感器和方向盘转角信息,提出一种新的适用于陆地车辆的MEMS-SINS导航方法。该方法通过分析车辆转弯和运动约束特性,构建角速度... 详细信息

针对城市环境中GNSS因遮挡导致MEMS-SINS精度快速降低的问题,在车辆运动学约束的基础上,结合四通道ABS轮速传感器和方向盘转角信息,提出一种新的适用于陆地车辆的MEMS-SINS导航方法。该方法通过分析车辆转弯和运动约束特性,构建角速度和加速度观测量,从而实现基于模型辅助的MEMS误差在线补偿;其次,ABS轮速信息与非完整约束条件结合可额外增加三维车体速度观测量,进一步维持卫星失效时组合滤波器的量测更新。跑车实验表明,在GNSS信号频繁丢失甚至长时间无法定位时,低精度MEMS惯性器件引起的快速误差积累得到有效抑制,与经典车体约束结合里程计算法相比,航向精度提高约70%,位置、速度精度也有相应的提高,验证了算法的有效性。

关键词： MEMS-SINS ABS轮速传感器运动学约束模型辅助